Successful Treatment with Ensartinib After Alectinib-induced Hyperbilirubinemia in ALK-Positive NSCLC dovepress.com/successful-…
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πŸ‘€︎ u/montaukwhaler
πŸ“…︎ Jun 02 2021
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Hyperbilirubinemia, bony lesions on CT scan. Found this on the smear and was suspicious.
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πŸ‘€︎ u/chxrrysodas
πŸ“…︎ Apr 30 2021
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Help me find out the diagnosis! Hyperbilirubinemia

Female, 21yo,50 kg, 159cm, Europe, medical student I was given a biomedical test results of a patient that has elevated levels of bilirubin and brown colour of urine. What are the possible diagnosis if all LFT's are within normal range? test results of patient

blood total protein 80 60-80 g/L albumin 45 35-50 g/L glucose 5 3.9-5.6 mM lakaline phosphatase 99 30-130 lU/L gamma-glutamyl transferase 40 10-55 lU/L alanine aminotransferase 35 5-50 lU/L Bilirubin 65. 0-20 uM urine colour brown yellow to amber pH 6 5.0-6.0 glucose negative. negative protein positive negative

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πŸ‘€︎ u/kacenka1999
πŸ“…︎ Oct 25 2020
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Bili-board for Hyperbilirubinemia
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πŸ‘€︎ u/grimesms
πŸ“…︎ Oct 30 2019
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Grading beer from polyuric to anuric with various stages of hyperbilirubinemia in between.
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πŸ‘€︎ u/nlsoy
πŸ“…︎ Feb 27 2019
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Which type of hyperbilirubinemia is present in galactosemia and why?
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πŸ‘€︎ u/aspirant179
πŸ“…︎ Mar 23 2020
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Gilbert's syndrome (constant mild hyperbilirubinemia) has shown clear protection from cardiovascular disease. New studies are showing it may also lower cholesterol and triacylglycerol concentrations and BMI scores. ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/avboden
πŸ“…︎ Dec 13 2014
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Familial inheritance of Gilbert's (hyperbilirubinemia)
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πŸ‘€︎ u/avboden
πŸ“…︎ Mar 10 2019
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Hyperbilirubinemia - Part One - Walker, Toddler Danger. hippoed.com/peds/rap/epis…
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πŸ‘€︎ u/HippoEducation
πŸ“…︎ Jan 02 2019
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How do you define conjugated hyperbilirubinemia?

Often in questions, it will say total bilirubin is 5 mg/dl and direct is 2.3 mg/dl is this a conjugated or unconjugated hyperbilirubinemia? This affects the thinking for my differential diagnosis

Before I read it was about 30%+ of the total, and some people have said 50%+, and I looked it up but couldn't find it either. So I was wondering if anyone knows the precise definition?

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πŸ‘€︎ u/svuu
πŸ“…︎ Jan 19 2018
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Use of D-Penicillamine in the Neonatal Hyperbilirubinemias (TBSND) - Juniper Publishers

Use of D-Penicillamine in the Neonatal Hyperbilirubinemias

D-penicillamine (DPA) was first recognized as a potential benefit for neonatal hyperbilirubinemia (NHBI) caused by hemolytic diseases or immaturity of UDP-glucuronyltransferase enzyme. During this time there was a remarkedly low incidence of retinopathy of prematurity(ROP) in the infants treated with DPA. Later, our studies were replicated in other institutes in Hungary, Poland, U.S. A., India and Mexico. It is important to note that there was no intolerance or short- or long-term toxicity of the medication, in spite of the fact that in the newborn period DPA was used 10-20 times higher doses than those in adult. Juniper Publishers

