Title: "Flavonoid-Like Components of Peanut Stem and Leaf Extract Promote Sleep by Decreasing Neuronal Excitability"
Author: Guo et al.
DOI: https://doi.org/10.1002/mnfr.202100210
URL: https://onlinelibrary.wiley.com/doi/ftr/10.1002/mnfr.202100210
Many thanks!
TL;DR: Lemons and some other citrus fruits have flavonoids that have been studied and shown to positively impact blood flow, veins, nerves, and cognitive functioning. Iβve been drinking water with the juice of one lemon several times a day for almost a week and have experienced noticeable and significant improvement in my long haul symptoms.
The Full Post: Had COVID March 2020 followed by reactivated Epstein Barr. Diagnosed with POTS and still have long haul symptoms including fatigue, shortness of breath, and intermittent nerve pain. I recently realized I felt significantly better after meals that included a substantial amount of lemon juice and zest. I researched lemons and discovered they and some other citrus fruits contain flavonoids that have been studied, albeit not extensively, and shown to positively impact blood flow, veins, nerves, and cognitive functioning. One of the flavonoids is being studied as a potential treatment for COVID.
Iβm not taking any medication where ingesting citrus is contraindicated (blood thinners are a big NO), so Iβve experimented with drinking water with an entire lemon squeezed into it several times a day. The improvement is striking. My fatigue improves. My shortness of breath is almost gone. I feel better - lighter inside. Now, the positive improvements last only a few hours and then I start to slump again, but drinking another glass of water with lemon juice brings on the improvements again. I average 4-5 lemons a day.
Iβve been at this a little less than a week, so thereβs no telling if the lemon juice will continue to help. Iβm also going to have to trade fresh lemons for supplements soon in order to protect my tooth enamel, and that may change how I respond to the flavonoids.
Over the course of the last 20 months Iβve tried multiple different herbal remedies, supplements, medications, physical therapy, acupuncture, chiropractic care, and I take atenolol and methylphenidate. Many things have not helped, some have helped a little, and a few have obviously pushed me closer ti reaching the recovery finish line. As of now, lemons fall into that last category.
I researched two of the flavonoids: hesperidin and diosmin.
Hesperidin is being studied as a possible treatment for COVID:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274964/
βHesperidin is a promising drug candidate for the prevention and treatment of COVID-19. To sum it up, hesperidin interferes with viral entry through ACE2 receptors, improves the ho
... keep reading on reddit β‘Sometimes when eating chocolate across any spectrum of quality (but typically always dark) there is a slight coconut node to it and itβs something that my already picky father is even more picky about even though he only eats dark chocolate he will only eat the chocolate without this node. Any info appreciated from someone more knowledgeable than myself.
https://www.sciencedirect.com/science/article/pii/S0006295210008014?via%3Dihub
In conclusion, eriodictyol acts as an antagonist of the TRPV1 receptor and as an antioxidant; it induces antinociception without some of the side effects and limitations such as hyperthermia that are expected for TRPV1 antagonists.
Key Points
- Researchers used Aboriginal medicinal plants to inhibit efflux pumps in aggressive forms of lung and colon cancer. Flavonoids from these plants suppressed transporter proteins that empower cancer cells to resist SN-38, the active substance of the chemotherapy drug, Irinotecan.
- The plant, Eremophila galeata, offers many medicinal benefits and has been used for thousands of years. The researchers believe related plants may provide even more promising flavonoids. The Eremophila genus, found only in the Australian deserts, comprises roughly 230 species and includes plants with anti-diabetic, anti-inflammatory, and other therapeutic properties.
- Antibiotic-resistant bacteria appear to produce similar efflux pumps, allowing them to purge antibiotics from their cells. The researchers believe this same flavonoid, which targets this specific pump protein, could also play a role in treatment of antibiotic resistance.
Abstract
Multidrug resistance (MDR) is a major challenge in cancer treatment, and the breast cancer resistance protein (BCRP) is an important target in the search for new MDR-reversing drugs. With the aim of discovering new potential BCRP inhibitors, the crude extract of leaves of Eremophila galeata, a plant endemic to Australia, was investigated for inhibitory activity of parental (HT29par) as well as BCRP-overexpressing HT29 colon cancer cells resistant to the chemotherapeutic SN-38 (i.e., HT29SN38 cells). This identified a fraction, eluted with 40% acetonitrile on a solid-phase extraction column, which showed weak growth-inhibitory activity on HT29SN38 cells when administered alone, but exhibited concentration-dependent growth inhibition when administered in combination with SN-38. The major constituent in this fraction was isolated and found to be 5,3',5'-trihydroxy-3,6,7,4'-tetramethoxyflavone (2), which at a concentration of 25 ΞΌg/mL potentiated the growth-inhibitory activity of SN-38 to a degree comparable to that of the known BCRP inhibitor Ko143 at 1 ΞΌM. A dye accumulation experiment suggested that 2 inhibits BCRP, and docking studies showed that 2 binds to the same BCRP site as SN-38. These results indicate that 2 acts synergistically with SN-38, with 2 being a BCRP efflux pump inhibitor while SN-38 inhibits topoisomerase-1.
Paper
https://pubmed.ncbi.nlm.nih.gov/34680166/
Articles
- [https://www.msn.com/en-us/news/technology/plants-use
Basically the title. Iβm learning more about organic flavonoids in school right now. I want to specifically learn more about their pH changing properties and how this effects the chemical structure of the compound. Any links to videos or articles would be appreciated.
