Quantum Mechanics and Path Integrals, 2nd edition, page 22
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Hey everyone, first of all I'm really glad to have found this sub, rectal progesterone has been a wonderful addition to my life and also i can tackle my hair loss/hair density loss consciously now - but that's a story for another day!
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So I'm in Germany and my current provider aims for E2 levels under 200pg/ml (I'm currently at 173pg/ml with 3 pumps of 0,75mg Oestradiol in alternating armpits spread throughout the day). I see that a lot of people here aim for values around 300pg/ml and higher and the consensus is that it's safe - however i want to find something more science-y to show to my doctor. I haven't made an argument for a dosage increase yet so she has do defensive walls up, and i want to compile my point well.
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Could you guys point me to research that has shown the beneficence and lack of harm(blood clots, cancer yada yada) of estradiol levels this high?
I would LOVE that and be very grateful.
In 2018, more than 67,000 drug overdose deaths occurred in the United States14 of which almost 47,000 (70%) were opioid-related. Over 70% of the 70,630 deaths in 2019 involved an opioid.15
“We are anxiously awaiting a new injectable gel formulation of dexamethasone and submission of data to the FDA for the treatment of radicular pain based on the results of a large, randomized, placebo-controlled, multi-center trial. If approved by the FDA, SP-102 would be the first corticosteroid with an indication for epidural administration in the U.S., resulting in rapid pain relief and addressing safety issues with off-label steroid preparations. SP-102 would be a welcome addition to the armamentarium of interventional pain physicians, providing a non-surgical, non-opioid alternative for a condition affecting millions of people,” said Dr. Steven P. Cohen, Chief of Pain Medicine and Professor of Anesthesiology & Critical Care Medicine, Neurology, Physical Medicine & Rehabilitation, and Psychiatry & Behavioral Sciences at the Johns Hopkins School of Medicine, and a Professor of Anesthesiology and Physical Medicine & Rehabilitation at Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences.
We believe that SP-102 could be the first FDA-approved epidural steroid gel injection product for patients suffering from this common, very painful condition,” said Jaisim Shah, President and Chief Executive Officer of Scilex Holding Company.
PLEASE READ THIS PARAGRAPH AGAIN. READ WHAT THE RESULTS WERE IN THE PHASE 2 TRIAL.
A Phase 2 trial to characterize the pharmacodynamics and safety of repeat dose SP-102 in subjects with lumbosacral radicular pain (sciatica), showed all subjects experienced rapid reduction of leg and back pain following an initial and repeat SP-102 injection treatment, with group median for average pain in the affected leg reduced by over 50% throughout 28 days (100% response rate). The lack of cumulative effect and rapid resolution of hypothalamic-pituitary-adrenal (H
... keep reading on reddit ➡This is the best tl;dr I could make, original reduced by 81%. (I'm a bot)
> Toxic metals in the environment may increase the risk of atherosclerosis, a buildup of plaque in the arteries that can prevent blood and oxygen from reaching major organs.
> Arsenic and cadmium, metals that can be found in food, water and tobacco, plus titanium, which can come from dental and orthopedic implants, cosmetics or auto manufacturing, were associated with a higher likelihood of having clogged arteries in the neck, leg and heart in this study of auto assembly workers in Spain.
> DALLAS, Dec. 9, 2021 - Environmental exposure to low-levels of the toxic metals arsenic, cadmium and titanium appears to increase the risk of plaque buildup in arteries in the neck, heart and legs, according to new research published today in the American Heart Association's journal Arteriosclerosis, Thrombosis and Vascular Biology.
> Prior research on the impact of metal exposure on atherosclerosis has traditionally centered on the carotid arteries, the major arteries in the neck.
> "This study supports that exposure to toxic metals in the environment, even at low-levels of exposure, is toxic for cardiovascular health," said study co-author Maria Tellez-Plaza, M.D., Ph.D., a senior scientist at the National Center for Epidemiology and the Instituto de Salud Carlos III in Madrid, Spain.
