http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2012.01192.x/abstract
Do the doctors just throw it away? And can you keep it if you ask?
Tea tree oil applied topically: Tea tree oil has frequently been mentioned as a cure for scabies [8], with multiple angles of benefit: first, it can kill the mites. Second, it may help with secondary complications such as with the proliferation of Staphylococcus Aureus and Streptococcus pyogenes [11][21]. Additionally, in one study, it was shown that tea tree oil had not exhibited any cytotoxicity to fibroblast cells [21]. In another study, it was shown that tea tree oil, even at very low concentrations, can inhibit the growth of various types of cancer [23][24][25].
But it isn’t without its limitations. Tea tree’s antibacterial properties may also kill good bacteria such as lactobacillus. By re-introducing good flora to the skin after tea tree oil is washed off, this negative impact may be countered. See Part 2 for details. An additional limitation of tea tree oil is in the potential (albeit low) for skin irritation in some individuals. (Definitely do a spot test before adding this to your regimen). The final limitation to tea tree oil is due to poor absorbency in the skin.
The main issue with tea tree oil is that there is very limited penetration into the epidermis layer of skin in its pure form, and it’s also very quick to evaporate [9]. To know how effectively the tea tree oil should penetrate the skin to provide a cure, it’s important to understand how deep scabies burrow. I’ve read that scabies burrow no deeper than beyond the stratum granulosum layer of the skin, which is part of the epidermis (diagram of skin here) [14, 18]. There are many sources that indicate that the mites primarily burrow in the stratum corneum (several layers above the stratum granulosum), but many which state stratum granulosum, and, if we want to find the most effective solution, it’s best not to assume the best. Therefore, a perfect cure would need to at least be absorbed into the stratum granulosum layer of the skin and remain within that part of the skin (or at least reasonably reapplied to this part of the skin) until all remaining mite eggs have hatched. [Edit] From my understanding, however, once the stratum corneum layer is penetrated, the drug can freely pass through to the dermis. Darn you, stratum corneum!
Overall, to fully eliminate mites, the mite kil
... keep reading on reddit ➡People get outrage about what happens before birth, then ignore what's done after. I've seen people get outraged at the POSSIBILITY of fetal tissue being sold and then act like the surgical removal of healthy functional tissue from a healthy infant is a non issue. Here is what most are ignoring:
https://www.lifelinecelltech.com/shop/cells/fibroblasts/dermal-fibroblasts/human-dermal-fibroblasts-neonatal-fc-0001/
These are harvested from the healthy foreskin of newborn babies. It's a huge profitable business. When there is a demand, a supply will be found and when most people will not question why a healthy child should have a surgery that is medically unnecessary because it's been normalized over time you will have a great supply available.
PIONEER Initiative Preliminary Findings Released:
"The PIONEER Initiative: Precision Insights On N-of-1 Effectiveness Research. Tissue Ownership by the Individual With the Return of Actionable Information to the Individual Patient and Physician (Precision Oncology)". Ignore the dates, the PIONEER initiative concluded mid 2021. There was a 6 month delay built in to allow industry experts to review the data and prepare accordingly.
I found 3 clinical trials all fast tracked into Stage 2 stemming directly from PIONEER . This is the validation we were looking for. PIONEER-Panc: Phase II Investigations of New and Emerging Therapies for Pancretic Cancer. The patent is held by the MD Anderson Cancer Center, this is proof of fast tracking development of a drug. Because all the information shared between the labs was uniform, decentralized clinical trials become a reality. Stay tuned, I need some more time to get through all of it. But I am very optimistic from what I just read. beta.clinicaltrials.gov/sea...
I have a few big thing to add to this later. Stay tuned
Dec 2021: Chewyknuckles releases my DD on my behalf as my reddit account was brand new. I wanted to post it under my own name, nothing changed. I will be doing a substantial update of the DD in the next day to to reflect the zPredicta acquisition.\
(FROM DEC 2021)
POAI, Cvergenx, & Specicare: Genomics for the masses
Theory: An announcement of a partnership between Predictive Oncology, Cvergenx, & Specicare is imminent.
This partnership will be born from the impending release of data from their “PIONEER” initiative (clinicaltrials.gov Identifier: NCT03896958). PIONEER provides non-NCI cancer centers genomic profiling services and research into experimental treatments. 85% of cancer patients receive care locally, while the majority of research is done at accredited (i.e. NCI certified) institutions that are highly centralized and often inaccessible. [1]PIONEER’s goal is to eliminate the logistical barrier by providing clinicians access to advanced clinical data via it’s bio-depository and tissue collection/genomic analysis infrastructure. By streamlining tissue collection, storage, and analysis, this bio-depository will allow POAI to work in tandem with researchers around the world as a vendor of data, AI driven genomic analysis,
... keep reading on reddit ➡Hi folks, this is just a quick and dirty list of some reddit posts or links with information and resources related to POTS/dysautonomia, EDS, HSD, and related issues like MCAS. A lot of these posts have several links within them, so this might be something to save and gradually work through to see what's applicable to your situation.
