http://www.akademiai.com/content/119696

I understand that since Annovera lasts for a full year (compared to Nuvaring that only lasts a month) it would have more restrictions, but 2 hours vs 48 hours is a very drastic difference.

Annovera does release slightly less estrogen than Nuvaring (13mcg vs 15mcg), but it also releases more progestin (150mcg vs 120mcg), so I don’t feel like those slight variances would make that much of a difference.

Is Annovera just being overly conservative with the adherence guidelines since it’s new? Or is there really that much of a difference between the two of them, and if so, why?

EDIT:

First, when I say “can be removed for x hours/month,” I meant during the 21 day period you are supposed to have it in. I am aware you are supposed to remove it during the break week, but I am not talking about that.

Second, Many of you pointed out that on the Nuvaring website it states it cannot be removed for >3 hours, however, both Planned Parenthood and UC Berkeley state that it is still effective for up to 48 hours. So a follow-up question would be why do both Berkeley and Planned Parenthood (both reputable sources) state 48 hours as the limit?

EDIT 2: Okay I’m tired of people saying “are you sure you interpreted Planned Parenthood/Berkeley correctly?” So here is a direct quote from the Berkeley source listed above:

>> [for] delayed insertion of a new ring or delayed reinsertion of a current ring for <48 hours since a ring should have been inserted • Insert ring as soon as possible. • Keep the ring in until the scheduled ring removal day • No additional contraceptive protection is needed

And a quote from Planned Parenthood:

>> ...sometimes the NuvaRing might slip out of your vagina. If the ring has been out of your vagina for less than 2 days, rinse it in cool water and put it back in right away. If you put it back in within 48 hours, you’ll still be protected from pregnancy.

EDIT 3: CDC and WHO (see page 52) also recommend the <48hr rule

I noticed there are no discussions regarding GHRP and cardiovascular health.

GHRP has profound effects that people with heart failure may potentially benefit from.

I don't want to cite all the studies. Just Google "ghrp heart" and you will see some promising information.

I figured I'd bring some awareness to some.

Hi all, I am hoping to gather feedback on a theory I have regarding cortisol. The literature informs us that secretion of adrenocorticotropic hormone (ACTH) stimulates secretion of cortisol by the adrenal glands - this action is mediated by the hypothalamic-pituitary-adrenal (HPA) axis.

https://pubmed.ncbi.nlm.nih.gov/27104844/

The HPA axis is influenced by; the hypthalamus, the pituitary gland and the adrenal glands.

https://www.sciencedirect.com/topics/neuroscience/hypothalamic-pituitary-adrenal-axis

My hypothesis is that you aim to dampen the potential of hpa-axis hyperactivity and attenuate HPA dysregulaton - this accomplished by controlling ACTH release using a corticotropin releasing hormone antagonist or a drug which operates akin to a CRH. What are the opinions and thoughts on this approach?

thanks in advance

The evidence regarding the effects of hormone blockers as well as their reversibility has been brought up here and there. I figure an evidence review on the subject can be helpful for everyone.

Personally, I note with some concern the number of areas where the evidence is weak or non existent.

https://www.evidence.nhs.uk/document?id=2334888&returnUrl=search%3fq%3dtransgender%26s%3dDate

As a man, I love boxes. When I go fishing, I go out onto a pier, I set a large box on the pier, I climb into the box, I stick my fishing rod out of a small hole in the box and I fish that way. It makes fishing very hard. Virtually impossible actually. I've never caught a fish this way. In fact I'm not even sure my line actually makes it into the water, there's no way for me to actually know because I'm in a box the whole time. If people are looking at me weird I can't see it. Okay? I spend 80% of my time in a box, and if I'm not in a box I'm thinking about boxes.

Most of this sub is women and I know you're probably all thinking "blah blah fishing sucks blah blah whats your obsession with boxes blah blah blah get psychological help" Let me explain something. You women, you're like arrows on a whiteboard. Okay? All you people do is point to bubbles with words in them. That's the feminine essence. It's pointing. That's why when the presentation was over, Avery wanted to spend all night pointing out things she didn't like, and all Ash wanted to do was stand on a pier and think about boxes. This is the masculine essence.

See, human relationships are like charges of electric energy. Opposite charges attract, like charges repel. When you have multiple relationships in succession, it's called a series relationship, when you engage in multiple relationships at the same time, we call that parallel. The thing to remember is no matter what, the sum of the totality of our directed energy potential differences is always equal to zero. I'm still struggling to understand how to calculate resistance and if anybody could help me with this I'd be deeply appreciative. But that's not the point.

Avery should have used her ionic feminine dominant hormones for good and not evil. Instead she got straight to work calcifying the pineal glands of all of Australia, which is probably why Stephanie and Erica have not been getting along. How can they when this alternating current of malevolent femininity is flying all over the country spreading her terrible orbitals and invading the valence shells of millions of people with her negative charges before dragging a man, helpless and naked, onto a pier without a box. Again, my electronics final is in two days and I am in desperate need of help. Thank you.

Just remember that while happiness leads to smiles, smiles also lead to happiness

Would she still be fertile at an older age or would the eggs not be viable?