https://www.ncbi.nlm.nih.gov/pubmed/31886878 ; https://journals.viamedica.pl/folia_morphologica/article/download/FM.a2019.0139/49803
El-Mehi AE1, Faried MA2.
Abstract
BACKGROUND:
This work was designed to clarify, for the first time up to our knowledge, the effects of high fructose diet (HFrD) induced metabolic syndrome (MetS) on the pituitary - gonadal axis of adolescent male rats continuing through adulthood period and to evaluate the possible role of ginger extract in ameliorating these effects.
MATERIALS AND METHODS:
Forty 4-week-old male albino rats, treated for 8 weeks, were randomly divided into 4 equal groups; control(fed standard diet), ginger extract treated (500 mg/kg once daily orally by gavage), HFrD induced MetS (fed a diet containing 60% fructose), HFrD and ginger groups. The assessment methods included biochemical, histological and immunohistochemical studies.
RESULTS:
HFrD fed rats exhibited a picture similar to MetS in the form of increased body weight and serum levels of glucose and insulin with an elevated HOMA-IR reflecting insulin resistance as well as dyslipidemia. Lipid peroxidation (increased MDA) and oxidative stress (decreased SOD) were implicated in this syndrome. This group exhibited a significant decrease of testicular weight and the levels of reproductive hormones (LH, FSH & testosterone). The pituitary gonadotrophs showed electron dense nuclei, large cytoplasmic vacuoles, destructed organelles in addition to decreased number of secretory granules. Furthermore, testicular specimens presented marked alterations. There were disorganized shrunken tubules with irregular basement membranes, reduced germinal epithelial thickness, vacuolations and degenerated mitochondria in the spermatogenic cells. Beclin1 and PCNA immunoexpressions were significantly downregulated with HFrD induced MetS. Ginger extract supplementation proved to be a potent protective agent against these harmful effects through its antioxidant, hypoglycemic, insulinotropic, androgenic and hypolipidemic effects in addition to its ability to induce testicular autophagy.
CONCLU
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annoying orange osu
norm had just arrived home after a long day at work, and was very sleepy. he walked up stairs and went to the bathroom and tooked a massive shit. he didn't wash his hands, nor did he flush. he was walking down the corridor to his room, when he heard loud banging and screaming sounds. he smashed the door down, only to find his wife fr*cking his brother. norm was devastated, and began to cry, and also piss and shit all over the place. his wife and brother were so startled by him that they jumped out of the window and fell to their deaths. norm saw their mangled bodies on his driveway, and felt extremely sad. he went down into his living room and watched tv, until he got bored and started watching youtube. he scrolled through the channels for several hours, but got nowhere, until... he found his favorite youtube channel, "the annoying orange". after binge watching every single video, all of his depression was gone, and he felt much better. "i feel much better!" norm said. norm began to do the whip and nae nae because he was so happy. he felt a grumbling noise in his tummy, so he went to the kitchen to get some food. he vored everything in the refrigerator, yet still felt hungry. "HOW COULD THIS BE!??" norm said aloud. "maybe try eating something healthier", said an odd looking orange sitting in an empty fruit bowl. no... could this be? the annoying orange had visited norm! "wowee!!" norm said gleefully. "yes, it is me, the annoying orange" orange said. "i am a really frickin huge fan of yours! seriously!!" norm said. "FRICK?!?? DID YOU JUST FUCKING SAY ""FRICK"" YOU FUCKING RETARDED PIECE OF SHIT?!??" orange said calmly. norm was so shocked to see orange get so angry. "YOU MUST BE PUNISHED FOR YOUR SINS!" orange grew a massive pair of human legs and jumped right into norms urethra, with the intent of killing him slowly and painfully. unfortunately for orange, norm was quite into that, and came on the spot. orange did an ahegao face, he was so surprised (and aroused) by how much semen norm could produce. "h-h... how could you do that?" orange asked. "its what i do." norm said, confidently. orange's legs shrunk back, yet out from in between grew orange's gigantic hawg. norm blushed, and so did orange. norm got a boner, it was arguably much larger than orange's. but it wasn't full length. norm wanted orange to help him attain his fullest length. orange wanted to help norm too. norm grabbed orange and shoved him up his ass. orange positioned himself facing toward
... keep reading on reddit ➡My boyfriend is Korean which means inevitably I will end up in Seoul. I'm kind of scared of high fructose corn syrup. I am "fructose intolerant" which means food high in fructose will, (TMI) make my ass explode. That means no honey (even a small amount causes cramping and the runs), no fruit juice (except for orange juice), no dried fruit, no sweet fruit - apples/pears/mango/watermelon (yes to grapes/rockmelon(cantaloupe)/berries/Honeydew melon/ oranges).
