Hello All!, I am a research scientist in Biotech. I am well versed with the wet lab techniques. I wanted to learn how to create genome scale metabolic models...so would like help from the people here...first impressions on doing some Google search and YouTube...I got to have a set of reactions and then convert that into smbl format and then we have many softwares available to use the smbl formats. Have I got it right? Also is there a way I can upload a genome and get the smbl model? Does Patric.org do it? Willing to learn python/ coding..just overwhelmed with the amount of info...any pointers will help..thanks in advance!
ADF Hypercom Broadcast, 17814.31 IE, 17 days since the arrival
I am Admiral Kinna, ADF commander Fenik prime. Under the planetary director's authority, and by my recommendation, the hyperspace mirror has been disengaged to broadcast this message. Please find attached reports of initial contact with the creature. Summary follows.
17 days ago, 17814.14 IE, a magnitude 9 psionic event was detected near Yimtra city. Event was determined to be a psionic gateway, which delivered an enormous creature. It was a mass of tentacles and eyes, with an enormous central beak. Initial contact resulted in 17 fatalities.
The creature generates some kind of psionic static which is planet-wide, possibly system-wide. Opening gateways through this static is impossible. Long range communication through this static is impossible. Even short range psionic communication is taxing. It is always there, scratching at the back of your mind.
Second contact attempted to communicate with the creature, failure. 14 casualties.
Sustained plasma lance fire was ineffective against the creature. A class 4 antimatter bomb detonated at a range of 2km was evaded by the creature.
We lost track of it on the second day. Psionic detection methods are rendered useless by the static. Sensors, scanners, and drones have so far failed to locate it. We know it did not leave the solar system, we can still feel the static.
Reports began to accumulate of people having terrible nightmares. I know how that sounds, but the reports were too numerous and detailed to be ignored. By the seventh day, everyone on the planet was having them, including myself. They usually don't make much sense, but they always feature pain and blood. If you believed experiencing pain in a dream was impossible, I'm afraid you are mistaken.
A new religion has begun to take hold in Yimtra city. They worship the creature and claim to understand the dreams as messages from it. I suspect brain damage as a result of psionic attack when the creature first arrived near the city. So far they have not caused any major problems, but I have ordered their activities monitored.
We cannot find and neutralize this threat. The fleet's assistance is requested. To that end I have ordered the hyperspace mirror to remain disabled until we have your response. I
... keep reading on reddit โก#Xhikaat
When I awoke, I looked in on Kasla's progress with the personal device. "Kasla, how are you progressing?"
"Warlord Xhikaat! It's going to take me a few days to build a proper interface. The technology itself isn't too unusual, but there are layers and layers of security programs, and the direct interface port is taking some time to map out. I'm grateful it's not as excessively complicated as the Voron's meshchain technology. And it also seems significantly more... Robust. We shouldn't have any problems with overloading."
I said, "That's good. as much as I dislike spying, we should explore their culture unguided."
Kasla said, "Yes, I agree. It would be faster if I deactivated the multiple layers of security, but if a common personal device has this many security functions, they must have enemies that utilize cyber combat almost exclusively. I don't want to compromise the ship. I built a separate computer just for this, and I have no connections of any kind to the rest of the ship. It also has a massive dataclutch connected, so we can download as much general information as possible."
That's what I like to hear. Kasla's a fine science officer! "Very good! Keep up the excellent work."
Joseph approached me a short time later, carrying something that smelled like food. That insistence on three meals a day. It's incredible just how much he eats, but his metabolism is a frightening thing.
Joseph said, "Xhikaat, I've been wondering... Would you have any interest in sampling Terran movies?"
"Terran movies? What kind?"
"I have all kinds! Old samurai flicks, horror films, biopics, hero films, wushus, historical dramas, comedies, science fiction, fantasy, I can easily fit every Terran film older than a hundred years on my data storage."
He held up a device that looked like an expedition canteen, but not curved. I asked, "What are hero films?"
