โ€˜2014 - The wonders of 2โ€deoxyโ€dโ€glucose iubmb.onlinelibrary.wileyโ€ฆ
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๐Ÿ“…︎ Oct 22 2021
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Patanjali researchers were the first to published a study on 2-Deoxy-D-Glucose which is now approved by DCGI. swarajyamag.com/news-brieโ€ฆ
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๐Ÿ‘ค︎ u/redhatGizmo
๐Ÿ“…︎ May 20 2021
๐Ÿšจ︎ report
DCGI has granted permission for emergency use of therapeutic application of drug 2-deoxy-D-glucose (2-DG) as adjunct therapy in moderate to severe COVID-19 patients. Being a generic molecule & analogue of glucose, it can be easily produced & made available in plenty: DRDO twitter.com/ANI/status/13โ€ฆ
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๐Ÿ‘ค︎ u/bearcubhooman
๐Ÿ“…︎ May 08 2021
๐Ÿšจ︎ report
2DG medicine: All you need to know about DRDO's 2-deoxy-D-glucose (2DG)

Defence Minister Rajnath Singh and Union Health Minister Dr. Harsh Vardhan on Monday released the first batch of anti-COVID drug 2-deoxy-D-glucose developed by the Defence Research and Development Organisation.

The anti-Covid therapeutic application of the drug has been developed by the Institute of Nuclear Medicine and Allied Sciences, a leading laboratory of the DRDO, in collaboration with Dr. Reddy's Laboratories in Hyderabad. Earlier this month, the Drugs Controller General of India has approved the oral drug for emergency use as an adjunct therapy in moderate to severe coronavirus patients.

DRDO Chairman Dr. G Satheesh Reddy said that DRDO and Dr. Reddy's lab had gone through the complete trials and conducted trials across 30 hospitals and on a large number of patients.

The drug comes in powder form in a sachet, which is taken orally by dissolving it in water.

Clinical trial results have shown that this drug helps in the faster recovery of hospitalized patients and reduces supplemental oxygen dependence.

The DRDO, along with its industry partner DRL, Hyderabad, started clinical trials to test the safety and efficacy of the drug in Covid-19 patients.

In Phase-II trials conducted during May-October 2020, the drug was found to be safe in Covid patients and showed significant improvement in their recovery, the ministry statement said adding, Phase-II was conducted in six hospitals, and Phase IIb clinical trial was conducted at 11 hospitals all over the country

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๐Ÿ‘ค︎ u/Iam-KD
๐Ÿ“…︎ May 18 2021
๐Ÿšจ︎ report
Questions about the DRDO released drug, 2-deoxy-D-glucose (2-DG)

This drug was first investigated by Patanjali Research Institute back in March of 2020.

From the research article "The present in silico study supports the potential benefits of using 2-DG and its glucopyranose derivative as repurposed drugs/prodrugs for mitigating the novel COVID-19 infection.......further empirical studies on model systems and human clinical trials to ascertain effective dose-response are warranted and should be urgently initiated"

I don't want to make any speculations here I am merely publishing the facts, l learned from this article.

I can't find any published study by the DRDO on this clinical trial. Would they have cited Patanjali's research in their clinical trial paper? If someone can find the study published by DRDO, please post the link in the comment section.

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๐Ÿ‘ค︎ u/UrUncleRick
๐Ÿ“…︎ May 08 2021
๐Ÿšจ︎ report
2-deoxy-D-glucose
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๐Ÿ‘ค︎ u/UPSCMagazine
๐Ÿ“…︎ May 17 2021
๐Ÿšจ︎ report
DRDO: DCGI has granted permission for emergency use of therapeutic application of drug 2-deoxy-D-glucose (2-DG) as adjunct therapy in moderate to severe COVID-19 patients.

https://twitter.com/ANI/status/1390937330723131392

DCGI has granted permission for emergency use of therapeutic application of drug 2-deoxy-D-glucose (2-DG) as adjunct therapy in moderate to severe COVID-19 patients. Being a generic molecule & analogue of glucose, it can be easily produced & made available in plenty: DRDO

The drug has been developed by DRDO lab Institute of Nuclear Medicine & Allied Sciences in collaboration with Dr Reddyโ€™s Laboratories. Clinical trial have shown that this molecule helps in faster recovery of hospitalized patients & reduces supplemental oxygen dependence: DRDO

Higher proportion of patients treated with 2-DG showed RT-PCR negative conversion in COVID patients. In efficacy trends, the patients treated with 2-DG showed faster symptomatic cure than Standard of Care (SoC) on various endpoints: DRDO

