I notice 2 different products I use that contain phenibut list them as such. What is the difference?
Just Labeled : Transitionโmetalโfree carbon isotope exchange on phenyl acetic acids is described. Utilizing the universal precursor CO2, the carbon isotope can be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with [14C] and [13C]. A proof of concept with [11C] was also obtained with low molar activity valuable for distribution studies.
Abstract
A transitionโmetalโfree carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO2, this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [14C] and [13C]. A proof of concept with [11C] was also obtained with low molar activity valuable for distribution studies.
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Sponsor: Rep. Jim Gerlach [R-PA6]
This bill or resolution is in the first stage of the legislative process. It was introduced into Congress on April 27, 2012. It will typically be considered by committee next.
So i started using phenibut mid april and at first it was a dream come true, until it got worse. Im sure this story isnt new to anyone. but its late december and now i am having to take it every three hours and that is even in the night. i only sleep about 2 hours at a time and then i wake up and i have to do more. i dose at 4.3 to 4.8 grams every 3 hours so that means 34 to 36 grams a day. what can i do to avoid a massive withdrawl or is there a taper guide?
As the title suggests, this is my current sunscreen collection, and I'll be reviewing the products and mentioning the ones I love and the ones I don't ! (This post might be half cooked, not very organised and all over the place, but it's my first time, so bare with me :P)
So as I mentioned, this is my first post here (eeep! :D) and initially I thought of sharing my entire shelfie, but I realised that being the junkie/hoarder I am, it'd end up being a terribly long post , hence after much deliberation I decided to post different categories of products separately (sunscreens, moisturisers, serums etc) and after I'm done with that, I shall be making a post with only the products I use in my current skincare routine!
Without further adieu let's get started! Please do like, share, subscribe and don't forget to hit the bell icon!... lmao jk
Skin Type : Oily - Combination, Comedonal Acne Prone, Rosacea Prone,
Major skin concerns : Hypersensitivity, Non inflammatory acne, Sebum Production.
Age : Early - Mid 20s, F
Current Climatic Conditions : Semi- Arid, Dry winter
Specie : Homo Sapien
Height : wait.. I'm not supposed to divulge all these details!
Product reviews :
Note : None of these products have been used by me on a strictly daily basis, except for a week (or two) in a row during vacations, as I rarely step out of the house (lockdown, duh!) and don't apply sunscreen indoors (*gaasp* ๐จ)
Rest assured, I've reapplied some when out, and have used them on and off in a span of 6 months.
From L-R
https://i.postimg.cc/s2C99g0N/IMG-20211119-184403.jpg
1- Nivea Sun Protect And Moisture, moisturising sun and collagen protection SPF 50+ PA++++
Quantity - Price : 125 ml - โน495 MRP
(bought on Amazon for โน396)
Ingredients : Aqua, Octocrylene, Glycerin, Titanium Dioxide, Butyl Methoxydibenzoylmethane, Butylene Glycol Dicaprylate/Dicaprate, C12-15 Alkyl Benzoate, Alcohol Denat, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Dicaprylyl Carbonate, Glyceryl Stearate Citrate, Panthenol, Hydrogenated Coco-Glycerides, Myristyl Myristate, Silica, Cetyl Alcohol, Phenoxyethanol, Stearyl Alcohol, VP/Hexadecene Copolymer, Xanthan Gum, Ethylhexylglycerin, Methylparaben, Dimethicone, Trisodium EDTA, Ethylparaben, Sodium Citrate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Citric Acid, Tocopheryl Acetate, Sodium Hydroxide, Linalool, Limonene, Butylphenyl Methylpropional, Benzyl Alcohol, Alpha-Isomethyl Ionone, Citr
... keep reading on reddit โกIt sounds like a really interesting method. Only slightly tough to get substance is the Manganese(III) Acetate but neither Manganese(II) or KMnO4 are expensive and you can synth it from that. Only problem seems to be the pretty low yield (1.34g) but maybe it can be increased?
>Free-Radical alkylation of Benzene with Acetone Catalyzed by Manganese(III)Acetate17 Phenyl-2-Propanone can be made in a single step by a free-radical reaction between benzene and acetone. The reaction relies upon the special oxidative powers of manganese(III)acetate, a compound easily prepared from potassium permanganate. The yield is relatively low, and requires high dilution of the reactants, but this can be improved, and the reaction is also applicable for other substituted benzenes, as can be seen in the comprehensive Manganese(III)acetate catalyzed aromatic acetonylation document on this site.
>A mixture of Manganese(III)acetate dihydrate (13.4g, 50 mmol), benzene (150ml), acetone (150ml) and glacial acetic acid (250ml) was refluxed under an inert atmosphere (argon, helium or nitrogen) until the dark brown color of manganese(III)acetate changed to the pale pink of manganese(II)acetate (about 90 min). The reaction mixture was partitioned between 400ml ether and 250ml water. The ether layer was separated and washed with 250ml water and with 2x250ml 5% Na2CO3 to remove any remaining acetic acid. The ether was then dried over anhydrous Na2SO4 (or MgSO4), the solvent evaporated and the residue fractionately distilled to recover unreacted benzene, and to give phenyl-2-propanone in 40% yield (1.34g) based on the reacted manganese(III)acetate, which is the limiting reagent in this reaction.
So Iโm looking for a synthesis route that goes from phenylacetic acid to phenyl acetone without using acetic anhydride because I canโt find it and itโs synthesis seems too difficult does anyone have a synthesis route for this ?
Do your worst!
I'm surprised it hasn't decade.
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies ๐
It really does, I swear!
Theyโre on standbi
Buenosdillas
Pilot on me!!
Saw a quora post about converting toluene to phenol. The route mentioned was toluene- benzoic acid- phenyl benzoate- phenyl. The article said esterification of benzonic acid with acid catalyst then hit it with NAOH to form phenyl and sodium benzoate. My question is on the esterification part. Iโm not sure how that would work or what alcohol would need to be present. Everything else I find says phenyl and benzoic acid but the whole point of the conversion was to get phenyl. Iโm super confused
A transitionโmetalโfree carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO 2 , this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [ 14 C] and [ 13 C]. A proof of concept with [ 11 C] was also obtained with low molar activity valuable for distribution studies.
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