Pharmaceutical microbiology Puns

Hello everyone!

I’m currently a university student who is interested in the pharmaceutical industry.

I am currently working on my bachelors in Microbiology.

I plan on getting my masters degree in a Western European country.

While doing research, I noticed that in Europe a lot of universities have a masters degree program in Pharmaceutical Sciences.

For my career, I am quite interested in drug development and discovery.

I am mainly interested in the research aspect of pharmaceutical industry.

So my main question is if it is better for me to obtain a Masters in Microbiology or a Masters in Pharmaceutical Science?

Which degree is more practical? And which degree would it be easier for me to find a job in?

Which do you think will lead to more opportunities for me?

Are both of these suitable?

Or did I already fuck up by majoring in Microbiology rather than chemistry or something for my undergraduate?

The main countries in Europe that I’m considering studying in are France, The Netherlands, Germany, Belgium, and Switzerland. Also a few others but they are not as high on my list.

So which major would help me a have better access to the job markets in these countries? Because I’m also trying to settle down in these countries once I graduate.

And if anybody has any information on the job markets within these countries feel free to hit me up.

Thanks for reading!

A recent paper (June 14th, 2021) that describes the versatility and promise of Antimicrobial Peptides (AMPs). AMPs are having their moment. Soon Brilacidin may have its star turn.

Excerpts:

Brilacidin is a synthetic AMP, successfully tested in Phase II clinical trials for treatment of acute bacterial skin and skin structure infections. A recent work demonstrated that Brilacidin displays an antiviral activity, inhibiting SARS-CoV2 virus in Vero African green monkey kidney cells and Calu-3 human lung epithelial cells and showing a synergistic inhibitory activity in combination with the antiviral Remdesivir.

Conclusions

AMPs can be considered unconventional therapeutic small molecules which have attracted great interest in recent years because of their promising potential, as they can be used as alternative or complement approaches for treatment of microbial infections. Due to their potency, broad-spectrum activity, different sources available in nature, lack of rapid development of resistance, low accumulation in tissue and rapid killing activity, these peptides show several advantages over conventionally used antibiotics. Moreover, AMPs also display immunomodulatory, antioxidant and anti-inflammatory activities and, for this reason, researchers are devoting considerable efforts to implement the use of AMPs as commercially available drugs. This review examined the features of AMPs, their mechanisms of action and their sources, highlighting their antimicrobial activity against several pathogens involved in human infections. Thus, the efficacy and potentially applicability of AMPs in human diseases has been analyzed. Particularly, we examined the beneficial role of several AMPs in the treatment of skin infections, but we also reviewed their potential use in respiratory diseases and oxidative-stress disorders, such as obesity, diabetes and chronic inflammatory intestinal disorders. Indeed, AMPs display several potential applications in medicine, since they can regulate pro-inflammatory reactions, stimulate cell proliferation, promote wound healing by modulating the cell migration, angiogenesis, chemotaxis and cytokine release. On these bases, pharmaceutical companies are performing great efforts to develop AMPs as therapeutic agents, improving their chemical and metabolic stability, setting up smart and novel formulation strategies, with the aim to improve AMP delivery and, consequently, their activity.

Full Text: [https://www.frontiersin.org/articles

Hi all, I am currently working as a medical writer at a global pharmaceutical company, with extensive experience in regulatory submissions, patient relations, data transparency, and medical communications. I have a strong background in microbiology and genomics, and a wide range of skills including programming, website design, and technical writing. I'm an outgoing, friendly, driven person looking to take the next leap in my career. I'd like to stay within the pharmaceutical industry, but I'm also willing to venture into medical communication agencies and even back into academia. I am absolutely in love with the UK, and I have a lot of friends and extended family in England. I'm ready to build a life there, but I'm finding it difficult to find sponsorship (seems to be a common theme here). Does anyone have any recommendations or resources to share on job searching in the UK for someone with my background? Any help would be greatly appreciated! Thank you!

It seems that most pharmaceutical scientists take a chemistry-focused route in their education, but is it still an option for what is essentially a biology degree?

I'm at UCLA for undergrad right now, if that makes a difference.

Hello Reddit!

I am a newly microbiologist for a small pharmaceutical company. For the time being I am tasked with the project of establishing and maintaining the environmental monitoring program. Being new to the industry, I am looking for suggestions and advice on how I can improve the EM program and how to best analyze the data that we get from environmental monitoring and bioburden sampling. What are the basics that a microbiological Environmental Monitoring program should have? Additionally, what's the best way to analyze the data?

