Gideon Shapiro a co-founder of bright Minds was the guy who created all of the science for this second generation ketamine company, Rugen Therapeutics
DUBLIN, Nov. 25, 2015 /PRNewswire/ -- Allergan plc (NYSE: AGN), a leading global pharmaceutical company, and Rugen Therapeutics, a start-up biotechnology company focused on the development of novel treatments for unmet CNS disorders and funded by the F-Prime Biomedical Research Initiative (FBRI), today announced that they have entered into an exclusive collaboration to support the discovery and development of novel therapies for Autism Spectrum Disorders (ASD) and Obsessive Compulsive disorders (OCD).
Logo - http://photos.prnewswire.com/prnh/20150612/222796LOGO
Importantly, Allergan sought out this collaboration due to its passion and willingness to invest in people with ASD and their families and to identify ground-breaking therapeutic modalities to help them.
The collaboration is another example of Allergan's commitment to its Open Science model - developing promising products that frequently originate with smaller, innovative companies throughout the biopharma innovation ecosystem.
Under the terms of the agreement, Rugen received an upfront initiation fee at the outset of the collaboration, and is entitled to development stage initiation and success-based milestone payments for advancing compounds in development. Allergan will have the exclusive option to acquire all rights, including the worldwide intellectual property rights and other assets, related to the compounds following clinical proof of concept studies.
As part of the collaboration, Allergan and Rugen will jointly focus on the development of novel small molecule drug candidates. The research collaboration initially includes early stage compounds, which are first-in-class orally active molecules being developed for multiple CNS disorders. Rugen has demonstrated efficacy for its compounds in animal models of ASD and OCD.
"Allergan is committed to finding breakthrough therapies in areas where there are limited treatment options. Autism Spectrum Disorders and OCD are areas of medicine where there continues to be a substantial amount of unme
... keep reading on reddit ➡OC/DC.
My dad ladies and gentlemen, give him a hand.
Hollander, Eric; Kwon, Jee H.; Stein, Dan J.; Broatch, James Journal of Clinical Psychiatry, Vol 57(8), 1996, 3-6.
If a person exhibits many of the symptoms, but not all and not the most obvious ones (like hand washing, neatness etc) could they still be OC and it isn't at the level of disorder necessarily? There are people who are high functioning autistic spectrum, are there similarly high functioning OC spectrum?
Additionally, I feel like there are certain environments that cause me to fall into certain unwanted behaviors more, so I really do best when I am distracted but once I start having thoughts or behaviors like those I share with the OCD symptom lists I really become addicted to them and it takes a lot of willpower and often hours or days to stop them.
I am asking the r/OCD community and not a psychiatrist because I really can't afford one at the moment but would like to understand better. My mother also seems to have several of the OCD symptoms, some quite strongly and consistently, and having a better understanding of how it all works will help me navigate things with her as well. I've seen a lot of videos of people who have been diagnosed with ASD later in life and that diagnosis had helped them.
For me it's about 30 Million. I wanted to stash more but I'm trying to find another Goliath to add to my fleet.
read above ^
so yeah.... one page. ONE PAGE filled with so much open-ended things... i have so many suggestions and ideas that i kind of want to share but like, "oh, this might be cool" and not "WAIT DO THIS OMG YES", which is me by nature.
they also have many, many, mAnY spelling, grammar and plot holes. i feel bad i commented on their thing with suggestions and criticism and hit the word limit. twice. i have not yet posted the comments. i'm trying to edit them to be a little more tactful... this friend has an easily damaged self-confidence. if needed, i can post the criticism here.
bottom line: ________ in all seriousness, tho, i want advice on how to help them edit their thing and make it nicer (for school, right, this story is for school) without taking away from the main storyline, damaging said friend's self-confidence or seeming way too pushy about things?
An uncomfortable thought or feeling appears. I COULD spend hours trying to convince myself over and over again that the thought means nothing or that everything is fine.
Or i could just scroll Etsy, Pinterest, Instagram, and Reddit for hours until i’m so tired i physically cannot keep my eyes open
I suffer from a mild to moderate degree of obsessive-compulsive personality disorder (OCPD) and I feel like it fuels my gaming addiction.
