Hi,
I wanna start off by saying that its important you consult with your doctor, im not a medical proffesional by any means.
So here is my story, I first started getting CU symptoms back in May 2021, when the temperature got increasingly hotter here in Norway. I was in extreme, untolerable itching and stinging pain whole summer, it was very hard to leave my house and stay outside in the heat, I had to have AC running at home 24/7, and luckily could stay in the car with AC on when I needed to go somewhere.
I tried going on H1 Cetirizine for a month, 2 morning and 2 evening, they didnt help at all.
Then I went and saw a dermatologist which suggested me to try desloratadine pills, first for 2 weeks, 2 morning and 2 evening, see if it helps, and then at least for 2-3 months until we can draw any further conclusions.
So thats what I did, and after 3-4 days I was shocked to find out that they actually provided relief, the condition isnt as severe anymore, and the pain has definitely been reduced.
Nowadays I still get the stinging reactions when I get warm after a long and intense walk for example, but they are nowhere near as painful as they were before, and as soon as i sit down they disappear very fast.
Before the pills the only relief for me was to apply something cold to my skin, or jump in the shower, now I dont need that anymore.
An important note that the dermatologist mentioned to me was that its very important to give antihistamines time, to stick to the schedule, before we draw any conclusions wether they help us or not.
Im still on schedule until mid-March for the 3 months period to end, and then will see what to do further. Im also quite curious how this summer is going to turn out. If it gets unmanageable I might consider going for Xolair.
I also had a couple of psychologist sessions, and started meditating daily using the Headspace app because of this condition. I highly recommend you giving it a try and seeing if it helps you, I can definitely say that I learned a lot and get a more positive day start nowadays.
I hope some of you find this helpful, and please feel free to discuss it with your medical professional.
According to the Asthma and Allergy Foundation of America, approximately 7.7 percent of adults and 7.2 percent of children experience symptoms of allergic rhinitis, commonly known as hay fever.
For these individuals, relief from symptoms may require the use of a medication to control allergy symptoms. Desloratadine is one of many allergy medications on the market that may be able to help.
What Is Desloratadine?
Desloratadine is a medication that belongs to a class of drugs called antihistamines, which are commonly used for the treatment of allergy symptoms. Desloratadine is the active ingredient in the brand-name drug Clarinex, and it is also sold as a generic medication. Desloratadine was first approved under the brand name Clarinex in 2001.
There are two generations of antihistamines that are commonly used for the treatment of allergies: first-generation antihistamines and second-generation antihistamines. First-generation antihistamines include medications like diphenhydramine, the active ingredient in Benadryl.
Medications in this generation work quickly to treat acute allergy symptoms but are commonly associated with more sedating side effects than second-generation antihistamines. First-generation antihistamines are commonly associated with more drowsiness and sedation because they easily cross the blood-brain barrier.
Due to the tendency of these drugs to cause significant side effects, researchers began working to develop second-generation antihistamines. These drugs do not cross the blood-brain barrier as easily as first-generation antihistamines and thus, they are associated with fewer side effects than first-generation antihistamines. Desloratadine is considered a second-generation antihistamine.
What Is Desloratadine Used To Treat?
Antihistamines like desloratadine are commonly used to treat allergic reactions. However, not all types of antihistamines are used to treat all types of allergic reactions.
Desloratadine is most commonly used to treat allergy symptoms that affect the nasal passages and sinuses, including symptoms of allergic rhinitis. Symptoms of allergic rhinitis commonly include nasal congestion, sneezing, runny nose, and itchy or watery eyes.
Desloratadine is also commonly used for the treatment of an allergic reaction called urticaria
... keep reading on reddit ➡
Final Edit:
Everything below is pretty much an assault of anecdotal observances and hasty guesses, that don't confirm any part of the title of this post. Please do not read into it too deeply. I am going to leave it all up, however, because it pretty accurately shows the evolution of my thought process, my anxieties, and eventual abandonment of the original concept.
I don't believe this post adheres to enough scientific rigor to be taken very seriously, but I do believe it serves as a good example of the dangers of assumptions and a haste to jump to conclusions.
I am left with various curiosities that I will chase out in my own time, slowly and thoroughly, while spending time to search through the literature thoroughly as well.
Thank you all for listening to my rambles, and like I said -- I only hope that this wall of text serves as an illustration of my thought process, and that the flaws in my logic can stay on display for others to learn from as well.
My key take-aways from the entire experience have been:
Desloratadine's strange pharmacological profile (variety of enzymatic inhibition, TCA structure, etc)
Anti-histamine's possible interactions with Nicotine (anecdotal personal experience from myself and another redditor, and this single study from 1985)
A desire to learn more about glutamate and histamine linkage
.....and the knowledge that, as much as I love it, it's probably time to stop smoking cigarettes.