Just a bit of a information: currently I am sampling our clean rooms using both air and contact agar strips, as well as an air particle counter machine. I use R to create statistical process control count charts to chart the CFUs of positive samples. Not sure if this is the best method, but would love some insight from anyone who may have experience in this area.

I am graduating with a bachelor of microbiology, I did 2 years of COOP ( lab based work). I am taking a gap year to work full time and pay off my student loan. I was wondering what career options do I have beside bench work/ working in a lab?

I leave in vancouver, anyone knows what’s the salary for a new microbiology grad with work experience is?

Thanks in advance.

Microbiological Culture Media: A Complete Guide for Pharmaceutical and Healthcare Manufacturers. Tim Sandle.

ISBN Number: 9781942911159

https://store.pda.org/ProductCatalog/Product.aspx?utm_source=echo4.bluehornet&utm_medium=Email&utm_campaign=Publications_MCM_11.28.17&ID=4037

Whether you’re looking for a job, hiring for a job, thinking about a new job, or hate your existing job: here’s your place to post it!

And feel free to brag: had a big win? Got a promotion? Experiment worked? Had a deal that closed? We wanna know!

Remember that biotech is a huge industry, that we all have very different educational backgrounds, and that the readers of the sub hail from all over the world.

So please, please, please: include location, education, role, and subsector where relevant, as this will help keep conversations flowing

January 20, 2022 at 9:00 AM ESTDownload PDF- COVISHIELD (STI-9167) neutralizing antibody (nAb) was discovered by scientists from the Icahn School of Medicine at Mount Sinai ("Icahn Mount Sinai") and further optimized and engineered by Sorrento scientists.
- Sorrento has obtained worldwide exclusive license rights from Icahn Mount Sinai as previously announced on March 9, 2021 (https://investors.sorrentotherapeutics.com/news-releases/news-release-details/sorrento-andmount-sinai-health-system-enter-exclusive-license).
- Compared to available published literature and head-to-head experiments, STI-9167 nAb is a potentially "Best-in-Class" nAb against the Omicron variant of SARS-CoV-2 and the first reported nAb with high potency against Omicron (+R346K mutation) and has demonstrated highly potent neutralization activities in vitro (IC50 of 25 ng/mL for Omicron live virus, 14.8 ng/mL and 23.9 ng/mL for Omicron and Omicron (+R346K mutation) pseudovirus, respectively), in addition to potent neutralizing activities against the SARS-CoV-2 virus and all of its variants of concern (VOCs).
- STI-9167 nAb demonstrated strong protection in vivo following Omicron virus challenge in a preclinical model of COVID-19, preventing weight loss and reducing virus titers in the lungs to levels below the limit of detection.
- GMP drug product manufacturing in support of large clinical development is in place at Sorrento GMP facilities.
- Sorrento is evaluating in-house GMP manufacturing and is in negotiations with major global CMOs for commercial scale manufacturing to secure capacity to manufacture and supply tens of millions of doses. Sorrento currently has in-hand sufficient cGMP drug substance for 100,000's of doses at the projected intranasal dose of STI-9199, the intranasal formulation of STI-9167.
- INDs to be submitted in the US, UK and Mexico within a month for use as either a small volume intravenous push or intranasal instillation.

SAN DIEGO, Jan. 20, 2022 /PRNewswire/ -- Sorrento Therapeutics, Inc. (Nasdaq: SRNE, "Sorrento") today announced the release of new data on the Omicron variant neutralizing antibody (nAb) STI-9167, COVISHIELD, an advanced stage antibody discovered and developed for clinical trials in an ongoing collaboration between immunologists and virologists at Sorrento and the Icahn School of Medicine at Mount Sinai ("Icahn Mount Sinai") in New York, NY.

Hi guys! I have a degree in Biology and a Master's Degree in Microbiology. For the past 6 years I have been working in the Healthcare Market Research Industry. My current job tittle is Senior Project Manager. My day to day is to manage healthcare projects for pharmaceutical companies. We do studies about new treatments and new medical devices. We talk to doctors, nurses, patients ... to better understand the treatments' pathway and how patients' lives could be improved. My degree and master helped me to get into this job but working in the Market Research industry was not my dream job. I got into MR by chance. When I was finishing my masters the opportunity came along and I took it. My orginal plan was to apply to work in a microbiology lab, perhaps doing clinical analysis, but when I actually looked into this type of jobs, I could only bring to the company academic experience and a little bit of working experience that I've got quite a few years ago in a Micro lab. I've stayed in MR because it can be quite interesting, I can work from home and they pay me well enough to make a decent living. I am currently considering the possibility of a career change; transition from Healthcare Market Research to another career closer to Biology and Microbiology.

