Stratified Columnar Epithelium Puns

To me, they look very similiar and I have a problem simetimes to tell them apart. How do you go about telling them apart effectively?

Can you still see normal Simple columnar epithelium on biopsy of the cervical transformation zone, even after dysplastic changes?

Hello, my doctor said that my endoscopy showed a columnar epithelium, classified at barret's esophagus at first but biopsy came back negative for intestinal metaplasia

I read online that columnar epithelium without metaplasia is classified as barret's esophagus in UK and ASIA, i'm very afraid and don't know if I should follow up this ???

My doctor said follow up is useless, and to come back only If I develop new symtpom

My professor has us memorize epithelial tissue as simple squamous mainly for gas exchange, simple cuboidal - secretion, simple columnar - absorption, and strat squamous - protection

Following that I'm not really sure why the uterus has simple columnar, unless its something about the uterus taking in nutrients to nourish a fetus?

Edit: Found sites saying that it lines the uterine tube where cilia moves the egg to the uterus. I'm hesistant to think that that's all I'd need to understand though

Thank you for all the answers!

Hello, noob question here. I am just starting an anatomy course and learning all of the ET.

In my textbook, there is listed: stratified cuboidal and stratified columnar.. however is seems that only the most superficial layer is of that type (either cuboidal or columnar) and the rest are other cell classifications.

My question is... does this truly count as stratified the same as a stratified squamous epithelium? Or would it be classified as 'simple'?

Thank you!

You may have seen some literature out there with talk of using the “thin edge” vs the thick edge of the chords. As best as I could discover in all my 20 years of singing so far, there is just the one edge! Before lessons I didn’t have this huge hole in my life from not feeling the thin edge. After I did the work and was told I was now using the “thin edge” I was like “wait a minute my sound didn’t change and I felt nothing different🤔”.

So what gives?

I think that a voice teacher was reading about how the vocal folds are made of stratified squamous epithelium. I suspect it was my last teacher, David Jones. He says a lot of untrue things. Some of them seem deliberate and others seem to be just him not getting basic concepts, but teaching advanced methods based on them anyway.

here is an article by my last voice teacher. It’s cited all the time as an authority. There is is right in there - the thin edge of the chords.

Now go find the thin edge of the chords, cuperto, or examples of Garcia and Lamperti using “ng” exercises. (No citations!).

I think Mr. Jones must have been drinking a lot of coffee on that day or smoking something because he appears to have taken the biological description of mucosa and turned it into some weird blade concept.

Your vocal folds do not act like blades with a thin edge and a blunt edge. But if we describe the material they are made of, it can sound like we are saying there is a thin edge and a thick edge. I’m gonna spare you the scientific description because I can show you the same type of material: it’s your LIPS.

Yup! Your lips! And just inside your lips. See that stuff? It’s not like skin. Got that? See any thin edges and thick edges you can use? Or just... lips? Yeah. It’s just lips. But it’s also just stratified squamous epithelium (different types, and we have pseudo-stratified as well but that’s TOO MUCH).

Forget about the thin edge of the chords! Whoever came up with that was reading anatomy and probably late to his next lesson. He gave a totally botched version and the student was fine with it so he went and turned it into an article. Other people loved it because nobody can check if you used the “thin edge” or not. You can get someone to do “thin edge” exercises for months, at like 150 bucks an hour!

If you want to know what your larynx is really like, just think “tiny pair of lips in my throat”, and think of your vocal tract

Hello all!

As the title says, I have a question about where you can find TGF-B (any isoform, TGF-B1/2/3) in relation to stratified epithelium comprised of oral gingival epithelium or oral keratinocytes.

From my reading, basically all papers discuss latent TGF-B in the extracellular matrix (ECM). However, FISH has been able to detect TGF-B1/2 and TGFBRI/II in suprabasal cell layers. As such, I am wondering if anyone here has any experience with TGF-B and could give me some insight (bonus points for any specific papers you can refer me to!). My questions are thus:

1. Can you find latent TGF-B within the non-ECM extracellular space, IE in or around tight junctions.

2. If TGF-B is not latently stored in the suprabasal extracellular space, why is it expressed in these layers? Does it somehow get produced by suprabasal cells but then traffics through the epithelium to the ECM? Is it secreted as small latency complexes that can be proteolytically activated in the suprabasal layers?

For clarification, I am not asking about this for some kind of homework assignment. I stumbled across a couple papers that may provide some interesting research opportunities and wanted to see if anyone had some experience in this area to give me a pointer. Unfortunately, my current experience lies in the field of virology and I have not had much exposure to TGF-B outside of its immune system effects. Thanks for your time!

Has anyone done this? Are their kits readily available? By large format, I'm thinking 6x7 minimum. BFO-9000 but column staggered would be pretty ideal.