[ASAP] Enantioselective Desymmetrization of 2-Aryl-1,3-propanediols by Direct -Alkylation with a Rationally Designed Chiral Hemiboronic Acid Catalyst That Mitigates Substrate Conformational Poisoning

Journal of the American Chemical SocietyDOI: 10.1021/jacs.1c00759

Carl D. Estrada, Hwee Ting Ang, Kim-Marie Vetter, Ashley A. Ponich, and Dennis G. Hall

https://ift.tt/3tkfzog

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πŸ‘€︎ u/TomisMeMyselfandI
πŸ“…︎ Mar 15 2021
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Le Monarque’s catalyst should add Explosive Head or allow for an extra .5-1 second draw time on poison arrows

At the very least it needs to create orbs. Honestly it’s an extremely powerful bow already and a catalyst might completely break it.

Adding the Explosive Head perk would be useful IF it poisoned after the explosion. It would make it great for shutting down a small area.

Allowing it to be drawn for .5-1 second longer and keeping Poison Arrows wouldn’t break it completely but it’d still be a lot more powerful.

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πŸ‘€︎ u/CivEngineeer
πŸ“…︎ Oct 26 2021
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Burst+ and 2 Catalyst+ makes for one poisoned Champ
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πŸ‘€︎ u/birkinshaw86
πŸ“…︎ Dec 23 2021
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4k+ poison with Nightmare + Catalyst reddit.com/gallery/rcs4ez
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πŸ‘€︎ u/Ramtram44
πŸ“…︎ Dec 09 2021
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The Silent with poison/Catalyst focus is my favorite means of winning. Omg.

Have only won a full victory twice against the heart, and both times were with poison builds that had more than one fully upgraded Catalyst. Multiplying poison over and over is just absolutely broken, since it stacks over several turns, freeing your energy to block later until you can get them to lethal dosage (should be called venom, not poison?)

I haven’t played any other build so easy to put together run-to-run on any character like with poison.

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πŸ‘€︎ u/MrWinks
πŸ“…︎ Sep 10 2021
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Le Monarque should get a Catalyst that removes the "fully drawn" requirement to activate poison arrows.

Do it Bungie. Wouldn't really be any more broken than what Trinity Ghoul or Ticuu's can already do.

We need our beloved void bow to have a catalyst too.

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πŸ‘€︎ u/Yourself013
πŸ“…︎ Feb 27 2021
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A successful Silent run this night( Catalyst ). It was quite stressful, because of the lack of block in the first act, but a lot of fun with poison stacking. My first Catalyst got from Neow and then 2 more from the first act. Slayed Donu and Deca with Corpse Explosion.

https://preview.redd.it/kdassoebmxm71.png?width=1920&format=png&auto=webp&s=f6e338b8466a2c79721db99135b8b92507c27b6d

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πŸ‘€︎ u/phenekus666
πŸ“…︎ Sep 11 2021
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Yesterday I reached 2061 poison with catalyst & nightmare combo. Today my Ritual Dagger reached 75 damage. What's your highest?
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πŸ‘€︎ u/Suddenslow
πŸ“…︎ Jun 09 2021
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loot from 1440 t4 tarantula. I got 4 digested, 5 tara talismans, 6 fly swatters (not shown) 1 epic tarantula, 55 arachne fragments, 18 scrolls to nest , 10762 toxic arrow poison, 92 bite runes, 34 bane books, 27 catalysts, and 74,783 tara webs. reddit.com/gallery/miukst
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πŸ‘€︎ u/h8re
πŸ“…︎ Apr 02 2021
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Is there a record for damage? 3861 Poison. Nightmare -> Catalyst is a beast
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πŸ‘€︎ u/Karnicorn
πŸ“…︎ Jun 09 2021
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Going through my first silent run on android like "I really need a catalyst or corpse explosion or SOMETHING to scale with my poison! " and then....
πŸ‘︎ 227
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πŸ‘€︎ u/DefNotBlitzMain
πŸ“…︎ Feb 06 2021
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Nightmare + Catalyst + Burst + 2 Dupe Potions = a wee bit of poison for the Heart (A15)
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πŸ‘€︎ u/wigglymister
πŸ“…︎ May 05 2021
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Help Reaching 99 poison without catalyst

So, I was was kindly informed by the people on this forum that my game glitched and the catalyst card won't unluck on my current save.

