Association of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus. (Pub Date: 2021)

https://doi.org/10.2147/DMSO.S297730

https://pubmed.ncbi.nlm.nih.gov/33948086

Abstract

Objective

This study aimed to investigate the association of the glycated albumin (GA)/glycosylated hemoglobin (HbA1c) ratio with the mean amplitude of glycemic excursion (MAGE) in type 2 diabetes mellitus (T2DM).

Methods

A total of 102 patients with T2DM who were first treated in Jinjiang Hospital of Fujian Province were enrolled in this study. The patients' general clinical data, including HbA1c, GA, fasting blood glucose, and fasting and peak C-peptide values upon diagnosis and after one year of follow-up, were collected, and their MAGE was calculated.

Results

With the increase of the GA/HbA1c ratio at baseline, the patients' fasting and peak C-peptide values decreased gradually from baseline to follow-up, while their MAGE, HbA1c, and fasting blood glucose increased gradually. A regression analysis demonstrated that the baseline MAGE was independently positively correlated with the GA/HbA1c ratio. A Cox regression analysis demonstrated that a baseline GA/HbA1c ratio of >2.78 was an independent risk factor for poor fasting blood glucose and HbA1c.

Conclusion

The GA/HbA1c ratio is closely related to the MAGE and islet function in patients with T2DM.

------------------------------------------ Info ------------------------------------------

Open Access: True

Authors: Bai-Rong Wang - Jun-Teng Yao - Hui Zheng - Quan-Min Li -

Additional links:

https://doi.org/10.2147/dmso.s297730

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088300

πŸ‘︎ 7
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πŸ‘€︎ u/Ricosss
πŸ“…︎ May 06 2021
🚨︎ report
Association of Exposure to Radio-Frequency Electromagnetic Field Radiation (RF-EMFR) Generated by Mobile Phone Base Stations with Glycated Hemoglobin (HbA1c) and Risk of Type 2 Diabetes Mellitus mdpi.com/1660-4601/12/11/…
πŸ‘︎ 5
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πŸ‘€︎ u/modernmystic369
πŸ“…︎ Jan 30 2021
🚨︎ report
elevated level of glycated hemoglobin shown to be associated with increased risk of cardiovascular outcomes and all-cause mortality in patients without Type 2 Diabetes Mellitus. The pathophysiology underlying this association is not clear but may be related to the development of severe & complex CAD gavinpublishers.com/artic…
πŸ‘︎ 8
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πŸ‘€︎ u/chelseastone
πŸ“…︎ Nov 26 2020
🚨︎ report
Paper modeling several COVID-19 proteins binding to glycated form of hemoglobin

..Preventing O2 and CO2 binding, which would explain the respiratory distress. Also explains why men are more likely to have severe symptoms (more hemoglobin), as well as elderly, obese and t2 diabetic: more glycated hemoglobin.

Also shows how chloroquine disrupts this porphyrin interaction, and Vitamin D also could have this effect.

https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173

πŸ‘︎ 15
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πŸ‘€︎ u/chickadoos
πŸ“…︎ Mar 28 2020
🚨︎ report
The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability cureus.com/articles/36738…
πŸ‘︎ 9
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πŸ‘€︎ u/CureusJournal
πŸ“…︎ Aug 13 2020
🚨︎ report
New Peer Reviewed Science: Is insulin resistance the cause of fibromyalgia? A preliminary report - Published May 6, 2019 "We show that most (if not all) patients with FM belong to a distinct population that can be segregated from a control group by their glycated hemoglobin A1c (HbA1c) levels"

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216079

Is insulin resistance the cause of fibromyalgia? A preliminary report

Abstract

Fibromyalgia (FM) is one of the most frequent generalized pain disorders with poorly understood neurobiological mechanisms. This condition accounts for an enormous proportion of healthcare costs. Despite extensive research, the etiology of FM is unknown and thus, there is no disease modifying therapy available for this condition. We show that most (if not all) patients with FM belong to a distinct population that can be segregated from a control group by their glycated hemoglobin A1c (HbA1c) levels, a surrogate marker of insulin resistance (IR). This was demonstrated by analyzing the data after introducing an age stratification correction into a linear regression model. This strategy showed highly significant differences between FM patients and control subjects (p < 0.0001 and p = 0.0002, for two separate control populations, respectively). A subgroup of patients meeting criteria for pre-diabetes or diabetes (patients with HbA1c values of 5.7% or greater) who had undergone treatment with metformin showed dramatic improvements of their widespread myofascial pain, as shown by their scores using a pre and post-treatment numerical pain rating scale (NPRS) for evaluation. Although preliminary, these findings suggest a pathogenetic relationship between FM and IR, which may lead to a radical paradigm shift in the management of this disorder.

