Curious as to if you have ever seen the difference it makes on your labs. If you had blood drawn fairly close to before and after the donation.

before you answer - yes, i know we are all different and our bodies will respond differently.

I am just curious as to what has been observed.

thank you

I'm going down a Speculative Evolution rabbit-hole with my setting and would appreciate whatever speculation can be offered.

Howdy studs, how often does hemoglobin pose an issue for you for HRT dosage? I’ve been struggling with medium/high levels and my dr has decreased my dosage every time I have gone for a check-up. Before it was an issue I was at .4 a week, it has slowly been bumped down, and now I’m at .3 a week. She called today to say that my levels are higher than they were last time and if they don’t improve then I’m going to either decrease again or have to stop taking my HRT for 2 weeks. My dr said that some people manage this by donating blood but my plasma site blocked me because I take PrEP and I didn’t know I should lie and say I’m not on it(:

Sources?

RN here, hoping it's ok that I post here asking a science question. It's something that I've wondered for awhile and I can't find sources as to what advantage it serves, just that androgens stimulate bone marrow to produce RBCs and oestrogen inhibits bone marrow production of RBCs (which anybody who had gone through school would know this already). I would think that women would need just as high of an H&H that men would, especially with monthly menstrual cycles. Or maybe women have lower H&H because estrogens promote clotting, so having a higher H&H would put women at higher risk of clotting?

I'm hoping it's okay to ask this here, as this is something I have thought about for awhile, and the providers on my unit are often too busy or in and out for me to want to delay them with a question like this. I have posted to /r/askscience and other subreddits, but my question keeps getting taken down for "asking medical advice" when it's a genuine biology question.

She came into the ER with hemoglobin 4.6. They ER waited to give her a blood transfusion (they called me before the cardiac arrest and I gave consent to treat, but they waited until early Saturday morning to give her the transfusion.) She went into cardiac arrest in the ER. Was resuscitated and intubated. Her hemoglobin was up to 8.5 on Monday. Down to 8.3 yesterday. And now today 7.5. They said they can’t find the cause of the anemia after GI endoscopy and colonoscopy. I’m still waiting to speak to hematologist, but worried they’re going to wait again to give her another transfusion. Cardiologist says her heart is strong. I’m growing frustrated at the pace that things are moving. Why are we 5 days into this and no cause of anemia pinpointed? They’ve been trying to extubate her since Sunday, but she gets too anxious for them to continue. Anyone know how/if I can better advocate for my mother?

Thanks for reading.

Association of Glycosylated Hemoglobin A1c Level with Sudden Sensorineural Hearing Loss: A Prospective Study

Provisionally accepted The final, formatted version of the article will be published soon Notify me Yanmei Feng1*, Ying Shen1, Zhong Zheng1, Chengqi Liu1, Lili Xiao1, Jingyi Guo2, Zhengnong Chen1, Yaqin Wu1, Haibo Shi1, Zhen Zhang1 and Yin ShanKai1 1Department of Otolaryngology Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Key Laboratory of Sleep Disordered Breathing, China 2Clinical Research Center,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, China Glycosylated hemoglobin A1c (HbA1c) level has strong relevance to microvascular disorders, which are also thought to be the current main aspect of sudden sensorineural hearing loss (SSNHL). So, we aim to elucidate the association of the HbA1c level with the severity, types and prognosis of SSNHL. In this study, comparative analyses based on propensity score matching of the severity, types and prognosis of SSNHL with the HbA1c level in 116 patients diagnosed as SSNHL were conducted, where they were divided into diabetes mellitus (DM) group and non-DM group. We finally found that among patients with SSNHL, diabetic patients had higher HbA1c level, more severe hearing loss and poorer prognosis than non-diabetic patients. The HbA1c level was found to be significantly correlated with the severity and types of SSNHL. While, no strong relevance was found between the higher HbA1c level and the poorer prognosis of SSNHL

https://www.frontiersin.org/articles/10.3389/fendo.2021.763021/abstract

Did anyone get deffered for low hemoglobin via fingerstick only to get it done at a lab and turn out normal? Happened twice in 5 years to me 🤔

And what is the lowest you’ve seen on a patient that lived?

We recently had a patient with a hemoglobin just under 2.0 who got themselves to the hospital.

It is said that blood is non-newtonian fluid because about half of it's volume and weight is red blood cells and hemoglobin. Does the strange flat disk shape of RBCs help or hurt flow? Is it good or bad to be non-newtonian?