This Reddit post shared a journal with some great content: Special Issue: Ehlers‐Danlos syndromes, Hypermobility Spectrum Disorders, and Associated Co‐Morbidities: Reports from EDS ECHO
u/Objective-Flow8163 made a POTS toolkit! Here is the direct google drive link
There’s a POTS discord
Postural Orthostatic Tachycardia Syndrome (POTS), the Vagus Nerve and Cervical Spine instability
Long COVID Dysautonomia research study being conducted
A POTS google doc from a doctor
[hypermobility spectrum and diagnostic tools](https://www.reddit.com/r/Hypermobility/comments/ngllvx/a_good_article_to_explai
... keep reading on reddit ➡Seems to be a controversial ingredient, but so far it appears to be the only skin-tightening topical other than maybe tretinoin. I’d love to hear from anyone who’s had good results with it.
Brazilian 2009 study showed DMAE increased dermal thickness and collagen fiber thickness.
Johnson & Johnson study tested a 3% DMAE facial gel in a randomized clinical study. Over a 16 week period it was “shown to be safe and efficacious in the mitigation of forehead lines and periorbital fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. These effects did not regress during a 2-week cessation of application.” The study was continued for an additional 8 months with no adverse long term effects.
The only negative study is this one testing DMAE on rabbit fibroblasts and human epithelial cells. Fibroblast mortality (aka cell death) increased by 25% and cell division slowed significantly after application. It also caused vacuolization in human epithelial cells, a process known to occur after cell damage.
Would like to hear your thoughts on *non filler or surgical based approaches* for increasing cheek volume. I'd also like to know if there are any studies (or even well based anecdotes, for that matter) on the difference on efficacy betwen adifyline and volufiline--I can't seem to fine any.
Seems like to increase cheek fat would be to increase 1) collagen/elastin production, 2) restore the subcutaneous fat layer in the cheeks. We want to achieve this without transdermal fillers/surgical interventions. Quick summary here: Here’s How Fat Cells Boost Collagen and Make Your Face Look Younger (healthline.com)
- For increasing collagen: To have more full cheeks, you could try a glycine supplement, and this link suggests increasing glycine intake as a precursor for collagen increase 200% increase in collagen production from 10g of glycine. Too good to be true? : StrongerByScience (reddit.com) and Everyone may need extra collagen/glycine : climbharder (reddit.com) . Increasing Vitamin C intake should also help as it is also a precursor of collagen.
- For fat layer: There is also PPAR gamma agonist PPAR gamma modulation for subcutaneous skin fat gan : estrogel (reddit.com), which has promise in restoring the fat layer. An example is the compound class of thiazolidinediones which are PPAR agonists, and have been shown to increase subcutaneous fat. A thiazolidinediones microemulsion for fat redistribution : estrogel (reddit.com). There are skin formulations with acetyl hexapeptide-38 aka Adifyline on the market, which increase activity on the PPAR agonist pathway--Here is a before/after of someone using Adifyline Before and after of Acetyl Hexapeptide 38 aka Adifyline after 6 months in bio female : estrogel (reddit.com) . The cream they were using wa
Quercetin is a plant pigment (flavonoid). It's found in many plants and foods, such as red wine, onions, green tea, apples, and berries. Quercetin has antioxidant and anti-inflammatory effects that might help reduce swelling, kill cancer cells, control blood sugar, and help prevent heart disease
These properties form the basis for potential benefits to overall health and disease resistance, including anti-carcinogenic, anti-inflammatory, antiviral, antioxidant, and psychostimulant activities, as well as the ability to inhibit lipid peroxidation, platelet aggregation and capillary permeability, and to stimulate mitochondrial biogenesis [2].
Quercetin-type flavonols (primarily as quercetin glycosides), the most abundant of the flavonoid molecules, are widely distributed in plants. They are found in a variety of foods including apples, berries, Brassica vegetables, capers, grapes, onions, shallots, tea, and tomatoes, as well as many seeds, nuts, flowers, barks, and leaves. Quercetin is also found in medicinal botanicals, including Ginkgo biloba, Hypericum perforatum, and Sambucus canadensis [6,7,8]. In red onions, higher concentrations of quercetin occur in the outermost rings and in the part closest to the root, the latter being the part of the plant with the highest concentration [9]. One study found that organically grown tomatoes had 79% more quercetin than chemically grown fruit [10].
