Биологи открыли гормон, похожий на инсулин по манере действия на уровень сахара: Речь идет о гормоне FGF1, чьи молекулы схожим образом влияют на расщепление жиров в клетках печени

Американские молекулярные биологи обнаружили, что уровень сахара в крови человека зависит не только от концентрации инсулина, но и еще одного гормона - FGF1, чьи молекулы схожим образом влияют на расщепление жиров в клетках печени. Об этом во вторник сообщила пресс-служба американского Института Салка.

© AP Photo/Mark Schiefelbein

"Уникальная способность гормона FGF1 понижать уровень сахара в крови мышей с инсулиновой невосприимчивостью открывает новые возможности для лечения пациентов с диабетом второго типа. Мы надеемся, что последующее изучение этого сигнального вещества приведет к появлению новых способов лечения этой болезни", - заявил старший научный сотрудник Института Салка в Ла-Хойе Майкл Даунс, чьи слова приводит пресс-служба организации.

По текущим представлениям биологов, клетки тела человека постепенно начинают терять чувствительность к действию инсулина в результате изменений в жизнедеятельности жировых клеток, которые порождаются постоянным перееданием и неправильной диетой. В итоге эти перемены вызывают серьезные проблемы с метаболизмом и ведут к развитию диабета второго типа.

Даунс и его коллеги выяснили, что эту проблему можно обойти при помощи молекул гормона FGF1, который играет схожую с инсулином роль в круговороте глюкозы в организме животных и людей. Они совершили это открытие в ходе экспериментов по изучению роли этого гормона в работе организма мышей.

https://preview.redd.it/tg5dtysmzs981.png?width=960&format=png&auto=webp&s=526b9854cafbe8c6a8c0afc7b6f236d61e22155a

Новое лекарство от диабета

Во время этих опытов ученые наблюдали за тем, как инъекции больших количеств FGF1 влияли на обмен веществ в жировой ткани, печени и в других частях тела грызунов. Эти эксперименты биологи проводили как на здоровых мышах, так и на их сородичах, страдавших от инсулиновой невосприимчивости.

Оказалось, что этот гормон действует на печень таким же образом, как и инсулин. Когда он проникает в клетки печени, они перестают поглощать молекулы жиров, а также расщеплять и превращать их в глюкозу, что постепенно приводит к снижению уровня сахара в крови. Что интересно, гормон FGF1 одинаково эффективно действовал как на здоровых грызунов, так и на мышей с диабетом второго типа.

Как показали последующие эксперименты, это было связано с тем, что FGF1 воздействует не на ген PDE3B, как инсулин, а на др

... keep reading on reddit ➡

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One injection stops diabetes in its tracks: In mice with diet-induced diabetes—the equivalent of type 2 diabetes in humans—a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. salk.edu/news/pressreleas…
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A single dose of recombinant FGF1 (rFGF1) results in potent insulin-dependent lowering of glucose levels in diabetic mice nature.com/nature/journal…
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SERIOUS: This subreddit needs to understand what a "dad joke" really means.

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

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Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

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This subreddit is 10 years old now.

I'm surprised it hasn't decade.

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Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

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These aren't dad jokes...

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

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[Removed]

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Notable mentions from the comments:

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