Well Chosen Puns

Does it have to do with being a Golden Child? Or they couldn't find somebody to marry her off to?

We were shown a demonstration of the usage of ozonated water for house mopping, laundry and washing of fruits and vegetables.

The ozonated (ozonized?) water is reportedly enough for the laundry and requires no addition of any kind of soap. So, the investment for a laundry is the same amount of water, a pretty small additional amount of electricity, and nothing else.

The demonstrated device seems to be a fairly common design of which many variants can be found on sites like Aliexpress, Amazon and, with a higher price tag and hopefully better support, on various companies around the world. The most common design consists of simply a water filter, an ozone generator, and a Venturi infuser to dilute the ozonized air into the water.

To anybody using one of these ozone generators for the laundry, are you satisfied with it? What difference did you notice on the clothing? Any side effects to care about?

Any general comments or ideas also appreciated!

TIA,

So I am looking for a series that does the whole chosen one-trope thing as well as the wheel of time. But I want it where the main character takes the chosen one role by the horn. I have only read the first four books. But Rand was always hesitant and because of his circumstances unable to train himself. Also, I really dislike most of the female characters and I hate the trope in general about miscommunications in the series.

It's like nobody in the series wants to properly communicate with each other to fix problems beforehand. Now it makes sense for moraine and others but sometimes it just makes me away too angry and stops reading.

One of the reasons I like mistborn and way of the king way more. It is similar to wheel of time but in mistborn characters do communicate with each other.

Genomic editing, particularly the CRISPR/Cas technique, is widely employed in experimental biology, agriculture, and biotechnology. CRISPR/Cas is one of several weapons used by bacteria to resist viruses. As the pathogen’s DNA enters the cell, Cas proteins detect it as foreign hereditary material and break it because its sequences differ from those of the bacteria. To respond to the virus quicker, the bacterium saves pieces of the pathogen’s DNA—much like a computer antivirus retains a collection of viral signatures—and passes them on to subsequent generations so that its Cas can prevent future attacks.

Teams from different laboratories independently adapted the CRISPR/Cas system to introduce arbitrary changes into DNA sequences in human and animal cells. It made genomic editing much easier and more efficient. The critical components of the mechanism are guide RNA, which “marks the site,” and the Cas9 protein, which cleaves DNA at that location. The cell subsequently “heals the wound,” but the genetic code has already been altered.

Quick Reading: https://www.marktechpost.com/2022/01/02/russian-bioinformaticians-have-created-a-neural-network-architecture-that-can-evaluate-how-well-an-rna-guide-has-been-chosen-for-gene-editing/

Paper: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab1065/6430490

I’m technically not supposed to let anyone know until it’s announced by the board. But I’m busting at the seams with excitement! Much thanks to Hecta and to all of you who supported me.

I’ve already got several plans to get the ball rolling too bridge the gaps in my community. I now get to help people on a bigger scale. I also plan on making sure the lgbtq is seen and heard and their loved ones get educated. Im about to be a wrecking ball of change and unity! Woo!

Props if there are strong friendships between characters.

The title basically says it all.(TL;DR at the bottom)

Darkest Dungeon 2 lost me along the way and I don't particularly find it fun or enjoyable at all. I understand Red Hook's decision and I support them in doing so, it's their game after all, but I most likely wont be playing it unless it gets some kind of massive overhaul. Like, game altering.

Main issues:

• Darkest Dungeon 1 was a game about making the best of bad situations and understanding that the characters you chose were not permanent. They died, they got overly afflicted, diseased, and they would either die in glory or you would dismiss them and in the great words of the Ancestor "Suffer not the lame horse, or the broken man." The whole game was built around this idea that you built a roster of mercenaries that were expendable, and I personally loved that. You still got backstory and lore for characters but I really loved that death had consequences and was entirely expected. That champion level character that you sank gold and time into leveling, arming, and curing could get absolutely railed, and that's ok because it was expected and you had to live with it and make the best of it. I really don't like the new party system, the character leveling, or this fake shallow sense attachment they're trying to push on these characters that were historically loners, outcast, and mercenaries.