So I'm trying to unlock the achivement for applying 99 poison to an enemy, but without this card it seems unlikely . What do you guys think, is it possible, is there a combination of cards, potions or relics that would allow me to reach 99?

Since I'm trying to get all achivements I can't really start a new save, since this would require me to unlock everthing again.

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πŸ‘€︎ u/DavidwithLove
πŸ“…︎ May 06 2021
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Massive deck, gambler's chip, lucky early calculated gamble, burst poison + catalyst into catalyst. Tori + tungsten rod = no heartbeat damage, blocks 3x12 damage.
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πŸ‘€︎ u/Lazerhest
πŸ“…︎ Apr 07 2021
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The Nightmare/Catalyst combo is too strong... Feeling poisonous.
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πŸ‘€︎ u/coniferkween
πŸ“…︎ Feb 25 2021
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Could we get a catalyst for Le Monarque that leaves behind a lingering cloud of poison on precision kills?
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πŸ‘€︎ u/RegularSelf
πŸ“…︎ Feb 03 2020
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I'm still new to the game, but started with Catalyst and Secret Technique, then went 18 floors without getting a poison card. This was true suffering.
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πŸ‘€︎ u/BrokenYozeff
πŸ“…︎ Apr 27 2020
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First victory run. I used poison deck (Even without catalyst) .
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πŸ‘€︎ u/MilesGamerz
πŸ“…︎ Nov 02 2020
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I finally had a worthy poison counter to put here. It’s pretty funny to have nightmare, catalyst, and the specimen
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πŸ‘€︎ u/Hattyhattington2
πŸ“…︎ Oct 19 2020
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I'm new to the game, just got it a few days ago, and I got 104 damage on one card lol
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πŸ‘€︎ u/awsamar
πŸ“…︎ Jan 01 2022
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My first attempt at the poison/catalyst strategy. Attempted the awaked one 4 times before surrendering. What should i do to improve this?
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πŸ‘€︎ u/eeveelord
πŸ“…︎ May 06 2020
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Scientists have found one new gold molecule, a catalyst containing exactly 25 gold atoms, that is powerful as well as sophisticated. It catalyzes the conversion of a variety of molecules, including the transformation of poisonous carbon monoxide into harmless carbon dioxide ornl.gov/ornl/news/featur…
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πŸ‘€︎ u/Libertatea
πŸ“…︎ Aug 25 2014
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Nightmare + Catalyst = nearly max stacked poison (982). Hopefully can replicate on the heart
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πŸ‘€︎ u/drmolarman
πŸ“…︎ Dec 23 2019
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Spoiler about real life stuff that’s going on with Tammy

Don’t read this if you don’t want to know what’s happening currently

SPOILER:

I’m not sure if there are people that follow this show that are unaware of the health crisis that Tammy just faced, and continues to face. We are beginning to see it play out on the show, and it will likely culminate with the season finale, because I’m sure they won’t continue filming without her.

So the Tammy we are watching, that’s gotten increasingly nasty and short fused is very sick, but she doesn’t know it yet. On next week’s episode, when she starts partying, I’m assuming that’s going to be the catalyst that leads to her upcoming mental breakdown, which really happened.

She was diagnosed with CO2 poisoning, as a result of Pickwickian Syndrome, somewhat common in the super-obese. They cannot breathe deeply enough to expel the toxins that normal sized people do, and she had toxic levels of it, developed pneumonia, became septic, was put on life support AGAIN (3rd time that we know of) and that’s when they put the tracheostomy in her throat. She was discharged from the hospital about two weeks ago to a skilled nursing facility where she will undoubtedly lose weight, but due to the precarious conditions of her health now, and the fact that she now has a trach, she is no longer considered a candidate for weight loss surgery. It will be quite a while before her health would be considered stable enough for her to be reconsidered, if ever. Having the trach poses a whole new host of problems for her. By her own admission, she will be in the facility she is in until June, at the very least.

Amy has purchased a home and moved out of the duplex and Tammy’s half is vacant. It’s been said that the owner of the building is fixing it up to rent to somebody else.

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πŸ‘€︎ u/TaterTotMansion
πŸ“…︎ Dec 29 2021
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Destiny 2 Hotfix 3.4.0.2

Source: https://www.bungie.net/en/News/Article/50930


##Activities

###Crucible

  • Fixed an issue in Iron Banner and Momentum Control playlists where capturing a zone on certain maps did not reward Super energy and show "zone captured" text.
  • Iron Banner Freelance node now properly displays the longer respawn time setting.