I've stopped playing online competitive games for almost three years and I'm currently not playing any online games (no co-op or MMOs); I've only been playing offline single player story-driven games. That's where my OCPD comes in. I get fixated on "completing" games. It's not so bad that I want to do every side quest and hunt every achievement but it's more of wanting to complete at least the main story of games within a series/franchise. I now mostly play story-driven games just for the sake of checking off an arbitrary checklist that I've created in my mind.
There's a particular franchise I've loved when I was younger but have mostly grown out of now. I played games 1-7 and 10. It really, really, REALLY bothers me to have skipped games 8 and 9. I switched to PC when 8 and 9 first released and they were not available on PC. Both games 8 and 9 have been ported to PC several years ago now and my brain has been nagging me to play them for years so that I can fill that "hole" between games 7-10. I have burned out of story-driven games long ago but this problem is what's driving me to continue to play them even when they feel like chores.
Just as I am typing this out, game 8 just finished downloading on Steam. My brain is telling me to just play them to get it "done and over with" and out of my system.
Does anyone else have similar experiences to this? How do you deal with it?
Hello everyone! I just wanted to share my story with sensorimotor OCD to see if anyone else here suffers from the same thing and how they got over it.
So I had this since I was a child and it manifested in different forms and degrees. I remember one time starting to feel hyperaware of the position of my nose in front of my eyes. I don't know how to explain this. Like when I'm seeing I can't ignore that my nose is there and it annoyed the hell outta me. I hope you guys get what I'm saying. It's kinds weird. Another time, I started becoming hyper focused on my breathing until I forgot how to breathe. Another time, I was hyper aware of the position of my tongue inside my mouth and I was afraid I would suffocate and die. I've had many more instances with this but I won't mention them all.
This is the most terrible of them all. Last summer, I started being hyper aware of my eye movements. I think about them all day long and as a result I no longer remember how I used to see, if that makes sense at all. And it gets terribly worse at night when I'm trying to sleep. When I close my eyes, I no longer remember what my eyes did when they're closed. I don't know where to look at and that causes me extreme anxiety. And to try to alleviate it, I tend to constantly move my eyes from side to side and up and down while they're closed. These compolsury movements put a strain on my eyes, they almost hurt and that creates more anxiety since now I'm afraid I'm going to lose my sight or something. I don't know if I'm making sense. This doesn't sound like much but believe me it can drive a person crazy.
I have been seeing a psychiatrist and taking medications. I have been diagnosed with OCD along with multiple different things. It gets sometimes better and sometimes it gets terrible. Now after months of treatment, I am much better than I initally was.
Has anyone else on here suffered from the same thing? And how did you get over it? Share you experiences please.
Obsessive compulsive
she said
as the numbers rang in my head -
7-8, 7-8
it’s getting late,
I state, syphoning those words
8-9, 8-9
do you repeat speech in that way?
she asks.
as though lines from a play?
9-10, 9-10
I rock her words in my pen -
obse-ssive compulsive
obse-ssive compulsive
10-11,10-11
I repeat
trying to turn off the heat of those words
11-12, 11-12
my foot taps in rhythm
as I writhe in her stare
12-13, 12-13
It’s a coping mechanism she says -
a trained reaction
13-14, 13-14
It must be time to go
the clock says so
14-15, 14-15
Good bye, till next week
I say
as they repeat in my head
Obse-ssive compulsive
obse-ssive compulsive
https://www.reddit.com/r/OCPoetry/comments/rmkdhf/she_liked_green_eyed_chads/hpodcys/?utm_source=share&utm_medium=ios_app&utm_name=iossmf&context=3
https://www.reddit.com/r/OCPoetry/comments/rmjl0x/aunts_couch_after_a_party/hpodphr/?utm_source=share&utm_medium=ios_app&utm_name=iossmf&context=3
Could split this stuff up and sell for more. Would rather sell as a package if someone loves this knife platform.
Knife is LNIB, never carried/cut (255). Factory edge, perfect centering, no play. drops with a bit of encouragement, hydraulic. Built out with SDK micarta scales (80), raw/matte Ti adrenalinxxx full hardware kit (no longer available 135), Taco bearings (25), Hinderer slotted working finish Ti clip and filler tab (75).
Comes with (LNIB):
All original black hardware, CF scales, bearings
MXG black cerakote Ti clip + tab (35)
MXG raw/matte Ti clip + tab (35)
Clips also work on all hinderer XMs and Eklipses
Second set of SDK micarta customized for MXG clips to lie flush (no filler tab needed 80)
420$
Will ship FedEx tonight or tomorrow.
