First-line osimertinib in patients with epidermal growth factor receptorโ€“mutant nonโ€“small-cell lung cancer and with a coexisting low allelic fraction of Thr790Met sciencedirect.com/scienceโ€ฆ
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๐Ÿ‘ค︎ u/montaukwhaler
๐Ÿ“…︎ Nov 11 2021
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The Ki-67 Proliferation Index-Related Nomogram to Predict the Response of First-Line Tyrosine Kinase Inhibitors or Chemotherapy in Non-small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor-Mutant Status ncbi.nlm.nih.gov/pmc/artiโ€ฆ
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๐Ÿ‘ค︎ u/montaukwhaler
๐Ÿ“…︎ Nov 26 2021
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Tumor Growth Rate After Nadir Is Associated With Survival in Patients With EGFR-Mutant Nonโ€“Small-Cell Lung Cancer Treated With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ascopubs.org/doi/full/10.โ€ฆ
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๐Ÿ‘ค︎ u/montaukwhaler
๐Ÿ“…︎ Oct 20 2021
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Real-world outcomes of first- and second-generation tyrosine kinase inhibitors first-line in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer: A retrospective observational cohort study journals.plos.org/plosoneโ€ฆ
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๐Ÿ‘ค︎ u/montaukwhaler
๐Ÿ“…︎ Jun 30 2021
๐Ÿšจ︎ report
In HER2 (Human Epidermal Growth Factor Receptor 2), is it the receptor that's number 2 / second variant, or is it the growth factor?

One would imagine from the fact that the 2 comes right after the "receptor" word that it means there is only one type of EGF, but two (or more) different receptors, but I also find many mentions of "Epidermal Growth Factor 2-positive Breast Cancer" or similar strings on the first page of Google, without the "receptor" bit. My educated guess is that these articles are being careless, because cancer cells express (or not) receptors for the growth factors, not the factors themselves. But I'm not an oncologist to know for sure.

As a medical translator, this kind of thing has been nagging me for quite a bit, because when translating, it matters to know which entity the "2" is attached to! For molecules which have many variants like "neuregulin 1", "neuregulin 2" etc., which could also plausibly have several variants of receptors, how would you know if the number is the neuregulin's or the receptor's? This stuff's tough.

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๐Ÿ‘ค︎ u/Kelvets
๐Ÿ“…︎ Jun 09 2021
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Medicinal herbs and bioactive compounds overcome the drug resistance to epidermal growth factor receptor inhibitors in nonโ€‘small cell lung cancer (Review) spandidos-publications.coโ€ฆ
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๐Ÿ‘ค︎ u/montaukwhaler
๐Ÿ“…︎ Jul 13 2021
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Efficacy and safety of first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) combined with chemotherapy or antiangiogenic therapy as first-line treatment in patients with EGFR-mutant non-small cell lung cancer: A systematic review and meta-analysis sciencedirect.com/scienceโ€ฆ
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๐Ÿ‘ค︎ u/montaukwhaler
๐Ÿ“…︎ Jun 15 2021
๐Ÿšจ︎ report
Activity of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) in patients with NSCLC with uncommon EGFR mutations: a real-world cohort study (UpSwinG) inoncology.com/sites/defaโ€ฆ
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๐Ÿ‘ค︎ u/montaukwhaler
๐Ÿ“…︎ Jun 15 2021
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