Hi fellas! I've been a fan of airfried fries since months ago. The best thing bout it? The crispiness minus the greasiness!
However - I've been seeing articles about Acrylamide recently. Some state not to go beyond the temperature advised, and some state not to fry beyond the advised time. It's quite unclear.
How do we keep the acrylamide level at bay? I understand that even baked or conventional oil-frying methods do create acrylamide compounds as well.
Just wanna enjoy my fries without worrying when or which fry will be my last
BMC Genomics. 2021; 22: 728.Published online 2021 Oct 8. doi: 10.1186/s12864-021-07951-1PMCID: PMC8499523PMID: 34625024
Transcriptomic analysis of the seminal vesicle response to the reproductive toxicant acrylamide
David A. Skerrett-Byrne,#1,2 Brett Nixon,#1,2 Elizabeth G. Bromfield,1,2,3 James Breen,4,5,6,7 Natalie A. Trigg,1,2 Simone J. Stanger,1,2 Ilana R. Bernstein,1,2 Amanda L. Anderson,1,2 Tessa Lord,1,2 R. John Aitken,1,2 Shaun D. Roman,1,2 Sarah A. Robertson,4,7 and John E. Schjenken📷1,2Author information Article notes Copyright and License information Disclaimer
Associated Data
[Supplementary Materials
... keep reading on reddit ➡A friend of mine was reading a warning label on a loaf of bread that she ate frequently while pregnant. The warning label, courtesy of our friends in California, was talking about Acrylamide and it's carcinogenic effects and potential birth defects. This made my friend extremely worried that she and her baby (now 4 months old) would get cancer or some other side effect.
Being a statistician, I like to read up on the studies that are the cause for the warning labels. I've talked to several medical professionals about NCBI, and they all agree that it is a trustworthy source for medical information (as opposed to Google). I came across this article on NCBI titled Dietary Acrylamide and the Risks of Developing Cancer: Facts to Ponder. The article frequently talks about acrylamide in rodents, but repeatedly mentions lines such as:
>"Since the discovery of Acrylamide [AA] in foods, numerous studies have set to explore the carcinogenic potential in humans. Although AA was shown to be carcinogenic in both male and female rodent models, numerous studies reported no statistically significant association between dietary AA intake and various cancers in humans, e.g., pancreatic, prostate, breast, ovarian, and endometrial cancer (23-30)."
>"To date, reproductive toxicity of AA in humans is unheard of. In laboratory animals, exposure to high levels of AA proven to cause reproductive toxicity (79, 80)."
I know that animal testing, specifically rodent and chimp, is often used to model how drugs could potentially harm humans, but without reproduction in humans (ethics aside), how can we simply extrapolate the harmful effects of drugs, chemicals, and compounds like Acrylamide to humans? The statistician in me says Reproducibility is vital. Perhaps I'm missing something or don't fully understand medical statistics.
Note: I have a Bachelors in Statistics and work as a Military Contractor, hence the potential misunderstanding.
Hey guys. I'm currently working on a project including a risk analysis of Acrylamide exposure and for that I've been using the software FDA-iRISK. However, I've been struggling with finding the correct dose-response model. If somebody could help me with this, I'd appreciate it very much. Thanks for any help.
I was trained in a huge, bootstrap lab. Made my own competent cells, purified my own Taq, and, of course, made my own gels for Westerns.
Competent cells? Store bought is totally fine. Switching to ordering polymerase may have saved me hundreds of hours at this point with no defect in my PCR.
But pre-cast protein gels? Wtf? This doesn't seem to be an unpopular opinion, either. A lot of the proprietary products I trust have been thoroughly optimized, but it seems like I and so many others just do not get the same quality of blot results with pre-cast gels.
Why is this the case?
Alkyl–alkyl bond‐forming with coinstantaneous formation of a stereogenic center is attractive yet challenging. Herein, the intermolecular, regio‐ and enantioselective formal hydrofunctionalization of alkenes to forge a stereogenic center in the α‐position to the newly formed alkyl–alkyl bond is reported for the first time, providing a facile access to a wide range of α‐branched chiral amides with broad functional group tolerance.
Abstract
The development of enantioselective alkyl–alkyl cross‐couplings with coinstantaneous formation of a stereogenic center without the use of sensitive organometallic species is attractive yet challenging. Herein, we report the intermolecular regio‐ and enantioselective formal hydrofunctionalizations of acrylamides, forging a stereogenic center α‐position to the newly formed Csp3–Csp3 bond for the first time. The use of a newly developed chiral ligand enables the electronically‐reversed formal hydrofunctionalizations, including hydroalkylation, hydrobenzylation, and hydropropargylation, offering an efficient way to access diverse enantioenriched amides with a tertiary α‐stereogenic carbon center which is facile to racemize. This operationally simple protocol allows for the anti‐Markovnikov enantioselective hydroalkylation, and unprecedented hydrobenzylation, hydropropargylation under mild conditions with excellent functional group compatibility, delivering a wide range of amides with excellent levels of enantioselectivity.
https://ift.tt/2Hqn1M0
An unprecedented highly enantioselective radical azidation of acrylamides is reported, in which arrays of acrylamides can be converted to the corresponding alkylazides in high yield with good‐to‐excellent enantioselectivity. Notably, employing a anionic cyano‐bisoxazoline (CN‐Box) ligand is crucial for the generation of a monomeric CuII azide species, rather than a dimeric CuII azide intermediate.
