Uterine myomectomy Puns

I mentioned a while back about having a uterine fibroid removed. That happened early this afternoon and I’m home. I’m told it went well. Questions for anyone who has had this done or something similar:

1. Did anything in particular give you pain?
2. Were bowel movements painful?
3. And if so, did you become constipated? What helped to resolve it?

Not really a lot of pain so far, but I suspect 2 and 3 might become a problem. I had not eaten since 9pm last night, and ate soup when I got home around 3pm.

A few details in case it helps anyone having this procedure: I was told no alcohol a week before surgery. Drink only water, black coffee, or non red gatoraid after midnight until 3 hours before surgery. No food after midnight the night before. Surgery itself took about an hour. They gave me an IV with sedative. I was awake when they wheeled me into the OR and put heart monitors on me. I remember nothing after that, until I heard a voice say “you’re all done”. I snoozed for about 30 minutes before I woke up and was taken to the recovery area. I was told some people take longer to wake up. The doctor gave my husband photos of what my uterus looked like before and after. Was advised ahead of time to get a ride home so I did. I can walk ok; trying to move slowly the next 24 hours.

I spent all of my adult life suffering from insane cramping and bowel issues. My mother and I went to multiple doctors in my teens to try and pinpoint what was wrong. Every doctor I had said everything looked fine and brushed me off.

In the past few years, I acquired actual decent health insurance. The doctors did MRIs and ultrasounds outside of the hysteroscopies I’d been given before. My scopes all came back completely clean, but I could feel something was incredibly wrong inside me. I didn’t know that being able feel your uterus is not the norm, but I’d been able to feel it by pressing on my stomach since I was 16.

At 33 it was recommended to me, after a LOT of complaining in my end, that I get a minimally invasive procedure called a uterine fibroid embolization. It took over 9 months to coordinate with the surgeon and my insurance to make it happen.

It was hell. What an embolization does is literally cut off blood flow to part of your uterus and starve out the tumors in the hopes they shrink. They did, a little. It was an 8 month recovery and I have never experienced pain on that scale in my life, and you’re talking to someone who punched through a wall during period cramps and didn’t even realize she did it until the next day.

Since then I’ve had a partial bowel prolapse as a result of straining past my fibroids that were pressing on my colon, and my cramps never improved. The 3 tumors that they embolized 3 years ago did stop growing, but no one told me that my problem was so much more extensive than they let on and that the fibroids they didn’t treat were still growing at a rapid pace.

Then I met my current gynecologist. A woman and an accomplished surgeon. I told her about my situation, and because all my problems had been treated so lightly in the past, it felt like she was really pressuring me when she shoved the pamphlet about myomectomy into my hands. It seemed so sudden and coercive. Like she was just trying to make a dollar off me.

Little did I know that she was worried. It is not common to have cramps that make you hurt yourself to get away from them. It is not normal to have bowel issues where I don’t poop for days. It it not normal to have sciatica at my age. She was worried, and because of it, she scheduled me for surgery within 2 weeks of my visit.

To me, it seemed like an overreaction, but here I am, post-op, and I can say, without a doubt, it was the most positive thing to have happened to me in my life. The fibroid embolization

I'm curious if any Australian ladies have had one of these done? Was it difficult to get your doctor to agree to do one instead of a hysterectomy?

I was told six months ago that I needed to have a hysterectomy but I declined. I was told to come back in six months (this month) to see if the fibroid was growing if it is I would need to have a hysterectomy done. I want to keep all my bits. I'll consider a myomectomy though and would like to hear of you experiences, please.