πŸ‘︎ 10
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πŸ‘€︎ u/dem0n0cracy
πŸ“…︎ May 07 2019
🚨︎ report
The association between fasting plasma glucose and glycated hemoglobin in the prediabetes range and future development of hypertension [Geva et al., 2019] ncbi.nlm.nih.gov/pmc/arti…
πŸ‘︎ 22
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πŸ‘€︎ u/dreiter
πŸ“…︎ Jul 22 2019
🚨︎ report
The association between fasting plasma glucose and glycated hemoglobin in the prediabetes range and future development of hypertension [Geva et al., 2019] ncbi.nlm.nih.gov/pmc/arti…
πŸ‘︎ 31
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πŸ‘€︎ u/dreiter
πŸ“…︎ Jul 22 2019
🚨︎ report
Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 Diabetes Consuming a Three-Meal Diet: A Randomized Clinical Trial

https://care.diabetesjournals.org/content/early/2019/09/18/dc19-1142

Abstract

OBJECTIVE In type 2 diabetes, insulin resistance and progressive Ξ²-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic control compared with an isocaloric six-meal diet (6Mdiet).

RESEARCH DESIGN AND METHODS Twenty-eight volunteers with diabetes (BMI 32.4 Β± 5.2 kg/m2 and HbA1c 8.1 Β± 1.1% [64.5 Β± 11.9 mmol/mol]) were randomly assigned to 3Mdiet or 6Mdiet. Body weight, glycemic control, continuous glucose monitoring (CGM), appetite, and clock gene expression were assessed at baseline, after 2 weeks, and after 12 weeks.

RESULTS 3Mdiet, but not 6Mdiet, led to a significant weight loss (βˆ’5.4 Β± 0.9 kg) (P < 0.01) and decreased HbA1c (βˆ’12 mmol/mol, βˆ’1.2%) (P < 0.0001) after 12 weeks. Fasting glucose and daily and nocturnal glucose levels were significantly lower on the 3Mdiet. CGM showed a significant decrease in the time spent in hyperglycemia only on the 3Mdiet. Total daily insulin dose was significantly reduced by 26 Β± 7 units only on the 3Mdiet. There was a significant decrease in the hunger and cravings only in the 3Mdiet group. Clock genes exhibited oscillation, increased expression, and higher amplitude on the 3Mdiet compared with the 6Mdiet.

CONCLUSIONS A 3Mdiet, in contrast to an isocaloric 6Mdiet, leads to weight loss, significant reduction in HbA1c, appetite, and overall glycemia, with a decrease in daily insulin. Upregulation of clock genes seen in this diet intervention could contribute to the improved glucose metabolism.

πŸ‘︎ 4
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πŸ‘€︎ u/dem0n0cracy
πŸ“…︎ Sep 27 2019
🚨︎ report
Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin Levels mdpi.com/2072-6643/10/12/…
πŸ‘︎ 11
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πŸ‘€︎ u/headzoo
πŸ“…︎ Feb 21 2019
🚨︎ report
Issues with glycated hemoglobin

Hi, I've been a few months doing a Low carb diet combined with intermitent fasting. I've recently done a blood analysis and I had a surprise having a 6,6 on glycated hemoglobin. The normal values seem to be below 6 if you are not diabetic. Below 7 you may develop pre-diabetes and below 8 diabetes. I'm surely not diabetic (and pretty sure not pre-diabetic). Why, after being months without sugar (most of the time) and a low carb diet this value is so high??

Thanks in advance!