Abstract
Asymmetric radical azidation for the synthesis of chiral alkylazides remains a tremendous challenge in organic synthesis. We report here an unprecedented highly enantioselective radical azidation of acrylamides catalyzed by 1 mol % of a copper catalyst. The substrates were converted to the corresponding alkylazides in high yield with good‐to‐excellent enantioselectivity. Notably, employing an anionic cyano‐bisoxazoline (CN‐Box) ligand is crucial to generate a monomeric CuII azide species, rather than a dimeric CuII azide intermediate, for this highly enantioselective radical azidation.
https://ift.tt/3phCSwT
Dear labrats, During my bachelor thesis, I worked with a lot of SDS PAGEs. My supervisor told me, as soon as the acrylamide is polymerized, it's not dangerous anymore and I can touch it with my bare hands. As he did so himself, I did not question it. This is 2 years ago now. I'm now studying at a new university and here I was informed that never all acrylamide is completely polymerised . So now I'm really worried that I will have some long term effects or won't be able to get healthy children just because of a stupid mistake I did during my bachelorthsis. What do you think? How severe is it? I know I'm probably overreacting but I can't stop thinking about it. All gels I touched where already stained and destined... I hope then most unpolymerized acrylamide should be out already? I'm just panicking cause it was over 6 months and I heard acrylamide accumulates in the body...
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c11334
Yan Xu, Jonathan J. Wong, Adrian E. Samkian, Jeong Hoon Ko, Shuming Chen, K. N. Houk, and Robert H. Grubbs
https://ift.tt/3qqkBz7
Alkyl–alkyl bond‐forming with coinstantaneous formation of a stereogenic center is attractive yet challenging. Herein, the intermolecular, regio‐ and enantioselective formal hydrofunctionalizations of alkenes to forge a stereogenic center α‐position to the newly formed alkyl–alkyl bond is reported for the first time, providing a facile access to a wide range of α‐branched chiral amides with broad functional group tolerance.
Abstract
The development of enantioselective alkyl–alkyl cross‐couplings with coinstantaneous formation of a stereogenic center without the use of sensitive organometallic species is attractive yet challenging. Herein, we report the intermolecular regio‐ and enantioselective formal hydrofunctionalizations of acrylamides, forging a stereogenic center α‐position to the newly formed Csp3–Csp3 bond for the first time. The use of a newly developed chiral ligand enables the electronically‐reversed formal hydrofunctionalizations, including hydroalkylation, hydrobenzylation, and hydropropargylation, offering an efficient way to access diverse enantioenriched amides with a tertiary α‐stereogenic carbon center which is facile to racemize. This operationally simple protocol allows for the anti‐Markovnikov enantioselective hydroalkylation, and unprecedented hydrobenzylation, hydropropargylation under mild conditions with excellent functional group compatibility, delivering a wide range of amides with excellent levels of enantioselectivity.
https://ift.tt/2Hqn1M0
Asymmetric radical azidation for the synthesis of chiral alkylazides remains a tremendous challenge in organic synthesis. We report here an unprecedented highly enantioselective radical azidation of acrylamides catalyzed by 1 mol% of copper catalyst, and arrays of acrylamides were converted to the corresponding alkylazides in high yield with good to excellent enantioselectivities. Notably, employing anionic cyano‐bisoxazoline (CN‐Box) ligand is crucial, which generates a monomeric Cu(II) azide species, rather than a dimeric Cu(II) azide intermediate, for this highly enantioselective radical azidation.
https://ift.tt/3phCSwT
To develop enantioselective alkyl‐alkyl cross‐couplings with coinstantaneous formation of a stereogenic center without the use of sensitive organometallic species is attractive yet challenging. Herein, we report the intermolecular regio‐ and enantioselective formal hydrofunctionalizations of acrylamides, forging a stereogenic center α ‐position to the newly formed C sp3 ‐C sp3 bond for the first time. The use of a new developed chiral ligand enables the electronically‐reversed formal hydrofunctionalizations, including hydroalkylation, hydrobenzylation, and hydropropargylation, offering an efficient way to access diverse enantioenriched amides with a tertiary α ‐stereogenic carbon center which is facile to racemize. This operationally simple protocol allows for the anti‐Markovnikov enantioselective hydroalkylation, and unprecedented hydrobenzylation, hydropropargylation under mild conditions with excellent functional group compatibility, delivering a wide range of amides with excellent levels of enantioselectivity.
https://ift.tt/2Hqn1M0
