Dear fellow Redditors! Our company developed a new image processing technology called Digital Variance Angiography (DVA). DVA allows the visualization of motion on image sequences generated by penetrating radiations. It requires angiographic image series, which are created by X-ray or fluoroscopic imaging and by the administration of contrast media (e.g. ICM, CO2) during various medical procedures. DVA technology provides 2-3 times higher SNR values compared to traditionally used DSA images, this opens the door to CO2 angiography and x-ray dose reduction. I'd really appreciate your thoughts and feedback about this technology. Next week we will have a free live webinar with one of our radiologist KOL. If you are interested in this technology please follow this link: https://register.gotowebinar.com/register/315037974124754946

https://preview.redd.it/pr75fnqr4vh41.png?width=1280&format=png&auto=webp&s=e94c02bef12a24ca36e7bfce921e38ce749f20de

DVA related publications: https://www.ncbi.nlm.nih.gov/pubmed/30829769 ; https://pubs.rsna.org/doi/10.1148/radiol.2018172927

https://doi.org/10.1016/j.numecd.2021.09.021

https://pubmed.ncbi.nlm.nih.gov/34906414

Abstract

BACKGROUND AND AIMS

Serum concentrations of glutamate (Glu), Glutamine (Gln) and Gln/Glu ratio have consistently been reported to be associated with metabolic disorders and diabetes. The aim of this study was to examine the relationship between these metabolites with the presence of coronary artery disease (CAD) and CAD severity in Chinese patients.

METHODS AND RESULTS

2970 Chinese patients undergoing coronary angiography (CAG) in Beijing Hospital were enrolled. Baseline demographics and medical history data was recorded by questionnaires. Serum Glu and Gln concentrations were analyzed by isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS). Statistical analysis showed that CAD patients had significantly higher levels of Glu and lower Gln/Glu ratios compared with non-CAD control group. Glu was significantly positively associated with body mass index (BMI), fasting blood glucose (FBG), triglycerides (TG), creatinine (Crea), and uric acid (UA), and negatively associated with high-density lipoprotein cholesterol (HDL-C), while inverse associations between Gln/Glu ratio and these risk factors were observed. Glu levels increased and Gln/Glu decreased with the increase of CAD severity as represented by either the number of stenosed vessels or the Gensini scores. Logistic regression analysis demonstrated that, after adjusting for smoking status, obesity or overweight, hypertension, dyslipidemia, diabetes, stroke and family history of premature CAD, high Glu level and low Gln/Glu ratio were positively associated with CAG defined CAD as well as CAD severity expressed by Gensini score.

CONCLUSIONS

We identified Glu and Gln/Glu ratio independently associated with CAG defined CAD as well as CAD severity in Chinese patients undergoing CAG.

------------------------------------------ Info ------------------------------------------

Open Access: False

Authors: Xinyue Wang - Ruiyue Yang - Wenduo Zhang - Siming Wang - Hongna Mu - Hongxia Li - Jun Dong - Wenxian Chen - Xue Yu - Fusui Ji -

Additional links: None found

As the title describes ... and if yes, what are the next steps?

Are there any treatments or surgeries if something is confirmed with these tests.

I have this feeling that all testing is good to rule out very bad cases, but in the end... does it change anything?

In the 9th edition of Kanski’s ophthalmology

It says “Fluorescein angiography (FA) is never needed these days. However, if undertaken it typically shows a round hyperfluorescent window defect with a hyperfluorescent centre”

Is this a typo as all the images I see have hypofluorescent centre or am I missing something

Eg: https://www.aao.org/image/cone-dystrophy-8

https://www.medhelp.org/posts/Urology/Painful-nocturnal-erections--AV-fistula-left-penile-artery--urgent-opinion/show/3053444

I’m very surprised I haven’t seen this before but it is fairly new (2020). Short summary:

• person has painful night time erections (as some do here and I have experienced as well) for years

• fluctuates between HARD flaccid and LONG flaccid. Has other symptoms as well

• angiogram shows fistula.

• other things are present as well with other tests but seem unrelated to symptoms

This isn’t a smoking gun but it lines up with u/Casperrb31’s arterial theory. The only downfall here is that the embolization could make him fully impotent because of the fistula location and the doctor isn’t 100% if they are connected.

Coronary angiography the test is used to find out if there is any blockage in the coronary artery, it is an imaging test that uses x-ray to view the blood vessels the X-rays provided by angiography are called as angiograms. This test is usually done to study narrow, blocked, malformed or enlarged arteries or the veins in the heart.