"Oh! Super heroes! Fictional accounts, usually of people with incredible, impossible powers."
That sounded fascinating! "What kinds are there?"
"Oh! Where to start? I've got Deadman, Green Arrow, the Batman trilogy, plus the Nightwing saga. I've got the Green Lantern trilogy, plus the Green Lantern Corps miniseries. I have the Star and Stripe movie, the Justice League movies, hawkgirl, the wonder woman movies, the Superman movies, the Howard the Duck quadrilogy, and I even have Livewire, if you're into crap. Oh! And the Leg
... keep reading on reddit โกI don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
I'm glad everyone is enjoying the story so far! I'm still pretty new at this, so constructive criticism is definitely welcome.
Ambassador Elisa Petrov had been having a good day until now.
As Earth's ambassador to the alien polity calling themselves the Orion Arm Compact she was in charge establishing formal diplomatic relations with our new neighbors, and overseeing the various cultural and scientific exchanges that were ongoing.
Not to mention trade deals.
Today's meeting with Ambassador Hool had gone especially well. His species, the Phaan, were amphibian-analogues and enjoyed the water, so she had arranged to have the station's pool reserved for their meeting. Hool had relished being able to swim around freely, as it had been weeks since he had been in any body of water larger than the meditation pool in his quarters. As they enjoyed themselves, the discussion of trade had come up, and Elisa had told him that the biomedical exchange team had found Earth's first major food export.
Apparently, while most of the species in the Compact were carbon based, Earth foodstuffs were rather...intense. That is not to say they were inedible, mostly. Although several spices were found to be intensely toxic across a wide spectrum of species, most were perfectly safe for alien consumption in moderation. While most species COULD enjoy and metabolize them, only a few could handle the doses common to human cuisine, and some had either euphoric or hallucinogenic properties in several species.
Indian food was going to require warning labels off-planet.
However, the real problem wasn't finding alien-compatible foods for export. It was that alien farming techniques were advanced enough that they didn't really need to import food. They didn't need Terran grain or potatoes. So any exported foodstuff had to be something unique and delicious enough that everyone would want it. And the research teams had found one.
Peanut Butter.
From what the biology team leader had told her, every single carbon based species who had volunteered to taste it loved the stuff.
A lot. Almost too much.
So much that the biomedical team had gone back to double check their own work to make sure it wasn't some sort of drug, and had Compact scientists
... keep reading on reddit โกDo your worst!
I'm surprised it hasn't decade.
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies ๐
It really does, I swear!
Because she wanted to see the task manager.
Theyโre on standbi
So this has been a thing since when i started photography. whenever i go out on a shoot, may it be in my hometown or somewhere else, the first hour im usually super creative and have tons of ideas, everywhere i look. but after roughly an hour, i can no longer think creatively enough or dont have any ideas anymore. its like i have a "hunger" for creativity and when i have been creative for a while, i get "full". almost always when taking pictures, im on a walk and after an hour, i start to get slightly tired. its almost like my creative state of mind vanishes.
maybe this is, because i have somewhat low body weitht, being a male with a fast metabolism, despite working on construction, i only weigh 60 kilos at 172 cm tall. i can eat more than any of my co workers and gain absolutely no weight. if i do more, i am more hungry, if i do less, i am not as hungry.
i have noticed when taking it more easy, lets say not walking as much on a shoot, i dont stay any more creative, but still feel like im exhausted, despite lower physical intensity. but i do enjoy photowalks a lot. i have also noticed that if i eat something like a sandwich that i dont stay more creative for any longer. can i maybe do something to stay creative for longer? could i eat certain foods that make me more alert and more creative for longer? do any of you experience the same?
Pilot on me!!
Nothing, he was gladiator.