Quercetin glycosides might be differently absorbed based on the type of sugar attached [21]. Available evidence indicates that quercetin glucosides (like those found predominantly in onion or shallot flesh) are far better absorbed than its rutinosides (the major quercetin glycoside in tea). The glucosides are efficiently hydrolyzed in the small intestine by beta-glucosidases to the aglycone form, much of which is then absorbed [22]. Quercetin glucuronic acid and its sulfuric acid derivatives were more easily absorbed than quercetin [22]. Thereafter, its absorption is affected by differences in its glycosylation, the food matrix from which it is consumed, and the co-administration of dietary components such as fiber and fat [23]. Thus different sugar types and sugar group conjugation sites will result in absorption variation.
Quercetin and derivatives are stable in gastric acid; however, there were no reports whether they can be absorbed in stomach. Studies suggest that quercetin is absorbed in the upper segment of small intestinal [24,25].
Among quercetin’s deriva
... keep reading on reddit ➡Hair grows in cycle with 3 distinct and concurrent phases, namely anagen, catagen and telogen phases. The anagen phase is also known as growth phase when hair follicles actively divide to form hair. Meanwhile, catagen phase begins when anagen phase ends, it is transitional period when hair follicles undergo apoptosis, disintegrating and cutting of the hair strand from nourishing blood supply. Last, entering into telogen phase, or resting phase when the hair and follicles remain dormant. The cycle starts over when telogen phase finished.
The differentiation and proliferation of hair matrix cells is regulated by a numbers of molecular factors, namely, fibroblasts growth factors (FGF-7), Vascular Endothelial Growth Factors (VEGF), Insulin-like growth factor-1 (IGF-1), hepatocytes growth factors (HGF).
Molecular factors such as FGF-7, VEGF, IGF-1, HGF are involved in the hair follicle growth. The expression of these factors in culture human dermal papilla cells was evaluated. The expression of HGF was up-regulated and showed significant difference. Hepatocytes growth factor (HGF) is a multifunctional polypeptide which was found to stimulate hair follicles growth during anagen phase.
Meanwhile, the expression of FGF-7 was up-regulated in samples containing spermidine 10, 100g/mL, the up-regulation of VEGF and IGF-1 was expressed at concentration of Spermidine-HF 100g/m. Above finding clearly suggested that Spermidine-HF promote hair follicles growth with up-regulation of hair growth promoting factors – HGF, FGF-7, VEGF and IGF-1 respectively.
https://preview.redd.it/jmljcab1si481.jpg?width=1003&format=pjpg&auto=webp&s=97463712cc390d37092b36375a8cb5235cd6baa4
Spermidine-HF - preparation with spermidine to regenerate hair follicles, strengthen hair, reduce hair loss
I have a small conflict that I’d love to have explained regarding PPD as an accurate measure of UVA1 rays in the spectrum of 340nm - 400nm.
UVA1 rays at or above 360nm seem to confer the most damage to skin such as induction of matrix metalloproteinases (i.e., MMPs/collagen degradation enzymes) and secretion of inflammatory cytokines. (1)
The Textbook of Cosmetic Dermatology, 2010 Edition, page 201, states that UVA2 is the portion of UVA mostly represented in the PPD testing. (2) Prompting the FDA to propose augmenting the PPD test with additional additional in vitro testing that provides a measure of UVA1 protection, specifically the ratio of UVA1 absorbance to total UV absorbance - which, incidentally, I believe is how it’s measured here in the UK.
Another paper in Sunscreens: Development: Evaluation, and Regulatory Aspects: Second Edition, directly states (p. 570) that About 7% of the total PPD response is ascribed to UVA2 and 92% to UVA1.(3)
These two items above seem to conflict directly. The last piece of information I found that might be helpful is below.
‘The action spectrum of PPD is maximum at short UVA wavelengths and gradually decreases from 320 to 400 nm.’ (4) Since UVA1 long rays begin at 340nm, and rays at or beyond 360nn seem to confer the most damage to skin, I take that to mean PPD is not an entirely accurate measure of protection against upper-end of spectrum UVA1 rays.
Please help me parse this out. I would greatly appreciate it.
(1) Vielhaber G, Grether-Beck S, Koch O, et al. Sunscreens with an absorption maximum of≥ 360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1, and interleukin-6 in human dermal fibroblasts. Photochemical & Photobiological Sciences. 2006;5(3):275–82. http://pubs.rsc.org/en/content/articlelanding/2006/pp/b516702g/unauth#!divAbstract
(2) [https://books.google.co.uk/books?id=rKHSBQAAQBAJ&pg=PA201&lpg=PA201&dq=PPD+is+primarily+a+measure+of+UVA2&source=bl&ots=5guv87spiv&sig=Mk1Rta73R2WWdVmUdKoKKOarZys&hl=en&sa=X&ved=2ahUKEwint7_ejt3cAhWCA8AKHRUmBIA4ChDoATABegQICBAB#v=snippet&q=UVA2%20is%20the%20portion&f=false](https://books.google.co.uk/books?id=rKHSBQAAQBAJ&pg=PA201&lpg=PA201&dq=PPD+is+primarily+a+measure+of+UVA2&source=bl&ots=5guv87spiv&sig=Mk1Rta73R2WWdVmUdKoKKOarZys&hl=en&sa=X&v
... keep reading on reddit ➡I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
We are very proud to announce our latest product LIQUID GHK-Cu.
