Selective Receptor Modulator Puns

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Please discuss, and you can vote in the /r/truscum poll that I made here.

I myself plan on initially just using the usual antiandrogen plus normal dose (not microdose) estradiol when I am able to restart HRT, and switching to that strategy if I were to become dysphoric over breast development.

Selective Androgen Receptor Modulators (aka SARMs) are synthetic drugs being tested for, but are not yet approved for, use in various medical conditions, and often marketed as "legal steroids" or "steroid alternatives". They are NOT recognized by FDA as dietary supplements, and are prohibited for use by DoD, NCAA, and WADA. In addition, these drugs have been known to adversely effect the liver and cholesterol levels.

For more information SARMs you can check out the article here from Operation Supplement Safety. Additionally, there are links to a list of product with SARMs in them to be wary of, and an infographic you can find here.

I just found out about SERMs, they're nicknamed "designer estrogen" because of their estrogen-like effects on bone density, and their anti-estrogen effects on chest tissue. However, similar to how hormone suppressants were designed as uterine and prostate chemo, SERMs are for breast cancer. I don't make enough hormones (afab he/him), just found out, but my endocrinologist doesn't want to give me SERMs because it's used to prevent osteoporosis in people with breast cancer who are over age 65. He said it's mostly concerning due to my age, mid 20s.

I'm prescribed half of an estrogen patch, but I don't realistically see myself being able to take estrogen or testosterone, regardless of consequences. The hope is having such a low dose of estrogen I don't really notice, we'll see. Any effects would be too distressing. Same goes for testosterone, so I'm out of options. Testosterone with finasteride to block some of it might be less terrible, but again not ideal or likely tolerable.

https://www.frontiersin.org/articles/10.3389/fendo.2021.701364/full

> Here, we discuss the theoretical use of Selective Estrogen Receptor Modulators (SERMs) for non-binary people assigned male at birth (AMAB) who are seeking an androgynous appearance through partial feminization without breast growth. Given their unique range of pharmacodynamic effects, SERMs may represent a potential gender-affirming treatment for this population, but there is a lack of knowledge regarding their use and potentially adverse effects in this context.

Just for information. U can see Roche's pipeline here.

The new drug candidate is in Phase 1. It is one of only a few drugs currently being developed for autism.

I posted about Balovaptan here

Hi everyone! My name is Dr. Justin Dubin and I am a Urologist at the University of Miami. I am asking members of this subreddit to take part in a research study evaluating the demographics of selective androgen receptor modulator users (Commonly known as SARMs). SARMs are very commonly used throughout communities like this but little is known about their side effects and impact on fertility. We feel it is an important topic that has not been discussed and we would like to shed some light on it through our research.

Below is the link to an anonymous survey that asks questions on the topic. We are asking all adults 18 and older to participate. The survey can range from approximately 10-30 questions (depending on your answers) and should take no longer than 6 minutes to complete.

Demographics of Selective Androgen Receptor Modulators (SARMs) Users

This survey has been approved by the moderators (/u/Troythetoyboy) and the study is IRB approved at UMiami. This is a one time survey and no follow up will be required. If you have any further questions feel free to message me or reach out via my contact information on the survey.

Thanks for your participation!

If at all possible I would like to ask for non-biased facts regarding SARMs. How do they impact the body’s natural ability to produce testosterone? How does it effect one’s metabolism regarding aging? Please, someone who is educated on the topic or experienced with SARMs, what was/is your experience?

ANy biotech company that is experimenting about these ones?

Selective androgen receptor modulator stocks

i always have to preamble that i have no science bkgrd. i just found below re bazedoxifene & remyelination - hopefully people who actually know when they're talking about can opine if this is useful or not. :-)

https://science.sciencemag.org/content/364/6436/twil

Remyelinating axons Claudia Pama

The search for therapeutic targets to support remyelination in demyelinating diseases such as multiple sclerosis is challenging. Existing oligodendrocytes in the brain do not remyelinate demyelinated axons. Selective estrogen receptor modulators have been suggested to make oligodendrocyte precursor cells (OPCs) differentiate into functional, myelinating cells. In the search for myelinization-promoting agents, Rankin et al. selected bazedoxifene from a high-throughput screen and tested it in vitro and in vivo. This drug increased the differentiation of OPCs into functional oligodendrocytes (both in murine and human cells) and did so when axons were demyelinated after an induced lesion. A genetic knockout experiment revealed that the mechanism of action is independent of its presumed target, the estrogen receptor. Bazedoxifene is already approved by the Food and Drug Administration (as it is regularly prescribed for vasomotor menopausal symptoms in women) and is known for having relatively few side effects, which makes it a promising therapeutic drug for multiple sclerosis.

J. Neurosci. 39, 2184 (2019).

referenced study: https://www.ncbi.nlm.nih.gov/pubmed/30696729

"Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors." J Neurosci. 2019 Mar 20;39(12):2184-2194. doi: 10.1523/JNEUROSCI.1530-18.2019. Epub 2019 Jan 29.