--------------------------------------------------------------------
EDIT: I should note, I am not asking for advice/medical advice at all. I am simply sharing the detailed series of events that lead to me digging a bit deeper into glutamate and the aforementioned compounds.
EDIT #2: I forgot to mention that I had been regularly applying triamcinolone (synthetic steriod) cream during these times. Not on ambulance day, but on the days after that (Rx'd for my worsening contact dermatitis). Turns out, desloratadine moderately inhibits some enzymes that are responsible for the urinary excretion of a variety of compounds, such as steroids, drugs...read the list here on the wiki.
Updates @ the bottom.
Hey y'all!
I am by no means a professional, and all of my limited knowledge of pharmacology is purely what I have managed to amass via reading through pharma literature in my spare time. I love
... keep reading on reddit ➡Due to severe allergies I usually take 10 mg of desloratadine where the normal dosage is 5mg. Never had any side effects. Today my allergies where worse than usual and I took 15mg. I quite a heavy guy but I still don't know if I should be worried. Any advice?
So I share my medication with you because for the last 2 weeks I am without any symptoms afer having a bad, if not the worst allergy season this spring to early summer. I used Cetirizine and Loratadine in phases but still suffered immensly.
So after some research in this sub (thanks guys) I decided to order some Desloratadine and Beclometasone nasal spray and started this medication experiment. I take 1 Desloratadine in the evening (5 mg) and use the nasal spray once a day as it is recommended.
I can't tell if one medication is giving more allevation than the other but I am just happy that my symptoms have ceased this effectively.
I will definetly use this medication in the next season and start earlier. I hope this helps some of you guys as much as it helped me. Take care of yourselfes.
So I was put on desloratadine a little less than 6 months ago and I feel like I’ve developed a lot of heartburn and indigestion. The last week or so has been awful. Maybe it’s unrelated and caused by something else (birth control, covid vaccine, idk) but I’m wondering if anyone else has experienced the same thing?
Hi everyone, I just moved to a new country and have gotten absolutely slammed by spring allergies. I was fine until the beginning of this week then suddenly I've had some issues with a runny nose, nasal pressure, a tight chest, and some fatigue. I hate taking pharmaceuticals due to the side effects I usually deal with but thought it was necessary due to how bad the allergies have affected me.
I've taken 5mg of Aerius (Desloratadine) for the last two nights before bed and I wake up feeling a bit groggy and am having loose stool (maybe not related, but thought I'd mention it). Most of the day I think it helps the allergy symptoms, but I can feel a little achy and tired and nauseous, so that seems to be the trade-off at this point. Not sure what is worse, tbh, I guess whichever one I'm experiencing at the time :) Do you find that side effects go away within a few days or it is what it is from the get-go?
Regarding moving to a new country, do you have any tips on how to stay ahead of new pollen allergies? I'm following the pollen count online and doing the whole "indoor/outdoor" clothing thing, plus showering before bed, and will try to eat some local honey as some say that is a holistic solution. Do you try to expose yourself to allergens somewhat so your body can try to adapt or just avoid going outside completely?
Thanks in advance!
After the crash I had with the anthistaminic chlorphenamine (that was actually a real SSRI) a few years ago, I study every possible drug that I have to take, specially anthistaminics, as some of them are true ''unlabeled' ' SSRI'S.
I was prescribed desloratadine, another anthistaminic and the only thing I can find about it is that it is muscarinic acetycholine receptors antagonist, does this represents any danger to PSSD? It's supposed to be similar to loratadine, but loratadine is not muscarinic antagonist as far as I've read. Loratadine is beneficial for PSSD in my case.
I don't want to screw everything again.
I would appreciate any opinions.
Thanks.
I had a weird interaction with my gp’s assistant today. About three years ago I got a prescription for desloratadine 5mg with a dose of 1-4 tablets a day (together with nasal spray and eyedrops). I got a new gp now since I moved places and she was surprised I had such a high dose but still send the order to the pharmacy.
This kinda spooked me and a quick google showed that it’s quite uncommon to prescribe such a high dose, especially for hayfever. Do any of you have a similar high dose or is this abnormal? In other words, should I go with the original prescription or make a new appointment to change meds schedule etc?
The meds work well (except for fatigue, I don’t do too much during hayfever season) but im mostly worried it creates a negative spiral which means I would need to keep upping the dosis each year. For reference, I’m located in the Netherlands.