What happens in Coronary angiography:-

In coronary angiography the doctor will inject a liquid I through the thin flexible tube called as catheter, the doctor will treat the catheter into the desired hartree from the access point the access point is generally the arm but it can also be your groin. This dye make with blood flowing inside the blood vessel visible on the accessories and this is used to examine any narrowed or blocked area in the blood vessels, did I know that is inserted is later on eliminated from the body by kidneys and urine. This test is also known as cardiac angiogram,  catheter arteriography or cardiac catheterization.

Why it is done:-

Coronary angiography is basically recommended in conditions like-

• Symptoms of coronary artery disease
• Chest pain
• Congenital heart diseases
• Any blood vessel problems or chest injury
• New or increasing chest pain
• Pain In chest, neck, jaw, or arms
• Any heart valve problem

Risks:-

With most of the procedures done to the heart and the blood vessels there are some risk such as radiation exposure for the x-rays that are used here are some of the major complications and potential risk that include-

• Stroke
• Heart attack
• Kidney damage
• Infection
• Excessive bleeding
• Arrythmias
• Injury to the catheterized artery

What to expect:-

Before the procedure:- Before the angiography procedure start total health checkup will be done including past medical history allergies and the medications you take, some vital examinations like blood pressure and pulse is also checked.

https://preview.redd.it/2gpfn9517v481.jpg?width=1200&format=pjpg&auto=webp&s=14a0dae6567ca1099bfee1032fb20d1eb6cd9950

During the procedure:- During the procedure and IV line is inserted into the vein of your arm, electrodes will be placed on the chest to monitor the process. Are small inches on is made at the entry side and a short plastic tube is inserted to the artery the catheter is inserted through the plastic tube into the blood vessels and a carefully threaded to the heart or the coronary artery. Die is

Has anyone ever had an eye angiography? Anyone know anything about fluorescein? They had to inject intravenously for eye angiography.

December 15, 2021

Francesco Bandello, MD, FEBO, will present Phase 3 pivotal safety and efficacy data from the NORSE TWO registration trial

ISELIN, N.J., Dec. 15, 2021 (GLOBE NEWSWIRE) -- Outlook Therapeutics, Inc. (Nasdaq: OTLK), a biopharmaceutical company working to develop and launch the first FDA-approved ophthalmic formulation of bevacizumab for use in retinal indications, today announced that Francesco Bandello,

MD, FEBO, Professor and Chairman of the Department of Ophthalmology, University Vita-Salute, Ospedale San Raffaele, Milan, will present pivotal safety and efficacy data from Outlook Therapeutics’ Phase 3 NORSE TWO registration trial for ONS-5010 / LYTENAVA ™ (bevacizumab-vikg), an investigational ophthalmic formulation of bevacizumab for use in wet age-related macular degeneration (wet AMD).

The presentation will take place at the 9th International Congress on OCT and OCT Angiography in Rome (ICOOR)/ FLORetina Symposia, on Saturday, December 18, 2021.

“The results observed for ONS-5010 in the NORSE TWO trial are potentially of great significance for retinal specialists and their patients suffering from wet AMD,” said Dr. Bandello. “I look forward to having an additional approved treatment option for patients that is on-label and specifically formulated and packaged to meet the stringent demands for ophthalmic use.”

Details for Dr. Bandello’s presentation are as follows:

Clinical and Efficacy Outcomes of the NORSE TWO Pivotal Study for ONS-5010, an Ophthalmic Formulation of Bevacizumab

Presenter: Francesco Bandello, MD, FEBO

Session: ICOOR 2021 Hall, Visions of Future by Industry and Engineers, Part 2

Date and time: Saturday, December 18, 2021, 5:48 AM – 5:54 AM Eastern Time (11:48 AM– 11:54 AM Central European Time)

For more information and to register for this event, please visit ICOOR 2021.

About ICOOR and FLORetina

The International Congress on OCT and OCT Angiography in Rome (ICOOR) and the FLORetina Symposia are conducted under the auspices of AP

Meetings. For almost 15 years, AP Meetings has catered to the scientific and medical communities and to surgical and pharmaceutical companies, organizing meetings with single and multiple sponsors, congresses, conventions, conferences, master courses of international and national importance. AP Meetings provides CME (Continuing Medical Education) and accreditation services for professional residential training and retraining and CPD (online) for healthcare (medi

I bought AC:NH digitally using my primary account and I am on US region in eShop. My Switch is linked to my brother's account and he also bought AC:NH digitally but he's on AUS region.