I have been ttc since April. I went to my doctor for my annual and he felt what he believed to be a small uterine fibroid. He scheduled me for an ultrasound to see what’s what since he knows we are ttc. I asked if he would do bloodwork and he said no, not until we hit a year. I ended up doing an at home one and the results indicated I might have PCOS. When I mentioned this my clinic said the ultrasound would look at my ovaries as well. Well now I’m sitting in the parking lot post ultrasound appointment sobbing my eyes out. Confirmed for PCOS. The tech said the fibroid is taking up damn near my entire uterus. She said she doesn’t know if my doctor can remove it or not without compromising the lining of my uterus (kind of important since that’s where implantation occurs). I’m still having regular periods (29 days with ovulation on CD13/14) which is apparently the silver lining here because when the fibroid hits the lining is when it can cause problems with your period so in all likelihood it hasn’t hit it (yet?). But she doesn’t know and I still need to talk to my doctor who I can’t see until the 10th. The over the stomach ultrasound was not even of use because she couldn’t see my uterus because the thing is so damn big. And now I am sitting here bawling because if the lining of my uterus is compromised then there go my dreams of becoming pregnant. I hate it here what the fuck you guys

My doctor says my uterine fibroid is about the size of a softball- 9cm. He is pretty sure he can remove it laparoscopically though. I was wondering if anyone else had a large fibroid removed without having to have a surgical incision/myomectomy?

Our members have all used IVF to build their families in the past, and are now either back in treatment or are considering resuming treatment in the future. This thread is for anything primarily related to infertility treatment, whether active or contemplated. Expected topics include treatment updates, medical questions, requests for protocol/timing advice, and emotions on all of the same. Topics related to life, parenting, or general infertility issues are more appropriate for the Weekly Chat Thread.

As per the rules, any positive pregnancy test results or concerns regarding a current early pregnancy go in the Weekly Results Thread.

Hey everyone, fellow fibro gal here. I am a 26 year old bi/pan single female who has always had painful periods (which have been made more painful with the fibro). I have uterine fibroids that have been recommended to be surgically removed, but most of the surgical options (myomectomies) have the same invasiveness and recovery time as a hysterectomy. I grew up thinking that I would get pregnant and have kids, but a lot of my life has turned out different than I imagined. I also really don't know if my body and chronic pain would handle a pregnancy, and I am willing to do just about anything to mitigate my current pain, including a hysterectomy. I also don't necessarily want to go through 2 surgeries (myomectomy now and hysterectomy later) and put my body through that if I don't have to. Another aspect is that I am bisexual/pansexual so I may not necessarily eventually have a partner that is the opposite sex, so the "natural" way to have a child may not be a possibility anyways. (I apologize for the long post and extensive back story 😅)

Has anyone else been pregnant and/or had a hysterectomy while having fibromyalgia? This is a tough decision to make and I would really appreciate hearing your input/experiences. 😊 Thanks!

Anyone ppl here with a uterus that have a had a myomectomy (uterine fibroid removal) with a local gynecologist? Open or laparoscopic. I have so many questions and am really having a hard time getting any answers. Have been told by three drs that I have a large uterine fibroid, ovarian cysts, and possible endometriosis. Would love to find a good surgeon/gynecologist who specializes in this type of surgery, rather than the usually ob who mainly does c-sections and the occasional hysterectomy.

Hello!

I recently got the news that I will be having an abdominal myomectomy at the end of January. They are needing to remove several uterine fibroids, 4 of them are each the size of baseballs. They will also need to do a uterine reconstructive surgery to allow me to get pregnant in the future.

I've never had a surgery before, so im a little nervous. I'm also considerably overweight; just under 300lb. I've put on about 100lb over the past 3ish years and it's been so hard for me to get any of it off.

Since I'm about a month out, I was curious if anyone had any tips that helped them prior to the surgery? Or even post op?

Thank you!

Hey all, for some background, I'm 33, I've been trying for a year, and haven't gotten pregnant once. I've been checked out via a HSG and 3 ultrasounds this year, and with the first two ultrasounds, the technician and RE #1 said I have fibroids, but they were not terribly concerned. I had my third ultrasound with another RE today, and he was the first to be more concerned about my fibroids. RE #2 was concerned about a fibroid that is within the uterine muscle (submucosal I believe), and suspected this could be a problem with implantation. He was also strongly convinced that I have a left ovary issue (possibly hydrosalpinx), that could be holding fluid and preventing implantation.