Metabolically unhealthy and overweight phenotypes are associated with increased levels of inflammatory cytokines, in a population-based study
https://www.sciencedirect.com/science/article/abs/pii/S089990072200003X
Authors: Fabrรญcia Geralda FerreiraaGiana ZarbatoLongoi
Show more Outline Share Cite https://doi.org/10.1016/j.nut.2022.111590 Get rights and content
HIGHLIGHTS โข Overweight plus metabolic alterations are associated with proinflammatory cytokines
โข MUNW and MHOW phenotypes are associated with higher levels of TNF-ฮฑ and IL-12p70
โข Metabolic alterations and overweight are important cardiovascular risk factors
โข Identifying metabolic phenotypes is important for prevention of chronic diseases
Abstract Objective The aim of this study is to determine the association between cytokine levels in metabolic phenotypes. Our hypothesis is that an unhealthy metabolic profile is associated to higher levels of proinflammatory cytokines.
Research Methods & Procedures The sample is composed of 743 Brazilian adult individuals classified in four phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy overweight (MHOW) and metabolically unhealthy overweight (MUOW). Sociodemographic, anthropometric, clinical and biochemical parameters were collected. Six different cytokines were analyzed from blood samples using the CBA Human Inflammatory cytokines kit and the values divided in quartiles for analysis. Logistic regression models were constructed to assess the association between metabolic phenotypes and cytokines concentrations, adjusted for potential confounders and p < 0.05 was used.
Results The MUOW phenotype shows a higher risk of increased levels of all cytokines analyzed compared to the reference (MHNW).
Conclusions These results indicate that weight excess and altered metabolic profile are related to inflammation, especially when both conditions are associated, possibly linked to visceral adiposity. Therefore, the categorization of metabolic phenotypes in populations is an important factor for prevention of chronic diseases, as inflammation associates to cardiovascular risk and obesity is not sole influencing factor.
Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.
This sub is mostly just NSFW puns now.
If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.
Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.
BamBOO!
Alrighty, things are starting to pick up now, Don't worry my intrepid readers, there is more action to come. But first, a bit of character development.
+ Prologue + Previous + Next +
_______________________
Chapter 4
The Feelingโs Mutual
Neirdith felt safe, not the kind of safe that lets you sleep at night, the kind of safe that allows one to truly let go and lose focus of their surroundings. After an indeterminate period of time Neirdith relaxed her arms and looked up to Skorr's eyes, seeing her move Skorr moved their hand and she stepped back from them letting one hand linger on their dark gray armour. Relishing the feeling of calm strength for just a moment longer she removed her hand and sighed deeply. While the powerful feeling was gone she still felt lingering traces of resolute calm inside her very soul. Standing straight and squaring her shoulders she stepped back far enough to look at Skorr's eyes more easily.
"I know we have an understanding, but we need to do something about the fact that you don't speak common. Why is that anyways?" Thinking about the way they had been partially buried inside a large amount of metal scrap she briefly toyed with the idea that they might be in fact older than the S.C.U. itself. But no, the S.C.U. was over 800 years old there was no way they would still be alive after who knows how much longer than that. 'Skorr is probably just from an unknown system, that's all' she thought to herself.
Looking back at Skorr she noticed their gaze on her and as they saw her looking the leaned forwards slightly and spoke in that same alien language, she clearly heard her name in it more than once but was unable to divine any meaning from it.
"Still don't get it." She said cheerfully while waving Skorr to follow her she walked over to the now quiet form of the former Captain Medrigil. Squatting next to them she said in a sing-song way "Wakey wakey captain."
The Yeown's only reaction was to scrunch up tighter.
'We can't have any of that' thought Neirdith with a frown, debating whether or not to kick them she settled on diplomacy. After all they were probably traumatized, she was a bit hersel
... keep reading on reddit โกWhen I got home, they were still there.
What did 0 say to 8 ?
" Nice Belt "
So What did 3 say to 8 ?
" Hey, you two stop making out "
I won't be doing that today!
[Removed]
Where ever you left it ๐คทโโ๏ธ๐คญ