Will I be able to play AC:NH on an earlier timeslot if I use my own account? AUS is 15 hours earlier than US EST time.

Thanks!

0. Preface

Hello apes. I am not a financial advisor and I do not provide financial advice.

A few things need to be cleared up, since there's some, uhh, chaos.

Options are extremely risky but it is not a demon-spawn that should be avoided like the plague. It is another tool at retail's fingertips just like DRS / direct registration. If you don't understand them, ignore the posts and do not participate in options.

But, the discussion should not be muted entirely just because a few people YOLO'd into deep OTM CALLs with 0 delta and lost their life savings. That is not the fault of options. That is the fault of their misunderstanding or greed of the play.

If anything, this can hopefully at least draw eyes back on the Variance Swaps DD which has oddly disappeared from discussion lately.

By fire be purged

1. Clearing Some Stuff Up

• No, you should NOT sell shares to play with options. I was hoping that was implied. I don't know how that idea spread around, but it is absolutely not something that should be done. It was a lack of foresight on my end to not state that immediately.

• DRS is the way and in my opinion should be the #1 priority because it locks the float. Apes should keep on direct registering their shares as this puts pressure on the SHFs and MMs by reducing the amount of shares in their pool to borrow.

• The reason that options are being floated around is because it can be used as additional pressure on the SHFs and MMs - especially for their Variance Swap hedge. I tried to touch on Variance Swaps in the previous post but I think it got overlooked heavily. I'll go into this for the next section.

• I did not imply to bet on weeklies or short-term option plays. The strikes that I posted were simply a reference to show how options effect hedging versus buying shares outright. In fact, I personally would NOT do short-term plays (expiring within the next few 8 weeks). If you're trying to do short-term option plays, there's a good chance you will get burned. Pickleman ( /u/gherkinit ) and others are thinking that the best strategy for the proposed upcoming futures cycle are ITM / ATM CALLs for February 2022.

  • Does that mean to follow suit? No. Does that gua

I noticed a trend that a lot of writers are using religion to serve as a basis for magic systems and not as the theological lens to view culture in a fantasy world.

But there’s nothing wrong with that, btw.

How many of you out there are using religion to showcase culture and provide no concrete evidence for the existence of your world’s deities leaving divine intervention up to interpretation by the world’s inhabitants?

Introduction

I have been asked to jot down some thoughts on variance by u/gherkinit and u/Criand

Variance/co-variance/volatility/simple variance/synthetic variance swaps, a year ago I had no idea what these were, over the past 3 months I and others have been diving into this black hole. u/MauerAstronaut has dug as deep on this as I have he is my VOLquant wanna be twin and a good friend, he has already had some post on the subject I highly recommend reading them before reading this. This subject is broad and extremely complex, the more reading the better here, without further delay let me share some thoughts.

Let me preface by first saying this post may not be for everyone, some of it may be slight speculation based off of actual events and or positions reported. Even though I will go into detail about being "long variance" it is hard to find breadcrumbs of long variance because the portfolio of options to be built as a hedge are in fact sold, or in common terms "short", meaning these positions are usually not reported limiting the evidence left. That being said those that are "short variance" do leave similar hedging breadcrumbs, that is what has led me here. Obligatory "this isn't advice" if you think it is, I feel terribly sorry for you.

Brief Breakdown and Effects

First thing is first, what is a variance swap? In simple terms it is a bet on volatility. The seller is going to receive a fixed payment called the "fair variance strike as vol" which is a fancy way of saying annualized implied volatility over a period of time (usually 30,60,90 days). The volatility strike is going to be calculated and agreed upon inception, that is going to be the fixed payment that the seller receives upon maturity. The opposite side of the trade is the buyer, the buyer is going to receive "realized variance" payment on maturity, meaning that it is going to get paid based on the volatility realized during the agreed upon period.

Here is an illustration showing the "vanilla" variance trade. Note the word "vanilla" not all trades are done this way:

https://preview.redd.it/08ncdf576mx71.jpg?width=892&format=pjpg&auto=webp&s=fe0ceb134c323771924505c7447b6bbb289abd74

The above came from this paper. Now to me this image illustrates a variance trade pretty well, it shows that the Market Maker buys variance as an insurance type play to their