For more Juniper Journals go through the below link

https://juniperpublishers.com

For more neurological disorders click on below link

https://juniperpublishers.com/tbsnd/index.php

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πŸ“…︎ Jan 02 2019
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Hyperbilirubinemia [Neonatal Jaundice]: Subcortical Mechanisms of Cognitive and Behavioral Dysfunction pedneur.com/article/S0887…
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πŸ‘€︎ u/subtextual
πŸ“…︎ Jan 14 2013
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Adult Neurobehavioral Outcome of Hyperbilirubinemia in Full Term Neonatesβ€”a 30 year Prospective Follow-up Study peerj.com/articles/294/
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πŸ‘€︎ u/subtextual
πŸ“…︎ Apr 09 2014
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Sulfonamides and neonatal hyperbilirubinemia

I'd like to pose a question to reddit, and please know that doctors have already been consulted on this matter and treatment has already taken a path that they suggested. I would like to get a medical thought outside of that, as well, for the sake of scratching my own itch.

My son was born last Tuesday, and soon moved to the NICU with low blood sugar that could not be corrected by feeding. IV dextrose was administered and it quickly corrected, but shortly thereafter his bilirubin levels spiked, the highest blood serum reading being 17.8 mg/dl. He immediately went on to phototherapy, and was in the NICU for a week before being released with stable (not rising) levels around 13 mg/dl.

Skip to this afternoon. My wife has mastitis, and was prescribed Bactrim (Sulfamethoxazole/Trimethoprim) by her OB because she is allergic to several other antibiotics that are typically prescribed for this. She is nursing. He checked the book (I watched him do it) to make sure everything was fine with it. He noted that it did pass into breastmilk and is contraindicated due to that, but the medication wouldn't actually be harmful to the baby.

Well, I noticed on the bottle tonight a warning about direct sunlight exposure, so I decided to get online and find out why that is a problem. I'm not a Google Hypochondriacβ„’ by any means, I was just curious. Well, what do I find but a thousand links that say this

> This drug passes into breast milk. While there have been no reports of harm to healthy infants, this drug may have undesirable effects on infants who are ill or premature or have certain disorders (jaundice, high blood levels of bilirubin, G6PD deficiency). Therefore, breast-feeding is not recommended for infants with these conditions. Consult your doctor before breast-feeding.

This morning (before the Bactrim), his level skin-tested at 16.8 at his pediatrician. He's going back to the hospital tomorrow for a blood test and some other things. The warning above, and others, claim that sulfonamides compete with bilirubin for binding to serum albumin, thus causing a rise in free unconjugated bilirubin. The 16.8 test this morning did not worry the doctors his because his age actually takes that level below what would be considered high risk. But it's close enough that I'm nervous about anything that could cause the bilirubin levels to rise. The Nurse Practitioner at the NICU we were at just told us over the phone that he would probably be okay for the night and to talk to t

... keep reading on reddit ➑

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πŸ‘€︎ u/The_Impresario
πŸ“…︎ Jan 21 2015
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26 y/o male. hyperbilirubinemia bilirubin levels of 2.0

Just got back from my doctors visit and found out I have a high bilirubin of 2.0. Doctor wasn’t too concerned and said it might be gilberts. I just remember my spleen being a little tender (1/10 on a pain scale). Doctor didn’t assess my spleen. Could this very well be due to a splenic issue?

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πŸ‘€︎ u/Urologistconsult
πŸ“…︎ Feb 03 2018
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DAD JOKES ARE NOT DIRTY.

Go post NSFW jokes somewhere else. If I can't tell my kids this joke, then it is not a DAD JOKE.

If you feel it's appropriate to share NSFW jokes with your kids, that's on you. But a real, true dad joke should work for anyone's kid.

Mods... If you exist... Please, stop this madness. Rule #6 should simply not allow NSFW or (wtf) NSFL tags. Also, remember that MINORS browse this subreddit too? Why put that in rule #6, then allow NSFW???

Please consider changing rule #6. I love this sub, but the recent influx of NSFW tagged posts that get all the upvotes, just seem wrong when there are good solid DAD jokes being overlooked because of them.

Thank you,

A Dad.