πŸ‘︎ 2
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πŸ‘€︎ u/Vicentelles
πŸ“…︎ Jan 15 2018
🚨︎ report
[J] [Magnetic Field Therapy] [Diabetes: Treatments] Magnetized water decreased blood glucose and glycated hemoglobin levels and reduced blood and liver DNA damages in STZ-induced diabetic rats. (2013) ncbi.nlm.nih.gov/pmc/arti…
πŸ‘︎ 3
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πŸ‘€︎ u/microwavedalt
πŸ“…︎ May 04 2018
🚨︎ report
[J] [Diabetes] Association of Exposure to Radio-Frequency Electromagnetic Field Radiation (RF-EMFR) Generated by Mobile Phone Base Stations with Glycated Hemoglobin (HbA1c) and Risk of Type 2 Diabetes Mellitus ncbi.nlm.nih.gov/pmc/arti…
πŸ‘︎ 2
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πŸ‘€︎ u/badbiosvictim1
πŸ“…︎ Oct 10 2016
🚨︎ report
Consistency of the Glycation Gap With the Hemoglobin Glycation Index Derived From a Continuous Glucose Monitoring System - June 2020

Joung HN, Kwon HS, Baek KH, Song KH, Kim MK. Consistency of the Glycation Gap with the Hemoglobin Glycation Index Derived from a Continuous Glucose Monitoring System. Endocrinol Metab (Seoul). 2020;35(2):377-383. doi:10.3803/EnM.2020.35.2.377

https://doi.org/10.3803/enm.2020.35.2.377

Abstract

Background: Discordances between glycated hemoglobin (HbA1c) levels and glycemic control are common in clinical practice. We aimed to investigate the consistency of the glycation gap with the hemoglobin glycation index (HGI).

Methods: From 2016 to 2019, 36 patients with type 2 diabetes were enrolled. HbA1c, glycated albumin (GA), and fasting blood glucose levels were simultaneously measured and 72-hour continuous glucose monitoring (CGM) was performed on the same day. Repeated tests were performed at baseline and 1 month later, without changing patients' diabetes management. The HGI was calculated as the difference between the measured HbA1c and the predicted HbA1c that was derived from CGM. The glycation gap was calculated as the difference between the measured and GA-based predicted HbA1c levels.

Results: Strong correlations were found between the mean blood glucose (MBG)-based HGI and the prebreakfast glucose-based HGI (r=0.867, P&amp;lt;0.001) and between the glycation gap and the MBG-based HGI (r=0.810, P&amp;lt;0.001). A close correlation was found between the MBG-based HGI at baseline and that after 1 month (r=0.729, P&amp;lt;0.001), with a y-intercept of 0 and a positive slope.

Conclusion: The HGI and glycation gap were highly reproducible, and the magnitudes of repeated determinations were closely correlated. Patients with similar mean glucose levels may have significantly different HbA1c levels.

http://www.e-enm.org/upload/pdf/EnM-2020-35-2-377.pdf

>If an individual has a measured HbA1c that is higher than expected from MBG levels (i.e., a high HGI), higher measured HbA1c levels than would be expected from MBG levels is likely to continue during repeated comparisons over time. Such individuals likely have a relatively long red blood cell (RBC) life span (i.e., a slow RBC turnover rate), a relatively high RBC glycation rate, or a variation in another yet undefined biological or genetic factor [15,16].

>*Factors that affect RBC survival or those that regulate intracellular glucose concentrations, such as gluc

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πŸ‘︎ 4
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πŸ‘€︎ u/Ricosss
πŸ“…︎ Jul 04 2020
🚨︎ report
TIL that there is a frog that can live in extremely cold conditions by allowing some extracellular fluids (blood/lymph etc) to freeze... Glycation of wood frog (Rana sylvatica) hemoglobin and blood proteins: in vivo and in vitro studies ncbi.nlm.nih.gov/pmc/arti…
πŸ‘︎ 17
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πŸ‘€︎ u/steinharterj
πŸ“…︎ Mar 07 2019
🚨︎ report
TG/HDL Ratio: A marker for insulin resistance and atherosclerosis in prediabetics or not? (Pub Date: 2021-10)

https://doi.org/10.4103/jfmpc.jfmpc_165_21

https://pubmed.ncbi.nlm.nih.gov/34934668

Abstract

Background

The spectrum of Diabetes Mellitus and various complications associated with it have been regarded as major global health challenges. Raised TG/HDL has been regarded as one of the valid markers for Insulin resistance. It leads to increased risk of CVD by causing Insulin resistance and also by its own effect on the vessel wall. Detection of raised TG/HDL ratio and early intervention before the patients develop clinical disease can help in mitigation of future consequences of CVD.

