Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c02545
Hikaru Kuramochi and Tahei Tahara
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Hey everyone. I am currently pursuing my bachelors in Mechanical Engineering from India. During my B.Tech, I have participated and won silverware in the SAE Aero Design competitions (in U.S.A) from 2019-2020 as the teams structural engineer. With research experience in the field of composite structures and internships in few manufacturing firms, I further cultivated interest in the aerospace structural domain. Nevertheless, to build on my field expertise I am now willing to pursue my master’s degree.
I currently have an admit from Cranfield university in the Aerospace Vehicle Design (AVD) program, the Aerospace Engineering program of ISAE-Supaero, and yet awaiting the results from TU-Delft. However, I am facing a tough time on how exactly should I identify the right course. Upon comparing the program offerings, I found the AVD program of Cranfield really appealing and most appropriate from an industrial stand-point. But generally, UK masters are of 1-year duration, and consequently I am worried that it would be less valued degree compared to the ones offered from TU-Delft or ISAE- Supaero, which could affect job prospects of an immigrant in the UK or EU irrespective of one’s credibility.
Thus, I am confused whether I should choose a program more suitable for my liking in aerospace structures (like Cranfield University) (even though it is of 1 year), or focus on the admit from more revered Aerospace institutes (like ISAE or Delft) which would improve my job prospects.
It would be great if there are any Cranfield, Delft or ISAE Alumni who can shed some more details on this.
The glycan structures of the receptor binding domain of the SARS‐CoV2 spike glycoprotein expressed in human HEK293F cells have been studied by using NMR. The different possible interacting epitopes have been deeply analysed and characterized, providing evidence of the presence of glycan structures not found in previous MS‐based analyses. The interaction of the RBD 13C‐labelled glycans with different human lectins, which are expressed in different organs and tissues that may be affected during the infection process, has also been evaluated by NMR. In particular, 15N‐labelled galectins (galectins‐3, ‐7 and ‐8 N‐terminal), Siglecs (siglec‐8, siglec‐10), and C‐type lectins (DC‐SIGN, MGL) have been employed. Complementary experiments from the glycoprotein perspective or from the lectin’s point of view have permitted to disentangle the specific interacting epitopes in each case. Based on these findings, 3D models of the interacting complexes have been proposed.
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