In preparation for my FET tomorrow, I’m info-loading. I found these transfer guidelines which summarizes multiple studies re: what does/doesn’t increase the chances of a live birth. I found the bed rest section particularly interesting (read that whole section, not just the summary statement)!
ETA: At least one study since the publication of this paper found no significant difference in pregnancy rates with immediate bedrest vs immediate ambulation.
Hi guys! Just heard that my RE, like many, will be attending the ASRM. Thought I’d peruse the topics and names of presenters to know who to google/pubmed search for my issues. Thought you all might want the opportunity to do the same. ASRM Schedule
This is going to be a very long post and I apologize. However I believe it is necessary to say because there are millions of Americans who don't see the things wrong with our society. My hope is that by them reading this they will gain a better understanding (I realize this exercise towards that goal may ultimately be futile).
I have ADHD. Unfortunately that mental disorder alongside of ADD has been heavily stigmatized in the US. Very often through my life I have heard things such as "Your just lazy" and "That's an excuse you use to get away with things". I do realize that there was a time that ADHD and ADD we're potentially over diagnosed but I can assure you I do have ADHD.
I was diagnosed in middle school since my Psychiatrist refused to diagnose me any earlier to ensure it wasn't just me being young and impatient. My ADHD has persisted into adult hood. I have taken various medications for ADHD ranging from Ritalin to Adderall and now take Atomoxetine. I prefer Atomoxetine as it is a non-narcotic and can be prescribed by my family Physician.
ADHD has many symptoms but some are much prevalent than others. Some of the most common symptoms are impulsivity, forgetfulness, absent mindedness, lack of restraint, and anxiety.
So with that out of the way let me explain what happened. I am now 38 and happily married (2nd marriage). However 12 years ago I was a very different person. I was divorced, living with my parents, and working a poor paying job. I was an Assistant Manager for a large Gas Station chain making $9/hr.
At the time I had not been taking medication for my ADHD because the reality was I could not afford it. Not only was the non-stimulant versions absurdly expensive, if I wanted a stimulant medication it required I go through another psychological evaluation as an adult and then receive a continued confirming diagnosis for ADHD. This was absurdly expensive and considering I only made 18k a year before taxes mixed with needing to pay for food, my car payment, car insurance, and other basic necessities as well as partial rent for room and board at my parents I obviously couldn't pay for assessments that could be upwards of a couple hundred dollars per visit.
So I went untreated. This resulted in my ADHD being in full force. I did things wrong at work, constantly forgot where I put things or to do important tasks when I was opening. The only reason my Manager worked with me was because she was best friends with my brother. This all came to a he
... keep reading on reddit ➡Hi there! I'm a scientist who specializes in endocannabinoid system pharmacology - my PhD was in the structural biochemistry of endocannabinoid system targets like the CB receptors, metabolic enzymes, and binding proteins.
As a scientist, I'm always saying "we need more research," but I want to take a moment to try to communicate what it is we already know. My talk yesterday focused on two main mechanisms: traditional pharmacology (how drugs directly interact with receptors and enzymes to cause therapeutic change) and a more modern/novel approach involving membrane structure alterations affecting receptor functionality.
Here is the summary:
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Traditional pharmacology:
- CBD has been shown to inhibit endocannabinoid-metabolizing enzymes. This leads to increased levels of endocannabinoids, which activate the endocannabinoid receptors CB1, CB2, GPR55, GPR18, TRPV1, etc. Inhibiting endocannabinoid enzymes is a mechanism for anxiolytic effects that has been under investigation for some time.
- CBD is an agonist at serotonin 5-HT1A receptors, which means that it activates these receptors and turns them on. This has been directly linked to CBD's anxiolytic and antidepressant effects in animal models (a note on animal models at the end). 5-HT1A agonism is one of the classic mechanisms of action for psychiatric drugs. They include Aripiprazole (abilify), Trazodone, Buspirone (BuSpar), and more.
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Alterations in Membrane Structure/Function
- Membrane elasticity: CBD has been shown to change membrane elasticity (the thickness of the phospholipid bilayer). Cannabinoids in general have also been shown to stabilize specific phospholipid conformations and alter membrane structures. Cannabinoids are fatty and are solubilized in the membrane, which is also how they access the receptors. Changes in membrane elasticity can cause changes in receptor kinetics and overall functionality.
- Cholesterol: Cholesterol can make up up to 40% of cell membranes, this depends on the type of cell. Many receptors display "cholesterol-dependent activity" which means that their ability to signal properly depends on a balance of cholesterol. Recently, it has been demonstrated that cholesterol levels control antidepressant effects and is partially responsible for the molecular mechanism of fluoxetine (prozac). Also let that sink in for a sec, we've been prescribing Prozac for ~50 years and just last month we discovered a BRAND NEW molecular mechanism for it! Meanw
Consent model for Egalitarian Reproductive Freedom
For the last decades, we’ve seen a huge discussion about woman’s reproductive rights, contraception, abortion, bodily autonomy, and everything related to have the freedom to decide whether a woman wants to be a mother or not, always being in the center of the discussion the possibility for them to decide about the outcomes that impact her lifes. But this discussion has been silenced for years when talking about men.
Besides the conception itself, there are a lot of steps until the final outcome of having a baby and currently, men are unable to decide about any step related to that process: if a woman wants, a man can be forced into paternity, backed by the state itself.