RE#2 is definitely more thorough than RE#1, which is great, and he is literally the first person all year to have showed real concern on something after hearing "everything looks good" on all my tests this year. He gave me the option of having a hysteroscopy (to check out fibroid), laparoscopy (to explore and fix issue with left ovary) and hysteroscopy, or myomectomy (to remove fibroids, especially the submucosal one, along with fix the left ovary issue). He said he was leaning towards the robotic myomectomy to clean everything up in one go, but without any procedure to go in and check, he cannot be sure just how much the submucosal fibroid is causing implantation issues.

A myomectomy is definitely major surgery, so I am very concerned about it. I've done research and several women have said it improved their quality of life as they had heavy bleeding during periods or terrible cramps often, so it was worth the pain of surgery recovery. However, if I never got checked out, I wouldn't even have known I had fibroids. I have very regular periods with moderate/light bleeding and no abdominal pain. I was wondering if anybody was in a similar position and still went for the myomectomy and felt it was worth it or not worth it.

Our journey trying to conceive began a little over three years ago. After a year of trying, I started seeing an RE I’m December 2019. We were diagnosed as Unexplained Infertility. I’m the fall of 2020, after three failed IUI’s, an HSG, SIS, and Colposcopy, we were staring down the hard road of deciding to pour our heart, soul, and bank account into IVF or keep trying on our own and hope for the best. My husband said the only answer we don’t have is whether or not I could have endometriosis. I called my RE who said I had several symptoms and set me up with an OB surgeon to discuss laparoscopic surgery to find out. After a consult with my new OB surgeon discussing symptoms I had which lined up with endometriosis, surgery was scheduled for this past January. My stage II endometriosis was confirmed and excised. We planned on doing another IUI in March, since we were essentially starting over with everything having been cleaned out, but I got pregnant naturally before my next cycle began. To say we were surprised and over the moon would be an understatement. I had labs drawn the day after my positive pregnancy test and again four days later. My HGC was not doubling and soon learned a miscarriage was imminent. My husband and I are still completely devastated. After the miscarriage in April, I went in for an ultrasound and that is when my submucosal fibroid was discovered. In May I had another saline ultrasound so the size could be determined. A hysteroscopic myomectomy was scheduled for the end of June. After waking up from that procedure I learned that it had not been removed because my RE could not see defined borders on the mass and was concerned about cutting deeply into the uterine lining to remove. An MRI would be required to get more precise photographs and make a better determination. That was scheduled for July. After reading the MRI, my RE said she believed what I had was an adenomyoma, a form of focal adenomyosis which is trickier to remove. She would be utilizing my OB surgeon who performed my laparoscopy in January to assist with the next surgery. My OB would go in laparoscopically with a camera while my RE went in via hysteroscopy and would be able to alert her if she was cutting too deeply into the uterine wall. That surgery was scheduled for the end of August. At the beginning of August my cycle began, and wouldn’t stop. I had never seen so much blood in my life, it was literally falling out of me nonstop. I ended up in the ER twice in two days.

What an experience. First, the important note: Vahn Jacob arrived via c section at 10:15pm on August 6th. He’s healthy and perfect and 7lb11oz at 37+5. I’m also doing well.