Aims

The aim of our study was to compare TG/HDL ratio between prediabetics and controls and further to look for any correlation between the TG/HDL ratio value with HOMA-IR and Carotid Intima Media Thickness (CIMT) in prediabetics.

Settings and Designs

A cross sectional study.

Methods and Material

Study was done at ABVIMS and Dr RML Hospital, New Delhi. 60 prediabetics and 60 age, sex, BMI matched controls were employed. In both cases and controls fasting and postprandial blood glucose, glycated Hemoglobin (HbA1C) and fasting Insulin levels were measured. HOMA-IR values in both the groups were calculated using fasting glucose and Insulin levels. Serum lipid profile was obtained and TG/HDL ratio was analysed in two groups. Values obtained were compared between the two groups. CIMT was only measured in cases using B mode ultrasonography.

Statistical Analysis and Results

Median (IQR) of fasting plasma Insulin (ΞΌIU/ml) in cases was 11.3 (10.175-13.505) versus that in controls being 5.73 (4.3-7.1). HOMA-IR (IQR) values in cases and controls were 3.12 (2.73 - 3.595) and 1.21 (0.918 - 1.505) respectively. Median (IQR) for TG/HDL ratio was 3.26 (2.712 - 4) for cases and 2.05 (1.755- 2.502) for controls. However no correlation was observed between either the mean CIMT (mm) or HOMA-IR with TG/HDL ratio.

Conclusions

Diabetes Mellitus and its various complications are of a great burden to society. Diagnosing the risk factors early before the onset of these manifestations can help us in combating these major issues. One of the risk factors among them is raised TG/HDL ratio. Early detection of elevated TG/HDL in prediabetics may serve in early detection of atherosclerotic complications and help physicians in framing primary preventive s

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πŸ‘︎ 7
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πŸ‘€︎ u/Ricosss
πŸ“…︎ Dec 27 2021
🚨︎ report
Examining the Efficacy of a Very-Low-Carbohydrate Ketogenic Diet on Cardiovascular Health in Adults with Mildly Elevated Low-Density Lipoprotein Cholesterol in an Open-Label Pilot Study. (Pub Date: 2021-12-16)

https://doi.org/10.1089/met.2021.0042

https://pubmed.ncbi.nlm.nih.gov/34918971

Abstract

Background: The objective of this open-label pilot study was to investigate the efficacy of a very-low-carbohydrate ketogenic diet (VLCKD), known as Nic's Ketogenic Diet, for 140 days on cardiometabolic markers in healthy adults with mildly elevated low-density lipoprotein cholesterol (LDL-C). Methods: Study assessments were conducted at Day 0, 28, 56, 70, 84, 112, and 140, and weight and blood pressure (BP) were measured and fasting blood was collected for analysis of plasma lipids. A DEXA scan was performed and body mass index recorded on Day 0, 70, and 140. Blood glucose, inflammatory, and thyroid markers were measured on Day 0 and 140. Compliance was assessed using weekly 3-day food records and daily blood glucose and ketone monitoring. Results: The results showed that body fat percentage decreased by 2.25% and 4.41% at Day 70 and 140, respectively (P  ≀ 0.012). Significant reductions in android, gynoid, and android/gynoid fat ratio and increases in muscle mass occurred by Day 70 and 140. Total cholesterol, LDL-C, and high-density lipoprotein cholesterol were increased and systolic BP and glycated hemoglobin (HbA1c) were decreased at Day 140 (P  < 0.05). Following this VLCKD for 140 days was found to be safe and was well tolerated. Conclusion: The VLCKD showed beneficial changes in body composition and cardiometabolic markers in eutrophic and overweight participants in a 140-day study suggesting a future role for this diet in populations at cardiovascular disease risk. Future research with larger sample size in a randomized double blind clinical trial is warranted to confirm these results. Clinical Trial Registration number: NCT04195594.