Other place where solid particles in fluid could be useful are hypothetical internal combustion engines where wood particles / saw dust is mixed in gasoline, petrol alcohol or kerosene and burned with the liquid. This would save the trouble and energy needed to process wood to burning fluid, at least maybe half of it. In special use, maybe also particles of coal, plastic or aluminum. Maybe for piston engine, wankel, jet engine, gas turbine, rocket, heater... Aluminum is made mostly with electricity, so maybe solar energy could be stored in aluminum particles, later burned in heater and the water and pile of aluminum oxide remains to heat the place while co2 is released?

If RBCs were filtered from blood for a while and there were a cutter / blood grinder that cuts the RBCs to 3 micron / 3 µm size pieces, how would that kind of blood work? Oxygen would still stick to hemoglobin?

What if there were 6 to 10 µm wide integrated circuit type microbots that have some ability to move relative to blood, could they push aside RBCs and also white blood cells? Would microbot treatment be a reason to somehow make blood thinner for the duration of the treatment? Cause temporary anemia while patient wears oxygen mask? How low could the hemoglobin level go safely in hospital conditions? One complication is that the microbots also would need oxygen to power their sensors, transistors, motors etc. ( Microbots and nanobots are hypothetical. )

If it turns out that normal size RBCs hinder microbot movement too much, one possibility might be to give the patient pharmaceuticals that cause microcytosis, in preparation for the treatment.

BRIEF RESEARCH REPORT article

Front. Nutr. | doi: 10.3389/fnut.2021.690855

Clinical Use of a Real-World Low Carbohydrate Diet Resulting in Reduction of Insulin Dose, Hemoglobin A1c and Weight

https://www.frontiersin.org/articles/10.3389/fnut.2021.690855/abstract

Provisionally accepted The final, formatted version of the article will be published soon. Notify me

📷Susan Wolver1*, Kristen Fadel2**,** Ethan Feiger2**,** Zein Aburish2**,** Brennen O'Rourke2**,** 📷Toni-Marie Chandler2**,** Dorian Shimotani2**,** Natasha Clingempeel1**,** Shuchi Jain3**,** Aashish Jain4 and 📷Puneet N. Puri1

• 1VCU Medical Center, United States
• 2School of Medicine, Virginia Commonwealth University, United States
• 3Virginia Commonwealth University, United States
• 4Virginia Tech, United States

INTRODUCTION
Type 2 Diabetes Mellitus (T2DM) is increasing in epidemic proportions. In addition to the morbidity and mortality, for those treated with insulin, the physical, psychological, and financial tolls are often greater.
Our real-world study evaluated a Low Carbohydrate Diet (LCD) in patients with T2DM on insulin with respect to glycemic control, insulin reduction, and weight loss.
MATERIALS AND METHODS
A prospective cohort study was conducted via an Electronic Medical Record search for patients attending the Virginia Commonwealth University Medical Weight Loss Program from 2014-2020 with Type 2 Diabetes Mellitus who initially presented on insulin. Data was extracted for one year after enrollment. The weight loss program focuses on a LCD.
RESULTS
Of 185 participants, the mean (±SD) age was 56.1 (9.9) years. 70% were female and 63% were black. 85 completed 12 months (45.9%), reduced their median (25-75% interquartile range, IQR) insulin dose from 69 to 0 units (0-18, p<0.0001), HbA1c from 8% to 6.9% (6.2-7.8, p<0.0001), and weight from 116 kg to 99 kg (85-120, p<001). 86% who completed 12 months were able to reduce or discontinue insulin, with 70.6% completely discontinuing. Among all participants who completed 3, 6, or 12 months, 97.6% were able to reduce or eliminate

Hemoglobin A1c Relates to Poorer Scores on a Test of Executive Function

https://academic.oup.com/cdn/article/5/Supplement_2/926/6292686

Aaron Smith, Xing Song, Matthew Taylor, Debra SullivanCurrent Developments in Nutrition, Volume 5, Issue Supplement_2, June 2021, Page 926, https://doi.org/10.1093/cdn/nzab049_039Published: 07 June 2021

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Abstract

Objectives

Poor glycemic control (GC) is associated with poorer executive function. However, data looking at the relationship between GC and cognition is limited. This study aimed to assess the relationship between GC and various cognitive tests using electronic medical record data (EMR). Hemoglobin A1c (HbA1c) was the main predictor variable.

