Researchers find that lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas. The data introduces the potential for lymphangiogenesis induction as "a novel immunotherapeutic strategy to consider in cancer vaccine design." advances.sciencemag.org/c…
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πŸ‘€︎ u/SeizeOpportunity
πŸ“…︎ Mar 25 2021
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Platelet interaction with lymphatics aggravates intestinal inflammation by suppressing lymphangiogenesis journals.physiology.org/d…
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πŸ‘€︎ u/AshleyvanderBeck
πŸ“…︎ Jun 17 2020
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Has the efficacy of cannabinoid-related inhibition of extracellular proteases such as MMP2 for reducing metastasis, tumor angiogenesis, and tumor-related lymphangiogenesis been overstated, based on replicated, peer-reviewed research?
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πŸ‘€︎ u/Uncle_Charnia
πŸ“…︎ Apr 30 2018
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Scientists from Switzerland and the US show that melanoma lymphangiogenesis enables both metastasis but also T-cell invasion, meaning they can actually boost immunotherapy. actu.epfl.ch/news/vessels…
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πŸ‘€︎ u/spesaeterna
πŸ“…︎ Sep 14 2017
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Lymphangiogenesis and crohn's. Also, do you rebound?

some things to think about. every time your gut is inflamed, your lymphatic system kicks in. Guess what...it's the superhighway for cytokines and leukocytes. It helps transport bad stuff away. Except, with Crohn's something funny happens in that little exchange. There is a feedback loop between the gut and the lymphatic system. Gut gets inflamed, lymphatic system kicks in. Some suspect the lymphatic-gut feedback loop is to blame for the chronic aspect of crohn's. Hence Tnf and Humira's excellent work done. Tnf is in the lymphatic system. so is VEGFC. Evidence shows dependent stimulation of lymphatic function (through direct lymphatic modulation like suppressing tnf, e.g. Humira) ameliorates experimental inflammatory bowel disease.

Ask your doctor about lymphatic modulation, along with Humira for the Tnf. Also ask why MAPs bacteria is so prevalent and, much like Johne's disease, is found in the gut lumen of crohn's sufferers. Is it tuberculosis of the butt? No but it fucking might as well be, my point being we know a lot about the Johne's disease, it is wide spread in the cattle and dairy industry and cannot be pasteurized out, of their milk or ground beef. Why is Johne's so similar to crohn's in humans?

I have fistulizing perianal crohn's and right now am currently suffering with a ischiorectal perianal abscess just fucking chilling on my sciatica, except it doesn't show up on a ct scan so I have to wait until it "produces itself". I cannot sit up for two weeks. Every six months I get abscesses drained from my rectum. Right now, I can stand and lay, only. I recently bought a trampoline b/c NASA says G-force will help flush my lymph nodes, i.e. my lymphatic system. Rebounding is jumping on a trampoline. NASA says the G-force helps clear the lymph nodes aka lymphatic system. I have yet been able to jump due to pain, but will start once pain subsides.I also take epsom salt baths daily. I have taken to try and not succumbing to pain pills, but I can only last so long and the steroids make me nuts, clearly.

If I have to solve this shit myself, I will. Ask your doc to consider the possibility of a direct feedback loop existing between the gut and the lymph vessels. Ask them why they keep ignoring this aspect when Tnf fighting Humira is so lauded? Push for more interest in lymphatic modulation and towards a deeper understanding of how our body functions as not just single parts, but mechanisms of a whole system. Western docs are short-sighted by this simbio

... keep reading on reddit ➑

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πŸ‘€︎ u/dookiedonkey
πŸ“…︎ Oct 12 2017
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Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis translational-medicine.bi…
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πŸ‘€︎ u/montaukwhaler
πŸ“…︎ Jun 20 2017
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SERIOUS: This subreddit needs to understand what a "dad joke" really means.

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

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πŸ‘€︎ u/anywhereiroa
πŸ“…︎ Jan 15 2022
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Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

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πŸ‘€︎ u/Leckzsluthor
πŸ“…︎ Jan 02 2022
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This subreddit is 10 years old now.