• The relationship system feels awful. I'm sorry, I know some people love it and I know some people hate it just like me but I really really cannot stand it at all. They took a rare mechanic from Darkest Dungeon 1 and built an entire gameplay and combat system around. Stress checks in DD1 were punishments for poor stress management and if you were lucky you rolled virtue, but more often than not you were afflicted. Now it feels as if there's a constant "stress/affliction/virtue" check constantly happening at random and it's incredibly annoying because it adds an insane level of RNG that the game didn't need. I'll state it again, RNG does not make a healthy game, at least not imo. Stress checks and virtue chances should have been limited to max stress situations. Also on another note about the relationship system, why are my characters that are in life or death situations worried about kill stealing? Why are they expressing jealousy in the middle of a combat situation? Why are they acting like spoiled brats that aren't about to get their heads ripped off by an eldritch abomination if they don't cooperate wit

A liar.

I'm referring to him answering the question on his podcast about the story behind Kyle Justin, Bootsy, and Mike Matei.

Well, apparently James and Kyle are still friends, guys! James was even going to have him play Spiderman in the Las Vegas episode, but he was too busy! I guess the testimony we have to the contrary, and the years of no contact were wrong everybody. Oh and Bootsy, he's still around! Yeah, no drama everyone. I guess Bootsy and Mike Matei was wrong, they're still friends!

First of all, I get that I'm preaching to the choir here. Watching James lie and deflect in such an obvious, even vindictive way gave me a visceral reaction. We saw in the recent BTS video how he got just plain immature and nasty while looking at the camera...I saw the same thing here.

I'm not just disappointed he didn't address the question and quickly changed the subject, I'm weirded out. In my personal life I recently left a job in which our boss would make up these weird, wild stories about his personal life that we eventually found out were either exaggerated or completely fake. The feeling I had wasn't one of "Haha, what a weirdo!" it was more like "I find it disturbing that this guy would make up these bizarre stories and tell us, straight faced, as if they were true. I don't know what he's capable of."

It's disturbing to me to watch him engage in this way. Before we saw him as just an extremely introverted, passive guy. Now there's a new nastiness that I hadn't seen previously, and I want absolutely nothing more to do with it.

https://discord.gg/WKHruvqtt7 the link to the server

"Please take the game a little more seriously."

"If you guys do this, there is a good chance some or all of your characters could die."

"Chill out with talking about that subject. It's not appropriate at the game table."

"Please put your phone away."

"Please pay attention to the game even when it's not your turn."

"Hold on for a minute, it's so and so's turn."

Many DMs are wary of this sort of small polite direction during gameplay. Don't be. Have a conversation with your players and tell them to expect gentle guidance from you during games. Get them to agree to listen to your polite requests before hand. Often these gentle reminders at the table can prevent r/rpghorrorstories from happening at your table.

Genomic editing, particularly the CRISPR/Cas technique, is widely employed in experimental biology, agriculture, and biotechnology. CRISPR/Cas is one of several weapons used by bacteria to resist viruses. As the pathogen’s DNA enters the cell, Cas proteins detect it as foreign hereditary material and break it because its sequences differ from those of the bacteria. To respond to the virus quicker, the bacterium saves pieces of the pathogen’s DNA—much like a computer antivirus retains a collection of viral signatures—and passes them on to subsequent generations so that its Cas can prevent future attacks.

Teams from different laboratories independently adapted the CRISPR/Cas system to introduce arbitrary changes into DNA sequences in human and animal cells. It made genomic editing much easier and more efficient. The critical components of the mechanism are guide RNA, which “marks the site,” and the Cas9 protein, which cleaves DNA at that location. The cell subsequently “heals the wound,” but the genetic code has already been altered.

Quick Reading: https://www.marktechpost.com/2022/01/02/russian-bioinformaticians-have-created-a-neural-network-architecture-that-can-evaluate-how-well-an-rna-guide-has-been-chosen-for-gene-editing/

Paper: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab1065/6430490