Current discussions about sexual and reproductive matters are driven by a concept that hasn’t been applied to male paternity yet: consent.
Non-consented paternity implies the imposition of also non-consented financial obligations, that directly translates into labor, and if that imposition is backed by the state, men are unable to opt-out – that sounds an awful lot like the “servitude” concept described in the article 4 of the Human Rights Act: “No one shall be required to perform forced or compulsory labour” but sneakily, they also included a clause stating that this “term shall not include any work or service which forms part of normal civic obligations” which is extensively interpretative, and ideological establishment could use it to frame non-consented paternity as part of the “normal obligations”.
But the reality is that we cannot normalize non-consented paternity, no matter in which way establishment try to frame it, the fact is that if it’s non-consensual, and forces someone into financial, physical or in any other kind of obligations, it is against basic human dignity: it should be a right to choose, for both men and women.
Consensual sex is not equal to consented paternity
A misandrist take we frequently hear is that if something goes wrong with contraception in a consensual sexual relation, woman should decide if she wants to keep the baby and become a mother and man (sometimes) can decide if he wants to be the father or “just” be obliged to be the provider, and this is exactly what prevents men from having Reproductive Freedom: **men can
... keep reading on reddit ➡Here's my theory: As a primitive society, your reproductive engine is entirely bottlenecked by the number of women you have.
50 men + 50 young women == 50 babies
1 man + 50 young women == 50 babies (and one very happy guy)
More is better, of course (genetic diversity, men can be helpful, etc), but I would say the driving force causing sexual dimorphism is the ways men can be helpful by taking the lion's share of collective risk.
Men are biologically warriors because their deaths are less impactful on the tribe, so it's their primitive role to carry out risk and violence.
- Beards for padding punches
- Extra tall, longer limbs (no need to be lower to the ground for the anatomical changes of pregnancy, better to be faster and have longer reach)
- Testosterone motivated behavioral changes such as
- Risk taking behavior
- Aggression
- More lean muscle development
- Faster metabolisms (moving, carrying, fighting, whereas women serve the tribe better by staying still/safe and consuming less calories)
I can't really think of any male-specific traits that can't be connected to expendability
Women are the natural intellectual leaders the way human's have evolved and that's why many early tribal societies were matriarchal. It doesn't make sense, strategically, to have critical leadership roles filled by men when they're more likely to die.
Patriarchy seems, then, like a byproduct of the agricultural revolution, when territory control allowed for crop yield, power projection, dominion, and wars/consolidation of violence became relevant, and men's roles became more significant in the welfare of a people.
I'm not an anthropologist, or any -ologist, just some dude who read "Selfish Gene," "Guns, Germs, Steel," and some Yuval Harari and now thinks he knows stuff.
Good day, people!
I am cis, so if I am somehow invading this subreddit, please let me know and I will delete this post immediately.
Onto my actual concern: I am currently writing my thesis and it is about sperm and infertility and it didn't sit right with me to constantly use the terms 'men' and 'male infertility' when I know that not every person who can ejaculate is a man and not every man can ejaculate. So I looked around for gender neutral terms in reproductive medicine and the results were ... underwhelming.
I now decided on using 'assigned male at birth' instead of 'men', but I still have problems with broader anatomical terms. Usually you weould read something along the lines of 'male reproductive system' and I couldn't find a gender neutral alternative that would also fit scientific requirements.
I thought maybe you guys have ideas? I would appreciate any suggestions!
Thanks and have a lovely day!
I was listening to an interview with Nigel Benn @3:46 I thought this was very interesting as he mentions that the whole concept of strength and conditioning, diet, experts in nutrition etc did not exist in his time and his time wasn't even very long ago (late 80's to mid 90's) - https://www.youtube.com/watch?v=CuVunG86vH4&ab_channel=iFLTV
We are in the era now where boxers have all the advantages with how to maximise endurance, recovery, they have the most efficient training methods, nutritionist, and also peds (forbidden topic that I'm not supposed to mention - sorry!), so naturally as we learn more, we are expecting to produce better athletes and therefore as each generation has gone by, we will also become better than the previous.
Like I don't get the cognitive dissonance, of course if you want to think about it more profoundly is because children are needed to keep the economy rolling, same reason why people trivalize death, a death means a loss in revenue taxpayer dollars. That's kinda a very sick way of objectifying people, when you think about it. Keeping people for economical means
Capiltalism, socialism, statism, revolutionism, etc don't matter the only solution to this would be to start barter trade systems similar to that of hunter gatherers, all modern day economical systems depend on profit, not human productivity.
I’ve talked to hundreds of patients about choosing a method of birth control, and I also teach medical students about evidence-based contraception care. I’m also involved in several Philadelphia-area reproductive health organizations. I frequently write about reproductive health issues for NPR.
Choosing a method of birth control is such an intimate decision. It's also a decision that's about way more than just birth control: It's about sex and relationships and all the baggage that comes along with those topics.
Come with questions about how birth control works, how different methods of contraception function, or anything you’re too embarrassed to ask your doctor. (But truly, there should be no question your doctor will find embarrassing — we are here to help!) Recently, I worked with NPR’s Life Kit podcast on an episode about how to navigate the many birth control options out there — Ask me anything!
I’ll start answering questions at 1PM Eastern.
Proof: https://i.redd.it/gck34cf4tck41.jpg