I showed up at L&D at the urging of my OB/MFM around 3pm with a promise of a csection at 5pm. My BP had been increasing since cutting out aspirin and switching to heparin from lovenox and we didn’t want to risk it. Nurses apparently think I’m just there to screen for pre e and check on my bp. So some confusion while I sit around and wait. They do 90% of the prep for a csection and then stop. My doctor comes in and says that the attending on duty today is the head of the department and is in the middle of a huge emergency surgery and has also taken all the more experienced residents. So a) not only was no one available to assist but b) he went through my file with a fine toothed comb and decided I didn’t need a csection today and they should send me home and on top of that he thinks I’m too much of a bleeding risk for a late night c (both because of my factor viii issue and accreta risk - which my doc didnt agree with there being a risk. Attending just said that because it’s an IVF pregnancy). Doc tries to reason with him and comes to my room to update me and to come up with some sort of game plan to get my c. Attending wanted to admit me and keep me at least overnight/into Sunday before they moved forward. He looks at my monitor and at my face “wait, you’re having regular contractions?!” At this point he hadn’t been focused on my monitors or anything because we were so focused on my csection. I said yes, since driving in actually. (I had my first real contraction right when I sat in the car and between 230pm and 7pm they went from 10min apart to 3.) He says he’ll do a cervical check and said “let’s hope you’re dialated”. He does a cervical check and I’m 3cm dialated and 90% effaced. He says, okay we’re doing this. You’re in labor and I’m not risking a uterine rupture. They get the OR ready while he goes to get the chief resident.

The OR. Wow. I don’t think I really grasped how anxiety inducing it would be. I had so many myomectomies and thought it would be okay but being awake was… a lot. And the shakes from the meds were adding to the intensity of the situation. I expected shaking/shivering. What I got were convulsions. I could barely see or think or breathe. I couldn’t process the world around me. I was regretting having a child in that moment and I absolutely remember decidi

Hi everyone (I'm not sure if anyone is even going to see this post, ha.)

I basically started this community because I had questions and concerns before and after this surgery and wanted to discuss it with people who are going/ went through fibroids and myomectomy, but I didn’t know where to post it and r/fibroids seems to be defunct. I saw some people post their questions to r/endo or r/womenshealth but I thought it would be nice if we had a community focusing just on fibroids and myomectomy where we could help each other out and share our concerns, questions, recovery experiences, advice, support etc. So here’s r/myomectomy!

Anyway, my period after surgery has been super light, which would have been great if it wasn’t a sign of intrauterine adhesions aka asherman's syndrome. I mostly see women still have a heavy period for the first few months post-op so of course I'm concerned. My fibroid was also on a posterior uterine wall and for some reason adhesions seem to be more frequent with this type (according to google). Anyone with a similar experience?

I am hoping to exclusively pump for my first due in January for a variety of reasons. I was wondering if anyone had any advice for how pumping after a c-section changed their routine or affected their choices.

I can choose between a free Lansinoh (or similar) pump from my insurance, or I can get $125 off a Willow/Elvie pump ($375). Does the wearable pump make more or less of a difference with a c-section? I am contemplating using a 20% off coupon for the Willow (only $25 extra to get both pumps) and just getting the free insurance pump, so that I have options. Do you realistically use both, or is a Lansinoh enough? Would you try it first and then buy the wearable, or would it help to have the wearable right away?

Does Willow's lying down while pumping feature help with a c-section? Or does it not matter since you aren't moving much anyways? I have had uterine surgery before (myomectomy and endo excision), so I'm thinking of this in terms of how little I could have done after that with a newborn.

Buying the Willow wouldn't be a huge financial burden, but I don't want to throw money away unnecessarily either.

Are there any additional considerations you would make in retrospect with a c-section? Anything you didn't anticipate or would have done differently if you had known?

If you tried EP after c-section, did you run into any difficulty with the nurses trying to force you not to pump? Does this even matter during the hospital stay with how long it takes milk to come in?

My reasons for EP for context:
Nursing does not appeal to me at all, especially given the c-section incision, but it's not something I want to do regardless

Low expectations for milk coming in given the early c-section, so there doesn't seem to be a point in stressing out over trying to do something that I don't want to do

Husband and others can feed the baby instead of only depending on me, especially while trying to recover.