"Abstract: A significant unmet need for patients with multiple sclerosis (MS) is the lack of U.S. Food and Drug Administration (FDA)-approved remyelinating therapies. We have identified a compelling remyelinating agent, bazedoxifene (BZA), a European Medicines Agency (EMA)-approved (and FDA-approved in combination with conjugated estrogens) selective estrogen receptor (ER) modulator (SERM) that could move quickly from bench to bedside. This therapy stands out as a tolerable alternative to previously identified remyelinating agents and other candidates within this family.

Using an unbiased high-throughput screen, with subsequent validation in both murine and human oligodendrocyte precursor cells (OPCs) and coculture systems, we find that BZA enhances differentiation of OPCs into functional oligod

Introduced: Sponsor: Sen. Orrin Hatch [R-UT]

This bill was referred to the Senate Committee on the Judiciary which will consider it before sending it to the Senate floor for consideration.

Sen. Orrin Hatch [R-UT] is a member of the committee.

Govtrack.us Summary

Hi everyone! My name is Dr. Justin Dubin and I am a Urologist at the University of Miami. I am asking members of this subreddit to take part in a research study evaluating the demographics of selective androgen receptor modulator users (Commonly known as SARMs). SARMs are very commonly used throughout communities like this but little is known about their side effects and impact on fertility. We feel it is an important topic that has not been discussed and we would like to shed some light on it through our research.

Below is the link to an anonymous survey that asks questions on the topic. We are asking all adults 18 and older to participate. The survey can range from approximately 10-30 questions (depending on your answers) and should take no longer than 6 minutes to complete.

Demographics of Selective Androgen Receptor Modulators (SARMs) Users

This survey has been approved by the moderators and the study is IRB approved at UMiami. This is a one time survey and no follow up will be required. If you have any further questions feel free to message me or reach out via my contact information on the survey.

Thanks for your participation!

Hi everyone! My name is Dr. Justin Dubin and I am a Urologist at the University of Miami. I am asking members of this subreddit to take part in a research study evaluating the demographics of selective androgen receptor modulator users (Commonly known as SARMs). SARMs are very commonly used throughout communities like this but little is known about their side effects and impact on fertility. We feel it is an important topic that has not been discussed and we would like to shed some light on it through our research.

Below is the link to an anonymous survey that asks questions on the topic. We are asking all adults 18 and older to participate. The survey can range from approximately 10-30 questions (depending on your answers) and should take no longer than 6 minutes to complete.

Demographics of Selective Androgen Receptor Modulators (SARMs) Users

This survey has been approved by the moderators and the study is IRB approved at UMiami. This is a one time survey and no follow up will be required. If you have any further questions feel free to message me or reach out via my contact information on the survey.

Thanks for your participation!

Hi everyone! My name is Dr. Justin Dubin and I am a Urologist at the University of Miami. I am asking members of this subreddit to take part in a research study evaluating the demographics of selective androgen receptor modulator users (Commonly known as SARMs). SARMs are very commonly used throughout communities like this but little is known about their side effects and impact on fertility. We feel it is an important topic that has not been discussed and we would like to shed some light on it through our research.

Below is the link to an anonymous survey that asks questions on the topic. We are asking all adults 18 and older to participate. The survey can range from approximately 10-30 questions (depending on your answers) and should take no longer than 6 minutes to complete.

Demographics of Selective Androgen Receptor Modulators (SARMs) Users

This survey has been approved by the moderators and the study is IRB approved at UMiami. This is a one time survey and no follow up will be required. If you have any further questions feel free to message me or reach out via my contact information on the survey.

Thanks for your participation!

Hi everyone! My name is Dr. Justin Dubin and I am a Urologist at the University of Miami. I am asking members of this subreddit to take part in a research study evaluating the demographics of selective androgen receptor modulator users (Commonly known as SARMs). SARMs are very commonly used throughout communities like this but little is known about their side effects and impact on fertility. We feel it is an important topic that has not been discussed and we would like to shed some light on it through our research.

Below is the link to an anonymous survey that asks questions on the topic. We are asking all adults 18 and older to participate. The survey can range from approximately 10-30 questions (depending on your answers) and should take no longer than 6 minutes to complete.

Demographics of Selective Androgen Receptor Modulators (SARMs) Users

This survey has been approved by the moderators and the study is IRB approved at UMiami. This is a one time survey and no follow up will be required. If you have any further questions feel free to message me or reach out via my contact information on the survey.

Thanks for your participation!

Hi everyone! My name is Dr. Justin Dubin and I am a Urologist at the University of Miami. I am asking members of this subreddit to take part in a research study evaluating the demographics of selective androgen receptor modulator users (Commonly known as SARMs). SARMs are very commonly used throughout communities like this but little is known about their side effects and impact on fertility. We feel it is an important topic that has not been discussed and we would like to shed some light on it through our research.

Below is the link to an anonymous survey that asks questions on the topic. We are asking all adults 18 and older to participate. The survey can range from approximately 10-30 questions (depending on your answers) and should take no longer than 6 minutes to complete.

Demographics of Selective Androgen Receptor Modulators (SARMs) Users

The subreddit mods have approved me reaching out to everyone and the study is IRB approved at UMiami. This is a one time survey and no follow up will be required. If you have any further questions feel free to message me or reach out via my contact information on the survey.

Thanks for your participation!