Hi,
I am conducting a GC-MS analysis and I want to switch my analyte solvent from ethanol to acetonitrile. Reason for switching is because ethanol reacts with one of my analytes (acetic acid). Acetonitrile is almost a direct replacement to ethanol (similar properties to EtOH) since I can retain the same method with almost no change. From a light reading, I've noticed acetonitrile is typically not used with GC-MS and some have raised grievances in forums on using it as solvent. Just checking if there are reasons (unique to acetonitrile) why it is not implemented as widely? Just looking for reasoned assurance. Thank you.
EDIT: Using polar INNOWax column and max temperature reached in method is 300°C
I’m trying to figure out why a mixture of acetonitrile and hexane would not be a good choice of mobile phase for spinach TLC (as opposed to a mixture of acetone & hexane) but I’m coming up blank. At first, I thought that it’d have something to do with polarity but acetonitrile is polar, like acetone (I think ???). so i feel like it should work
Hi all, I just got an SDS (safety data sheet) for for a 1cp-LSD solution in acetonitrile that I'm thinking of buying. Now I know that acetonitrile can cause cyanide poisoning but the SDS toxicology section says that acute toxicity is caused at 64ml/kg in a human male (I am a man who weighs about 63 kgs)
Since the solution has a concentration of 100 ug/ml I would never go anywhere near the acute toxic dose.
My question is whether or not this is safe to ingest, even if a dose won't cause any immediate harm could I still have long term consequences? It's also very likely that I'm misreading the SDS (I'm just an undergrad have mercy on me) but I'm not sure if I'm allowed to post the pdf of the sheet here
How would one go about doing this recrystallization of an amine•hcl salt. Would it be the same way of taking your salt dissolving minimum amount in boiling solvent than freezing?
I'm working with a metal complex that's poorly water soluble. I've been dissolving it in minimal DMSO to get into solution before adding to water, however I have concerns about it's stability in DMSO over time>24hr.
To run NMR I've found acetonitrile is acceptable. So this is a possibility, but my colleague is concerned about adding small percentages of acetonitrile to cells and nucleic acids.
We need some way to get this into biological experiments. Does anyone have any ideas, tips or tricks?
Thanks
I'm generally good with OChem, it feels like I'm having brain damage.
Does this reaction work well? I read that it hadn't been proven to work online, but also read lots of posts about it working well online.
Also, as a chemistry ignorant person, why is acetonitrile used? Can anything be substituted? Sorry for the spoon feeding, but I don't have time to study chemistry at the moment.
Also, kind of confused about what is produced from this? Is it p2p, or an imine? I read a post on the vespiary about this and it seemed like an imine was formed which had to undergo a separate reaction to p2p. I'm sure this sounds silly, but again, no chemistry knowledge.
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09420
Minglun Li, Bilin Zhuang, Yuyuan Lu, Lijia An, and Zhen-Gang Wang
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This is my first job after getting a masters in organic chemistry. We also weigh all of our APIs and products at a balance that is not in a hood. In general there is bad air circulation in the lab and I’m really worried. I want to look for a new job but I’m afraid that all Pharma companies in NJ work like that.
I'm trying to do a metabolomic extraction from anaerobic bacteria, and we are concerned about the oxygen sensitivity of the metabolites. A paper I found left acetonitrile in the anaerobic chamber for 48 hours, but nobody in the lab really wants their cultures exposed to these vapors. Are there better options?
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04570
https://ift.tt/3kjgm5d
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02316
https://ift.tt/3ioPpfj