The drug comes in powder form in sachet, which is taken orally by dissolving it in water. It accumulates in the virus-infected cells and prevents virus growth by stopping viral synthesis and energy production: DRDO

More about 2-deoxy-D-glucose (2-DG): https://en.wikipedia.org/wiki/2-Deoxy-D-glucose

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๐Ÿ‘ค︎ u/yogimodi
๐Ÿ“…︎ May 08 2021
๐Ÿšจ︎ report
India approved anti-COVID-19 drug 2-DG (2-deoxy-D-glucose) developed by DRDO youtube.com/watch?v=7fV4yโ€ฆ
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๐Ÿ‘ค︎ u/qptbook
๐Ÿ“…︎ May 08 2021
๐Ÿšจ︎ report
Could 2-deoxy-D-glucose (glucose metabolism blocker) and ketones treat drug-resistant sepsis in the ICU ?

Journal article: https://www.cell.com/cell/fulltext/S0092-8674(16)30972-2 Newspaper article: https://www.theatlantic.com/science/archive/2016/09/glucose-inflammation/498965/

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๐Ÿ‘ค︎ u/KetosisMD
๐Ÿ“…︎ May 08 2019
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2-Deoxy-D-glucose

https://en.wikipedia.org/wiki/2-Deoxy-D-glucose

Looks like a cool molecule. Increases BDNF, NGF, ARC, and FGF2. idk what ARC and FGF2 would do but I feel like they would help. ARC might improve synapses(?), while FGF2 might help cell growth.

2-DG also inhibits cancer selectively because of it's ability to be taken up by glucose transporters, which tumors have a greater amount of, yet when interacting with cells it inhibits cell growth.

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๐Ÿ‘ค︎ u/BigYellowLemon
๐Ÿ“…︎ Apr 08 2016
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Metfornin and 2-Deoxy-D-Glucose

Hello, Im 22 years and I might have oral dysplasia, Dr said me It can be oral dysplasia or just reactive

I Want to take Metfornin and 2-Deoxy-D-Glucose to prevent any cancer I will also into NAD, Sulfurophane , resveratrol

Do you any other drug that can prevent cancer ?

Any immunomodulator ?

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๐Ÿ‘ค︎ u/MarcelusWat
๐Ÿ“…︎ May 26 2018
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I made Block Bot from Pokรฉmon: Destiny Deoxys :D reddit.com/gallery/rqvaa7
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๐Ÿ‘ค︎ u/Denshi98
๐Ÿ“…︎ Dec 29 2021
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Itโ€™s my 4th attempt and I thoughts Iโ€™d make my CWE Taste good atleast ll Crushed up phen tabs , glucose syrup and extracted codeine baby
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๐Ÿ‘ค︎ u/acidrosss
๐Ÿ“…︎ Dec 19 2021
๐Ÿšจ︎ report
Master Glucose Guardian please bless a skykid (pt.2) reddit.com/gallery/ropgmq
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๐Ÿ‘ค︎ u/SyrPanck
๐Ÿ“…︎ Dec 26 2021
๐Ÿšจ︎ report
Willing to trade 1 or 2 of these for a arcues, shaymin, or deoxys (if you choose toxel I can give you 2 of them) and idc if what I receive is shiny or not reddit.com/gallery/rzkjxe
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๐Ÿ‘ค︎ u/Dreamsucksasslmao
๐Ÿ“…︎ Jan 09 2022
๐Ÿšจ︎ report
Glucose numbers. I had 2 eggs wheat toast and an orange, about 40 g of carbs, would you say this rise is okay? 99 before eating, 142 1 hour post meal and 135 1.5hour later
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๐Ÿ‘ค︎ u/laulau11111
๐Ÿ“…︎ Jan 08 2022
๐Ÿšจ︎ report
I'd probably react the same way as Peter if Deoxys showed up at my door
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๐Ÿ‘ค︎ u/KabootyYakushi
๐Ÿ“…︎ Nov 27 2021
๐Ÿšจ︎ report
FT: self caught shinies LF: Shiny Articuno, Zapdos, moltres, Deoxys (a,S, d)
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๐Ÿ‘ค︎ u/SirLewis
๐Ÿ“…︎ Dec 12 2021
๐Ÿšจ︎ report
[US, US] [H] A bit of everything (Shadowless base-Celebrations, Ray/Deoxys Legend top, Sealed Shiny Magikarp 20th aniv. promo, Pop 2 Celebi ex, etc.) [W] Trades Only

Binder here
After a decently long hiatus I'm mainly fielding trade offers and looking at binders today. Most stuff is NM aside from the Holo Crystal Celebi (MP+/LP-), Neo Lugia (NM-), and a couple other smaller cards.