EP seems more practical, since I can keep track of how much baby is eating and don't need to be responsible for always feeding the baby (husband has paternity leave and could help more)

Currently well controlled pre-gestational diabetes makes keeping track of how much milk I'm feeding the baby and being able to feed the baby with a bottle more important to me

I would like to resume medication that is not compatible with breastfeeding after 6 months if I can. I'm hoping it will be easier to work up to a higher supply and a fr

I posted previously about having a uterine fibroid removed via hysteroscopic myomectomy last March. April was mostly uneventful, but occasional out of cycle heavy bleeding started again in May, with giant friggin clots/chunks. The unexpected clots are the worst - instantly bleed through any tampon even if it’s only been in 30 minutes. I wanted to think this was due to the Covid vaccine, but then unexpected bleeding happened again in June. It was suggested that I take a stronger birth control pill. Had been on the same pills for 15 years. So I used a stronger prescription. That seemed to work for July, before - you guessed it - heavy bleeding again! Feeling really frustrated. I’ve been told my opinions are another hysteroscopy with Mirena IUD, ablation, or hysterectomy. These all scare me. I keep reading about horror cramp/ weird re-embed/painful insertion IUD stories. With the ablation, I read it can cause permanent cyclical pain, and the only way to fix that is with a hysterectomy. Hysterectomies sound extreme and like you just kind of dry up. Doctor won’t give me pros/cons over text or email - wants me to go in for a visit. If you’ve been in this predicament, which did you choose and did it work out for you?

I recently underwent an open (ex-lap) myomectomy for a very large uterine fibroid. I was mostly asymptomatic leading up the procedure. All I felt was some light pressure in my abdomen that I thought was related to weight gain. I had a Mirena IUD placed about 5 years ago, so my periods had been relatively light. I have a physical job in healthcare and I do HIIT workouts 5-6x/week.

While switching doctors, my new PCP noticed the firmness and ordered an ultrasound. When she saw the results of the ultrasound showing a large fibroid, my PCP then got me into my new gynecologist, who then ordered an MRI. The MRI showed a 20cm fibroid at the top of my uterus, slight pressing onto the ureter of one of my kidneys and compressing the Fallopian tube of one of my ovaries. I then got referred to a gyn-onc surgeon whose specialty is preserving fertility. I am recently married and wanting multiple children. The surgeon stated that it would have to be an open surgery because of the size and location of the fibroid. This meant a 2 night stay in the hospital and future child bearing via c-section.

All of the testing/surgery scheduling happened within 4 months.

The day of surgery went as perfect as could be. Despite the surgeon discussing possible complications of a hysterectomy or loss of an ovary (so much depended on what she found when she went in there), she was able to preserve everything and I have normal anatomy again! I have a large incision from my pubic bone to above my bellybutton. I had a pain pump for the first night that got taken away the following morning. I have been managing the pain with ibuprofen and toradol in the hospital and just ibuprofen at home. Getting in/out of bed remains the most uncomfortable movement, but I am able to take small walks. The gas pains were the worst pain of everything so far.

Feel free to ask any questions! I am off from work for at least a month, so I can keep updating with my recovery.

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

Sorry for the standalone, but this is pretty specific so I wanted to make sure I got as many eyes as possible on it.

I’m going through an ERA cycle now (scheduled for W 8/25) ahead of transferring again in hopes of a second infertilitybaby. At my monitoring appointment on Tuesday, my RE noticed a fibroid that is impinging on my uterus. Never mentioned this before, but after looking at my chart she said it’s always been there, but never impinging before. RE says move forward with ERA, then likely have a myomectomy, then FET. Ok, so my timeline just got A LOT longer than I was expecting, but nothing to be done about that.

Then- I read on Igenomix’s website (thanks to a fellow r/infertility etc friend) that uterine surgery after an ERA can basically invalidate the ERA results. My clinic says this happens 1% of the time. Igenomix won’t talk to me to verify this 1% stat. So finally, my question:

Anyone have an ERA, and then a uterine surgery and have success? I’m trying not to freak out about throwing money down the drain and potentially transferring embryos at the incorrect time because the surgery changes my receptivity. Thoughts?

