A list of puns related to "ATP binding cassette transporter"
I have a particular cassette (Nas - Illmatic) that I was having issues with on my old deck. It would sound like it was binding constantly sometimes playing for a bit OK but the slowing down/warbling/etc.
As I had a few other cassettes that this old deck struggled with I figured it was just it being an old deck as it also struggled rewinding tapes and even struggled FFWDing at times (it used an idler wheel that was 40 some years old and likely needed to be re-rubbered and I just didn't have the means to do that).
So...ended up getting a new deck. A more modern (late 90s) Yamaha. I replaced all the belts.
Plopped the cassette in, did a full FFWD/RWD, then played and...sounded fine! I enjoyed listening to side A all the way through and thought I had figured it out. Put in side B and...WORBLE WARBLE WORBLE WARBLE
Crap.
I did a bit of FFWD and got to the middle of side B and...still bad. Flipped it back over to side A and...still bad.
Is there anything particular that would cause this other than the reels physically binding/sticking to the cassette case? I feel zero actual resistance when manually winding them. The tape, itself, looks quite good (not mint, but you gotta look closely to see any signs of previous playing.)
Is this just a quirk with some cassettes where they otherwise look and feel find but for whatever reason, decks struggle with them? Maybe something on the tape itself causing the capstans to slip?
I know that the ATP binds to myosin heads and for some reason I think that there is a hydrophobic pocket on the myosin heads which is somehow involved in this. I believe I read it in one of my friends notes but not sure. I am trying to look up if I am correct but I only found this which is quite old and seems to be suggestive rather than definitive. So is there a hydrophobic pocket for binding of ATP on myosin heads?
Hey there,
It is known that - lets say - monoamine transporters are responsible for the reuptake out of the synaptic cleft and therefore for the inactivation of monoamines. Research also indicates that reduced serotonin transporter binding is associated with symptoms of depression
And here is the thing: As far as I understand, reduced Serotonin transporter binding means that the serotonin transporter binds less of the serotonin and therefore leaves more serotonin in the synaptic cleft, therefore enhancing serotonin transmission?! AFAIK this should have a positive impact on depression symptoms as reduced serotonin transmission is known to be related to depression.
Can anyone shed light into this?
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c11336
Valentina Arkhipova, Haigen Fu, Mark W. H. Hoorens, Gianluca Trinco, Lucien N. Lameijer, Egor Marin, Ben L. Feringa, Gerrit J. Poelarends, Wiktor Szymanski, Dirk J. Slotboom, and Albert Guskov
https://ift.tt/2LSySVh
Hey there,
It is known that - lets say - monoamine transporters are responsible for the reuptake out of the synaptic cleft and therefore for the "inactivation" of monoamines. Research also indicates that reduced serotonin transporter binding is associated with symptoms of depression
And here is the thing: As far as I understand, reduced Serotonin transporter binding means that the serotonin transporter binds less of the serotonin and therefore leaves more serotonin in the synaptic cleft, therefore enhancing serotonin transmission?! AFAIK this should have a positive impact on depression symptoms as reduced serotonin transmission is known to be related to depression.
Can anyone shed light into this?
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