Persistent SARS-CoV-2 infection in patients with secondary antibody deficiency: successful clearance following combination casirivimab and imdevimab (REGN-COV2) monoclonal antibody therapy - Annals of Clinical Microbiology and Antimicrobials ann-clinmicrob.biomedcent…
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πŸ‘€︎ u/ConorRowlandIE
πŸ“…︎ Jan 10 2022
🚨︎ report
REGENERON'S COVID-19 OUTPATIENT TRIAL PROSPECTIVELY DEMONSTRATES THAT REGN-COV2 ANTIBODY COCKTAIL SIGNIFICANTLY REDUCED VIRUS LEVELS AND NEED FOR FURTHER MEDICAL ATTENTION investor.regeneron.com/ne…
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πŸ‘€︎ u/vladmuresan02
πŸ“…︎ Oct 28 2020
🚨︎ report
Regeneron's REGN-COV2 Antibody Cocktail Reduced Viral Levels and Improved Symptoms in Non-Hospitalized COVID-19 Patients newsroom.regeneron.com/ne…
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πŸ‘€︎ u/jaguaracer
πŸ“…︎ Sep 29 2020
🚨︎ report
REGENERON ANNOUNCES START OF REGN-COV2 PHASE 3 COVID-19 PREVENTION TRIAL IN COLLABORATION WITH NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) investor.regeneron.com/ne…
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πŸ‘€︎ u/fouriergold
πŸ“…︎ Jul 06 2020
🚨︎ report
Regeneron releases new data showing REGN-COV2 reduces rate of hospitalization investor.regeneron.com/ne…
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πŸ‘€︎ u/shmolex
πŸ“…︎ Oct 28 2020
🚨︎ report
Regeneron's REGN-COV2 Antibody Cocktail Reduced Viral Levels and Improved Symptoms in Non-Hospitalized COVID-19 Patients newsroom.regeneron.com/ne…
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πŸ‘€︎ u/jaguaracer
πŸ“…︎ Sep 29 2020
🚨︎ report
Donald Trump's medical team threw him a coronavirus 'Hail Mary pass' with an experimental cocktail of antibodies called REGN-COV2 abc.net.au/news/2020-10-0…
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πŸ“…︎ Oct 06 2020
🚨︎ report
EMA issues advice on use of REGN-COV2 antibody combination (casirivimab / imdevimab) ema.europa.eu/en/news/ema…
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πŸ‘€︎ u/getcelltrion
πŸ“…︎ Feb 26 2021
🚨︎ report
REGN-COV2 Independent Data Monitoring Committee Recommends Holding Enrollment in Hospitalized Patients with High Oxygen Requirements and Continuing Enrollment in Patients with Low or No Oxygen Requirements investor.regeneron.com/ne…
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πŸ‘€︎ u/Expat_analyst
πŸ“…︎ Oct 30 2020
🚨︎ report
REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters biorxiv.org/content/10.11…
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πŸ‘€︎ u/Werkintoomuch
πŸ“…︎ Aug 03 2020
🚨︎ report
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19 nejm.org/doi/full/10.1056…
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πŸ‘€︎ u/chilladipa
πŸ“…︎ Dec 19 2020
🚨︎ report
No Evidence that REGN-COV2 (Regeneron) Antibody Cocktail Has Clinical Benefits via Anand Swaminathan, MD rebelem.com/no-evidence-t…
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πŸ‘€︎ u/srrezaie
πŸ“…︎ Jan 02 2021
🚨︎ report
Regeneron COVID-19 treatment enters final stage trials - The drug, called REGN-COV2, is a combination of two antibodies that block the coronavirus' "spike protein" which it uses to invade human cells. ctvnews.ca/health/coronav…
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πŸ‘€︎ u/TOMapleLaughs
πŸ“…︎ Jul 06 2020
🚨︎ report
REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters biorxiv.org/content/10.11…
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πŸ‘€︎ u/D-R-AZ
πŸ“…︎ Aug 04 2020
🚨︎ report
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19 nejm.org/doi/full/10.1056…
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πŸ‘€︎ u/geoxol
πŸ“…︎ Dec 17 2020
🚨︎ report
The experimental antibody drug cocktail REGN-COV2 that they have given Trump is only in a early trial of 275 patients cbsnews.com/news/trump-co…
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πŸ‘€︎ u/FLtimeTraveler
πŸ“…︎ Oct 02 2020
🚨︎ report
Regeneron's REGN-COV2 Antibody Cocktail Reduced Viral Levels and Improved Symptoms in Non-Hospitalized COVID-19 Patients newsroom.regeneron.com/ne…
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πŸ‘€︎ u/avivi_
πŸ“…︎ Sep 30 2020
🚨︎ report
One of the world’s largest efforts to find effective COVID-19 treatments will evaluate the impact of REGN-COV2 on mortality, hospital stays, and the need for ventilation: RECOVERY COVID-19 phase 3 trial to evaluate Regeneron’s REGN-COV2 investigational antibody cocktail in the UK recoverytrial.net/news/re…
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πŸ‘€︎ u/mubukugrappa
πŸ“…︎ Sep 14 2020
🚨︎ report
TWO SCIENCE PUBLICATIONS HIGHLIGHT POTENTIAL OF REGN-COV2 ANTI-VIRAL ANTIBODY COCKTAIL TO PROTECT AGAINST SARS-COV-2 ESCAPE MUTANTS investor.regeneron.com/ne…
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πŸ‘€︎ u/throwmywaybaby33
πŸ“…︎ Jun 11 2020
🚨︎ report
One of the world’s largest efforts to find effective COVID-19 treatments will evaluate the impact of REGN-COV2 on mortality, hospital stays, and the need for ventilation: RECOVERY COVID-19 phase 3 trial to evaluate Regeneron’s REGN-COV2 investigational antibody cocktail in the UK recoverytrial.net/news/re…
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πŸ‘€︎ u/mubukugrappa
πŸ“…︎ Sep 14 2020
🚨︎ report
@NBCNews: NEW: Regeneron Pharmaceuticals says it provided "a single 8 gram dose of REGN-COV2," an investigational Covid-19 therapy, in response to a "compassionate use" request from the president’s physicians - @CNBC mobile.twitter.com/NBCNew…
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πŸ‘€︎ u/-en-
πŸ“…︎ Oct 02 2020
🚨︎ report
Regeneron's REGN-COV2 Antibody Cocktail Reduced Viral Levels and Improved Symptoms in Non-Hospitalized COVID-19 Patients