For anyone that is or has experienced uterine fibroids, were your symptoms debilitating as well?? I have had ongoing menstrual bleeding since June 23rd due to the stupid depo shot I was given mid May to help suppress the bleeding. The fibroids have maximized this. The unpredictability of the symptoms is so stressful and driving me insane. I can’t even walk, climb stairs or stand for a long time because then I start to hemorrhage. I am getting a myomectomy for the fibroids. I guess I don’t have a question or anything like that.. just looking for some comfort ☹️

I'm so excited to be included in this year's National Infertility Awareness Week AMA series. I can't wait to chat with you!

My name's Katy and I founded Chasing Creation in 2018 to provide support, resources and community for those who are childless not by choice. My platform of choice is Instagram so feel free to connect with me there at Chasing.Creation. Through Chasing Creation, I offer: monthly Childless Support Circles; monthly Happy Hours with my co-host Brigid of The Fruitless Figtree; a webinar series called Childless Chats where I invite guests to talk with me about topics related to being childless; and this year I hosted the first ever, Childless Collective Summit which had over 2,800 attendees and 28 speakers over four days.

I started Chasing Creation for my own healing because I felt so alone in my experience of going through infertility and not ending up with a baby. Since then, I have connected with so many amazing people and am now focused on building our community so that no one else has to feel that they're going through this alone.

A little about how I got here. I went through almost four years of infertility. During that time, I was diagnosed with uterine polyps, uterine fibroids, endometriomas, and deep infiltrating endometriosis. I had three surgeries to remove all of the above (polyps removed twice, one myomectomy, excision for the endometriosis twice, endometriomas removed twice) and I made the decision to have a hysterectomy with the last surgery in 2017.

I did go through one cycle of IVF but it resulted in no viable embryos and was really hard on my body so I decided not to do a second round. I decided after my last surgery to stop pursuing parenthood and to start designing my unexpectedly childless life.

I know that for many of you, my outcome is your worst case scenario. I never thought I'd end up here, let alone be a public voice for this. I'm now three years out from TTC and, while I have gone through an awful amount of grief, I feel happy, whole and fulfilled in my current life. I didn't think that could be possible for me without a baby and yet, here I am.

Please note that I am neither a therapist or a medical professional so I'm just here to share my experience and what I've seen in the childless community.

I'm pretty much an open book so feel free to ask me anything that's on your mind! There are some questions regarding my personal relationships that I'm not comfortable answering but I'll answer pretty much anythin

Hey all, this may be a long post but I'll try to keep it shorter and clear.

My spouse missed her period last week but told me that she was feeling cramps and some tenderness in the breasts. Yesterday she did a in-home pregnancy test and to our joy and surprise the test was positive, she did another 1 today and it was positive, hooray!

We're excited but also worried. We've been trying to conceive for 6 months now. She is 4 years older than me. We tried fertility supplements, she's been using some app to track her ovulation time. So after some time of no success, we decided to see infertility specialist, my insurance provides good infertility coverage hence why I have not left my job yet but that's another story.

Anyways, we finally got an appointment with a fertility specialist a week and a half ago, he did an ultra sound the same day and the ultra sound showed that my spouse has multiple fibroids. He suggested that we both do some blood and urine test to check our fertility and she would need to have an MRI for the fibroids. He also suggested that she would need to do a myomectomy but the MRI needs to be done first. She was expecting her period shortly after the appointment but it didn't come. Couple of years ago she missed her period for about couple of months right after doing a pap smear. They analysis found that there is something abnormal so she had to go in so they can get a tissue sample, so our initial thought was the ultra sound might have been the cause of her missed period. At the same time we were being hopeful that she might actually be pregnant. Now we have even more hope and are positive that she is pregnant after the test was positive 2 days in a row.

But where do we go from here? Should she still do an MRI, does it affect the fetus in any way? Should she wait until babies birth to remove the fibroids, would that require a c section? We definitely want to minimize all chances that the fibroids might affect fetus growth, birth complications and anything else that might cause some health issues in the baby or my spouse.