###Dares of Eternity

  • Lowered recommended Power level to 1100.
  • Fixed an issue where players could be auto launched into Dares of Eternity before acquiring a Heavy weapon.
  • Additional physics objects are cleaned up between rounds to prevent crashes during long Dares sessions.
  • Fixed an issue where rewards level (platinum, etc) would be displayed at the end of the activity in regular difficulty.

###Presage Exotic Mission

  • Fixed an issue preventing players from interacting with datapads within the Presage Exotic mission. Datapads and their connected compartments/chests must be accessed in order as players move through the Glykon.

    • In addition to this fix, the weekly lockout for earning lore book pages for Presage completions was removed. Players will now earn one lore book page per activity completion without any weekly lockout. This should allow players to finish the lore book in the time remaining before The Witch Queen launches.

###Dungeon: Grasp of Avarice

  • Fixed an area where players can get out of the environment in Sunken Lair.
  • Added geometry to prevent exploiting an encounter by completing it without engaging its mechanics.

###Lost Sectors

  • Fixed an issue where some of the Champions in the Chamber of Starlight lost sector were not counting towards the total for the purpose of calculating rewards, allowing players to skip them and still achieve platinum.

###Public Events

  • Fixed an issue where public event rally flags would not fully regenerate Super energy for Supers in the longer cooldown tiers.

###UI/UX

  • Updated Deuteranopia, Protanopia, and Tritanopia colorblind modes default colors to make it easier to distinguish between combatant health bars.
  • Fixed an issue where some emblems were not displaying properly.
  • Fixed an issue where some emblems were not displaying correct art.

##Gameplay and Investment

###Armor

  • Fixed an issue where Icefall Mantle could be activated immediately after Glacial Guard fell off the Titan.

###Weapons

  • Added guaranteed drops of Dreaming City weapons from completing the Blind Well event.
  • Fixed an issue w
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πŸ‘€︎ u/DTG_Bot
πŸ“…︎ Jan 11 2022
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Title
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πŸ‘€︎ u/BlackPlumbum
πŸ“…︎ Dec 13 2021
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TIL intangible does not cap at 999
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πŸ‘€︎ u/StabbyMcStabson
πŸ“…︎ Dec 22 2021
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Nightmare / burst / catalyst. Loooots of poison!
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πŸ‘€︎ u/Eranok
πŸ“…︎ Apr 07 2019
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208 POISON BOI. Stacked up deadly poisons with 2 catalyst+.
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πŸ‘€︎ u/implaying
πŸ“…︎ Aug 14 2019
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13 poison + Burst+ + 2x Catalyst+
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πŸ‘€︎ u/BeSeQel
πŸ“…︎ Feb 04 2019
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30th Anniversary Weapons Breakdown

Hello Guardians, my name is u/PandaPaxxy. I am back!.. sort of. Did you miss me? I have a lot of work to do if I want to truly say I'm back, but who knows if I'll catch up on my backlog. But this is a small breakdown for the 30th anniversary update and I do miss making these for you.

If you haven’t seen my breakdowns before I do things a little differently. I will be organizing the new weapons by activity, weapon slot, and then alphabetically. That means the new 6 man activity, kinetic and then alphanumeric. Then comes energy for the same activity and so on.

Included in this one breakdown are MnK recommendations, Controller recommendations, and my own personal roll for the weapon I'm chasing.

I will not be linking my older breakdowns because my last one was Season of the Chosen...yikes.

Without further ado, let's start with the new seasonal content's perks. I hope you're as excited for this as I am. The Dares are so much fun, and the dungeon should be giving out incredible loot. (PS it's the first dungeon I've solo flawlessed).


New Perks:

Legacy PR-55 Frame - Customized frame with dramatically increased accuracy, stability, and targeting while hip firing. (Only on the BxR-55 Battler)

Blunt Execution Rounds - Damaging nearby combatants with melee abilities dramatically increases handling and damage. Expires after a short duration or the next shot. > Rolls on the BxR-55 Battler

Cold Steel - Powered Sword hits slow targets. > Rolls on Zephyr

Duelist’s Trance - Sword final blows grant increased charge rate, efficiency, and defense until this weapon is stowed. > Rolls on Half-Truths, Hero of Ages, The Other Half

Eager Edge - Gain increased Sword lunge distance immediately after switching to this weapon. > Rolls on Half-Truths, The Other Half

Golden Tricorn - Final blows with this weapon grant bonus damage. While this buff is active, grenade or melee kills of the same damage type greatly increase its damage and duration. > Rolls on 1000 Yard Stare, Matador 64, Retraced Path

Light Battery - Lightweight, agile battery.

