Platelet derived growth factor Puns

Has anyone tried any of these options? PRF is a new generation PRP, said to be vastly more effective. Exosome treatment is also fairly new but hard to find.

As for topical EGF, cosmetic brands like Bioeffect and Easydew claim to have effective topical formulations, but I'm mostly interested in this gel for indicated for burns, necrosis and diabetic foot ulcers. It's not known to be used cosmetically (contrary to what this website is advising), but what if it could help?

https://okdermo.com/product/regen-d-60-recombinant-human-epidermal-growth-factor-gel-bharat-biotec-15g/

http://www.inifoundation.org/index.php/education/neuroscience-anthology/212-intermittent-fasting-implications-for-neurogenesis-and-the-treatment-of-neurological-and-neurodegenerative-disorders

INTERMITTENT FASTING – IMPLICATIONS FOR NEUROGENESIS AND THE TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS

By Roomana Patel

The practice of intermittent fasting (IF), or cycling between periods of ingesting and abstaining from food, has long been revered in religious and spiritual communities as a demonstration of self-restraint, discipline, empathy, and as a method of mental and bodily detoxification.

Scientists have only recently begun testing and validating the significance of IF, discovering a host of compelling findings resulting from the practice. Some of these findings include the onset of ketogenesis, substantial shifts in metabolic pathways and some cellular processes, retardation of age-related neurodegenerative diseases such as Alzheimer’s Disease and Huntington’s Disease, and the increase of hippocampal neurogenesis (Bruel-Jungerman E, et al., 2007; Longo V. & Mattson M., 2013; Manzanero S., et al., 2014). The implementation of IF, therefore, has the potential to serve as a potent, noninvasive and inexpensive strategy within prevention and treatment modalities for several neurological, metabolic, and mood disorders.

Neurons in the hippocampus play an essential role in cognitive processes such as learning and memory, and they are susceptible to dysfunction and deterioration in cases of stroke, traumatic brain injury, epilepsy and age-related neurodegenerative disorders like Alzheimer’s Disease (Longo V. & Mattson M., 2013). As humans and animals age, there is also a general decline in the production of hippocampal neurons, increasing the existing neurons’ vulnerability to these traumas and degeneration. IF induces a mild stress response in brain cells, increasing activity in hippocampal neurons, and producing brain-derived neurotropic factor (BDNF). BDNF, a key protein in brain plasticity, stimulates the growth and upkeep of synapses and dendrites, and increases neurogenesis (Longo V. & Mattson M., 2013; Martin B., et al., 2006). These findings imply that IF can be a viable tool to help replace injured, diseased, and non-proliferating hippocampal neurons, reducing the impact of trauma, and aiding in the deceleration of some neurodegenerative disorders.

**Recent studies have also shown that the proliferation of hippocampal