We found some other non invasive procedures like cutting off the blood supply to the fibroids so they don't grow larger and hopefully go away. This procedure is Uterine artery embolization (UAE), also known as uterine fibroid embolization (UFE). We are not sure what the best course of action is. We are scheduling doctor appointments to get some medical advise but also feel that this community can als

I was just told that having a myomectomy isn't really an option for me as I may bleed too much during surgery and they may have to do an emergent hysterectomy because of the bleeding. I then asked about uterine fibroid embolization and was also shut down, as the doctor thinks that UFE won't be an option either based on the location of my fibroid (6cm posterior myometrial fibroid that extends from the serosal surface to the endometrium of my uterus). Apparently this is a vascular area (I thought the entire uterus was vascular...). Not really sure why UFE would be an issue??

I guess why I am posting is because I feel absolutely lost and hopeless. This fibroid is causing me so much pain and suffering and I just need it gone. I also REALLY want to have my own children in the future but I feel like this fibroid is just taking everything away from me.

I am so desperate for any advice, support, or to hear about a similar situation. My heart goes out to any woman who has struggled with thier fertility because of fibroids. 💔

Do your worst!

I'm surprised it hasn't decade.

The Company: ObsEva (ticker: $OBSV) is a biopharmaceutical company developing and commercializing novel therapies to improve women’s reproductive health.

The Pipeline:

https://preview.redd.it/vh37oyeq7qh61.png?width=1360&format=png&auto=webp&s=50ba20ea9244be557be85c64060602565ef6bbfe

Yselty: From what I can tell, the big winner in their pipeline right now is Yselty, a treatment for uterine fibroids that has potential best-in-class efficacy. This is what I plan to focus on for this DD.

Uterine fibroids are benign neoplasms (masses/tumors/growths) that arise from the myometrium of the uterus. They most commonly occur in women of reproductive age and they are reported in ~70% of women by the age of 50. About 20% to 50% of uterine fibroids are symptomatic and may require treatment. The most common symptoms are abnormal uterine bleeding, heavy menstrual bleeding (HMB), and pelvic or abdominal pain/pressure.

Currently, surgical treatment is the only definitive long-term therapy for uterine fibroids. This can be in the form of the more conservative hysteroscopic myomectomy (a procedure to remove the fibroids) or the much more aggressive hysterectomy (removal of the uterus). Given that women of reproductive age are most affected by uterine fibroids, it’s important to recognize that definitive surgical management comes with significant risks such as early menopause and infertility. There are some options for medical management (NSAIDs for pain, GnRH agonists and oral contraceptives for bleeding), but none have been proven to be safe and effective for long-term, definitive treatment.

And this is where Yselty comes in. Yselty is a novel, orally administered gonadotropin-releasing hormone (GnRH) receptor antagonist that provides management of heavy menstrual bleeding (HMB) associated with uterine fibroids (UF).

So, how is Yselty different than what is currently on the market? Unlike GnRH agonists, Yselty has the potential to be administered orally once a day, with symptoms relieved within days, while potentially mitigating the initial worsening of symptoms often associated with GnRH agonist treatments.

https://preview.redd.it/g326717s7qh61.png?width=1074&format=png&auto=webp&s=1e0b5608c83726c4241347da9d6a424bee72010f

Oriahnn (made by $ABBV, you can read a little about

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

It really does, I swear!

I have 2 uterine fibroids (& suspected endometriosis - they said they won’t know until I have surgery) & have gone through all the motions: pap smear to blood work to ultrasound to biopsy to MRI to the consultation & now that it’s time to schedule the surgery my insurance is stating that 1. They don’t think I need anesthesia for a laparoscopic myomectomy (wtfffff?!? 🙃) and 2. They don’t feel it’s important to cover the resection of endometriosis. Even the hospital was in disbelief. Has anyone dealt with this before? Any tips/suggestions to appeal or override this? I’m so upset & discouraged right now.

