Been reading more about climate change again after watching the Netflix film Don’t Look Up. I was wondering if there’s anything that can chelate methane and if we could do something to decrease the mass amounts that are released each (and possibly prepare for the methane that could be released from the ice caps).
From an uninformed redditor
Hey everyone. So I’m battling a lot of fight or flight type responses with the constant stress im under and im attempting to heavily supplement with magnesium amongst other things. Is l threonate that superior as opposed to other forms of magnesium? What do you guys think is best? Appreciate any info!
Some people take it daily so it appears to me that if it actually is significant those people should all have to take supplements on top right ? I take it on the occasion for Learning - should I be concerned about this ? Because I dont supplement with anything.
( Enzymes: Protease, Hemicellulase, Cellulase, Amylase, Glucoamylase, Serrapeptase, Nattokinase, Lumbrokinase, Chitonase )
“Focus: When you began to work at dissolving the biofilms, did you find the bugs?”
Article Insert - - “ Cohen: Oh yes! But I found something else that was just as fascinating, something nobody was thinking about. Think about what that biofilm might really be made of. The biofilm matrix has a horizontal and a vertical weave. It’s standard knowledge that biofilm bacteria sequester calcium, magnesium and iron to help build that matrix. Minerals give the biofilm integrity—as if you’re building a wall. You don’t only want bricks, you want cement. To address this, first you use fibrinolytics to help dissolve the fibrin, then you use EDTA to chelate out the minerals. And guess what? We started getting huge dumps of toxic metal. Now why is that? I think the answer points to something so huge, whether we’re dealing with autism or lyme disease or multiple sclerosis or lupus or even cancer.
Focus: Why were the kids dumping toxic metals when you began to degrade the biofilms?
Cohen: Well, think about it. These are all positively charged cations, that’s why EDTA is able to chelate them well. Mercury, and copper, and other heavy metals are also positively charged. Why would the bug preferentially insert calcium or magnesium? It could use any positively charged metal. This has been the most fascinating part of my year-long work on biofilms. As we degraded this biofilm matrix and liberated these bugs, not only did the organic acid levels get higher—one child bounced into the 400’s—but the kids started to dump metals into the bowel. I felt like I’d exposed these little … in a cell.
Focus: So the metals and the bugs are both in the gut?
Cohen: Right. At an Autism One Conference in Chicago last May, one researcher presented his proton analysis of brain tissue, attempting to verify the presence of mercury in the brains of autistic children, and he couldn’t find it. Yet he still found evidence of activation of the microglia (a type of glial cell that acts as the first and main form of active immune defense in the central nervous system) as a consequence of toxic metals. So where are these metals? I’m suggesting they are in the biofilm, along with the bugs, in the gut. If the biofilm wasn’t using toxic metals, along with common minerals, to build the biofilm, then why all of a sudden do I get these huge dumps of metals on stool tests?
Focus: What exa
... keep reading on reddit ➡It showed up in gen chem anki deck but i have never heard of this before...
Hi! As a part of my research I need to determine stability constants of some metal chelates, eg. FeEDTA. I read in different sources, that quite common program that was used for calculating these constants was FROTRAN program BEST. I can't find it anywhere to download it (good website let's say). These literature sources are quite old, thus idk if this program is actually still used? I was wondering, if someone could tell me if maybe there are some better options that might help? Or any tips from people that know something around this topic?
(I already posted this in the r/chemistry subreddit but it was removed by mods. Don't understand why as I'm genuinly interested in the mechanism and this whole reaction is legal pretty much everywhere... So I'll try to ask you guys)
Due to curiosity I'm currently investigating a certain reaction originally described by T. Kametani in his paper "Part DXLII, T. Kametani, et al., Heterocycles 1, 257". (Appended as an Image in this post)
In this paper he described the formation of Tryptamine by heating the Cu(II) Tryptophan chelate in a high-boiling solvent like DMSO. The chelate was formed by the reaction of CuOAc and L-Tryptophan in solution. The resulting complex was added to DMSO and heated to 175°C for several minutes. This resulted in the vanishing of the blue-colored complex and the formation of a yellow solution. He proceeded to extract tryptamine from this solution by crashing it out with water, adding NaOH and extracting with cholorform. After purification by HPLC the reaction yielded Tryptamine with a 40% yield.
Sadly in this paper no mechanisms were proposed nor have the byproducts been characterized. I'm currently trying to understand the mechanism behind this reaction and after alot of research I'm still pretty confused as to how tryptamine could possibly form during such a reaction.
My current idea is that due to the high oxidation potential of Cu(II) decarboxylation is achieved through a intramolecular redox reaction creating a carboxylamine radical intermediate. This radical will quickly degrade into CO2 and thus forming a tryptamine radical. Now this is where I don't understand how this reaction proceeds. In order to form tryptamine from this radical would be to form a hydrogen bond with the radical carbon atom. My best guess would be that this hydrogen is taken from another tryptamine radical thus creating tryptamine and 2-(3-indolyl)ethylimine. (A picture of my proposed mechanism is attached to this post)
Recently I found another paper describing the same process but with alanine instead of tryptophan (In the same conditions). They proposed a mechanism which doesn't make sense at all to me as it doesn't lead to the formation of any amine. Also in their mechanism the copper leaves as its oxide CuO (Which I also don't understand. Why would the copper bind with the remaining oxygen atom rather than oxidizing it?). I tried to run the synthesis with tryptophan multiple times and it was always elemental copper that precipitated out of soluti
... keep reading on reddit ➡
question above ^^ also do they effect Ksp or anything else?
Anyone else? I think I’m going to take both, though.
When water is added to the DMSO/tryptamine solution, brown tryptamine freebase will fall out-of solution. This was recovered, and washed with some water.