What do you guys work on? What type of jobs do you do with your degree? What type of industry? I would imagine that some people out here my have a degree in the field but actually do other types of work. I am looking to better understand what type of job I could do given my skills, academic and work experience.

Thanks :)

Hey everyone! I’m a biology major about to graduate in May. I found out about medical lab science careers too late in my degree path to change anything. I’m wondering if it’s possible to get into the field with no specific degree or clinical experience. I was planning on going into pharmaceutical science but this seems interesting to me to and I just wanted to see if it was possible. I have 3 years of experience of doing research in an academic microbiology lab.

Edit for more info: I live in Indiana but am willing to relocate for the right position.

Findings

1. Bucillamine is a proven (in vitro) iron chelator. This is a claim that neither NAC nor GSH can make (also proven in vitro) [1].
2. There are at least 17 studies that suggest iron chelation therapy for COVID-19 [2, 5-12, 16-18, 21-27]. There is commentary on one of them arguing iron chelation would be dangerous [3]. This commentary is also refuted [4].
3. There is one retrospective patient study that identified a lower, but non-significant, mortality rate in patients taking an iron chelator [13]. However, I believe the effect is actually larger due to some flaws/limitations in the analysis (see Discussion).
4. There are three ongoing clinical trials for iron chelation therapy to treat COVID-19. [14, 19, 20]

Opinion

I think it’s likely we’ll get some therapeutic value from Bucillamine’s iron-chelating ability.

Discussion

Regarding finding #3, the limitation I see in the analysis is that the authors are comparing the mortality rate of apples to oranges. The apples are the group of 14 patients with < 1000 ng/mL ferritin, which aren’t taking an iron chelator. The oranges are the group of 11 with > 1000 ng/mL ferritin, which are taking an iron chelator. The mortality rate of the apples is 25% and that of the oranges is 18%. The problem with comparing the two is that the oranges are already at a higher risk than the apples because of their high ferritin levels [9, 15]. In other words, the mortality rate of the oranges would likely be greater than that of the apples (25%), had they not taken an iron chelator. The better comparison would have been oranges to oranges where half of them were taking an iron chelator. The researchers had a limited sample size so it’s understandable. I reached out to them to get their opinion.

As always, please fill or poke holes in my logic.

References

[1] Mazor, Dalia, et al. "Antioxidant properties of bucillamine: possible mode of action." Biochemical and biophysical research communications 349.3 (2006): 1171-1175. https://www.sciencedirect.com/science/article/abs/pii/S0006291X06019802

[2] Abobaker, Anis. "Can iron chelation as an adjunct treatment of COVID-19 improve the clinical outcome?." European Journal of Clinical Pharmacology 76.11 (2020): 1619-1620. https://link.springer.com/article/10.1007/s00228-020-02942-9

[3] Garrick,

The so called ‘Covid vaccines’:

• Do NOT prevent infection } so there is no public health reason for insisting on vaccinating everyone
• Do NOT prevent transmission } so there is no public health reason for insisting on vaccinating everyone
• They were originally developed purely to reduce the risks of serious illness requiring hospitalisation (but recent evidence demonstrates they’re failing in that published objective)
• They only affect the individual receiving them – they have zero impact on any other individual (NB. they are not traditional vaccines which aim to disrupt the chains of both infection and transmission)
• The new drugs do not meet the historic long-established medical definition of a ‘vaccine’
• The new drugs are not licensed (they only have Emergency Use Authorisation’s* attached)
• The pharmaceutical companies have been given complete immunity from any legal action against them in relation to these (misnamed) experimental vaccines, which has never been granted before – why?
• The companies issued EUA’s* have been granted a 55-year delay before they are obliged to publish triall results, a complete list of ingredients, and any data relating to safety and efficacy – which is unprecedented. Why?
• The new drugs underwent very limited and truncated trials with very small, restricted coverage (e.g., healthy 19 – 55-year-olds only, no pregnant women, no Covid-recovered volunteers) which did not follow standard vaccine trial protocols, and were unblinded
• The new drugs are experimental – they use completely novel gene therapy technology; nobody knows how this affects the human body, but it has been proven to alter our DNA (as confirmed by the pharmaceutical companies’ own scientists)
• The new drugs (all still in phase 3 trials) have zero medium or long-term safety data
• No proper toxicity studies have been carried out by any of the 4 ‘vaccine’ developers receiving EUAs
• No fertility impact studies have been carried out by any of the 4 ‘vaccine’ developers receiving EUAs (confirmed in their own documents)
• Those who are vaccinated and develop symptoms carry equal or even higher viral loads than symptomatic unvaccinated individuals.
• Two of the four vaccines given EAUs contain genetically modified spike proteins. Those spike proteins are in themse

Please help! sometime we need don't just need money. We also need peoples with the specific talents.

