Curious as to the vaccines' relation to triggering genetic predisposition to Acute cerebellar ataxia in adolescence. Here, I mean the vaccines' relation as a contributing factor, not as the confounding factor in this onset. Specifically, my husband's nephew (Caucasian, 15 years old, 6 ft tall, not overweight, possible Asperger's Syndrome / high functioning Autism). Vaccines' impact on the blood brain barrier, from NIH, source below.
Thought they were treating an ear infection. Then he had vertigo repeatedly, loss his ability to walk, vision is not balanced / has double vision. Doctors said the tests will take months to confirm what they think it is - though they wouldn't tell his parents what they thought it was. This happened in Canada.
- Some Unanswered Questions about Vaccine Induced Thrombocytopenia and Thrombosis
- It appears that these clots are primarily caused by autoantibodies against PF4 (currently, it is unclear why these form). These are probably IgG and can cross the blood–brain barrier, causing platelets to aggregate and collect in specific locations such as the cerebral sinus vein*.* ‘HIT with thrombosis’ is another rare disorder with the same constellation of findings (low platelet counts and thrombosis) that is caused by treatment with heparin but at a much higher frequency (1–5%) than TTS. Whereas HIT with thrombosis has clear risk factors, no clear risk factors have so far been identified for TTS. Heparin complexes with PF4 during HIT with thrombosis, which then attaches to platelets to trigger Fc receptor mediated platelet activation. Much about TTS still remains unclear. It appears that the mechanisms of TTS and HIT with thrombosis are quite similar in being mediated by PF4 antibodies, but clots in the brain are uncommon in HIT with thrombosis for reasons that are not clear. One possibility is that there may be differences in blood flow patterns and the size of the platelet aggregates in the two conditions.
An Update on COVID-19 Vaccine Induced Thrombotic Thrombocytopenia Syndrome and Some Management Recommendations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400504/
Additional source:
*In an in vitro study of the blood-brain barrier, the S1 component of the spike protein promoted loss of barrier integrity, suggesting that the spike protein acting alone triggers a pro-inflammatory response in brain endothelial cells, which could explain the neurological
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I am a 25-year-old male with cerebellar ataxia from a hemorrhagic stroke when I was a kid. I have been considering microdosing psilocybin for a while. I have read positive studies and anecdotal stories about psilocybin and stroke due to its neurogenesis. I have heard good things about ataxia and psilocybin , but they were through the grapevine, so I am wondering if anyone here has more knowledge about this?
Even without actually having read a study between psilocybin and ataxia, I would speculate it to be beneficial because of course, neurogenesis would seem to be beneficial to something degenerative.
Also if somebody just happens to know about some groundbreaking research in ataxia, feel free to share lol
Hi All,
Using a throwaway account, I just want to quickly praise you all, been viewing this subreddit for a few days and it is really inspiring to see all of those happy to help others!
So, I suffer with a nasty condition (as mentioned in the title) and it is getting worse and worse overtime. There are things like running, meeting friends, working which are all things that I used to do but I am not able to now. I am 22 years old (Male). There is a part of me that wants to try to improve but most of the time I just feel like I can't live with myself anymore, I suffer with anxiety and low self esteem. I have no idea how to keep moving forward and things only get worse, I have fallen over a few times recently, my vision is really poor, I have slurred speech, these are only a few of my struggles. I want to improve its just holding me back and I feel like I am suicidal only because I am scared of the future and I have nothing to live for, life is just really unfair and doing even the simple tasks are so hard sometimes, it's so mentally draining and I just can't bare living with the pain now, I have tried everything but it only makes things worse.
Right now, I can barely walk, I've given up driving and returned my car, I don't work, my parents keep on to me a lot about working. All of my other issues. It's just too much to handle and I just want a way out or for it to stop. I don't feel like I have a future so I am thinking about suicide a lot recently, I don't see any other way to stop feeling this way.
I would appreciate any help that anyone can give! I just feel so lonely and worthless all time time.
My grandma (on my dad's side), my dad, his sister all have SCA-type 1. When my grandma had it, nobody knew what it was. When my dad started showing symptoms in his 40s, they ran a gamut of tests and eventually landed on this. I was around 15 at the time. He started with needing a cane, then a walker, and now is in a wheelchair full-time. He is mentally as sharp as ever, and I can see how frustrating it is for him that his body not to be able to keep up with his mind, and that he's so beholden to people around him for various everyday things. I told my partner before we got really serious that there was a 50% chance that I might have this - I didn't decide to get tested until this year, when we started talking about the kids thing seriously. He has been lovely and incredibly supportive. I got my results back two weeks ago, and I tested positive. The protein sequence repeats that cause this are present in a higher number for me than my dad, so that means that I will likely start showing symptoms sooner and that it will be a little more severe than what my dad's coping with.
I believe it's a fairly rare condition, so I guess I'm hoping to bring some awareness to the whole thing. Also, talking about it I think will be cathartic for me. So, AMA!
Links about SCA:
https://ghr.nlm.nih.gov/condition/spinocerebellar-ataxia-type-1
http://www.ataxia.org/pdf/NAF%20Web%20Content%20Publication%20SCA1.pdf
My proof: I've provided private proof to the mods.
Is there anyone on this forum that has spinocerebellar ataxia?
I had a disease in the part of my brain that controls balance and movement, my cerebellum. I couldn't eat, walk, speak, or sit up for weeks, and had to learn how to walk again afterwards. It happened when I was 8; I'm 23 now, and will do my best to answer all questions!
Edit: wanted to add that at the time, I was either the only person in Australia or in the world that they didn't know what had caused it.
Hello fellow redittors! Please help me by donating in my campaign (https://gogetfunding.com/assistance-for-possible-cerebral-softening-diagnosis-and-medical-healing/) or by sharing this post! Have a great day!
This might also interest youh (ttps://doodlrph.wordpress.com/2018/02/10/the-three-titans/)