------------------------------------------ Info ------------------------------------------

Open Access: True

Authors: Nikolaos Tzenios - Erin D. Lewis - David C. Crowley - Mohamad Chahine - Malkanthi Evans -

Additional links:

https://doi.org/10.1089/met.2021.0042

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πŸ‘€︎ u/Ricosss
πŸ“…︎ Dec 27 2021
🚨︎ report
Since this homemade, educational copypasta got removed several times over on AskReddit for no reason, I'm posting it here and expanding it out of spite. I'm limiting it to 10,000 characters so it can be fit into a comment, but an additional source is found below
  • Journal of the American Dietetic Association: It is the position of the American Dietetic Association that appropriately planned vegetarian diets, including total vegetarian or vegan diets, are healthful, nutritionally adequate, and may provide health benefits in the prevention and treatment of certain diseases. Well-planned vegetarian diets are appropriate for individuals during all stages of the life cycle, including pregnancy, lactation, infancy, childhood, and adolescence, and for athletes.

  • British Dietetic Association: One of the UK’s longest-standing organisations that represents dietetics and nutrition, the British Dietetic Association, has affirmed that a well-planned vegan diet can β€œsupport healthy living in people of all ages” in an official document signed by its CEO. [...] The BDA has renewed its memorandum of understanding with The Vegan Society to state that a balanced vegan diet can be enjoyed by children and adults, including during pregnancy and breastfeeding, if the nutritional intake is well-planned."

  • Critical Reviews in Food Science and Nutrition (meta-analysis): Eighty-six cross-sectional and 10 cohort prospective studies were included. The overall analysis among cross-sectional studies reported significant reduced levels of body mass index, total cholesterol, LDL-cholesterol, and glucose levels in vegetarians and vegans versus omnivores. With regard to prospective cohort studies, the analysis showed a significant reduced risk of incidence and/or mortality from ischemic heart disease (RR 0.75; 95% CI, 0.68 to 0.82) and incidence of total cancer (RR 0.92; 95% CI 0.87 to 0.98) but not of total cardiovascular and cerebrovascular diseases, all-cause mortality and mortality from cancer. No significant association was evidenced when specific types of cancer were analyzed. The analysis conducted among vegans reported significant association with the risk of incidence from total cancer (RR 0.85; 95% CI, 0.75 to 0.95), despite obtained only in a limited number of studies.

  • Translational Psychiatry (systematic review): Based on this systematic review of randomized clinical trials, there is an overall robust support for beneficial effects o

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πŸ‘︎ 38
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πŸ‘€︎ u/Yeazelicious
πŸ“…︎ Nov 29 2021
🚨︎ report
I have all these test results but I have no idea what any of it means

I’ve gotten tested for so many different things but a doctor has never actually sat down & explained what it means. I’m sitting here trying to figure out what PCOS type I have and none of this is adding up. Could someone help just explain what the tests mean/ what they’re for.

Hemoglobin A1C: Glycated Hemoglobin 5.2% A1C Interpretation - Normal Est. Avg. Glucose - 103 mg/L

DHEAS: 4,351 ng/mL Sex Hormone Binding Globulins: 152.6 nmol/L Testosterone, total 129 ng/dL

After the results of my DHEAS & testosterone, my endo had me get the ACTH stimulation test. She said the results of that were normal but did not provide other explanations for the cause of the high DHEAS. She just told me to try the β€œSouth Beach Diet”. Not sure where to go from here and none of this makes sense.

πŸ‘︎ 2
πŸ’¬︎
πŸ“…︎ Sep 06 2021
🚨︎ report
Use of glycated albumin for the identification of diabetes in subjects from northeast China. (Pub Date: 2021-02-15)

https://doi.org/10.4239/wjd.v12.i2.149

https://pubmed.ncbi.nlm.nih.gov/33594334

Abstract

BACKGROUND

Metabolic memory is important for the diagnosis and treatment of diabetes in the early stage, and in maintaining blood glucose concentrations within the normal range. The clinical diagnosis of diabetes mellitus is currently made using fasting plasma glucose, 2 h-plasma glucose (2h-PG) during a 75 g oral glucose tolerance test, and hemoglobin A1c (HbA1c) level. However, the fasting plasma glucose test requires fasting, which is a barrier to screening, and reproducibility of the 2h-PG level is poor. HbA1c is affected by a shortened red blood cell lifespan. In patients with anemia and hemoglobinopathies, the measured HbA1c levels may be inaccurate. Compared with HbA1c, glycated albumin (GA) is characterized by more rapid and greater changes, and can be used to diagnose new-onset diabetes especially if urgent early treatment is required, for example in gestational diabetes. In this study, we provided cutoff values for GA and evaluated its utility as a screening and diagnostic tool for diabetes in a large high-risk group study.