Has it ever occurred to you that you are watching online someone else play The Sims and you get really stressed out because they WON'T PAUSE THE GAME, not even once? Is 'Obsessive Compulsive Pause' syndrome a thing? I'm constantly pausing the game everytime I make a choice.
Sim wakes up. Pause. Check his needs. Sim is really hungry. Order Sim to eat. Un-pause.
Sim finish eating. Pause. Check his needs. Bladder is close to turn yellow. Check his aspiration. Needs to read a book. Order Sim to read something. Un-pause.
Sim finish reading. Pause. Check his needs. Bladder is yellow. Hygiene is almost also yellow. Order Sim to use the toilet and take a shower. Un-pause.
Now that my siblings are dead and she's caught in the grip of Alzheimer's, I'm desperately trying to remember all of her old habits.
-
When mining out steel in a mountain wall near my base. I can't let the mining site be uneven. Even if it costs me time for nothing, I have to mine an area so that it's flat lines and no bumps. For example if it's a long flat mountain wall and 1x + 2x3 pieces of stone sticks out I have to mine them.
-
I can't make rooms that are even numbers (Like 8x9, 7x6, 10x10). All rooms and buildings HAVE to be odd numbers (7x7, 9x5, 7x11) - because if not - a door won't be in the exact middle of the room, or if 2 doors, they need to have the exact length to each corner.
Hello i just need some advice or opinions. Ive always struggles as a teen with focusing & getting things done. Like cleaning up my house, remembering to pay bills all the time. Just alot of things I can’t even think of right now. So i got fed up & decided to get tested for adhd. The results came back yesterday & they said the computer stimulating test came back strong for the inattentive type. Which i agree with. But then she said I tested strongly or severely for OCD on the other test, which was questions or scenarios about my self. Then after researching OCD im like yup that’s me. I also read they are easily confused for each other all the time. I have an appointment Friday with my primary care physician to start medication for the add. & an therapy appointment Monday evening. Monday is also my first day of my new job & i just want my brain to finally be able to function properly so i can excel. But now i feel like treatment for ocd suits me better. I don’t know a little insight would help
So yesterday I went to my therapist and we had a good session but she was saying how being raised in a traumatic environment like the JW cult can cause a degree of ptsd as well as how when kids are put under a lot of stress and can’t make their own choices they either go one of 2 ways they rebel or they try to control everything since we had no control in life I went that route suposably and that’s how and why I’m called a control freak all the time as well as my panic episodes thank you jw cult may many future generations never experience you , honestly I can’t wait for the jws to fall from their high tower
That was my question. I always miss the dip waiting to see how low it's going to go and then it turns around and I'm stuck on the outside totally missing out! (Which isn't terrible mind you, fomo looses it's effect, you just have to exercise it, lol) Is there a rule of thumb or percentage you go by, or can you see it in the charts, or is it just a personal decision based on your particular feelings about the price?
I’m so very sad, lonely, mad, and I just want to be better. I’m too old for this crap! Today is first day of many times I’ve tried to quit but I know now that my life depends on me addressing all the issues. I hope I can some kindred spirits here.
I used cbd before, 10 mg was enough for the first week, it sounded very good, but in the following weeks it started to not work well. I increased it up to 40 mg and still could not see the benefit. I was going to look for more, but I had to quit because it was expensive in my country. I want to start again after 6 months because I have anxiety and obsessive compulsive disorder that will affect my social life.I haven't left the house for 4 years (I just go jogging on the beach in the morning, I actually like this lifestyle but I feel like I'm wasting it).
I have recurring obsessions, even though I know it's ridiculous.
Do you think cbd will destroy obsessive compulsive disorder and anxiety in long-term use? By the way, I am engaged in advanced fitness sports. That's why I take pre-workout drinks containing 200mg of caffeine. (max 200). I know that caffeine triggers anxiety because after it wears off, I feel my anxiety increase. Should I quit caffeine while using cbd? If I don't drink caffeine before training, I feel very passive and I can't raise my hand. I feel like if I don't train, I get more depressed. This time, I'm thinking of going up to 200 mg without giving up cbd. What is your suggestion ? I use the Purelife brand.
Hollander E, Kwon JE, Stein DJ, Broatch J, Rowland CT, Himelein CA. 1996. Obsessive-compulsive and spectrum disorders: overview and quality of life issues. J Clin Psychiatry 57:3–6.