I'm surprised it hasn't decade.

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πŸ‘€︎ u/frexyincdude
πŸ“…︎ Jan 14 2022
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Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies πŸ˜‚

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πŸ‘€︎ u/Vegetable-Acadia
πŸ“…︎ Jan 11 2022
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What starts with a W and ends with a T

It really does, I swear!

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πŸ‘€︎ u/PsychedeIic_Sheep
πŸ“…︎ Jan 13 2022
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What is a a bisexual person doing when they’re not dating anybody?

They’re on standbi

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πŸ‘€︎ u/Toby-the-Cactus
πŸ“…︎ Jan 12 2022
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Geddit? No? Only me?
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πŸ‘€︎ u/shampy311
πŸ“…︎ Dec 28 2021
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I wanna hear your best airplane puns.

Pilot on me!!

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πŸ‘€︎ u/Paulie_Felice
πŸ“…︎ Jan 07 2022
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E or ß?
πŸ‘︎ 9k
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πŸ‘€︎ u/Amazekam
πŸ“…︎ Jan 03 2022
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What did Spartacus say when the lion ate his wife?

Nothing, he was gladiator.

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πŸ‘€︎ u/rj104
πŸ“…︎ Jan 15 2022
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Pun intended.
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πŸ‘€︎ u/Sharmaji1301
πŸ“…︎ Jan 15 2022
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No spoilers
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πŸ‘€︎ u/Onfour
πŸ“…︎ Jan 06 2022
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Covid problems
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πŸ‘€︎ u/theincrediblebou
πŸ“…︎ Jan 12 2022
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These aren't dad jokes...

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

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πŸ‘€︎ u/Lance986
πŸ“…︎ Dec 15 2021
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What did 0 say to 8 ?

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "

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πŸ‘€︎ u/designjeevan
πŸ“…︎ Jan 03 2022
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I had a vasectomy because I didn’t want any kids.

When I got home, they were still there.

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πŸ‘€︎ u/demotrek
πŸ“…︎ Jan 13 2022
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Spi__
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πŸ‘€︎ u/Fast_Echidna_8520
πŸ“…︎ Jan 11 2022
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I dislike karma whores who make posts that imply it's their cake day, simply for upvotes.

I won't be doing that today!

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πŸ‘€︎ u/djcarves
πŸ“…︎ Dec 27 2021
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The Ancient Romans II
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πŸ‘€︎ u/mordrathe
πŸ“…︎ Dec 29 2021
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I'd like to dedicate this joke to my wisdom teeth.

[Removed]

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πŸ‘€︎ u/ThoughtPumP
πŸ“…︎ Jan 14 2022
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I did it, I finally did it. After 4 years and 92 days I went from being a father, to a dad.

This morning, my 4 year old daughter.

Daughter: I'm hungry

Me: nerves building, smile widening

Me: Hi hungry, I'm dad.

She had no idea what was going on but I finally did it.

Thank you all for listening.

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πŸ‘€︎ u/Sk2ec
πŸ“…︎ Jan 01 2022
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It this sub dead?

There hasn't been a post all year!

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πŸ‘€︎ u/TheTreelo
πŸ“…︎ Jan 01 2022
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How do you stop Canadian bacon from curling in your frying pan?

You take away their little brooms

πŸ‘︎ 6k
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πŸ‘€︎ u/Majorpain2006
πŸ“…︎ Jan 09 2022
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School Was Clothed
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πŸ‘€︎ u/Kennydoe
πŸ“…︎ Jan 08 2022
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Letting loose with these puns
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πŸ“…︎ Jan 13 2022
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Couch potato
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πŸ“…︎ Dec 31 2021
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All dad jokes are bad and here’s why

Why

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πŸ‘€︎ u/LordCinko
πŸ“…︎ Jan 13 2022
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Baka!
πŸ‘︎ 5k
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πŸ‘€︎ u/ridi86
πŸ“…︎ Jan 09 2022
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concrete πŸ—Ώ
πŸ‘︎ 5k
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πŸ‘€︎ u/Fast_Echidna_8520
πŸ“…︎ Jan 07 2022
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