AIM

To evaluate the utility of GA in identifying subjects with diabetes in northeast China, and to assess the diagnostic accuracy of the proposed GA cutoff in the diagnosis of diabetes mellitus.

METHODS

This cross-sectional study included 1935 subjects, with suspected diabetes or in high-risk groups, from 2014 to 2015 in the Second Affiliated Hospital of Harbin Medical University (Harbin, China). The use of GA to identify diabetes was investigated using the area under the receiver operating characteristic curve (AUC). The GA cutoffs were derived from different 2h-PG values with hemoglobin A1c cutoffs used as a calibration curve.

RESULTS

The GA cutoff for the diagnosis of diabetes mellitus was 15.15% from the receiver operating characteristic (ROC) curve. ROC analysis demonstrated that GA was an efficient marker for detecting diabetes, with an AUC of 90.3%.

CONCLUSION

Our study supports the use of GA as a biomarker for the diagnosis of diabetes.

------------------------------------------ Info ------------------------------------------

Open Access: True

Authors: Guo-Yan Li - Hao-Yu Li - Qiang Li -

Additional links:

[https://doi.org/10.4239/wjd.v12.i2.149](https://doi.org/10.42

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πŸ‘︎ 9
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πŸ‘€︎ u/Ricosss
πŸ“…︎ Feb 18 2021
🚨︎ report
Glycemic dysregulations are associated with worsening cognitive function in older participants at high risk of cardiovascular disease: Two-year follow-up in the PREDIMED-Plus study

ORIGINAL RESEARCH article

Front. Endocrinol. | doi: 10.3389/fendo.2021.754347

https://www.frontiersin.org/articles/10.3389/fendo.2021.754347/abstract

Glycemic dysregulations are associated with worsening cognitive function in older participants at high risk of cardiovascular disease: Two-year follow-up in the PREDIMED-Plus study

Provisionally acceptedThe final, formatted version of the article will be published soonNotify meCarlos GΓ³mez MartΓ­nez1, 2, 3**,** Nancy Babio1, 2, 3, 4*, Jordi JΓΊlvez2**,** Nerea Becerra TomΓ‘s1, 2, 3**,** πŸ“·Miguel Á. MartΓ­nez GonzΓ‘lez3, 5, 6**,** πŸ“·Dolores Corella3, 7**,** Olga CastaΓ±er3, 8**,** Dora Romaguera3, 9**,** JesΓΊs Vioque10, 11, 12**,** Ángel M. Alonso GΓ³mez3, 13**,** Julia WΓ€rnberg3, 14**,** πŸ“·JosΓ© A. MartΓ­nez3, 5, 15**,** πŸ“·Lluis Serra Majem3, 16**,** πŸ“·RamΓ³n Estruch3, 17**,** πŸ“·Francisco J. Tinahones3, 14**,** JosΓ© Lapetra3, 18**,** πŸ“·Xavier PintΓ³3, 19**,** πŸ“·Josep A. Tur3, 9**,** JosΓ© LΓ³pez Miranda3, 20**,** Aurora Bueno Cavanillas10, 21, 22**,** JosΓ© J. Gaforio10, 23**,** Pilar MatΓ­a MartΓ­n24**,** πŸ“·Lidia Daimiel15**,** Vicente MartΓ­n SΓ‘nchez3, 25**,** Josep Vidal17, 26**,** Clotilde VΓ‘zquez3, 27**,** πŸ“·Emilio Ros3, 17**,** πŸ“·SΓΈren Dalsgaard28**,** Carmen SayΓ³n Orea5**,** πŸ“·JosΓ© V. SorlΓ­3, 7**,** πŸ“·Rafael De La Torre3, 8**,** Itziar Abete3, 5**,** Lucas Tojal-Sierra3, 13**,** Francisco J. BarΓ³n LΓ³pez3, 14**,** Noelia FΓ©rnandez Brufal29**,** πŸ“·Jadwiga Konieczna3, 9**,** **Anton