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πŸ‘€︎ u/Von_Bostaph
πŸ“…︎ Jun 18 2021
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Infant with multiple medical conditions and CPS involvement.

This case involves my daughter and granddaughter. This case is very complicated, so this will be an extensive post.

We found out that granddaughter had bilateral clubfoot during my daughters 2nd trimester scans. Within the next week we went to OU Children’s hospital for additional scans and consultation with a pediatric orthopedic surgeon to get the diagnosis confirmed. Which it was. We immediately went into research mode and started gathering as much information as possible, and we joined a support group. We started putting together a treatment plan with recommendations from our support group as well as information from the our Dr’s.

Now, this is where everything gets complicated. My daughters OB called a couple of weeks later with some upsetting news. My daughter is Rh negative, which the OB knew about and this was her 2nd pregnancy, also something she knew, but she had failed to give her the rohgam shot, so she became sensitized. This condition obviously took precedence. We had to go weekly appointments to make sure baby wasn’t developing hydrops, which thankfully she did not. However, when she was born she developed hemolytic disease/hemolysis hyperbilirubinemia and she was admitted into the NICU for 3 weeks and had 5 blood transfusions. Her highest billi level was 23, but they held off on doing the blood tranfer/exchange because of the significant risk of brain damage that occurs with that procedure. However, we were informed of the damage already caused by her high billi levels as well as the damaged caused by the RH disease. This list included Cerebral Palsy. Of course this realization that there were going to be some cognitive and/or developmental disabilities was devastating news for all of us, but we did what we do and went into research mode.

Back to the clubfoot. Normally babies with clubfoot are evaluated and treated within the first few days of birth, but that wasn’t an option for us. She didn’t get her first evaluation until she was 6 weeks old. She was referred to Scottish Rite in Frisco TX. We took her there for her first 6 castings. We decided to seek a second opinion when the Dr wanted to do the tendonectomy and we just didn’t think her feet looked right. When then went to Shriners in Shreveport. One Dr at Shriners examined her feet and agreed that she was not ready for the tendonectomy and she needed more casting. Another Dr also evaluated her and wanted a neurological referral because she thought that her

... keep reading on reddit ➑

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πŸ‘€︎ u/sirSkillzAhlot
πŸ“…︎ Apr 15 2021
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There are only two white people in the movie Black Panther

Martin Freeman, and Andy Serkis.

They also play roles in Lord of the Rings.

I guess that makes them the Tolkien white guys.

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πŸ‘€︎ u/jzagri
πŸ“…︎ Jun 24 2021
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Rational
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πŸ‘€︎ u/mainhoonmadrasi
πŸ“…︎ Jun 30 2021
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My 3 yr old daughter made her first pun today and I almost cried. She was eating an apple and I asked her if she liked apples.

She said apple-lutely

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πŸ“…︎ Jun 29 2021
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What did the left eye say to the right eye when they got married?

'Eye-do'

This is my first post pls don't kill me lol.

The people in the comment section is why I love this subreddit!!

Cred once again my sis wants credit lol

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πŸ‘€︎ u/tieyz
πŸ“…︎ Jun 27 2021
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What was a very common name in the middle ages?

I heard parents named their children lance a lot.

First post please don't kill me

Edit: i went to sleep and now my inbox is dead, thank you kind strangers for the awards!

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πŸ“…︎ Jun 24 2021
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Apologies if it's a bit corn-y
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πŸ‘€︎ u/mediashiznaks
πŸ“…︎ Jun 26 2021
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My wife blocked me on Facebook because I post too many bird puns.

Well, toucan play at that game.

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πŸ‘€︎ u/Zayan-ali
πŸ“…︎ Jun 30 2021
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so many choices
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πŸ‘€︎ u/SailorNebula
πŸ“…︎ Jun 07 2021
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Gottemm
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πŸ‘€︎ u/Un_FaZed211
πŸ“…︎ Jun 29 2021
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Well that didn't cross my mind
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πŸ‘€︎ u/JasonPetreasCoach
πŸ“…︎ Jun 11 2021
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He knows too much
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πŸ‘€︎ u/Potato_salad123
πŸ“…︎ Jun 24 2021
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where do pirates get their hooks?

second hand stores!

