Medical literature retrieval Puns

Abstract: PMDD is a mood disorder that affects approximately 3% of menstruating women in the luteal phase of the menstrual cycle. The symptoms of PMDD have significant overlap with the symptoms of hypocalcemia. A literature review shows that women with PMDD have significantly lower urine calcium values in the luteal phase as well as lower plasma levels of 1,25(OH)2 vitamin D and IGF-1. These lower calciotropic hormone values lead to impaired bone calcium and access and lower intestinal absorption. Testing these values would allow clinicians to monitor these micronutrient deficiencies and the effectiveness of supplementation in their patients.

I think we all know what PMDD is so I'm going to skip some of the introduction.

Introduction:

There is significant symptom overlap between PMDD and hypocalcemia which begs the question of whether PMDD causes hypocalcemia or if the symptoms of PMDD are exacerbated by an underlying calcium deficiency. Monitoring calcium levels in women with PMDD and addressing low levels could provide a simple, low-cost intervention that may improve the symptomology of women with PMDD.

PMDD: Depression (sadness, lethargy, social isolation, decreased motivation), Anxiety (insomnia, paresthesia), Fatigue, Irritability, Labile mood, Food cravings, Edema, Bloating, Abdominal cramps, Headache, Generalized aches and pain

Hypocalcemia: Depression, Anxiety, Paresthesia, Fatigue, Impaired memory, Impaired intellectual capacity, Personality disturbances, Neuromuscular irritability, Muscle cramps, Tetany

The average adult human body contains around 1000 grams of calcium, 99% of which is in the form of hydroxyapatite and is located in the skeleton. One percent of calcium is found in the extracellular fluid. In blood 50% of this calcium is ionized and measurable while 40% is protein bound and 10% is complexed with citrate and phosphate. Diet is our only source of calcium, and the only loss of calcium is excretion in the urine. Vitamin D and parathyroid hormone (PTH) are the most important up-regulators. While calcitonin is the most important down-regulator. Vitamin D is a transcription factor that increases intestinal absorption. PTH increases renal tubule reabsorption and hydroxylation of 25(OH) vitamin D to the active form 1,25 (OH)2 Vitamin D as well as increasing calcium levels by stimulating osteoclast activity and bone breakdown. 12

The menstrual cycle is divided into two primary phases; the follicular phase which starts on the first da

I am looking for advice on WHERE / HOW to get a copy of my In-service medical records. I have retrieved my OMPF. I am totally confused on the in-service medical record side. I ETS's active duty 7/12/1992. I finished inactive reserves 7/12/1997.

The 1992 time period is when Army shifted where they archive medical records. Is it the VA? Is it the NPRC? MilConnect did not have them, only my OMPF file. I have my VHA records from when I saw the PCP at the VA clinic after I received 70% rating, but I am specifically looking for the in-service medical.

Thanks in advance for any info.

I'm doing a review in medical journals and I see some articles that do not report 95%CI. I see in twitter a big war on the p-values and how it may bolstering some bias and how P-values reports are mainly catastrophic (mainly tweets by Darren Dahly and sometimes prof. Frank Harrel). I don't why reporting p-values is a catastrophic practice and I wonder if having 95% CI will lessen the problem

The second issue is that I'm personally triggered by the method section copy-past phrase of "continuous variable analyzed by t-test or U test as a appropriate, categorical values ...". However, the authors present their tables with bland p, significant or not. No indication which test was used for which variable. I wonder if there is any basics to providing this piece of information or am I just overreacting?

Thanks

I have an appointment with a urologist on the 24th. Can you guys send me links to the best new medical literature in regards to varicocele affecting testosterone levels and libido. I want to be prepared in case the doc wants to disregard the varicocele’s affect on my sex drive.

Please and Thank You!!!

So with Medical gameplay in 3.15 coming in a T0 format, I think there is another loop that could be added to the game relatively easily. I know it's too late for it actually to be added but it got me thinking about how we could create some gameplay ourselves.

When someone dies they are now going to be transported to the respawn of their choice. Now if the ship is destroyed that's one thing. But often you die just walking around in a cave or something.

What if this triggered a mission to retrieve their ship and bring it to their hospital or clinic. That way they don't have to salvage a perfectly intact ship.

This would also be a good group activity because you would need at least two crew to do it. One to get there and the other to fly the ship back. I could see this being a great use for ships like the C2 and the 890j that have hanger bays. (Fast Quantum jumps)

If it paid enough I know I would do it.

Now I know that at some point there will be the ARGO SRV that can do this (depending on ship size) but that's not on the roadmap so this might be fun for now.

It could work something like this.

The claim time on your ship is based on how far away you are from it. If it's the same system it's under 25 minutes but on another planet, it goes higher. So it still makes sense to pay someone to get your ship for you. Of course, if you have other ships and want to get it yourself or if you don't want to wait you can fly something else while waiting, then fine.

https://www.cureus.com/articles/82162-ivermectin-prophylaxis-used-for-covid-19-a-citywide-prospective-observational-study-of-223128-subjects-using-propensity-score-matching

2 seperate doctors told me low dose Seroquel would be the preffered combination tratement reageding cymbalta. I do have obvious reservations regarding seroquel though, most importantly I wonder what it does to the Dopamin system as I feel like I'm already lacking there.

Does anyone have experience with this supposedly common combination?

1 Kim ES, Jeon MT, Kim KS, Lee S, Kim S, Kim DG. Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells. Viruses 2021 October 8;13(10). 2 DeOre BJ, Tran KA, Andrews AM, Ramirez SH, Galie PA. SARS-CoV-2 Spike Protein Disrupts Blood-Brain Barrier Integrity via RhoA Activation. J Neuroimmune Pharmacol 2021 October 23;1-7. 3 Barhoumi T, Alghanem B, Shaibah H et al. SARS-CoV-2 Coronavirus Spike Protein-Induced Apoptosis, Inflammatory, and Oxidative Stress Responses in THP-1-Like-Macrophages: Potential Role of Angiotensin-Converting Enzyme Inhibitor (Perindopril). Front Immunol 2021;12:728896. 4 Li F, Li J, Wang PH et al. SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling. Biochim Biophys Acta Mol Basis Dis 2021 December 1;1867(12):166260. 5 Jana S, Heaven MR, Alayash AI. Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells. Int J Mol Sci 2021 August 22;22(16). 6 Raghavan S, Kenchappa DB, Leo MD. SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity. Front Cardiovasc Med 2021;8:687783. 7 Kucia M, Ratajczak J, Bujko K et al. An evidence that SARS-Cov-2/COVID-19 spike protein (SP) damages hematopoietic stem/progenitor cells in the mechanism of pyroptosis in Nlrp3 inflammasome-dependent manner. Leukemia 2021 October;35(10):3026-9. 8 Meyer K, Patra T, Vijayamahantesh, Ray R. SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells. J Virol 2021 August 10;95(17):e0079421. 9 Colunga Biancatelli RML, Solopov PA, Sharlow ER, Lazo JS, Marik PE, Catravas JD. The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells. Am J Physiol Lung Cell Mol Physiol 2021 August 1;321(2):L477-L484. 10 Theoharides TC, Conti P. Be aware of SARS-CoV-2 spike protein: There is more than meets the eye. J Biol Regul Homeost Agents 2021 May;35(3):833-8. 11 Lei Y, Zhang J, Schiavon CR et al. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. bioRxiv 2020 December 4. 12 Babendreyer A, Ludwig A. Mechanic Forces Promote Brain Endothelial Activation by SARS-CoV-2 Spike Protein. Stroke 2021 January;52(1):271-3. 13 Buzhdygan TP, DeOre BJ, Baldwin-Leclair A et al. The SA

Can anybody recommend to me any foundational or current medical anthropological literature on trauma? For example, if you wanted to focus on trauma as it relates to medical anthropology, where would one start in terms of core literature that they should know, before diving into specific works?

Hi everyone! I’ve built an app to read the latest medical literature from top impact factor journals. It uses a machine learning algorithm to sort paper into specialties and then further into subspecialties. Please let me know what you think: medr

The only article published in the medical literature that I have found so far that accurately connects the "pulling pain" to a cure by excision of a urachal remnant is the following:

https://www.hindawi.com/journals/criem/2018/6051871/

"We report the case of a 21-year-old male who presented to the emergency department with purulent drainage from his umbilicus in association with a chronic intermittent “pulling sensation” in the umbilicus and suprapubic areas."

