I don't have long covid but I am wondering if anyone has tried any of the over the counter products that are shown to break down fibrinogen? Something like the enzyme nattokinase.
I'm asking because there is some recent data pointing to microclots as the root cause. If those microclots are protected by fibrinogen like the data is showing then the body would have a very hard time breaking down those proteins without help.
I don't understand this card, including the post already on it a year ago. I thought that since fibrinolysis is when you cleave fibrin and fibrinogen, disorders of fibrinolysis would prevent this cleavage, therefore you'd have increased fibrinogen. Would love an explanation!
I was hoping to get a clarification, according to Pathoma there are no elevated D-Dimers in disorders of fibrinolysis but according to an article on Up To Date called "Thrombotic and hemorrhagic disorders due to abnormal fibrinolysis", D-Dimers are elevated in primary hyperfibrinoylsis which includes various genetic deficiencies that can cause an overactive plasmin. I am assuming secondary hyperfibrinolysis due to cirrhosis of the liver would also be the same.
I understand Pathoma's explanation on why D-Dimers are normal due to the lack of fibrin/thrombus formation. I was curious why there was a discrepancy or whether I am missing something?
AnKing card in Question:
Do disorders of fibrinolysis present with elevated D-dimers?
No
Thank you very much for the help!
Do the Red blood cells and platelets that get involved in a blood clot, remain functional after fibrinolysis?
I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
Recently our friend u/boschtg shared an article about persistent/resistant micro clots as a hallmark of long-COVID. Here is the story as well as the paper associated with it:
https://pubmed.ncbi.nlm.nih.gov/34425843/
Recent in vitro evidence has shown that NAC is able to help break and reduce the occurrence of these types of clots in patients with severe COVID:
>Resistance to fibrinolysis in critically ill COVID-19 patients is associated with thrombosis and clinical severity. NAC could represent a new adjunct therapy to promote endogenous fibrinolysis in severe COVID-19 patients.
>
>https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-1509001?lang=en
>We demonstrated that intravenous NAC administration promotes lysis of arterial thrombi that are resistant to conventional approaches such as recombinant tissue-type plasminogen activator, direct thrombin inhibitors, and antiplatelet treatments. Through in vitro and in vivo experiments, we provide evidence that the molecular target underlying the thrombolytic effects of NAC is principally the VWF that cross-link platelets in arterial thrombi. Coadministration of NAC and a nonpeptidic GpIIb/IIIa inhibitor further improved its thrombolytic efficacy, essentially by accelerating thrombus dissolution and preventing rethrombosis. Thus, in a new large-vessel thromboembolic stroke model in mice, this cotreatment significantly improved ischemic lesion size and neurological outcome. It is important to note that NAC did not worsen hemorrhagic stroke outcome, suggesting that it exerts thrombolytic effects without significantly impairing normal hemostasis.
>
>https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.117.027290
There is also in vivo evidence that NAC corrects residual pulmonary fibrosis, which, from my understanding, is a result of insufficient clot degradation. This evidence doesn't explicitly illustrat
... keep reading on reddit ➡( Enzymes: Protease, Hemicellulase, Cellulase, Amylase, Glucoamylase, Serrapeptase, Nattokinase, Lumbrokinase, Chitonase )
“Focus: When you began to work at dissolving the biofilms, did you find the bugs?”
Article Insert - - “ Cohen: Oh yes! But I found something else that was just as fascinating, something nobody was thinking about. Think about what that biofilm might really be made of. The biofilm matrix has a horizontal and a vertical weave. It’s standard knowledge that biofilm bacteria sequester calcium, magnesium and iron to help build that matrix. Minerals give the biofilm integrity—as if you’re building a wall. You don’t only want bricks, you want cement. To address this, first you use fibrinolytics to help dissolve the fibrin, then you use EDTA to chelate out the minerals. And guess what? We started getting huge dumps of toxic metal. Now why is that? I think the answer points to something so huge, whether we’re dealing with autism or lyme disease or multiple sclerosis or lupus or even cancer.
Focus: Why were the kids dumping toxic metals when you began to degrade the biofilms?
Cohen: Well, think about it. These are all positively charged cations, that’s why EDTA is able to chelate them well. Mercury, and copper, and other heavy metals are also positively charged. Why would the bug preferentially insert calcium or magnesium? It could use any positively charged metal. This has been the most fascinating part of my year-long work on biofilms. As we degraded this biofilm matrix and liberated these bugs, not only did the organic acid levels get higher—one child bounced into the 400’s—but the kids started to dump metals into the bowel. I felt like I’d exposed these little … in a cell.
Focus: So the metals and the bugs are both in the gut?
Cohen: Right. At an Autism One Conference in Chicago last May, one researcher presented his proton analysis of brain tissue, attempting to verify the presence of mercury in the brains of autistic children, and he couldn’t find it. Yet he still found evidence of activation of the microglia (a type of glial cell that acts as the first and main form of active immune defense in the central nervous system) as a consequence of toxic metals. So where are these metals? I’m suggesting they are in the biofilm, along with the bugs, in the gut. If the biofilm wasn’t using toxic metals, along with common minerals, to build the biofilm, then why all of a sudden do I get these huge dumps of metals on stool tests?
Focus: What exa
... keep reading on reddit ➡Do your worst!
I'm surprised it hasn't decade.
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂
It really does, I swear!
Because she wanted to see the task manager.
Heard they've been doing some shady business.
but then I remembered it was ground this morning.
Edit: Thank you guys for the awards, they're much nicer than the cardboard sleeve I've been using and reassures me that my jokes aren't stale
Edit 2: I have already been made aware that Men In Black 3 has told a version of this joke before. If the joke is not new to you, please enjoy any of the single origin puns in the comments
They’re on standbi
Pilot on me!!
A play on words.
Nothing, he was gladiator.