Nothing is for sale, trades only please.

Trade values based on recent eBay sales and TCGP.

Thanks!

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๐Ÿ‘ค︎ u/ArcticMew
๐Ÿ“…︎ Dec 28 2021
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New study shows SARS-COV-2 increases circulating protein GP73 that causes Dysglycaemia. Elevated GP73 increase blood glucose and onset of Diabetes. GP73 promotes Tumor formation and Metastasis. nature.com/articles/s4225โ€ฆ
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๐Ÿ‘ค︎ u/waynebluechip17
๐Ÿ“…︎ Jan 07 2022
๐Ÿšจ︎ report
Hi all, I'm a physicist by background and spent some trying out CGMs as part of my role in a start up, I thought it might be interesting to dive into how the detection of Blood Glucose actually works, I'd love to know what you think youtube.com/watch?v=UYo4sโ€ฆ
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๐Ÿ‘ค︎ u/benupscience
๐Ÿ“…︎ Oct 08 2021
๐Ÿšจ︎ report
Blood glucose high 2 hours after eating normal?

I was recently diagnosed as pre-diabetic so I have been doing the keto diet for about 2 months now. This week and last week Iโ€™ve been alternating OMAD with keto and today I tested my blood sugar after eating a low-carb breakfast (2 egg omelette with cheese and kimchi and nuts). An hour after eating it was 102 mg/dl then two hours after it was 126 mg/dl. Is this normal? I mean it is within normal range but I always assumed the higher spike would be an hour after eating. Could stress play a factor too? During the second hour I was in a meeting that was pretty tense.

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๐Ÿ‘ค︎ u/isopod_interrupted
๐Ÿ“…︎ Jan 12 2022
๐Ÿšจ︎ report
Been fasting for 18 hours and took blood glucose testing fasted, and feeded +2 hours.
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๐Ÿ‘ค︎ u/mhero94
๐Ÿ“…︎ Jan 01 2022
๐Ÿšจ︎ report
2nd glucose load pre-study within 2 weeks before clinical research study trying to stimulate beta cell growth. Everything for my fellow T1Ds!
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๐Ÿ‘ค︎ u/uddgard
๐Ÿ“…︎ Dec 13 2021
๐Ÿšจ︎ report
Exogenous d-ฮฒ-hydroxybutyrate lowers blood glucose in part by decreasing the availability of L-alanine for gluconeogenesis Adrian Soto-Mota, Nicholas G. Norwitz, Rhys D. Evans, Kieran Clarke First published: 16 November 2021

Exogenous d-ฮฒ-hydroxybutyrate lowers blood glucose in part by decreasing the availability of L-alanine for gluconeogenesis Adrian Soto-Mota, Nicholas G. Norwitz, Rhys D. Evans, Kieran Clarke First published: 16 November 2021 https://doi.org/10.1002/edm2.300 Funding information: Adrian Soto-Mota is funded by CONACYT and INCMSNZ. The KE drinks were provided by TdeltaS Ltd, Oxford. About Sections

Share on Abstract Background

Interventions that induce ketosis simultaneously lower blood glucose and the explanation for this phenomenon is unknown. Additionally, the glucose-lowering effect of acute ketosis is greater in people with type 2 diabetes (T2D). On the contrary, L-alanine is a gluconeogenic substrate secreted by skeletal muscle at higher levels in people with T2D and infusing of ketones lower circulating L-alanine blood levels. In this study, we sought to determine whether supplementation with L-alanine would attenuate the glucose-lowering effect of exogenous ketosis using a ketone ester (KE).

Methods

This crossover study involved 10 healthy human volunteers who fasted for 24 h prior to the ingestion of 25 g of d-ฮฒ-hydroxybutyrate (ฮฒHB) in the form of a KE drink (ฮ”Gยฎ) on two separate visits. During one of the visits, participants additionally ingested 2 g of L-alanine to see whether L-alanine supplementation would attenuate the glucose-lowering effect of the KE drink. Blood L-alanine, L-glutamine, glucose, ฮฒHB, free fatty acids (FFA), lactate and C-peptide were measured for 120 min after ingestion of the KE, with or without L-alanine.

