Threose Nucleic Acid Puns

Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c02895

Yao Wang, Yueyao Wang, Dongfan Song, Xin Sun, Ze Zhang, Xintong Li, Zhe Li, and Hanyang Yu

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I can recogonize them if shown them, but I have been really struggling to draw them out precisely. Like I know I can draw out the rough features and I know how to differentiate between them.

Weibo forwarding: Auntie said that her stomach hurts at 7pm on January 1, 2022. When it was delivered, it was already over 8pm, but she was not allowed to enter at the door. It was delayed until more than 10pm, saying that the nucleic acid exceeded For 4 hours, my aunt sat at the door for a while. It was not because of the delay for so long that it caused heavy bleeding. I saw the video sent by my uncle. My aunt was sitting on a chair with her hands supporting her body very hard. The blood ran down the chair and pants, and the blood on the floor was sent to the operating room. As a result, the 8-month-old child suffered a miscarriage because of the delay in treatment, and the 8-month-old child was stillborn because of the time delay. No more heartbeat! Originally, I was thinking about telling this story on other platforms. I actually saw a screenshot of the host’s story told by my friend in Moments just now. I read the comments and found that I was not alone in this hospital. This kind of thing, I just cry!

Important updates to this post including that a clinical trial was based on "misreported data" and the fact #Exicure CEO David Giljohann, one of the developers of the #SphericalNucleicAcids in Chad Mirkin's group is "separating" from the company.

https://raphazlab.wordpress.com/2021/11/22/allegations-of-research-improprieties-at-spherical-nucleic-acids-company-exicure/

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Nucleic acids are chemically modified to fine-tune their properties for biological function. Chemical tools for selective tagging of base modifications enables new approaches; the photosensitizers riboflavin and anthraquinone were previously proposed to oxidize N6-methyladenine (m6A) or 5-methylcytosine (5mdC) selectively. Herein, riboflavin, anthraquinone, or Rose Bengal were allowed to react with the canonical nucleosides dA, dC, dG, and dT, and the modified bases 5mdC, m6A, 8-oxoguanine (dOG), and 8-oxoadenine (dOA) to rank their reactivities. The nucleoside studies reveal that dOG is the most reactive and that the native nucleoside dG is higher or similar in reactivity to 5mdC or m6A; competition in both single- and double-stranded DNA of dG vs. 5mdC or 6mdA for oxidant confirmed that dG is favorably oxidized. Thus, photosensitizers are promiscuous nucleic acid oxidants with poor chemoselectivity that will negatively impact attempts at targeted oxidation of modified nucleotides in cells.

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