How do we assign point groups to anything in a meaningful way if different conformational isomers would be assigned to different point groups?

Just off the top of my head, hydrogen peroxide would lose it's C2 axis of rotation if it's in any conformation except 'anti-periplanar' if that even makes sense to call it that, like a Z.

why do we even say it can undergo this symmetry operation if it has to be in one specific conformation to do so and all the others will not allow it?

Edit: Also when we get to more complex molecules the problem just seems to balloon out of all proportion (if it is indeed a problem), if you imagine ethylene glycol, it can adopt many more 'unsymmetrical' conformations than 'symmetrical' ones.

What is the resolution to this guys? I'm struggling a little

By my first question, I mean do structural formulas include spatial orientations or just arrangements of atoms?

The question I was assigned to do was: State all possible types of isomerism your organic compound can exhibit.

My organic compound is (-)-Carvone, and I have no idea if it can have conformational isomers. What makes a molecule have conformational isomers? I'm trying to understand as well and most of the resources online feel too advanced for my comprehension.

Flaming Spoon Series on Opioidography - Oxycosmopolitan Production

Dμchess Vσn δ + “Notorious Gibbs Free Energy” presents...

Morphinan History X: A High-Heeled “Codone” Stomp of cis/trans-isomerism Drug-Prohibition Bigotry…

Molecusexuality of Opioid Stereochemistry: The Morphinan In the Mirror, Part I

A non-IUPAC approved Molerotic adventure in anthropomorphic Molecular sterics

By:

Edie Norton w/ a Fire Crotch, Sufentstress of the morphinomimetic mattress, the π-pair-o-skinny-jean molecuho, Mini-Thinny Mouse, the RemiFenny Skank, the μ-gμrμ…

Dμchess Vσn δ

A well cited exploration into the Stereochemistry, Geometry and Sterics of the Opiosphere

The idea for this post came about as I was working on another post about N-aralkyl substituted morphinans entitled “Tetracycles in Tiaras”. [see u/jtjdp for this post]

In prep’n for that post, I did my typical image hosting on Imgur. The concepts of cis-(1,3-diaxial) piperidine fusion, cis-B:C and trans-C:D ring fusion are important to the morphinan and polycyclic classes. As such, several of my images featured these cis/trans (molecular) orientations quite prominently. It soon earned a slew of downvotes.

I discovered the reason for this lack of opio-enthusiasm when a confused Imgurian left an interesting comment:

>“Yo, why do you gotta assign genders?”

Technically these molecusexual orientations were assigned by people. While they aren’t genders as much as geometric orientations, either way, it is forcing nomenclature onto a quantized state of matter. And forced conformations are no a laughing matter.

Forcing a Fetty to be a Frannie, or a Diladdy to be a Maddy, or a Thebby to be Thaddy, is in contravention to the “UN Resolution on Stereochemical Self-Determination.”

A clear cut “heroin rights violation.”

But enantiomers don’t resolve themselves. They need a helping hand.

And that’s how I came up with the idea for Molecusexuality.

Clearly there is a need to explain the long history of the brave pioneering molecules that came out of the cis/trans closet long before the LGBTQ community was even a thing. Nature leads the charge. Humanity eventually followed.

There are some reactions, such as the Knoevenagel (benzaldehyde + nitroalkane), which still remain in the closet, at least until the P2NP nitrostyrene provides the confidence needed to stand proud outside of sa

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

Do your worst!

I'm surprised it hasn't decade.

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

It really does, I swear!

They’re on standbi

Pilot on me!!

Nothing, he was gladiator.

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

When I got home, they were still there.

I won't be doing that today!

[Removed]

This morning, my 4 year old daughter.

Daughter: I'm hungry

Me: nerves building, smile widening

Me: Hi hungry, I'm dad.

She had no idea what was going on but I finally did it.

Thank you all for listening.

There hasn't been a post all year!

You take away their little brooms

Why

It’s pronounced “Noel.”

After all his first name is No-vac

What, then, is Chinese rap?

Edit:

Notable mentions from the comments:

• Spanish/Swedish/Swiss/Serbian hits

• French/Finnish art

• Country/Canadian rap

• Chinese/Country/Canadian rock

• Turkish/Tunisian/Taiwanese rap

There hasn't been a single post this year!

(Happy 2022 from New Zealand)

Nothing, it just waved

Him: I can explain everything!

(It's his best joke yet I think)

Bob

So that I could frequently say, "I am going to walk 5 miles now."

Edit: My most popular post on Reddit! 😀 Thank you for the awards.

Just to clarify, 12345678

Me grabbing a soda from my (what I thought was) half full 12pk...

Notices there's only 2;

Me: "Awe man... This is a damn bird box!" Her: "What the hell does that mean?!" Me: (Pulls both cans out & shows them to her) "It's only got Toucans."

I'm not ashamed to admit the look on her face was glorious.

I was just sitting there doing nothing.

[PART II] Morphinan History X - A Survey of Opioid Stereochemistry - Part II: Further Ring Fusions

REVIEW:

Part I of this monograph on opioid stereochemistry-ligand geometry established some foundational concepts such as stereospecific binding (SSB) [Goldstein, PNAS, 1971, v 68, p 1742], that is, the preferential affinity of one stereoisomer over another at bio receptors. Also explored were the steric effects of the most influential shared structural feature of the morphinan nucleus: cis-(1,3-diaxial) fusion of the imino-ethano system in the D-ring (Piperidine).

As a result of the nature of the constrained morphinan nucleus, this iminoethane bridge, anchored at C9 and C13, is forced to one side of the molecule. This provides steric hindrance which blocks access to the important C-ring of morphine derivs such as thebaine, forcing Diels-Alder cycloaddition to form the 6,14-endo adducts upon the reverse face of the C-ring.

Part I related how these steric limitations force dienophiles (during Diels-Alder rxn) to attack the diene system of thebaine from the least sterically hindered side of the morphinan nucleus (http://ineosopen.org/io2106r).

The electron-rich C-ring of thebaine allows for the ready cycloaddition of a diverse range of dienophiles leading to a range of Diels-Alder adducts [Tetrahedron, 1973, 29, 2387]. This includes unhindered dienophiles [KW Bentley, “The Alkaloids” (1971) v 13, p 75], substituted ethylenes [Tetrahedron, 1979, 30, 1201], nitroso carbonyls [JCS Perkin Trans I, 1981, p 3250] and nitroso arenes [JCS Perkin Trans I, 1979, p 3064].

The cycloaddition occurs under electronic control with C7-substitution occurring exclusively with very little, if any, isomeric C8-substituted product. Most of the adducts have 7-α stereochemistry. The notable exception to this being acrylonitrile dienophiles which favor 7-β formation [JACS, 1967, 89, 3267].

The most important takeaway from this molecular C-ring song-and-dance routine is the formation of the 6,14-endo***etheno bridge in a critical endo orientation on the reverse face of the morphinan nucleus, allowing for an important hydrogen bond interaction between the 19-O***H and 6-***O***CH3. While the 6-oxygen function is nonessential to high MOR affinity in the pentacyclic morphine series (cf. desomorphine has 10-fold morphine potency despite a complete lack of 6

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "