Livedoid vasculitis Puns

(25 Study links as references follow discussion)

This post connects research which identifies a direct physical connection and interaction between a SARS CoV2 binding site candidate and an enzyme which has well established deficiency symptoms that closely correspond to those of Covid-19. This is intentionally brief and may be relevant to other similar disorders such as influenza.

Untreated symptoms of Adenosine Deaminase 2 Deficiency include pulmonary alveolar proteinosis, cough, fever, difficulty breathing, vasculitis, rash and - in teenagers - stroke.

DPP4/CD26 is a hypoxia-inducible, VIP & Angiotensin Converting Enzyme, T-Cell activator SARS 1&2 and MERS binding site candidate (in addition to ACE2) which also binds/complexes (hypoxia inducible) Adenosine Deaminase 2 (ADA2).

ADA2 Deficiency is usually only inherited but causes severe combined immune deficiency (SCID), alveolar proteinosis, fever, vasculitis, cough, difficulty breathing, lividoid rash and - in adolescents - stroke. Adenosine and inosine also have involvement with taste but this discussion does not focus on that aspect.

I have good reason to propose Covid-19 as an acquired form of the inherited disorder and that understanding suggests an inexpensive and universal treatment regardless of the variant.

Although it is a scientifically accepted fact that DPP4 is an Adenosine Deaminase 2 complexing protein and they are known to interact, both having an effect on immune function the fact that these are connected has not featured in any Covid-19 research yet provides so many insights.

To be clear; this proposal supports the possibility that the ACE2 enzyme / receptor is used but does not rely upon it. Broadly speaking; the virus has a means of replicating/spreading and a means of causing harm which need not be via ACE2.

Observation:

Besides more obvious direct disruption, it appears possible that ACE2 disruption would impact DPPIV since they both contribute to the Angiotensin system; one activating and the other deactivating it .Example: Dipeptidyl Peptidase IV in Angiotensin-Converting Enzyme Inhibitor–Associated Angioedema which, incidentally, states: “Bradykinin and substance P, substrates of angiotensin-converting enzyme, increase vascular permeability and cause tissue edema in animals.” Whilst it is possible that this additional association is purely a coincidence, it seems worthy of note. The

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

The doctor says it terminal.

Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.

THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB

Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"

I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual

So check out r/jokes for all types of jokes

r/unclejokes for dirty jokes

r/3amjokes for real weird and alot of OC

r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes

Punchline !

Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub

Edit 2: don't touch the thermostat

Do your worst!

How the hell am I suppose to know when it’s raining in Sweden?

Mathematical puns makes me number

We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.

Ants don’t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.

But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.

They were cooked in Greece.

I'm surprised it hasn't decade.

He lost May

Now that I listen to albums, I hardly ever leave the house.

Two muffins are in an oven, one muffin looks at the other and says "is it just me, or is it hot in here?"

Then the other muffin says "AHH, TALKING MUFFIN!!!"

Don't you know a good pun is its own reword?

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

It really does, I swear!

And now I’m cannelloni

Because she wanted to see the task manager.

But that’s comparing apples to oranges

And boy are my arms legs.

Put it on my bill

Heard they've been doing some shady business.

but then I remembered it was ground this morning.

Edit: Thank you guys for the awards, they're much nicer than the cardboard sleeve I've been using and reassures me that my jokes aren't stale

Edit 2: I have already been made aware that Men In Black 3 has told a version of this joke before. If the joke is not new to you, please enjoy any of the single origin puns in the comments

BamBOO!

They’re on standbi

A play on words.

Calcium, nickel, neon

My daughter, Chewbecca, not so much.

Pilot on me!!

Christopher Walken

Until he discovered it was extra sharp.

Nothing, he was gladiator.

Amy

The bartender says, "Sorry, no minors”

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

Or would that be too forward thinking?

(25 Study links as references follow discussion)

This post connects research which identifies a direct physical connection and interaction between a SARS CoV2 binding site candidate and an enzyme which has well established deficiency symptoms that closely correspond to those of Covid-19. This is intentionally brief and may be relevant to other similar disorders such as influenza.

Untreated symptoms of Adenosine Deaminase 2 Deficiency include pulmonary alveolar proteinosis, cough, fever, difficulty breathing, vasculitis, rash and - in teenagers - stroke.

DPP4/CD26 is a hypoxia-inducible, VIP & Angiotensin Converting Enzyme, T-Cell activator SARS 1&2 and MERS binding site candidate (in addition to ACE2) which also binds/complexes (hypoxia inducible) Adenosine Deaminase 2 (ADA2).

ADA2 Deficiency is usually only inherited but causes severe combined immune deficiency (SCID), alveolar proteinosis, fever, vasculitis, cough, difficulty breathing, lividoid rash and - in adolescents - stroke. Adenosine and inosine also have involvement with taste but this discussion does not focus on that aspect.

I have good reason to propose Covid-19 as an acquired form of the inherited disorder and that understanding suggests an inexpensive and universal treatment regardless of the variant.

Although it is a scientifically accepted fact that DPP4 is an Adenosine Deaminase 2 complexing protein and they are known to interact, both having an effect on immune function the fact that these are connected has not featured in any Covid-19 research yet provides so many insights.

To be clear; this proposal supports the possibility that the ACE2 enzyme / receptor is used but does not rely upon it. Broadly speaking; the virus has a means of replicating/spreading and a means of causing harm which need not be via ACE2.

Observation:

Besides more obvious direct disruption, it appears possible that ACE2 disruption would impact DPPIV since they both contribute to the Angiotensin system; one activating and the other deactivating it .Example: Dipeptidyl Peptidase IV in Angiotensin-Converting Enzyme Inhibitor–Associated Angioedema which, incidentally, states: “Bradykinin and substance P, substrates of angiotensin-converting enzyme, increase vascular permeability and cause tissue edema in animals.” Whilst it is possible that this additional association is purely a coincidence, it seems worthy of note. The ACE