If you have any friends in China, Shanghai, who accidentally have met these JD, please, send this link to him.

it's not only for virology, but also for QA, Quality Process Researcher, Virus Packaging Technician, Director of Process Development...

https://www.bdgenetherapeutics.com/showKcTopic.html?topicId=2c918f8575fdeed50176562645bf008f

Job description translation:

I. Quality Analyst:

job's duty:

1. Ensure that reagents, consumables, packaging materials, cells in culture, and cryopreserved cells meet the requirements and quality standards and issue relevant reports in a timely manner;
2. Ensure that necessary inspections related to cell product safety are completed, and inspection reports are issued on time;
3. To ensure the implementation and tracking of ISO compliance, deviations, changes, corrective and preventive measures in all aspects of production quality management;
4. Participate in the development and verification of quality analysis methods; quality standards, sampling methods, inspection methods and other quality management procedures, in line with GMP operating requirements;
5. Upgrade to maintain SOP and operation records, in line with GDP specifications;
6. Carry out part of the methodological verification work, including the drafting, implementation of the plan and the drafting of the report. Responsible for part of the environment and instrument verification work.

job's requirements:

1. Bachelor degree or above in biology, microbiology, molecular biology related majors;
2. Familiar with cell therapy technology, with more than 2 years of quality control work experience;
3. Familiar with GMP, ISO and other regulations and certification experience is preferred; familiar with routine inspection techniques (microbiological inspection);
4. Familiar with the theoretical knowledge of cell biology,
5. Working experience in a pharmaceutical company, proficient in microbial detection technology, molecular biology technology, and cell function analysis technology is preferred.

II.Quality Analysis Supervisor

job's duty:

1. Responsible for the establishment, improvement and management of the quality control system of gene therapy product research and development and clinical samples in accordance with drug management laws and quality man

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

News Link: https://www.accesswire.com/685789/pressure-biosciences-ultra-shear-technology-commercialization-achieves-key-milestone-production-scale-system-commissioned-at-ohio-state-to-serve-food-industry

Installation of BaroShear MAX UST System in Acclaimed The Ohio State University Food Pilot Plant Will Introduce Global Food Industry to Preparation of Safer, More Nutritious Liquid Foods and Beverages

SOUTH EASTON, MA / ACCESSWIRE / January 27, 2022 / Pressure BioSciences, Inc. (OTCQB:PBIO) ("PBI" or the "Company"), a leader in the development and sale of broadly enabling, pressure-based instruments, consumables, and process development services to the worldwide food and beverage, biotherapeutics, and personal wellness industries, among others, today announced the commissioning of its first production-scale, patented Ultra Shear Technology™ ("UST™") platform. The BaroShear MAX UST processing system was installed and commissioned in The Ohio State University College of Food, Agricultural, and Environmental Sciences ("CFAES"). Along with the previously announced formation of the Food Industry Consortium, co-led by PBI and Ohio State, this completes one of the last remaining critical milestones in the UST platform deployment at Ohio State to serve the global food industry.

The Consortium's mission is to help companies manufacture higher quality, longer shelf-life, and safer liquid foods and beverages. Utilizing PBI's proprietary UST platform, producers can reduce/remove chemical additives and damaging heat in current processing methods, enabling the production of healthier, more nutritious products with greater appeal to modern consumers. The Consortium is open to food companies worldwide. Ohio State and PBI plan to initiate an aggressive outreach program in the Spring 2022 and expect to welcome a global group of preeminent food & beverage companies as Consortium members shortly thereafter. Members will help direct Ohio State and PBI efforts across a universe of prospective liquid food and beverage products, with emphasis on microbiology, stability, nutrition, sensory qualities, and increased bioavailability. UST applications development will also extend into nutraceutical products, such as infused water, functional sports beverages, and other health

My brother, father and (especially) my mother are against the vaccine, and not all vaccines just these ones. They are good people so refrain from being derogatory please. Honestly, I'm on the fence about it as they have spooked me with all their claims and things they have shown me, and my job is mandating it come January so I need to make a decision. My mother is literally at the point of having panic attacks over the thought of me getting it and wants to move me out of the country so I'm not mandated to get it. This makes me anxious to get it and they raise some good points that I don't have the knowledge (feel like I need a degree in Statistics, Immunology and Microbiology) or data to refute. If anyone can help answer these concerns then I may feel a bit better about getting it, but I have to go against my whole families wishes to do so which makes it a really hard decision for me. I'm not that great at arguing in the first place, especially with people I love, but honestly I don't even know they would ease up about it if I perfectly countered every single argument they had. But I'll try my best to list their concerns (I won't be able to remember them all);

