Link: http://www.ncbi.nlm.nih.gov/pubmed/15907237 Source: J Coll Physicians Surg Pak. 2005 May;15(5):276-9. Naz R1, Naz S, Mehboob M, Achakzai A, Khalid GH.
Have tried Libgen, any help would be much appreciated.
In hindsight it all started 3 weeks back when I had an episode of sudden projectile vomiting which I attributed to my neck pain due to excessive phone use at the prior night. I had no other symptoms at that time. No headache, no blurred vision, etc. The doctor I went to suspected acute gastritis and started medications. The vomiting stopped after 2 days as I went on full liquid diet. The weakness was on extream level. Did tests for vitamin D and B12 deficiency, and they were extreamly low. Started supplements, and the weakness went away; and then one day suddenly, I noticed I am having a double vision when I see at distant objects. Went to opthalmologist, who diagnosed me with swollen optic discs, and said I should consult a neurologist to be on the safe side.
2 days later, I am admitted for the treatment of DCVT, and will be on the anticoagulant for 6 months.
Don't know what to expect, as it's very sudden. 3 weeks ago, I could have never guessed I something like this will happen to me.
I am very afraid of having a stroke. Have any of you have had stroke while still on medication? How was your experience was like?
Regarding the pathophysiology of deep venous thrombosis, I read that one important event is the recruitment of platelets. Now, consider a case of DVT due to blood stasis in the context of a hypercoagulable blood, but without endothelial damage. In this instance, how do platelets get activated if there is no endothelial damage? Thanks in advance!
From 2001 through 2015, 39 Olmsted County residents developed acute incident CVST. A total of 29 patients (74.4%) had a predisposing venous thromboembolism risk factor (eg, infection, active cancer, or oral contraceptives [for women]) within 92 days before the event. The median age at diagnosis was 41 years (range, 22-84 years); 22 residents with CVST (56.4%) were female. The overall age- and sex-adjusted CVST incidence was 2.34 per 100 000 person-years (PY) (95% CI, 1.60-3.08 per 100 000 PY). Age-adjusted CVST rates for female and male individuals were 2.46 per 100 000 PY (95% CI, 1.43-3.49 per 100 000 PY) and 2.34 per 100 000 PY (95% CI, 1.22-3.46 per 100 000 PY), respectively. Men aged 65 years or older had the highest CVST rate (6.22 per 100 000 PY; 95% CI, 2.50-12.82 per 100 000 PY), followed by women aged 18 to 29 years (4.71 per 100 000 person-years; 95% CI, 2.26-8.66 per 100 000 PY) (Table 1).
As of May 7, 2021, 8 727 851 Ad26.COV2.S vaccine doses had been administered in the US; 46 potential CVST events occurring within 92 days after Ad26.COV2.S vaccination were reported to VAERS. Eight events were excluded because they were potentially duplicate reports (4) or were not objectively diagnosed (4). Twenty-seven of 38 objectively diagnosed cases of CVST after Ad26.COV2.S vaccination (71.1%) occurred in female individuals. The median patient age was 45 years (range, 19-75 years). The median time from vaccination to CVST was 9 days (IQR, 6-13 days; range, 1-51 days); 31 of 38 cases of CVST (81.6%) occurred within 15 days after vaccination, and 36 (94.7%) occurred within 30 days.
The overall incidence rate of post–Ad26.COV2.S vaccination CVST was 8.65 per 100 000 PY (95% CI, 5.88-12.2
... keep reading on reddit ➡Authors: Kujath P. · Spannagel U. · Habscheid W. Journal: Haemostasis 1993;issue 23:p 20–26. Links: http://www.karger.com/Article/Pdf/216905 OR http://www.ncbi.nlm.nih.gov/pubmed/8388353.
Thanks a lot!
- UK AZ Cerebral venous sinus thrombosis: 24 cases, 4 fatal
- UK Pfizer Cerebral venous sinus thrombosis: 2 cases, 0 fatal
Sources:
- https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/975786/COVID-19_AstraZeneca_Vaccine_Analysis_Print.pdf
- https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/975808/COVID-19_mRNA_Pfizer-BioNTech_Vaccine_Analysis_Print.pdf
NOTE: there's a discrepancy between the 24 cases recorded in the MHRA analysis print and the 22 cases reported in the MHRA commentary below - that may be a genuine error, or just be down to different reporting dates.
MHRA commentary:
> Blood clots > >Our rigorous review into the UK reports of rare and specific types of blood clots is ongoing. Up to and including 24 March, we have received 22 reports of cerebral venous sinus thrombosis (CVST) and 8 reports of other thrombosis events with low platelets, out of a total of 18.1 million doses of COVID-19 Vaccine AstraZeneca given by that date. There were no reports for the Pfizer/BioNTech vaccine. To note, the current analysis prints include data up to and including the 21 March. > > On the basis of this ongoing review, the benefits of the vaccines against COVID-19 continue to outweigh any risks and you should continue to get your vaccine when invited to do so.
Thrombo-embolic events > > Our review has looked in detail at the 30 reports of blood clots with low platelet counts received up to and including 24 March. These reports have been analysed by MHRA scientists and clinicians, as well as by the Commission on Human Medicines (CHM), as part of an ongoing review. > >The risk of having this specific type of blood clot is very small. Up to and including 24 March, we had received 22 reports of cerebral venous sinus thrombosis (CVST) and 8 reports of other thrombosis events with low platelets, out of a total of 18.1 million doses of COVID-19 Vaccine AstraZeneca given by that date. There were no reports for the Pfizer/BioNTech vaccine. We have thoroughly analysed each and every report as soon as it has come in. To note the current analysis prints include data up to and including the 21 March. > >On the basis of this ongoing review, the benefits of the vaccines against COVID-19 continue to outweigh any risks and you should continue to get your vaccine when invited to do so. > > The British Society for Haemat
... keep reading on reddit ➡I [24F] was diagnosed with venous sinus thrombosis on July 4th. I was told the cause was likely from birth control but may have also been from the COVID vaccine that I received 5 days before. Basically I have clotting in the sinus part of my brain and was told I would have likely had a fatal seizure if I didn’t admit myself to the hospital when I did. They started me on what I believe was called heparin for 2 days and switched me to eliquis (blood thinner). I feel a lot better 2 weeks later. I have a slight headache, my ears are a little sensitive, but the worst thing is my vision. I’m seeing double and it’s absolutely driving me insane. My primary doctor admitted to me that she did not know much about my condition because it’s very rare. My other problem is that I cannot see a neurologist until October (all booked up). I don’t know if this double vision is normal and if it’s permanent? The whole thing has me very scared. I guess my question is more about my eyes, but also curious to see if anyone else may have some knowledge on this “illness”. The doctors were very kind but not the best at explaining things to me. I was not given any idea how long it would take to recover either. Any help would be great
https://jamanetwork.com/journals/jamacardiology/fullarticle/2783051?s=09
