Ive taken a truckload (up to 3k mg) of edibles in one sitting from different reputable dispensaries without any luck in relief. I haven't had my DNA sequenced, but i suspect that i have a CYP2C9 variant (the bad kind). I have the kind that doesn't allow my liver to convert the delta 9 in to 11-Hydroxy.
With that said, would RSO work orally? Or does the RSO also use the liver to convert the delta 9 in to 11-Hydroxy? Does anyone use RSO here because traditional edibles dont work?
Source: https://www.leafly.com/news/health/considerations-before-ingesting-edibles
An inactive CYP2C9 gene=hindered THC metabolism. If CHS is supposedly caused by an overload of cannabinoids in our cannabinoid receptors, shouldn't a hindered THC metabolism heighten the chances of suffering from CHS?
I have recently felt stomach pain after waking up (I am a stomach sleeper) but, hipochondriacally searching for my fatal stomach disorder, I came across this subreddit. I'v vaped one bowl from my Mighty every night for about a year and a half, and am monitoring myself for prodromal phase symptoms, as I have woken up with a weird, blunt stomach pain, and not the greatest appetite, which is unusual for me.
While researching, I stumbled upon the fact that THC is metabolized by the enzyme encoded by gene CYP2C9. Having already submitted my 23andme raw data to Promethease, I found in my results that I have an inactive CYP2C9 gene, meaning that my THC blood concentration could be as much as three times higher than someone with an active CYP2C9 gene.
I may only be fretting because of my hypochondria, as I don´t feel that I have notorious prodromal symptoms (only a bit of stomach pain upon waking, which I attribute to sleeping on my stomach/having dinner too late), but the question stands for the sake of this disease´s cure.
I am a medical cannabis patient who uses the plant to treat chronic pain caused by fibromyalgia and other various neuropathies. Unfortunately, it has been a lot harder for me to smoke lately as a method of ingestion due to my lung capacity being slightly diminished. Edibles have never worked on me, and I recently found out that I am an "ultra slow metabolizer" which means that THC doesn't reach an appropriate plasma level for effective usage when consumed orally, AND the effects are shorter when smoked.
Is there any way to potentially bypass this issue so edibles can be more effective for me? I'd really like to medicate without smoking/vaping if possible, but this genetic issue is making it quite difficult.
CYP2C9 Poor Metabolizers CYP2C9 poor metabolizers require different dosages for drugs such as tamoxifen, warfarin, fluvastin, and many nonsteroidal anti-inflammatory agents such as aspirin, ibuprofen and naproxen.
Should someone with CYP2C9 take more ibuprofen? Less ibuprofen?
http://bloodjournal.hematologylibrary.org/content/119/3/868.long
I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
Do your worst!
I'm surprised it hasn't decade.
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂
It really does, I swear!
Buenosdillas
They’re on standbi
Pilot on me!!
Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.
This sub is mostly just NSFW puns now.
If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.
Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.
When I got home, they were still there.
What did 0 say to 8 ?
" Nice Belt "
So What did 3 say to 8 ?
" Hey, you two stop making out "
I won't be doing that today!
[Removed]
Nothing, he was gladiator.
You take away their little brooms
This morning, my 4 year old daughter.
Daughter: I'm hungry
Me: nerves building, smile widening
Me: Hi hungry, I'm dad.
She had no idea what was going on but I finally did it.
Thank you all for listening.
There hasn't been a post all year!
It’s pronounced “Noel.”
After all his first name is No-vac
What, then, is Chinese rap?
Edit:
Notable mentions from the comments:
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Spanish/Swedish/Swiss/Serbian hits
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French/Finnish art
-
Country/Canadian rap
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Chinese/Country/Canadian rock
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Turkish/Tunisian/Taiwanese rap