This is the best tl;dr I could make, original reduced by 91%. (I'm a bot)


> Regeneron Pharmaceuticals, Inc. today announced the first data from a descriptive analysis of a seamless Phase 1/2/3 trial of its investigational antibody cocktail REGN-COV2 showing it reduced viral load and the time to alleviate symptoms in non-hospitalized patients with COVID-19.

> "After months of incredibly hard work by our talented team, we are extremely gratified to see that Regeneron's antibody cocktail REGN-COV2 rapidly reduced viral load and associated symptoms in infected COVID-19 patients," said George D. Yancopoulos, M.D., Ph.D., President and Chief Scientific Officer of Regeneron.

> Serological status highly correlated with baseline viral load. Seropositive patients had much lower levels of virus at baseline, and rapidly achieved viral loads approaching lowest levels quantifiable, even without treatment.

> In the untreated patients, seropositive patients had a median time to alleviation of symptoms of 7 days, compared to seronegative patients who had a median time to alleviation of symptoms of 13 days.

> Patients with increasingly higher baseline viral levels had correspondingly greater reductions in viral load at Day 7 with REGN-COV2 treatment.

> In addition to this trial in non-hospitalized patients, REGN-COV2 is currently being studied in a Phase 2/3 clinical trial for the treatment of COVID-19 in hospitalized patients, the Phase 3 open-label RECOVERY trial of hospitalized patients in the UK and a Phase 3 trial for the prevention of COVID-19 in household contacts of infected individuals.


