Polymer-coated nanoparticles to promote drug delivery to the brain inrs.ca/en/news/polymer-c…
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📅︎ Nov 06 2021
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Indian researchers have developed silica nanoparticles with pores tuned to absorb hydrophobic drugs with more stable surfaces and effective absorption properties that can improve drug delivery systems (DDS), an official statement said. twitter.com/ians_india/st…
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👤︎ u/_lameboy_
📅︎ Dec 20 2021
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Polymer-coated nanoparticles to promote drug delivery to the brain inrs.ca/en/news/polymer-c…
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👤︎ u/rtbot2
📅︎ Nov 06 2021
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Co-delivery of metformin and silibinin in dual-drug loaded nanoparticles synergistically improves chemotherapy in human non-small cell lung cancer A549 cells sciencedirect.com/science…
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📅︎ Aug 28 2021
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Engineered nanoparticles injected within or outside the window of breached blood-brain barrier in traumatic brain injury (TBI) mice showed threefold higher brain accumulation. Data suggests that this nanoparticle platform is a promising next-generation drug delivery approach for the treatment of TBI advances.sciencemag.org/c…
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👤︎ u/rustoo
📅︎ Jan 02 2021
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Nanoparticle drug-delivery system developed to treat brain disorders medicalxpress.com/news/20…
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👤︎ u/Sorin61
📅︎ Jan 02 2021
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Co-delivery of Etoposide and Cisplatin in Dual Drug Loaded Nanoparticles Synergistically Improves Chemoradiotherapy in Non-Small Cell Lung Cancer Models sciencedirect.com/science…
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📅︎ Feb 09 2021
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My drug delivery nanoparticles fav.me/de2y3uc
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📅︎ Aug 10 2020
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Nanoparticle drug-delivery system developed to treat brain disorders medicalxpress.com/news/20…
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📅︎ Jan 02 2021
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[Article] "Computational and Experimental Approaches to Investigate Lipid Nanoparticles as Drug and Gene Delivery Systems" (Chun Chan, Shi Du, Yihzou Dong, Xiaolin Cheng)
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👤︎ u/slavickid
📅︎ Dec 01 2020
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Ribbon of DNA Lattice on Gold Nanoparticles for Selective Drug Delivery to Cancer Cells

Self‐folding DNA ribbon : A programmable DNA ribbon is constructed from long‐chain DNA molecules with a user‐defined repetitive padlock sequence. The DNA ribbon can be further combined with gold nanoparticles (AuNPs) to create a composite nanomaterial that contains an AuNP core and a high‐density DNA crown carrying a cancer‐cell‐targeting DNA aptamer, a fluorescent tag for location tracking, and a cell‐killing drug.

Abstract

Herein, we report on the design of a programmable DNA ribbon using long‐chain DNA molecules with a user‐defined repetitive padlock sequence. The DNA ribbon can be further combined with gold nanoparticles (AuNPs) to create a composite nanomaterial that contains an AuNP core and a high‐density DNA crown carrying a cancer‐cell‐targeting DNA aptamer, a fluorescent tag for location tracking, and a cell‐killing drug. This composite material can be efficiently internalized by cancer cells and its cellular location can be tracked by fluorescence imaging. The system offers several attractive characteristics, including simple design, tunable DNA crown, high drug‐loading capacity, selective cell targeting, and pH‐sensitive drug release. These features make such a material a promising therapeutic agent.

https://ift.tt/3gCI5Mb

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📅︎ Jul 10 2020
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[ASAP] Probing the Local Nanoscale Heating Mechanism of a Magnetic Core in Mesoporous Silica Drug-Delivery Nanoparticles Using Fluorescence Depolarization

Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13082

https://ift.tt/2TBb60o

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📅︎ Mar 04 2020
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Red-blood-cell-mimicking nanoparticles enhace blood circulation time and tumor penetration of nanoparticle-based drug delivery systems materialsviews.com/red-bl…
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📅︎ Jan 25 2016
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Nanoparticles trick body into accepting organ transplants – Yale researchers have developed a drug-delivery system that could reduce organ transplant complications by hiding the donated tissue from the recipient's immune system. news.yale.edu/2017/08/04/…
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📅︎ Aug 04 2017
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University of Louisville researchers have uncovered how to create nanoparticles using natural lipids derived from grapefruit, and have discovered how to use them as drug delivery vehicles louisville.edu/medschool/…
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📅︎ May 22 2013
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Engineers have designed tiny magnetic robots that help drug-delivery nanoparticles push their way out of the bloodstream and into a tumor/disease site. The microrobots, inspired by bacterial propulsion, could help to overcome one of the biggest obstacles to delivering drugs with nanoparticles. eurekalert.org/pub_releas…
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👤︎ u/kPuTEr5S2Y
📅︎ Apr 27 2019
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While we are here fighting and whining, the work continues at Inovio: “Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drive rapid and potent 2 immunogenicity capable of single-dose protection” cell.com/cell-reports/pdf…
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📅︎ Jan 11 2022
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A recent study has found that while engineered gold nanoparticles are attractive for smart drug delivery, they come with a downside: great potential to disrupt a woman’s fertility. nanowerk.com/nanotechnolo…
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👤︎ u/dandebeige
📅︎ Feb 19 2015
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Stanford researchers have created a computer simulation, validated by experimental results, to help design drug-delivery nanoparticles that carry cancer-fighting medicines directly to tumors, while minimizing the potential side-effects on healthy cells. engineering.stanford.edu/…
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👤︎ u/edwinksl
📅︎ Sep 26 2018
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Tiny robots powered by magnetic fields could help drug-delivery nanoparticles reach their targets aktu.io/news/content/stor…
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👤︎ u/guybedo
📅︎ Apr 27 2019
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Washington University scientists developed a new nanoparticle nasal spray that could allow a therapeutic dose of medicine to reach the brain within 30 minutes to one hour. This non-invasive approach could someday make drug delivery as simple as a sniff for patients with brain injuries or tumors. source.wustl.edu/2017/04/…
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👤︎ u/mvea
📅︎ Apr 17 2017
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Robust genome editing in (mice) adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA luriechildrens.org/en/new…
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📅︎ Jan 05 2022
🚨︎ report
Ribbon of DNA Lattice on Gold Nanoparticles for Selective Drug Delivery to Cancer Cells

Herein we report on the design of a programmable DNA ribbon using long‐chain DNA molecules with a user‐defined repetitive padlock sequence. The DNA ribbon can be further combined with gold nanoparticles (AuNPs) to create a composite nanomaterial that contains an AuNP core and a high‐density DNA crown carrying a cancer cell‐targeting DNA aptamer, a fluorescent tag for location tracking and a cell‐killing drug. This composite material can be efficiently internalized by cancer cells and its cellular location can be tracked by fluorescence imaging. The system offers several attractive characteristics, including simple design, tunable DNA crown, high drug‐loading capacity, selective cell targeting and pH‐sensitive drug release. These features make such a material a promising therapeutic agent.

https://ift.tt/3gCI5Mb

👍︎ 2
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📅︎ May 29 2020
🚨︎ report

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