Findings

The KE drinks elevated blood ฮฒHB concentrations from negligible levels to 4.52 ยฑ 1.23 mmol/L, lowered glucose from 4.97 ยฑ SD 0.39 to 3.77 ยฑ SD 0.40 mmol/L, and lowered and L-alanine from 0.56 ยฑ SD 0.88 to 0.41 ยฑ SD 0.91 mmol/L. L-alanine in the KE drink elevated blood L-Alanine by 0.68 ยฑ SD 0.15 mmol/L, but had no significant effect on blood ฮฒHB, L-glutamine, FFA, lactate, nor C-peptide concentrations. By contrast, L-alanine supplementation significantly attenuated the ketosis-induced drop in glucose from 28% ยฑ SD 8% to 16% ยฑ SD 7% (p < .01).

Conclusions

The glucose-lowering effect of acutely elevated ฮฒHB is partially due to ฮฒHB decreasing L-alanine availability as a substrate for gluconeogenesis.

https://onlinelibrary.wiley.com/doi/10.1002/edm2.300

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๐Ÿ‘ค︎ u/dem0n0cracy
๐Ÿ“…︎ Nov 20 2021
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This Is after 2 Glucose Tablets...Weird Sensitivity To Carbs The Last 2 Days. Why Is This Happening?
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๐Ÿ“…︎ Dec 16 2021
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High-Sugar Diets Impair Longevity; Glucose Downregulates Aging Defense Pathways (2-minute audio clip from Dr. David Sinclair) podclips.com/c/kf9oX1?ss=โ€ฆ
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๐Ÿ‘ค︎ u/bestpodcastclips
๐Ÿ“…︎ Jan 13 2022
๐Ÿšจ︎ report
Any type 2 diabetics able to get their blood glucose down to 70-90 mg/dl with metformin only???

If so, how did you do it? I have gotten my levels back in the 120 fasting-180 after eating range, but it does not seem like my body is capable of the 70-100 range, I had it got that low once, but that's when I was sick and not eating. Can the 70-90 be achieved with low carb diet and exercise alone? Alternate day fasting is a little too extreme for me, Intermittent fasting is doable but very difficult.

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๐Ÿ‘ค︎ u/_Fuckit_
๐Ÿ“…︎ Nov 23 2021
๐Ÿšจ︎ report
My fasting insulin is 10.52 micro iu/ml and my fasting glucose is 81 mg/dL . This gave me a homa ir of 2.1 on the online calculator and quicki of 0.34 . Are these results worrisome ?

I've been suspecting insulin issues due to my overactive bladder . I did the fasting insulin and ogtt test . I calculated my HOMA ir online using the fasting insulin and glucose levels . I did this at an independent lab because no docs are listening to me except my Dermatologist who said I may have PCOS . Should I be worried about these results ?

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๐Ÿ‘ค︎ u/googleroneday
๐Ÿ“…︎ Dec 09 2021
๐Ÿšจ︎ report
Oddy recently diagnosed diabetes type 2, he is a big cat (not just in weight) 3.5U is not doing much- every weekly check up and glucose curve, his levels are too high. HE feels great, playing and eating as it was before his diagnose. Is normal that takes long to get the right dosage? reddit.com/gallery/rtymra
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๐Ÿ“…︎ Jan 02 2022
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Type 2 want a glucose monitor

So I am newly diagnosed and my doctor has high expectations of getting me down too an A1C of 5. Something. I am 27 and my A1C is 9.9 so she wants me in practically perfect range. I am doing manual checks for my glucose monitoring and the supplies that are covered by insurance only allow me to check twice a day.

This seems tedious and isn't giving me a big picture when I am checking my fasting and only one of my meals. Have you asked your doctor for a monitor? Do they only prescribe them if your blood sugar is out of control? Are there down sides to having them?

Also i should add i am not insulin dependent.

Shall we discuss? ๐Ÿ˜ถ

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๐Ÿ‘ค︎ u/Locaisha
๐Ÿ“…︎ Nov 09 2021
๐Ÿšจ︎ report
DRDO and Dr. Reddy who have repurposed a cancer drug 2-Deoxy-D-Glucose (2DG) to treat Covid-19 +I've patients showed extremely high effectiveness in combating the virus. PATANJALI run by Baba Ramdev was the first Indian company to published a research paper to suggest this medicine in March 2020

Link to the research paper where Patanjali Research Institute was the first one to suggest the use of Glucose antimetabolite 2-Deoxy-D-Glucose and its derivative as promising candidates for tackling COVID-19: Insights derived from in silico docking and molecular simulations

https://www.researchgate.net/publication/340332773_Glucose_antimetabolite_2-Deoxy-D-Glucose_and_its_derivative_as_promising_candidates_for_tackling_COVID-19_Insights_derived_from_in_silico_docking_and_molecular_simulations

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๐Ÿ‘ค︎ u/Legionoo7
๐Ÿ“…︎ May 10 2021
๐Ÿšจ︎ report

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