In Australia it's a really easy diet because we use sugar in everything and if one of the other items is in something then it's usually bragged about (like honey sausages I saw today). I fully expect to be exposed to it. Don't worry, I am learning Korean and definitely will learn the word for corn syrup.
This is especially prevalent if the person is someone who is generally much nicer than they are acting at that time. And, if this person is someone you either feel comfortable doing this with, or someone you know will respond positively to you reaching out, ask if they need anything. No need to be direct, sometimes all they need is a friend who they can talk to.
I'm going to give a basic high level overview on how to form THCA crystals because I think diamonds are a stupid fad. You take potentially good concentrate and crash THCA out just so someone else will pay a premium for an inferior product. Lame.
Maybe people won't pay a premium when the basic approach is more prominent. Literally, the same thing you do to make sugar crystals apply here, just with adjustments to the variables.
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Do an extraction/obtain concentrate. Make sure your concentrate is dewaxed for better results.
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Take concentrate and immerse in large volume of solvent(s). Terpenes work; most are applicable solvents, d-limonene is an economical one. (If you're extract is HIGH level of terpenes, this is why your concentrate "sugars" it's forming micro crystals, naturally, as the terps react/evap)
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The idea is to lower the volume of solvent over time. By doing so, the "like" compounds group together, forming crystals. The size and structure of crystal depends on temperature, solvent, and purity of starting extract. Reaction over time is also a variable, but its a function of all three of the former.
Those are the variables to tune. Keep in mind, you don't necessarily need to apply heat to get to the temperature you want (but most likely, you should shoot for ~110F-130F; the bullseye is in there).
Keep in mind, this is a science experiment. Unless your goal is to create a worse product, or just for curiosity sake, that's about the only justification for this besides trying to charge someone more money for worse product. Unless you're a patient who literally needs 98% purity THCA to address their debilitating illness; all the power to you.
Enjoy.
Edit: LMAO, uh oh, a guy who works at a "lab" and admins the sub tagged my post because his pride is hurt.
I'll wear his tag with pride though, because I have a feeling I know A LOT more about labs and SOPs than most.
Dude, instead of snobbing, let's talk SOPs. A lot of dog shit SOPs out there, how are yours?
Let's talk quality systems. What do you use? Qualtrax?
What do you use for LIMS? LabVantage? LabWare? Core Informatics? Nothing?
You integrated with metrc?
What's your accreditation? ISO 17025? GMP?
What states do you operate in? Oh, you haven't scaled outside of your state. It's cool bro, it's hard. If you need an assist, I'll share my experience, maybe.
What countries do you operate in? Oh, you haven't scaled outside of your country. It's cool bro, it's even harder.
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Taxes.
Doing them, even with turbotax or online services, is like trying to decode a legal textbook without professional help. Every single year I learn about a category i could've cashed in on, or should've tracked in the first place.
Seriously, I'm at the point where I think in 2021, I'm straight up gonna excel document every last thing down I purchase, down to that $3 taco I bought at the food truck for lunch with cash or the metal spoon set i bought at target. Along with: date of purchase, location of purchase, purpose of purchase(?).
Taxes are just wtf man?!....