After some time drying the mass of crystals started to become very tar like with exposure to air. At this point and time the solid wrenched of tryptamine, a notable sweet feces like aroma. The "gunk" was dissolved in acetone yield a solution which was dark colored, yet still has an excellent fluorescence under UV light.
At this point the chemist can go through two means of purification. Column chromatography, or repeated extract and recrystalize till the the product is pure.
Test done on the product showed it was in fact tryptamine, yet has massive impurities within it. I will post my procedure later this week.
In terms of feasibility, it is feasible, and does actually make tryptamine! However, with DMSO atleast, the process is immensely dirty and creates alot of waste which must be disposed of properly! Copper salts, various sulfur compounds from DMSO decomposition, the smells are ungodly, and of course, the product gets inevitably oxydised in both the high heat of reaction, and the byproducts in formation.
I recently found out I have iron deficiency anemia, and I'm looking into different kinds of supplements. Each kind I look into seems to be a different type of iron, like ferrous gluconate, ferrous sulfate, ferrous bisglycinate chelate, etc. Is there a resource that breaks down the differences? Do each of the different types serve different purposes?
I always confuse chelate with complex ion... anyone have a mnemonic? I know complex ions are formed by coordinate covalent bonds BUT the chelate have RING structures.
https://preview.redd.it/dx7g7r9nvjx61.png?width=952&format=png&auto=webp&s=78f2c38fc9e9283eb454527e813dda5929d2c41f
https://preview.redd.it/8hvgcl8jvjx61.png?width=812&format=png&auto=webp&s=817d4735bae313269af7e1272bc6de6b72f79f07
Can someone please explain the difference to me?
Should i take one after lunch? Is there any side effects I can experience with 200mg? Is 200mg too little amount to take at first?
Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c00566
Shuoyan Xiong, Manar M. Shoshani, Xinglong Zhang, Heather A. Spinney, Alex J. Nett, Briana S. Henderson, Thomas F. Miller, III, and Theodor Agapie
https://ift.tt/3tK4Eon
Looking to do an extended fast, over 14 days. I currently take Magnesium Chelate daily - would that take the place of the recommended magnesium during a fast? Or do I need to take additional magnesium along with potassium and salt? Just curious to get some input. Thanks!
So I'm currently trying to synthesize some Tryptamine from L-Tryptophan. Important to say is that the product isn't the most important thing but rather the practical aswell as theoretical chemistry behind this synthesis.
I recently performed the following synthesis:
- L-Tryptophan was dissolved in water and an excess of Copper(II)Acetate was added (results in the formation of the L-Tryptophan Copper Complex).
- The precipitate was cleaned and dried.
- 2g of the complex were added to 15ml DMSO and heated under reflux for 15min (or until no further generation of CO2 was noted) (at 130-150°C) resulting in a color change from blue to a dark brown color.
- The cooled reaction mixture had a yellow colour to it and elemental copper sank to the bottom.
Now because I don't have any expensive analytical equipment at home it's a bit difficult to determine all the byproducts. So my only way to do this would be either with a TLC (which I have ordered and should arrive in a few days) or by doing theoretical analysis which I prefer. Could any of you fellow bees help me determinig all the possible byproducts that could form?
My guess is that primarily Tryptamine aswell as Tryptophan should have formed. It could also be that some Tryptamine/Tryptophan was oxidized to Indole-3-Acetaldehyde and maybe even Indole-3-Acetic acid. What are your thoughts on this?
I didn't want to use melatonin because the ones in Australia are too weak and I'd rather have my body naturally produce it. I researched and found Magnesium to be a good alternative and I am really pleased with the results. I used to have broken sleep, sleeping for 3 hours, then suddenly waking up and then sleeping for 3 hours again, along with falling asleep to be very hard. I was a chronic insomniac but somehow these magnesium chelate pills have helped me sleep easily and stay asleep for 10 hours average. I now also have vivid dreams unlike before. I just wanted to share my experience.
Edit: I take Magnesium Chelate 500mg 1 pill before bed. I heard it is best taken on an empty stomach.
Edit: The specific product I use is Nature's Own Magnesium Chelare 500mg. I believe any Magnesium Chelate would be just as effective (I saw people reported having good sleep especially with Magnesium Chelate so I decided to try it out).
Edit: Don't forget to get vitamin D in the day time
I know that question sounds a bit overthought but as a someone who consumes Green tea a lot (which has significant amount of aluminium) most preferably with black pepper and citrus fruits (they increase bioavailability of egcg) I wouldn't want aluminium to accumulate in my brain.
https://pubmed.ncbi.nlm.nih.gov/3391623/ (citric acid effect on aluminium
https://bazawiedzy.ue.poznan.pl/info/article/UEPd4bc3d5d1a354be5b42397a4bed3b848/ (and here the one study argued lemon juice can make aluminium from green tea more absorbable)
Normally, I follow a whole food plant based diet and don't take magnesium supplements and don't need it as I notice signs of magnesium deficiency from my endurance strength/libido/sleep quality, which were all fine. However, I am eating like shit lately and overdosed vit d a bit, which certainly depleted my magnesium stores as I am having awful insomnia and heart palpitations.
As a result, I decided to buy magnesium supplement and tried couple of different brands and types only to get frustrated and disappointed. They literally had no effect, (only noticed some significant relaxation with Solgar's magnesium citrate)
So to check up; I just decided to eat more of spinach and raw cacao, just 200 gr of spinach or 30 gr of cacao granted me desired relaxation effect.
What's the deal? I am aware effects I get from spinach or cacao can be attributed to flavonoids or other essential nutrients but I don't notice psychoactive relaxation from non magnesium rich antioxidant foods like blueberries.
I'd like to know if there's any scientific study in that subject.
magnesium? copper? iron? all of them?
