162,000 infected in the UK today with no brakes
Theres gonna be a lot more subscribers to r/covidlonghaulers
source: https://coronavirus.data.gov.uk/
Title. Thanks!
80M non smoker, 120lbs
I’m currently caring for my Dad who is in the end stage of Pulmonary Fibrosis. He seemed to improve over the holidays but has declined rapidly this past 2 weeks. He now can’t move without having a panic attack. He’s on Lorazepam and Morphine and we’ve had to increase that. He’s dreaming a lot and isn’t sure what’s real when he wakes up and is struggling to speak. He’s really frail now and I’m trying to understand how long to expect this stage can go on for. Does anyone have any experience who can shed some light. Hate to see him suffering
Hi everyone, recently my dad (who is extremely against the COVID vaccine) just got diagnosed with pulmonary fibrosis. For those of you who don’t know what that is, it’s a non curable lung disease.
He got COVID around Christmas and spent three days at a hospital. It wasn’t until this week where he was diagnosed with pulmonary fibrosis after still having trouble breathing.
I decided to post here because I’m having a hard time coming to terms with it. I’m really angry at my dad for not getting the vaccine and being anti-vax (along with my mom) and it putting a big strain on our relationship. I’m also angry because I feel as if he had gotten the vaccine, he wouldn’t be in this bad of a situation. My parents are also the not the type to comfort or let you be emotional with them so I’ve been basically just taking his diagnosis in by myself which had been hard.
Also, I feel as if my parents did not do a good job of explaining what he was diagnosed with either. They basically just called me into another room and told me he was diagnosed with pulmonary fibrosis and then that was it. I had to go to room and actually look it up to see what it even was.
It’s been hard to live with them because they constantly talk about how terrible the vaccine is and how it kills people and they spill all this bullshit. And whenever I try to talk about it with them, they yell at me and just shut me down. Now with my dad being diagnosed with a terminal condition, it has really taking a toll on me and my siblings . I wish my parents weren’t so blinded by anti vax propaganda because it could have saved my dads life and I feel as if I would have a better relationship with them.
If anyone has been through something similar I would greatly appreciate advice on how to deal with this!
(Also sorry for any errors I typed this on my phone)
Authors: David Bédard Méthot , Évelyne Leblanc, Yves Lacasse
Unfortunately due to this subreddits ridiculous OTT auto moderator, I can’t seem to link my previous post on this subject but please check my post history and you should find it.
Grandad is now on oxygen and has been for a couple of days and has lung scarring (Pulmonary Fibrosis)
Now I know PF is a common complication with covid but seeing as he also has the advanced COPD, I am now beginning to worry a little that things may be going downhill. He now is on oxygen (which he did not need at first)
Can anybody advise on what all this means. I would expect this scarring with Delta, but not Omicron. Confused and can’t get through to actual doctors on phone.
I am seeing a pulmonologist today. I think I have pleurisy, but my bigger concern is that I suspect that I have interstitial lung disease. I have slowly developed shortness of breath during exertion over the last few years along with a dry cough. It feels the way ILD is described. I am really hoping there is no permanent scarring. Anyway, I read (in the Lupus Encyclopedia) u/LupusEncyclopedia that if active inflammation of the interstitial tissue doesn't show up on a CT scan or other test, a round of steroids may be used as a test--basically, see if the problem improves with steroid use. While I really don't want to be on steroids, I may suggest this if the tests don't turn up anything. (I had a CT scan after a blood clot recently and no abnormalities were noted. I think that if I do have inflammation of the interstitial tissue, it's minor. But I want to catch it before it gets worse or causes scarring).
Anyone know how long one needs to be on steroids to tell if the SOB and coughing is due to ILD? And whether it's a high dose?
Also, for those of you who have had ILD and active inflammation: What has worked?
Thank you!
*Update: Lung scan was clear, although the DLOC was slightly abnormal. Pulmonologist diagnosed costochondritis and said maybe pleurisy, but definitely no ILD. That is a huge relief, but the coughing and shortness of breath is still a mystery. Rheum wants me to see ENT for possible vocal chord dysfunction, but I don't know that this would explain the symptoms. Need to see GI to follow-up about possible silent reflux cause. Honestly, it feels mysterious. I'm really frustrated. Will update if I get to the bottom of it, or it goes away.
https://www.nhlbi.nih.gov/news/2021/researchers-engineer-cells-help-reverse-pulmonary-fibrosis
Pulmonary fibrosis is a serious, mostly irreversible lung disease that can lead to scarring, or fibrosis, in the lungs due to damage or an unchecked immune response. But a new study shows that even after lung tissue has been damaged, it may be possible to reverse fibrosis and promote tissue repair.
Researchers engineered a thin microgel containing a small protein called tumor necrosis factor-alpha, or TNF-alpha, that could boost the therapeutic potential of mesenchymal stromal cells, or MSCs. Much like stem cells, MSCs have the capacity to self-renew and divide and develop into multiple specialized cell types. MSCs have also been studied for their potential to treat conditions like fibrosis. The microgel containing TNF-alpha acted as an inflammatory signal and encouraged MSCs to synthesize an enzyme called collagenase to degrade excess collagen and promote the restoration of the damaged, fibrotic lung tissue.
For optimization, the researchers designed a microfluidic device to encapsulate individual cells rapidly and consistently in the thin gel. In mouse models of fibrotic injury, researchers observed reduced indicators of scaring and increased indicators of healthy lung tissue, such as normal collagen levels and architecture, among mice treated with encapsulated individual MSCs in thin gel with TNF-alpha. The study, published in Nature Biomedical Engineering external link , was partly funded by NHLBI.