  • Inc
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πŸ‘€︎ u/pandapaxxy
πŸ“…︎ Dec 13 2021
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Over One Hundred Uses of Silver
  1. Silver sulfadiazine used as a topical cream to treat burns. It made WHO’s list of essential medicines, as an anti-infective medicine.
    1. Treatment of warts and corns usually in the form of a caustic pencil. The silver compound silver nitrate, is widely used, and is formed by reacting silver with nitric acid.
    2. SilverCoat Foley catheters are used in urology to prevent urinary tract infections from catheter use. Canadian company Covalon is pushing the boundaries on medical technologies that saves lives. This SilverCoat technology is one of them.
    3. Use in Radiology, silver halides are still being used in conventional x-ray film as an image receptor. Many third-world countries that don’t have access to advanced technology use this type of x-ray.
    4. Silver is used in bandages and dressings to prevent the spread of infection. There is also many uses as gels and ointments for minor scrapes and cuts.
    5. Surgical mesh. 3D Silver mesh to aid in support the organs or tissues during surgery. Loosely woven sheets made of either 3D gold or 3D silver.
    6. Conjunctivitis drops for newborn babies. Silver nitrate has been used for a long time as drops for newborns to prevent pink eye. However, this is slowly being replaced by modern antibiotics such as erythromycin.
    7. Prevent cavities with the use of silver diamine fluoride. Kids and cavities go hand in hand, so what better way to prevent that than with a little silver. Reported by DentistryIQ.
    8. Silver needles & sutures used by surgeons to close up wounds. This was first discovered in the early 1900’s by a man named Reuben Ottenberg.
    9. Silver bearing coatings for hip joint implants named as SMART-HIP. Bearings such as these, not only aid in preventing infection in implants but also reduce friction by silver’s self-lubrication for longer use and durability.
    10. Dental fillings are often composed of liquid mercury along with powder mixture of silver, copper, and tin to give it that β€˜silver’ look.
    11. NASA utilized silver ions as a lightweight water purifier for the Apollo spacecraft. Instead of using traditional chlorine, NASA employed silver ions to be released in the water to destroy bacteria which is later then filtered out. Using a combination of copper and silver ions revealed to be effective in killing E. Coli, Staph, Strep, Salmonella and other common bacteria. The Russians are also known to use silver to purify water in orbit aboard the International Space Station.
    12. H
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πŸ‘€︎ u/OneTroyOunce
πŸ“…︎ Jan 13 2022
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Some day…
πŸ‘︎ 5k
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πŸ‘€︎ u/ProRetard117
πŸ“…︎ Sep 16 2021
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What are decks for fighting A0 Heart with on Ironclad/Silent/Defect?

I've been blitzing Watcher for a week and forgot how to play anyone else, but I need the achievements for taking down the Heart and I know if you go in with the wrong deck you'll die to it's mechanics.

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πŸ‘€︎ u/TheMystiquest
πŸ“…︎ Jan 12 2022
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Think this is enough poison to kill it?
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πŸ‘€︎ u/420xXowoXx420
πŸ“…︎ Dec 25 2021
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I broke it, oops Multiple poisons cards, turned catalyst into an X type card and had like 45 energy retained lmao
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πŸ‘€︎ u/Lapidot-Wav
πŸ“…︎ May 25 2019
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Oof, ouch, owie
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πŸ‘€︎ u/userno81
πŸ“…︎ Dec 20 2021
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3.7k poison. Gotta love catalyst+ nightmare
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πŸ‘€︎ u/MacGrubler
πŸ“…︎ Oct 01 2019
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4000 poison on turn one v.redd.it/n2hrce46tdw71
πŸ‘︎ 972
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πŸ‘€︎ u/veico_cm
πŸ“…︎ Oct 29 2021
🚨︎ report
The Silent Nightmare Catalyst is almost 1200 poison OTT?.. No. Full Act 2 run in comments. Fingers crossed for the heart!
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πŸ‘€︎ u/theisal
πŸ“…︎ Apr 26 2019
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Nightmare + Snecko Eye + Catalyst+ = 24k+ poison imgur.com/a/wvusQhK
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πŸ‘€︎ u/TurbanatorGD
πŸ“…︎ Feb 06 2019
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