> "The levels of metals in our study population were generally lower compared to other published studies. Metals, and in particular arsenic, cadmium, and titanium, likely are relevant risk factors for atherosclerosis, even at the lowest exposure levels and among middle-aged working individuals."
Summary Source | FAQ | Feedback | Top keywords: metal^#1 study^#2 artery^#3 level^#4 health^#5
Post found in /r/science and /r/biology.
NOTICE
... keep reading on reddit ➡Covid for example, could we mutate it artificially so that once infected there are no adverse effects? Then infect people with this mutated virus to build immunity.
Hello people, I got my booster 2 days ago and I'm fine, no adverse effects! I wonder if my sore throat was an adverse effect, but honestly, I didn't have even a sore arm! Moreover, my SOB seems to be almost gone, I will wait until 1 week mark to give you updates :).
Saying that the vaccine manufacturer does this creates even more problems and avenues for discrediting.
What do you think should be done?
I use the Mod Limit Adjuster, but I still like to keep my number of mods down as much as I reasonably can. One way I do this is by "merging" mods that have no conflicting files by just combining their folders. For example, if Mod A only has scripts, and Mod B only has .bundle and .store files, I'll put one's files into the other's folder and voila, two mods for the price of one folder. I also do something similar with multiple script mods, as long as no file overwrites.
My theory is, although the game is loading the same number of files, as far as it's concerned it's loading fewer mods, since there are less mod folders. Maybe it's the placebo effect but I feel as though this is easier on the game since it's having to look inside fewer folders and thus, technically, load "fewer" mods.
That's just how I look at it, and it's probably a load of bollocks. But maybe there's some truth to it? That's partly why I made this post. I've read somewhere that what the game considers a "mod" might actually be certain types of files, not the folders that contain them. If that's the case then, well, guess I'm dumb.
I'm, of course, careful with how I do this merging process. I make sure to never overwrite anything, and I generally only merge the smaller, simpler mods together. If a mod has a bunch of .strings files, or is on the more complex side, I'll avoid merging it with anything just to be safe. I also try to avoid merging any mod folder that has an accompanying DLC folder, and I always keep conflicts/priorities in mind.
I keep a text document handy that lists which mods are merged into which folders, and what their files are, so I don't really lose track of anything. Obviously this isn't as easy as each mod having their own folder, but I've grown accustomed to it.
As far as I can remember, I've never actually encountered any issues from merging mods this way. But this hasn't stopped my paranoia of certain mods somehow not functioning as well as they could when merged, than if they were separate. So I've come here in the hopes that someone can set this straight for me once and for all, for peace of mind.
Full post with nicer formatting and more blood pressure and food effect studies here.
For my studies to determine ways to reduce my blood pressure, the first intervention I'm testing is deep breathing protocols. Here I report my initial results:
Summary
- Background:
- Numerous studies, reviews, and meta-analyses have shown deep breathing to lower blood pressure in both the short and long-term (example 1, example 2).
- Effect sizes are moderate (3-5 mmHg) and statistically significant for large patient populations (>10,000 patients in some studies).
- Numerous breathing protocols have been tested, with varying results.
- My own quick tests suggested a possible effect.
- Approach:
- Blood pressure and pulse were measured each morning before and after the following protocols:
- 8s inhale, 8s exhale, 5 min.
- Normal activity, 5 min.
- 8s inhale, 8s exhale, 15 min.
- Normal activity, 15 min.
- Each protocol/time combination was measured 5 times.
- Average and 95% confidence intervals were compared for each metric & protocol.
- Blood pressure and pulse were measured each morning before and after the following protocols:
- Results & Conclusions:
- For each time condition, a blood pressure drop was observed on average during deep breathing, while an increase was observed during normal activity. The opposite effect was observed for pulse (increased during deep breathing).
- Due to the high variance in the measurements, the 95% confidence interval for the difference overlaps zero, so the results are not statistically significant and could easily be due to chance.
- Next Steps:
- I will repeat the experiments, but measure blood pressure [5 times for each observation](https://www.quantifieddiabetes.com/2021/12/reduce-blood-pressure-without-medication-phase-0-mea
