Immunoglobulin domain Puns

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

A few weeks back, I posted part 1 of this discussion on immune responses to COVID. Part 1 covered the innate immune response and you can read it here, if you missed it. This post will introduce adaptive immunity and there will be a third post to discuss adaptive immunity in more detail, since it is a complicated topic.

Reminder on Innate Immunity

First, let’s remember a bit about innate immunity. As I described in the prior post, there are two major layers of the immune response that are generally described - innate immunity and adaptive immunity. Innate immunity responds very rapidly and provides an early defense against infection. But it doesn't remember prior infections and hence cannot provide long-term protection when the body encounters the same germs that it has seen before. Innate immunity is provided by a numerous different cell types in the body, including epithelial cells, neutrophils, macrophages and NK cells (see the link for the prior post above if you want to remember more about these innate immune responses). Adaptive immunity takes longer to get going, but it provides immune memory. Immune memory is how the body remembers when it has encountered a pathogen before, which allows a quicker and more robust response to that same pathogen when it is encountered a second (or third, fourth, etc) time. Adaptive immunity is pretty complicated, but I am going to break down the various parts and hopefully help people understand how it works.

Key players in innate immunity

There are several key players in adaptive immunity, but the most important cells that participate are called B cells and T cells. Both B cells and T cells can be subdivided into subsets based on their specific functions and activities. Another key player in the adaptive immune response is a cell type called a dendritic cell. Dendritic cells are actually part of the innate immune system, because they don’t have immune memory themselves. But dendritic cells are crucial to help the adaptive immune system respond properly, so we will include them. In this part 2 of the discussion, we are going to focus on the B cells. In part 3, we will talk about T cells and how they interact with dendritic cells to promote an immune response.

As you will see by the time we get to the end of this discussion, the adaptive immune response is complex with ma

Do your worst!

I'm surprised it hasn't decade.

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

It really does, I swear!

They’re on standbi

Pilot on me!!

Nothing, he was gladiator.

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

When I got home, they were still there.

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "

I won't be doing that today!

[Removed]

You take away their little brooms

This morning, my 4 year old daughter.

Daughter: I'm hungry

Me: nerves building, smile widening

Me: Hi hungry, I'm dad.

She had no idea what was going on but I finally did it.

Thank you all for listening.

There hasn't been a post all year!

Why

It’s pronounced “Noel.”

After all his first name is No-vac

What, then, is Chinese rap?

Edit:

Notable mentions from the comments:

• Spanish/Swedish/Swiss/Serbian hits

• French/Finnish art

• Country/Canadian rap

• Chinese/Country/Canadian rock

• Turkish/Tunisian/Taiwanese rap

There hasn't been a single post this year!

(Happy 2022 from New Zealand)

Nothing, it just waved