1. Covid isn't actually that harmful, especially to young people, and case numbers are being pushed up by faulty PCR tests that label everything as Covid. So it's all risk and no reward.
2. Any studies that I show them about the rates of severe adverse reactions are being chalked up to adverse reactions being seriously under reported, and thus the data is not accurate. With any adverse reaction 14 days after vaccination being not counted as connected to the vaccine etc. AKA, if you get the vaccine you're getting life-long heart problems. This is the most worrying one for me personally, as there are people that get severe reactions so who says it won't be me?
3. Huge overall distrust of the scientific community and government. A common point they raise is that of vested interest, how can research by, or funded by, pharmaceutical companies (or their associates) be considered objective. I think this is a reasonable claim. Moreover, they claim that physicians are being payed per vaccination that they give out (not sure if this is true?) so it's in their financial interests to vaccinate people regardless of it's efficacy. Essentially, it's about money and not about health.
4. Why have physicians been gagged from speaking about covid with patients if there wasn't something to hide. Why is no one (doct

The huge pharmaceutical company are keeping them eyes to the small competitors due to possible better vax and drugs can stop their actual power on states media and trillion dollars busines. Think about how they have been approved without never doing a real clinical test as should be per fda. The test for first time is on field direct to the population, how long can go on this shame? At the moment many state are going to third dose. As such it will be present cyclically. This means that vaccination campaigns accounted for one plausible scenario long-term. Pfizer Biontech have announced the request for authorization, but the FDA and the CDC in the US, the EU and even the WHO do not currently deem it necessary pending studies and confirmations of the advisability of the third injection. According to the analysis from a few weeks ago to weeks ago Antonio Cassone – former director of the ISS infectious disease department and member of the American Academy of Microbiology – e Roberto Tail – Director of Infectious Disease at “Gemelli” in Rome -, “there are clinical studies on animals that lead us to believe that multiple administrations of Rna vaccines, may not be acceptable without proper testing“. The authors of this hypothesis, signed in La Repubblica, explain that these are molecules that strongly activate the immune system, while this is advantageous for the first doses of the vaccine, if instead they are repeated at short intervals “they can even cause a reduction in capacity immunizing, as also claimed by Margaret Liu, Harvard academic studying immune responses to vaccines, past President of the International Society of Vaccines ”.

https://www.italy24news.com/News/amp/141190

The doctor says it terminal.

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23531. (eBook PDF)Fingerprinting Analysis and Quality Control Methods of Herbal Medicines by Ravindra Kumar Pandey , Shiv Shankar Shukla , Amber Vyas , Vishal Jain , Parag Jain , Shailendra Saraf

23532. (eBook PDF)Healthcare Affordability by Sr., Paul Walter Odomirok

23533. (eBook PDF)An Anthropology of Contemporary Art by Thomas Fillitz , Paul van der Grijp

23534. (eBook PDF)The Project Management Coaching Workbook by Susanne Madsen

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23538. (eBook PDF)Mineral Exploration Principles and Applications, 2nd Edition by Swapan Kumar Haldar

23539. (eBook PDF)Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates by Al Postigo

23540. (eBook PDF)Structural Health Monitoring For Advanced Composite Structures by M H Ferri Aliabadi , Z Sharif Khodaei

23541. (eBook PDF)Introduction To Computational Earthquake Engineering Third Edition by Muneo Hori

23542. (eBook PDF)Cancer Cell Chemoresistance And Chemosensitization by Ajaikumar B Kunnumakkara , Ajaikumar B. Kunnumakkara , Devivasha Bordoloi , Javadi Monisha

23543. (eBook PDF)Compassionate Moral Realism by Colin Marshall

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23546. (eBook PDF)Charles Olson and American Modernism by Mark ers

23547. (eBook PDF)The Changing Face of Volunteering in Hospice and Palliative Care by Ros Scott , Steven Howlett

23548. (eBook PDF)Challenges for Humanitarian Intervention by C. A. J. Coady , Ned Dobos , Sagar Sanyal

23549. (eBook PDF)Central Banking in Turbulent Times by Francesco Papadia ,

Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.

THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB

Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"

I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual

So check out r/jokes for all types of jokes

r/unclejokes for dirty jokes

r/3amjokes for real weird and alot of OC

r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes

Punchline !

Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub

Edit 2: don't touch the thermostat

Do your worst!

How the hell am I suppose to know when it’s raining in Sweden?

Mathematical puns makes me number

We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.

Ants don’t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.

But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.

They were cooked in Greece.