...

"We propose that the “pulling sensation” described may be a clue to the diagnosis in some patients in which the urachal remnant is attached to the bladder and that the sensation was due to the mechanical connection between the bladder and the umbilicus. The sensation resolved postremoval status of the remnant. This does not appear to have been previously proposed in the literature."

If you need to speak to a doctor, you can present this as evidence of the pain being related to a urachal remnant, beyond just the theory of laypeople on the internet or your "own research". Unfortunately this case involves discharge from the umbilicus, which it is clear is not necessary for the rest of the symptoms to be present.

Every time I try to do a research about Fibromyalgia; I am served with unsatisfactory answers; and it frustrates me. Moreover, new researches that come up lead to dead ends despite showing promise. I would like to know what a fibro patient feels about this.

I guess I missed this lecture in school or something, but I'm having trouble coming up with a good way to store and organize all the various PDFs I save. Right now they're just sitting on my network drive at work vaguely organized by topic (Critical Care, CV, OB, etc.) but I still find it hard to find exactly what I'm looking for in a quick manner. I often know the gist of the article but I want to reference something specific.

What I'd love to be able to do is tag a PDF with various tags and have those be searchable.

For example I'll just grab whatever's on the front page of NEJM (https://www.nejm.org/doi/full/10.1056/NEJMoa1814468?query=featured_home). I'd like to able to 'tag' this with say... apixaban, anticoagulation, cancer, thromboprophylaxis such that searching for any of those terms would bring up this article. I know I could just title it like, "Apixaban for cancer thromboprophylaxis" but that could produce issues with articles being too similar to eachother.

I'd also like to be able to access it from home which isn't easy using my work network drive.

Is there a solution already offered for this? How do you organize your literature? What works for you?

Thanks

Currently taking 7.5g of piracetam every 3 hours like this guy. Someone please debunk this for me, because I don't believe in miracle drugs (post is from Isochroma on Longecity Forums):

==============================

And being a heavy piracetam user who does loads of intellectual work all day, that it enhaces both. It enhances everything, memory, visualization, other drugs, sleep, dreaming, on and on and on. Check my post history for more posts on what a regime like this can do.

In short, piracetam is a miracle drug that rebuilds damaged and aged brains, and slows and prevents new damages. The effects are immediate, and also cumulative. It also adds some new capabilities - extending existing functionalities beyond even their peak in natural performance - without the toxic depletion caused by stimulants like caffeine.

One of these is the elimination or drastic reduction in vertigo, motion-induced in particular. That's when you spin around for a while and suddenly stop - the world's still spinning for a while if you're a normal undosed humanoid.

Many users don't take enough to really see its full benefits, and thus complain about not benefiting.

Thus I recommend to take a full saturation dose to begin: one level tablespoon every three hours all day. The stuff's so cheap that maintaining full saturation is not only economical, but ensures that every day you're getting the absolute maximum possible benefit.

The results of a saturation dose can be revolutionary, as my previous posts indicate. Read 'em to find out what it's been like to lose the need to sleep but yet sleep whenever I like, and never once in months - soon to be years - actually feel tired. Yet sleep like an artistic perfection with super dreams so full of screams, beasts howling and impossible growlings, and total recall - yeah, total fucking recall - and be awake before even waking up totally refreshed, all without any caffeine or alcohol of course.

The effects get stronger after taking it longer - every single day is slightly better than the last (yes, I can still notice daily improvement after over a year and three months from beginning). This is because piracetam is one of only a handful of builder drugs, rather than depleter drugs or noneffect drugs. When I think about drugs (and other stuff put into the body), in terms of what it does to base health, especially metabolic health - they can all fit nicely into one of these three categories. Depleter drugs include: stimulants, stimulan

Hi everyone! I’ve built an app to read the latest medical literature from top impact factor journals. It uses a machine learning algorithm to sort paper into specialties and then further into subspecialties. Please let me know what you think: medr

Hi everyone! I’ve built an app to read the latest medical literature from top impact factor journals. It uses a machine learning algorithm to sort paper into specialties and then further into subspecialties. Please let me know what you think: medr