How can I handle the pronounced upregulation of genes that code for ribosomal proteins in bulk RNA sequencing analysis?

Hi. I have used DESeq2 to analyse bulk RNA sequencing data where I compare a control versus a test group and I noticed a strong upregulation of genes that code for ribosomal proteins in the test group.

10X genomics proposes the removal of principal components that correlate with ribosomal proteins. Can this proposal be applied to the analysis of bulk RNA seq data and how?

Thanks in advance.

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πŸ‘€︎ u/USSr90
πŸ“…︎ Dec 04 2020
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The evolution of the ribosome: an absolutely facinating analysis of the origins of ribosomal RNA (originally published in Nature, PDF) hoffman.cm.utexas.edu/cou…
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πŸ‘€︎ u/808140
πŸ“…︎ Aug 06 2011
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Class Analysis - Spacer

Hey guys new video, this time taking a closer look into the "Spacer" class : https://www.youtube.com/watch?v=TKV7fzItQVg

I'm working on this series until I get through all the different classes and you could check out the playlist so far here : https://www.youtube.com/watch?v=GN6FJYnhN5I&list=PLKLdiLUpNWO4cQiJi8nN_Xj-YntnnfPTU

Hope you guys enjoy the video and find it helpful!

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Happy Smashing!

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πŸ‘€︎ u/yanno-
πŸ“…︎ Apr 12 2019
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Class Analysis - Spacer (Super Smash Bros. Ultimate) youtube.com/watch?v=TKV7f…
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πŸ‘€︎ u/yanno-
πŸ“…︎ Apr 12 2019
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Kinetic Analysis Suggests Evolution of Ribosome Specificity in Modern Elongation Factor-Tus from β€˜Generalist’ Ancestors academic.oup.com/mbe/adva…
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πŸ‘€︎ u/chromoscience
πŸ“…︎ Apr 30 2021
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