They’re on standbi

Pilot on me!!

This is my original post: https://www.reddit.com/r/Ovariancancer/comments/o1mfmy/ovary_the_size_of_an_orange_bloating_and_pelvic/

So my gyno was great and got the ball moving to figure out what was up. Two weeks ago I had a uterine biopsy which came back benign. Yesterday I did a laparoscopic cystectomy and myomectomy. He was surprised at what we thought was a cyst turned out to be an sterile abscess on my ovary. My ca-125 level was 291 which he ultimately attributed to inflammation. Pathology didn’t show anything. I’m sore today and lost 80% of my right ovary but still thankful. I I was septic last year so probably a result of that. Thank you so much to those that responded with your experiences on my last post, you all are awesome and so strong!

Nothing, he was gladiator.

NOT MY DD - u/bluelemoncows

The Company: ObsEva (ticker: $OBSV) is a biopharmaceutical company developing and commercializing novel therapies to improve women’s reproductive health.

The Pipeline:

https://preview.redd.it/nmhdx2sg0qh61.png?width=1360&format=png&auto=webp&s=f2592848f927457ade4b0f85731fb0637ca06c6d

Yselty: From what I can tell, the big winner in their pipeline right now is Yselty, a treatment for uterine fibroids that has potential best-in-class efficacy. This is what I plan to focus on for this DD.

Uterine fibroids are benign neoplasms (masses/tumors/growths) that arise from the myometrium of the uterus. They most commonly occur in women of reproductive age and they are reported in ~70% of women by the age of 50. About 20% to 50% of uterine fibroids are symptomatic and may require treatment. The most common symptoms are abnormal uterine bleeding, heavy menstrual bleeding (HMB), and pelvic or abdominal pain/pressure.

Currently, surgical treatment is the only definitive long-term therapy for uterine fibroids. This can be in the form of the more conservative hysteroscopic myomectomy (a procedure to remove the fibroids) or the much more aggressive hysterectomy (removal of the uterus). Given that women of reproductive age are most affected by uterine fibroids, it’s important to recognize that definitive surgical management comes with significant risks such as early menopause and infertility. There are some options for medical management (NSAIDs for pain, GnRH agonists and oral contraceptives for bleeding), but none have been proven to be safe and effective for long-term, definitive treatment.

And this is where Yselty comes in. Yselty is a novel, orally administered gonadotropin-releasing hormone (GnRH) receptor antagonist that provides management of heavy menstrual bleeding (HMB) associated with uterine fibroids (UF).

So, how is Yselty different than what is currently on the market? Unlike GnRH agonists, Yselty has the potential to be administered orally once a day, with symptoms relieved within days, while potentially mitigating the initial worsening of symptoms often associated with GnRH agonist treatments.

https://preview.redd.it/glwec3fi0qh61.png?width=1074&format=png&auto=webp&s=a072bfdba85664cc4d51a9c6fa1abc45f6fa2b20

Oriahnn (made by [$ABBV](https://finance.yahoo.com/quote/ABBV?p=ABBV&.tsrc=fin-sr

I was just told that having a myomectomy isn't really an option for me as I may bleed too much during surgery and they may have to do an emergent hysterectomy because of the bleeding. I then asked about uterine fibroid embolization and was also shut down, as the doctor thinks that UFE won't be an option either based on the location of my fibroid (6cm posterior myometrial fibroid that extends from the serosal surface to the endometrium of my uterus). Apparently this is a vascular area (I thought the entire uterus was vascular...). Not really sure why UFE would be an issue??

I guess why I am posting is because I feel absolutely lost and hopeless. This fibroid is causing me so much pain and suffering and I just need it gone. I also REALLY want to have my own children in the future but I feel like this fibroid is just taking everything away from me.

I am so desperate for any advice, support, or to hear about a similar situation. My heart goes out to any woman who has struggled with thier fertility because of fibroids. 💔