Hello! I have an important question. Can usage of antihistamines - desloratadine (Aerius) have a bad affect on my TSW healing journey? I'm 10 months in. And now I started having some allergies (pollen), because summer is starting where I live. My nose and throat are itchy and I am sneezing. I would like to help myself, because already TSW is all over my body and this is already uncomfortable enough, i don't need the extra itching and sneezing and feeling like i'm sick. I wonder if and of you have any advice or experiences with this particilar antihistamine and its effects on TSW? This is the one i got perscribed. I have already used it years ago for my allergies and I remember it kinda helped. (blue tablets) Would be very very happy to hear some thoughts! :)
So I wrote here about a week ago about the allergy symptoms I've been experiencing recently. Usually my allergies last a couple of weeks and I don't even take a pill it's so mild. This time since I'm dealing with new pollens due to the new location I'm in, and I think its made allergies that were sort of a non-issue into something troublesome.
Aerius seems to have tamped off the runny nose, fatigue, and little bit of congestion I was dealing with. Now what's left is my least favorite symptom: this randomly occurring tightness behind my breastbone that turns into a constricting feeling that makes it harder to breathe.
It's not so bad that I'm fearful for passing out or anything, and it's usually short-lived (it helps if I go take a couple snorts off my OTC nasal spray bottle) but I do not like it. I find that right before I seem to feel a bit cold/uncomfortable, get a tightness in my sinuses at the top of my nose, and have a somewhat raspy feeling throat, then the chest tightness kicks in.
I've thought that maybe it's an anxiety thing, as the brain works in mysterious ways. But I feel pretty chilled out before it happens, generally. I also thought it might be an issue with sitting at my desk with less than great posture.
Any words of advice?
19F, 148cm, 48kg.
Hi, I’ve been on Aerius for almost a year now. I started the medication last Dec and it’s on a “take when necessary” basis, and one pill max daily.
My allergies are towards Dog, Cat, and three different type of dust mites. I’ve always known that I’m “sensitive” towards dogs, despite growing up with lots of dogs, but it seemed to be an “adult onset” case as I never had any problems as a kid, I’ve only decided to get checked because of the one time incident when I went on a camp. I felt strange the moment I enter the dorms, and later it felt as if I’m choking and I couldn’t breathe properly. My throat still feels weird after I return home and things only went back to normal after 3days away from camp, which is about 6days since first reaction. I went to my allergist and got checked and was prescribed Aerius and a nasal spray. Both of them work wonders and I’m able to do what I want without worrying about my allergies acting up.
One thing I’ve noticed ever since I started was that I get tired easily, it was so bad that I fell asleep in classes. I’ve begin to time the duration between when I take the pill and when I first feel tired, it usually is about 12hours, 13 at max. Back then, my classes starts at 8am and goes all day until 5pm, I leave my house at 7am, so I prep myself and take my pills at 6.30-6.45am. So when the 12hour mark hits, I’m usually on the commute, super tired and constantly forcing myself to stay awake.
The 12-hour mark only applies to the lone days when I take the pills, meaning I don’t take it the day after or before, or within the same week. If I were to take the pills on consecutive days, I felt tired earlier than 12hours, and the tiredness is much worse. It also cause lingering tiredness if I take the pills more than once a week. On a bad day, my maximum functioning hour is 8hours.
I told my allergist about it, since I doesn’t really need it as frequently, he told me it’s okay for the moment and that I shall plan my day around the 12hour if I need to take the pill. I was supposed to have an appointment early April but I had to cancel and it was postponed indefinitely due to COVID-19.
To be honest, it doesn’t really affect my day to day since I can plan things around it, and I don’t take it that much, only once a week and sometimes once a fortnight. I’m just super concerned because it wasn’t supposed to cause tiredness, at least not to my knowledge.
I will talk to my allergist again when I get to visit aft
... keep reading on reddit ➡I have started to take Escilatopram (Lexapro) 20mh for about 50 days now. I have a polen allergy and I usually take Desloratadine to help me with the symptoms. I have forgotten to ask my psychiatrist if I can mix those medications. Please if someone could help me and tell me if I am allowed to do that. I’m having a hard time with the Lexapro side effects and don’t want to make it worse. Thank you!!
Hey, has anyone tried desloratadine? It is supposed to have mast cell stabilizing properties.
Desloratadine inhibit manganese from entering the cell walls of Borrelia, so i was wondering if anyone have tried using it, and if it has had any positive outcomes.
I increased the dose and ate 25 mg after masturbating in the evening. My symptoms were way better. Also took additional 25 mg next morning and 10 mg in the evening.
How much antihistamines do you take?