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πŸ‘︎ 5
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πŸ‘€︎ u/dem0n0cracy
πŸ“…︎ Sep 22 2021
🚨︎ report
Kratom and Diabetes (type 1): my happy and encouraging experience

I'll try to sum up as much as possible:

since I started using kratom 3 years ago I soon realized that while I had in it in my body my blood sugar was easier to control, in fact sometimes I commited a mistake and I used the same amount of insuline that I would use when not having kratom in my system and I had some hypoglycemias...

later I discovered some scientific papers, most of them from Malaysian or Thaland universities, that backed up my intuition and experience: yes, kratom does have synergistic action with insulin and hypoglycemic qualities, specially in diabetic (rats). You can just google and you'll find a couple of articles.

So then my insulin intake has been reduced between 25 and 40% depending on my kratom intake, exercise and type of food (carbs) I took. Not only that but the most happy event happent this last week when I visited my doctor to receive the results of my last HbA1c (glycated hemoglobin test), this test measures your average sugar levels and somewhat diabetic health in the last 3 months...

I knew that the HbA1c was going to be much better than the last time (a year ago more or less) when I had horrible levels, unhealthy levels of 8.5 (more than 8 means very bad control). I expected to have lowered it around a point so around 7.2 or 7.5 but.... it came being 6.6!!

I couldn't believe... When I had 8.5 I was starting having kratom in a regular basis but much less often than nowadays (I still do want/need to do regular tolerance breaks) but I was worried about the results cause the last time (8.5 time) my kidneys and liver were behaving not very good so I mistakenly attributed it to the kratom since I had started taking it somewhat more often than before. However the liver and kidney levels had not only not worsened but were completely normal, the overall test result was PERFECT in all parameters. The fault for my liver and kidney problem was poor diabetes control.

It is true that not only I have to thank the kratom for my improvement, I have had some changes in my eating patterns such as reducing the intake of carbohydrates, especially at dinner. However, I have NO DOUBT that kratom has managed to help me in an impressive way to regulate my blood sugar levels, especially helping me to keep stress and cortisol levels low, which have a very, very negative influence on blood sugar levels and life in general.

My HbA1c has not been this good for as long as I can remember, possibly more than 10 years. Getting to a

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πŸ‘︎ 95
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πŸ‘€︎ u/Ethnopharmacist
πŸ“…︎ Mar 20 2021
🚨︎ report
Would love to help grow this community!

I posted my story yesterday over at r/fasting here and a commenter mentioned that this community was ramping up. I am glad to see I am not alone and hope more people are able to see a more flexible approach to fasting is possible and still be able to achieve the results they are looking for.

I have not had labs done in a couple of months now, but my GTT, FBS and Glycated hemoglobin are all well within normal range, despite the fact that I do not follow Keto, LCHF or something similar as far as diet and I drink zero calorie monster every morning to start my day.

πŸ‘︎ 11
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πŸ‘€︎ u/ChiTownDerp
πŸ“…︎ May 04 2021
🚨︎ report
Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

πŸ‘︎ 5k
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πŸ‘€︎ u/Leckzsluthor
πŸ“…︎ Jan 02 2022
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Carnitine Orotate Complex Ameliorates Insulin Resistance and Hepatic Steatosis Through Carnitine Acetyltransferase Pathway. (Pub Date: 2021-08-19)

https://doi.org/10.4093/dmj.2020.0223

https://pubmed.ncbi.nlm.nih.gov/34407600

Abstract

Background

Carnitine orotate complex (Godex) has been shown to decrease glycated hemoglobin levels and improve steatosis in patients with type 2 diabetes mellitus with non-alcoholic fatty liver disease. However, the mechanisms of Godex in glucose metabolism remain unclear.

