Maternal vitamin D deficiency reduces docosahexaenoic acid, placental growth factor and peroxisome proliferator activated receptor gamma levels in the pup brain in a rat model of preeclampsia (Nov 2021) plefa.com/article/S0952-3…
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πŸ‘€︎ u/basmwklz
πŸ“…︎ Nov 16 2021
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The Polymorphisms of the Peroxisome-Proliferator Activated Receptors’ Alfa Gene Modify the Aerobic Training Induced Changes of Cholesterol and Glucose ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/H_Elizabeth111
πŸ“…︎ Mar 30 2021
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Peroxisome Proliferator-Activated Receptors and Caloric Restrictionβ€”Common Pathways Affecting Metabolism, Health, and Longevity mdpi.com/2073-4409/9/7/17…
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πŸ‘€︎ u/basmwklz
πŸ“…︎ Jul 27 2020
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The peroxisome proliferator-activated receptor gamma (PPARΞ³) agonist, rosiglitazone, ameliorates neurofunctional and neuroinflammatory abnormalities in a rat model of Gulf War Illness journals.plos.org/plosone…
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πŸ‘€︎ u/HearTomorrow
πŸ“…︎ Nov 16 2020
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Safflower yellow improves insulin sensitivity in high-fat diet-induced obese mice by promoting peroxisome proliferator-activated receptor-Ξ³2 expression in subcutaneous adipose tissue (2020) pubmed.ncbi.nlm.nih.gov/3…
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πŸ“…︎ Jul 26 2020
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Peroxisome proliferator-activated receptor-Ξ΄ (PPARΞ΄) inhibitor GW501516 enhances running endurance and utilization of fatty acids both alone and in combination with exercise in trained and untrained rodent subjects. nature.com/articles/srep0…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ Oct 02 2015
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A peroxisome proliferator-activated receptor-Ξ΄ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson’s disease [Neuroscience, Jun 2013 β€” free full-text] ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/isosafrole
πŸ“…︎ Dec 05 2013
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Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma.[2014] ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/postemporary
πŸ“…︎ Dec 08 2014
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Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor ... - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/AG_Atanasov
πŸ“…︎ Aug 30 2015
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Peroxisome proliferator-activated receptor gamma (PPARΞ³) coactivator-1 (PGC-1) proteins play a prominent role in skeletal muscle transcriptional reprogramming induced by external stimuli. cell.com/trends/endocrino…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ May 07 2015
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Peroxisome Proliferator-Activated Receptor Ξ³ Controls Ingestive Behavior, Agouti-Related Protein, and Neuropeptide Y mRNA in the Arcuate Hypothalamus jneurosci.org/content/35/…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ Apr 29 2015
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Promising link between selenium and peroxisome proliferator activated receptor gamma in the treatment protocols of obesity as well as depression - (2016) ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/Harown
πŸ“…︎ Mar 13 2016
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Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-Ξ³ coactivator 1Ξ± regulated Ξ²-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models pubmed.ncbi.nlm.nih.gov/2…
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πŸ‘€︎ u/greyuniwave
πŸ“…︎ Dec 20 2020
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If pertussis inhibits alpha-2 adrenergic receptor activity therefore inhibiting adenylyl cyclase activation, then how does this lead to whooping cough?

Cholera leads to the constant activation of adenylyl cyclase, and so does pertussis (by different inhibition mechanisms). I understand how cholera leads to the constant opening of Cl channels, leading to diarrhea since water follows ions out, but how does pertussis lead to whooping cough in this regard?

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πŸ‘€︎ u/babyelephants3
πŸ“…︎ Dec 08 2021
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Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases | Thrombosis Journal thrombosisjournal.biomedc…
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πŸ‘€︎ u/Robert_Larsson
πŸ“…︎ Dec 03 2021
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Structure-guided optimization of light-activated chimeric G-protein coupled receptors biorxiv.org/content/10.11…
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πŸ‘€︎ u/sburgess86
πŸ“…︎ Dec 15 2021
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Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome ncbi.nlm.nih.gov/labs/pmc…
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πŸ‘€︎ u/Robert_Larsson
πŸ“…︎ Nov 29 2021
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Live action shot of Phentolamine knocking out alpha receptors v.redd.it/6k4ug4v08d981
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πŸ‘€︎ u/jennahoot
πŸ“…︎ Jan 03 2022
🚨︎ report
Scientists have discovered that skin cells have olfactory receptors. They activated the cells with a specific scent and found that it increases the rate of proliferation, migration, healing. theconversation.com/your-…
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πŸ‘€︎ u/notscientific
πŸ“…︎ Jul 07 2014
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Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARΞ± signaling pathway [2021] elifesciences.org/article…
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πŸ“…︎ Jan 26 2021
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Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex elifesciences.org/article…
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πŸ‘€︎ u/masterofdasein
πŸ“…︎ Apr 30 2021
🚨︎ report
Something which I learned in my undergraduate degree which I'm sure some stoners would find interesting. When smoked, weed activated the exact same receptors as paracetamol

The only problem is obviously weed is far more broadly acting (also acts on many other receptors), meaning it also gets you high, so it might not the perfect replacement for everyone.

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πŸ‘€︎ u/ITSMEFRANKIE
πŸ“…︎ Jun 27 2021
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Amphetamine and Methylphenidate suppress social play through activation of Alpha-2 Norepinephrine receptors; Alpha-2 antagonists reverse the a-social effect [mouse study] (2014) ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/CytoGuardian
πŸ“…︎ May 10 2019
🚨︎ report
2nd generation antihistamines block histamine receptors and inhibit cytokine release (including TNF-alpha)

https://waojournal.biomedcentral.com/articles/10.1097/WOX.0b013e3182093e19

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πŸ‘€︎ u/Tarragon83
πŸ“…︎ Nov 14 2021
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Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex elifesciences.org/article…
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πŸ‘€︎ u/masterofdasein
πŸ“…︎ Apr 30 2021
🚨︎ report

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