Methods

De-identified data were gathered from an midwestern academic medical center's EMR in an i2b2 based clinical data repository. Participants were seen at the hospital's memory clinic with a HbA1c lab value (CPT Code: 83,036) on record. 566 participants were used in the final analysis. The most recent cognitive score from the following cognitive tests were used as the response variables, Trail Marking Part A and B and Verbal Fluency. The median value was derived from each participant's three most recent HbA1c values. We constructed ordinary least squares regression models to assess HbA1c's relationship with individual cognitive tests. The model included race, Mild Cognitive Impairment, Alzheimer's Disease, income, and age as covariates. Statistical analyses were performed using R (v. 3.6.2; R Foundation, Vienna, Austria). Statistical significance was set at p < 0.05.

Results

Participants were 54% male and had a mean age of 75 ± 9.2 years. Mean

I'm blood bank, I had this patient just as I was leaving work so I had no chance to ask the ER what the diagnosis was. It's bugging me because she wasn't pregnant (serum HCG <5). Principal complaint "vaginal bleeding" in the ER, hgb of 8 at noon and 6 at 2pm. Flurry of panic to crossmatch, as you can imagine.

What could cause such a rapid bleed if not some sort of ruptured tumor?

hi so...as the title says, ive been on T for not even a year yet and found out today my hemoglobin levels are super high (i believe the dr said 18.9 ?) even though they were just normal (12.9) in february. she's super confused how it jumped that fast bc it's usually a gradual thing...but because of this, she said i have to stop my shots until further notice which im super upset about. has anybody else had this happen (i assume so, she said its common)? what ended up happening, when were you able to start doing your t shots again/any advice? im just super upset this is happening (,: pls help

I've recently taken a blood examination and have noticed that my hbg is pretty high. Is it a bad thing or a good thing? ( I have asthma ) and want a second opinion since some say it could be lethal or just genes?

She is on blood thinners. No blood on stool. She was fatigued but not as much now. I am panicking a. It because she was moved in critical care for the night. They had done a colonoscopy fairly recently and it was normal.

Hi everyone! I’ve been dealing with severe chronic fatigue, memory and concentration problems for years now. Nowadays I suffer from daily headaches/migraines, joint pain and tachycardia too. Getting out of bed is a struggle. My symptoms match with CFS, POTS, UARS and many other conditions. I’m still trying to find a cause. I’ve read that people with iron deficiency experience similar symptoms. My hemoglobin has always been normal, but I’ve never checked my ferritin levels. A few months ago I got my ferritin levels checked and the result was 58.9. I was a bit disappointed because those levels are considered normal. I’ve kinda brushed this diagnosis off and moved on to trying to figure out if I have a different condition. But I’ve recently stumbled upon an article, which mentioned iron deficiency without anemia. Apparently, people can have iron deficiency and experience severe symptoms with normal hemoglobin and normal ferritin levels (>30). So I’ve thought, maybe I should give iron supplements a try? Or maybe I should get more lab tests done? What else should I check? It’s basically pointless mentioning these symptoms to doctors unfortunately so I have to figure things out myself

The blood bank worker said the low level is 13 and the high is 20, and my number was 15!

About a week before donating I had been eating a serving or two of Quaker Oats cereal which has 80-90% of the iron RDA added as a supplement. Along with a few mandarin oranges before and after to boost Vitamin C levels which helps iron uptake.

But before that cereal I had essentially done nothing special concerning iron since I became vegan in June 2017.

The fact that iron absorption is coupled so closely with your blood Vitamin C level is - I think - a key indicator of just how fundamentally important it is to be eating a wide range of plant foods. There is no Vitamin C in traditional American meat products. The Inuit use raw seal brain for Vitamin C sometimes, so there's that.

Anyways I just wanted to share my blood donation story because I was pretty happy when he said my iron level was good, and then I dropped the vegan bomb on him and he was like "w-what do you eat? no meat no dairy?" as if he couldn't believe I could have that good an iron level haha.

(20f, 5’3 & 100lbs, and take birth control pills and iron supplements)

I recently had a blood test done at an urgent care after going in for frequent urination (I made a post a while back with the specifics). The doctor ruled out liver/kidney issues/UTI after a urine test, but my blood came back today testing very high in bilirubin and hemoglobin. I think she said my hemoglobin levels were 12, and my bilirubin levels were a 3.5 when the normal is apparently a 0.2 something..

She mentioned these were just my total levels and I need to see a general doctor for a test of specifically my indirect vs. direct bilirubin levels. I found a doctor and am calling tomorrow but I’m afraid it might be a while before I can get an appointment. What could this mean? I really don’t have any other symptoms that I notice besides extremely frequent urination. Everything I read online says liver or kidney issues, but the doctor I saw at urgent care said my liver and kidneys are functioning perfectly fine.