Summary Source | FAQ | Feedback | Top keywords: patient^#1 Regeneron^#2 REGN-COV2^#3 viral^#4 trial^#5

Post found in /r/COVID19 and [/r/Coronavirus](http://np.reddit.com/r/Coronavirus/comments/j2765u/regenerons_regncov2_antibody_cocktail_reduced/

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πŸ‘€︎ u/autotldr
πŸ“…︎ Sep 29 2020
🚨︎ report
@CBSNews: RT @stevenportnoy: The WH physician says Trump, as of this tweet, has been treated with the following: β€” Remdesivir β€” Regeneron REGN-COV2 antibody cocktail β€” Zinc β€” Vitamin D β€” Pepcid β€” Melatonin β€” Aspirin mobile.twitter.com/CBSNew…
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πŸ‘€︎ u/-en-
πŸ“…︎ Oct 03 2020
🚨︎ report
Regeneron antibody Cocktail REGN-COV2 improved symptoms in non-hospitalized Covid patients fitveno.com/singlenews.ph…
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πŸ‘€︎ u/fitveno
πŸ“…︎ Oct 06 2020
🚨︎ report
REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters biorxiv.org/content/10.11…
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πŸ‘€︎ u/Kujo17
πŸ“…︎ Aug 04 2020
🚨︎ report
Therapeutics Tracker

COVID-19 therapeutics tracker

Posted 10 December 2021 | By Jeff Craven

πŸ“·

A handful of therapeutics have been approved specifically to treat COVID-19 in different countries around the world. Among those treatments are dexamethasone,Β  Avigan (favilavir), Veklury (remdesivir), Lagevrio (molnupiravir),Β Xevudy (sotrovimab), Regkirona (regdanvimab), and Ronapreve (casirivimab and imdevimab). Regulators around the world have allowed additional treatments to be used on an emergency-use basis.

This tracker will be updated biweekly with the latest in developments for treatment candidates who have advanced to at least Phase 1 study.Β If you notice an issue with this data or wish to submit an update, please emailΒ Regulatory FocusΒ atΒ news@raps.org.

Updated 10 December with new information about Lagevrio (molnupiravir), Evusheld, Regkirona, Actemra/RoActemra, amubarvimab/romlusevimab, heparin, Vascepa, Paxlovid, Xevudy, bamlanivimab + etesevimab, lenzilumab, and convalescent plasma. Please note this will be the last update of the Regulatory Focus COVID-19 therapeutics tracker for 2021. Our next update will be published on 7 January 2022.

SHOW/HIDE STUDY DESIGN & DETAILS Show 102550100 entriesSearch:Medication classTrade name (generic name)Developer/ResearcherSponsorTrial PhaseLast updateAntiviralMolnupiravir (Lagevrio, formerly known as MK-4482 and EIDD-2801)Ridgeback Biotherapeutics; MerckRidgeback Biotherapeutics; MerckPhase 310-Dec-2021Monoclonal antibodyEvusheld (tixagevimab and cilgavimab; AZD7442)AstraZeneca; Vanderbilt University Medical CenterAstraZeneca; BARDAPhase 310-Dec-2021Monoclonal antibodyRegkirona (regdanvimab, CT-P59)CelltrionCelltrionPhase 310-Dec-2021IL-6 receptor agonistActemra/RoActemra (tocilizumab)RocheVariousPhase 310-Dec-2021Monoclonal antibodyAmubarvimab and romlusevimab (formerly BRII-196 and BRII-198)Brii Biosciences LimitedNIAIDPhase 310-Dec-2021AnticoagulantHeparin (UF and LMW)NHLBIOperation Warp Speed; University of PittsburghPhase 2/3/410-Dec-2021Lipid-lowering agentVascepa (icosapent ethyl)[Amarin Corporation](https://amarinco

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πŸ‘€︎ u/Biomaniac--Reddit
πŸ“…︎ Dec 15 2021
🚨︎ report
UK has purchased doses of Roche/Regeneron antibody treatment

There's very little information about this available anywhere, but the UK government have published the supply agreement (direct link) to purchase an unknown number of doses of Roche and Regeneron's antibody treatment for COVID-19.

Obviously all the juicy bits are redacted, so we'll probably have to hope for an official announcements for any more information.

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πŸ‘€︎ u/_c9s_
πŸ“…︎ Apr 02 2021
🚨︎ report

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