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πŸ‘€︎ u/bigus-_-dickus
πŸ“…︎ Jun 25 2021
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I've spent all morning trying to think of a quality pun, just to come up with THIS otter rubbish.
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πŸ‘€︎ u/awesome_smokey
πŸ“…︎ Jun 28 2021
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I've just deleted all the German names off my pre owned iPhone..

it's Hans free now..

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πŸ‘€︎ u/HugoZHackenbush2
πŸ“…︎ Jun 28 2021
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My 6 year old wanted me to share his joke with you all. What is a horses favorite store?

Old Neeeeiiiiighvy

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πŸ‘€︎ u/WantedDadorAlive
πŸ“…︎ Jun 28 2021
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3.14159265387279 snek
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πŸ“…︎ Jun 20 2021
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Did you know 10+10 and 11+11 are the same?

10+10 is twenty and 11+11 is twenty too

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πŸ“…︎ Jun 27 2021
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How much does it cost for a pirate to get his ears pierced?

A buck-an-ear!

I Thank ye kind Matey for the booty! I be truly overwhelmed! Thank you!

Holy cow! Thank you everyone for the upvotes and awards! I wasn’t expecting this!

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πŸ‘€︎ u/motherduck5
πŸ“…︎ Jun 25 2021
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Rock bottom
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πŸ‘€︎ u/Theo19555
πŸ“…︎ Jun 23 2021
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My Son Ate a Bunch of Scrabble Tiles. My Wife is Scared but I'm not...

He should have a good vowel movement. His next diaper change could spell disaster though.

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πŸ‘€︎ u/hypeaze
πŸ“…︎ Jun 23 2021
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Chinese takeout: $11.77. Price of gas to get there: $3.00

Making it all the way home and realizing that they forgot one of the containers:

Riceless

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πŸ“…︎ Jun 28 2021
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Two drunk guys were about to get into a brawl. One of the guys grabs a stick and draws a line in the dirt and says "If you cross this line, I'll hit you in the face"

That was the punchline

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πŸ“…︎ Jun 29 2021
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I threw up in the toilet
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πŸ“…︎ Jun 25 2021
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Is the presence of pale stools specific for cholestatic jaundice, i.e, do pale stools rule out hepatocellular jaundice?

From Siegenthaler's Differential Diagnosis in Internal Medicine:

Impaired Bilirubin Secretion

The secretion of bilirubin from liver cells into the bile canaliculi is the limiting step in bilirubin metabolism, while the glucuronidation of bilirubin is a relatively stable function with a high reserve capacity. Jaundice from hepatocellular damage in acute and chronic liver diseases is, therefore, characterized by a rise in conjugated bilirubin levels. The urine is dark brown second- ary to conjugated bilirubinuria. The stool color depends on the extent of hepatocyte damage, i. e., the greater the damage, the lighter the stool.

Intrahepatic and extrahepatic cholestasis also belong to this group. Biliary obstruction results in conjugated hyperbilirubinemia. In complete bile duct obstruction, the stool is acholic and urobilinogen cannot be detected in the urine.

^^If im understanding this correctly, it says that even hepatocellular damage from chronic liver diseases can cause stools to become lighter, by virtue of the fact that bilirubin cannot be excreted from within the cells to the bile canaliculi, regardless of any post-hepatic obstruction.

However, UpToDate does not list pale stools as a symptom anywhere in the cirrhosis page.

Harrison's doesnt seem to particularly rely on any aspect of the history to differentiate between hepatocellular and cholestatic jaundice, and i cannot find any specific information regarding the utility of pale stools there.

Could someone kindly shed some light on this? Thanks!

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πŸ‘€︎ u/hermxt4lyfe
πŸ“…︎ May 01 2021
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