He is one of my Best friends ... He has a fabulous sense of humor, is a musician, hard construction worker and a street clown. Always opened to meeting new people whomever they are and quite often leaves them smiling. At work people wont assume he is capable on a first encounter but he is the most capable person I have ever worked with. He had his first child roughly 3 years ago and the poor baby had his skull fused together. The operation was successful in splitting the bones allowing the brain to grow. Just when they think they are in the clear as a family he had a rough bout with a lung biopsy that came back with 2 kinds of cancer. He is on chemo now and the latest test indicated "Idiopathic Pulmonary Fibrosis" they believe the only option for survivability is a double lung transplant. I dont quiet know how the medical bills will be paid but this gofundme, at the very least, helps support the standard living cost and food for him and his family while he is unable to work. his health at the moment is not able to walk without coughing fits and attached to an oxygen tank. he is 36 years old. Our group of friends is rich in life and humor but unfortunately not rich in $$$. Anything helps! Thanks for reading. https://gofund.me/0e261438
proof of me -iserable count account
Hi everyone,
just wondering if any of you have any comments on this.
It is not my first time to have a bird, Ive had a few cockatiels and lovebirds when I was younger, so I am sure that I am not allergic. But it is my first time to have a lovebird as a parent of 2 (5 and 6 year old) kids.
Im sure most of you have also been more paranoid because of the pandemic. We only have one bird, but my sister has sent me this information and it just made me worried. Wondering if you guys have any thoughts. My sister works in the US as a pulmonologist. here is what she sent me:
"Birds can cause hypersensitivity pneumonitis, and you can get pulmonary fibrosis from them. As pulmonologists, we always ask that question when a patient comes in complaining about their breathing -do you own birds? They have protein in their dander that are highly antigenic to us humans. They cause inflammation in the lungs, and then fibrosis. No treatment for that -a lot of my patients ultimately get lung transplants."
just a bit of info, bird is in a cage and in a room that is ventilated. not airconditioned and window is always open. Im also in the Philippines. weather here is either hot or raining.
Tried to research on this, this disease is usually found with people who breed birds. but was just wondering if you guys have any other info.
Thanks!
#Involvement of 4-hydroxy-2-nonenal in the pathogenesis of pulmonary fibrosis
Edilburga Reyes-Jiménez et al. Mol Cell Biochem. 2021 Dec.
Abstract
Pulmonary fibrosis is a chronic progressive disease with high incidence, prevalence, and mortality rates worldwide. It is characterized by excessive accumulation of extracellular matrix in the lung parenchyma. The cellular and molecular mechanisms involved in its pathogenesis are complex, and some are still unknown. Several studies indicate that oxidative stress, characterized by overproduction of 4-hydroxy-2-nonenal (4-HNE), is an important player in pulmonary fibrosis. 4-HNE is a highly reactive compound derived from polyunsaturated fatty acids that can react with proteins, phospholipids, and nucleic acids. Thus, many of the altered cellular mechanisms that contribute to this disease can be explained by the participation of 4-HNE. Here, we summarize the current knowledge on the molecular states and signal transduction pathways that contribute to the pathogenesis of pulmonary fibrosis. Furthermore, we describe the participation of 4-HNE in various mechanisms involved in pulmonary fibrosis development, with a focus on the cell populations involved in the initiation, development, and maintenance of the fibrotic process, mainly alveolar cells, endothelial cells, macrophages, and inflammatory cells. Due to its characteristic activity as a second messenger, 4-HNE, in addition to being a consequence of oxidative stress, can support maintenance of the inflammatory and fibrotic process by spreading the effects of reactive oxygen species (ROS). Thus, regulation of 4-HNE levels could be a viable strategy to reduce its effects on the mechanisms involved in pulmonary fibrosis development.
Keywords: 4-hydroxynonenal; Inflammation; Metabolism; Oxidative stress; Pulmonary fibrosis; Signal transduction.
https://pubmed.ncbi.nlm.nih.gov/34463938/
DOI/PMID/ISBN: https://doi.org/10.1164/rccm.202011-4153OC
Hey there everyone. 29y/o female here with a history of asthma. Coming up on my one year covidversary on the 26th of next month. Throughout this past year, since contracting Covid, I’ve had so many symptoms that have come and gone, some to stay gone and some to return during flare ups... However, my constant symptoms have been tightness in my chest/lungs, sob, and excess mucus production. I did have a bout of bronchitis during initial infection, however I’ve had 9 xrays since July2020 and all have come back clear, never having pneumonia. I had ekgs and and echo that were normal as well. I have a pulmonary function test coming up on the 29th of June and based on those findings, my doctor will possibly order a ct scan. I’ve been making myself worried sick, wondering if it may be fibrosis of the lungs causing my ongoing symptoms. The inflammation in my lungs was so bad for months that I had to be on multiple tapers of prednisone and was using my nebulizer and albuterol inhalers multiple times a day. I have seen improvement in myself, going from not able to walk around or lay down to now being able to walk a mile, sometimes 2 miles if my lungs allow. I guess the point I’m getting at is, has anyone been diagnosed with post covid pulmonary fibrosis without ever having covid pneumonia? Would O2 sats sit at 97-100 if one had fibrosis? And would you see improvement with activity if it were fibrosis or would someone be declining? I know I need to just wait for my test results, but my anxiety has been through the roof just thinking of what could be going on in these lungs of mine. 😞 any info or advice is greatly appreciated! Thanks y’all 🙏🏻❤️
