Seattle's hit rate when they have multiple first round picks in a season is amazing.
In 1997, they got Shawn Springs (played 7 seasons and made the Pro Bowl in 1998) and Walter Jones (Hall of Fame tackle who made it to 9 Pro Bowls).
In 2000, they got Shaun Alexander (all-time leading rusher in franchise history and a 3-time Pro Bowler) and Chris McIntosh (bust- only played 2 seasons).
In 2001, they got Koren Robinson (3,567 receiving yards in 4 seasons, including a 2002 campaign with 1,240 yards) and Steve Hutchinson (3-time Pro Bowler with the Seahawks and a finalist for the Hall of Fame this year).
And, in 2010, they got Russell Okung (made the Pro Bowl with the Seahawks in 2012) and Earl Thomas (possible Hall of Fame safety who made 6 Pro Bowls with the Seahawks).
In these drafts, the Seahawks have picked 8 guys in the first round. Seven of them were positive players, and these players combined for 23 Pro Bowls just in their time with Seattle.
https://preview.redd.it/mii0gxac6di71.jpg?width=800&format=pjpg&auto=webp&s=73cff02d6576c4e905db764daead26b4581132c6
Https://en.wikipedia.org/wiki/World_population#Global_demographics
https://twitter.com/brett_mcmurphy/status/1466465016450850816?s=21
https://www.youtube.com/watch?v=EojulXiOfjc
A wonderful presentation on the gut with loads of interesting pieces.
Description:
The gut endocrine system comprises a collection of enteroendocrine cells scattered throughout the intestinal epithelium, producing hormones that signal locally within the gut and distantly at tissues such as the brain and pancreas. In the field of diabetes and obesity, the best studied gut hormone is glucagon-like peptide-1 (GLP-1), which has been exploited therapeutically for the treatment of type 2 diabetes and obesity through the development of GLP-1 receptor agonists and DPP4 inhibitors. Our research is focussed on gaining a molecular understanding the enteroendocrine system and its involvement in the control of metabolism and food intake. Technical advances now make it possible to apply live single cell recording and transcriptomic techniques to human enteroendocrine cells using intestinal organoid models engineered by CRISPR-Cas9 to express fluorescent sensors in specific cell types of interest. Mirroring previous findings from mouse models, we have shown that human GLP-1 secreting cells utilise a variety of signalling pathways for nutrient detection, including electrogenic glucose uptake and activation of specific G-protein coupled receptors by free fatty acids and amino acids. Overall, we aim that our research will identify new drugs for type 2 diabetes and obesity that act by targeting gut endocrine cells, thus mimicking the gut endocrine consequences of bariatric surgery.
-------------------------------------------------
What I got from it:
- Long chain and short chain fatty acids also trigger GLP-1 hormone release -> this means that the insulin response to carbohydrates in the diet is increased.
- Bile acid absorption also stimulates GLP-1. Bile acid is released when we eat fat.
- The hypothalamus has a receptor for GLP-1 (https://pubmed.ncbi.nlm.nih.gov/27908915/) so the fatty acids also trigger satiety feeling in the brain and aid in glucose control
- Covering the hypoglycemia in gastric bypass... It is possible that with the extension of the villus due to fructose, more GLP-1 is secreted because of a bigger gut. So fructose could be responsible for increasing episodes of hypoglycemia. (https://www.nature.com/articles/s41586-021-03827-2). Nature's w
... keep reading on reddit โกhttps://twitter.com/Brett_McMurphy/status/1465034622170025993