Methods

Male C57BL/6J mice were divided into four groups: normal-fat diet, high-fat diet, a high-fat diet supplemented with intraperitoneal injection of (500 mg or 2,000 mg/kg/day) Godex for 8 weeks. Computed tomography, indirect calorimetry, and histological analyses including electron microscopy of the liver were performed, and biochemical profiles and oral glucose tolerance test and insulin tolerance test were undertaken. Expressions of genes in the lipid and glucose metabolism, activities of oxidative phosphorylation enzymes, carnitine acetyltransferase, pyruvate dehydrogenase, and acetyl-coenzyme A (CoA)/CoA ratio were evaluated.

Results

Godex improved insulin sensitivity and significantly decreased fasting plasma glucose, homeostatic model assessment for insulin resistance, steatosis, and gluconeogenesis, with a marked increase in fatty acid oxidation as well as better use of glucose in high-fat diet-fed mice. It preserved mitochondrial function and ultrastructure, restored oxidative phosphorylation enzyme activities, decreased acetyl-CoA/CoA ratio, and increased carnitine acetyltransferase content and pyruvate dehydrogenase activity. Carnitine acetyltransferase knockdown partially reversed the effects of Godex in liver and in vitro.

Conclusion

Godex improved insulin resistance and steatosis by regulating carnitine acetyltransferase in liver in high-fat diet-fed mice.

------------------------------------------ Info ------------------------------------------

Open Access: True

Authors: Jung-Hee Hong - Moon-Kyu Lee -

Additional links:

https://www.e-dmj.org/upload/pdf/dmj-2020-0223.pdf

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πŸ‘€︎ u/Ricosss
πŸ“…︎ Aug 21 2021
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SENSEONICS- IS EVERYBODY MISSING THE BIG PICTURE ?

FRI 02/19/2021 SENSEONICS- IS EVERYBODY MISSING THE BIG PICTURE ?

Sorry, a little long, can't help it... Probably more than you would ever like to know. But if you are an investor or just an interested party you may want to spend a few minutes reading.

Please note that these are just my own personal opinions and may likely be totally inaccurate. I am no medical or financial expert, nor am I a diabetic, nor do I possess any "inside information" whatsoever. Your own opinions may be completely different/opposite from mine, and give it a thumbs-down, which is okay with me (I'm a "Reddit neophyte", member only a couple of weeks and not well versed in most of its general user practices). Please DO NOT consider any of this medical or financial advice in any way. You must perform your own due diligence ! Thanks for reading.

I have no idea how this stock will perform in the future, but in my opinion, most everyone may be underestimating this company and its product. So again, please DO NOT consider this medical or financial advice in any way. And yes, I do own shares in the SENSEONICS company (since Jan 2021). And yes, I wouldn't mind if those shares became more valuable in the future. And I am planning on holding them long term. And this is why...

(1) First, baby steps... You can skip this section if you'd like, then goto (2) if you already know the basics of the disease/costs/etc...

What is the fundamental problem of the disease DIABETES type-1 or type-2 / aka Chronic HYPER-glycemia ? It is the inability to regulate the hormone insulin in order to metabolize/absorb carbohydrates/sugars into the cells for energy, resulting in abnormally elevated levels of glucose (sugar) in the blood and urine. Continuous high levels of blood/urine glucose are toxic and inflammatory and will eventually damage body tissues which lead to many serious chronic health conditions, or even death (in layman's terms... it makes your body age faster).

DIABETES type-1 (formerly aka "juvenile diabetes") is the body's inability to produce insulin or only in extremely small/insufficient amounts (no known prevention or cure).

DIABETES type-2 (formerly aka "adult-onset diabetes") is the body's inability to fully utilize the insulin it produces. Over time as the disease progresses, these patients can be diagnosed as "type-1" as well (may possibly be preventable or reversible in some cases).

PRE-DIABETES type-2 (aka "early-stage insulin resistance") is when blood glucose levels are h

... keep reading on reddit ➑

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πŸ‘€︎ u/FractionalShare
πŸ“…︎ Feb 19 2021
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This subreddit is 10 years old now.

I'm surprised it hasn't decade.

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πŸ‘€︎ u/frexyincdude
πŸ“…︎ Jan 14 2022
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Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies πŸ˜‚

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πŸ‘€︎ u/Vegetable-Acadia
πŸ“…︎ Jan 11 2022
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