The first ever ready-to-use fully bioavailable GHK-Cu that may be variably administered.
https://www.biopuresupplements.com/index.php?route=product/product&product_id=53&tracking=6117e3862a219
- Anti-aging
- Regenerative and protective actions for skin, lung connective tissue, bony tissue, liver and stomach lining
- Skin Regeneration
- Tightens loose skin, improves elasticity, skin density, and firmness, while reducing fine lines and wrinkles, reducing photodamage and hyperpigmentation, while increasing keratinocyte proliferation
- Stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, and supports dermal fibroblast function
- Accelerates skin and wound healing and skin inflammation by modulating multiple cellular pathways
- Accelerates hair follicle regeneration
- Promotes angiogenesis
- Accelerates scald wound healing by promoting cell proliferation and angiogenesis
- Improves skin and wound healing via antibacterial properties
- Anti-aging properties not limited to skin, and possible therapeutic agent against age-associated neurodegeneration and cognitive decline
- Promotes tissue remodeling for minimizing scarring
- Induces anti-cancer expression of DNA repair genes
- Suppresses fibrinogen
- Anti-inflammatory
- Reduces oxidative stress
- Anxiolytic effects
https://preview.redd.it/guk0ylx1hch71.jpg?width=1080&format=pjpg&auto=webp&s=01dccb327912cd8017c267508ec1d8995fb4d2be
Take Back Your Health
Do your worst!
I'm surprised it hasn't decade.
$POAI (Predictive Oncology), Cvergenx, & Specicare to announce partnership!!(extensive DD, references, links, and GoogleDoc provided)
***************************************About 10 days ago I had shared the infamous DD that GunboatWillie had presented to Stocktwits! Well, he has returned and asked me for a favor to share all of his findings. Every word is his own, I do not take any credit. I am just the messenger.
This partnership will be born from the impending release of data from their “PIONEER” initiative (clinicaltrials.gov Identifier: NCT03896958). PIONEER provides non-NCI cancer centers genomic profiling services and research into experimental treatments. 85% of cancer patients receive care locally, while the majority of research is done at accredited (i.e. NCI certified) institutions that are highly centralized and often inaccessible. [1]PIONEER’s goal is to eliminate the logistical barrier by providing clinicians access to advanced clinical data via it’s bio-depository and tissue collection/genomic analysis infrastructure. By streamlining tissue collection, storage, and analysis, this bio-depository will allow POAI to work in tandem with researchers around the world as a vendor of data, AI driven genomic analysis, and be-spoke biomarkers/tissue samples for experimentation. POAI’s recent partnership with Cellevate offers a glimpse into this potential future where they were able to create 3D nano-fiber cell cultures, cultivated from human dermal cells capable of mimicking a tumor in the body for study of a cancer by the request of patient. [2] April 11th, 2019 Precision Therapeutics (now POAI) and B4CC Inc. (DBA as Specicare) announce “Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership” (PIONEER). [3] Two outcomes measures are listed:
-
“To establish a data and tissue biobank comprised of high quality biological specimens and associated clinical data that will support drug discovery, diagnostic assay development, oncology biomarker discovery, molecular biology, immuno-oncology therapies, translational medicine and other future discoveries as novel methods become available.” -
To facilitate and accelerate oncology research, including genetic research (e.g. whole genome sequencing), by providing a pipeline of high quality specimens and associated clinical data for researchers to access.
The original trial description 03.28.2019 anticipated 200 patient pa
... keep reading on reddit ➡Hi folks, this is just a quick and dirty list of some reddit posts or links with information and resources related to POTS/dysautonomia, EDS, HSD, and related issues like MCAS. A lot of these posts have several links within them, so this might be something to save and gradually work through to see what's applicable to your situation.
This Reddit post shared a journal with some great content: Special Issue: Ehlers‐Danlos syndromes, Hypermobility Spectrum Disorders, and Associated Co‐Morbidities: Reports from EDS ECHO
u/Objective-Flow8163 made a POTS toolkit! Here is the direct google drive link
There’s a POTS discord
Postural Orthostatic Tachycardia Syndrome (POTS), the Vagus Nerve and Cervical Spine instability
Long COVID Dysautonomia research study being conducted
A POTS google doc from a doctor
[hypermobility spectrum and diagnostic tools](https://www.reddit.com/r/Hypermobility/comments/ngllvx/a_good_article_to_explai
... keep reading on reddit ➡
