Anyone that knows me would be aware of the fact that I hate sharing personal things on social media… or in any context for the matter. Withstanding that, I’m proud to announce that I’ll be running the Melbourne Marathon this year for the Children’s Medical Research Institute- better knows as ‘Jeans for Genes’… their cultivated slogan that you’d all be aware of from that one day a year where you wear jeans and raise awareness for the cause… but a charity like this deserves more than one day in the limelight per year. This is a charity that helps discover treatments and cures for the 1 in 20 kids facing a birth defect or genetic disease. This includes cancer, cystic fibrosis, thalassemia and other rare conditions. As a child, I was perfectly happy and healthy… I say this because every kid deserves to have this, no one this young should have to battle illness and spend large portions of their childhood in hospital. This marathon was the best way I figured that I could get involved for a cause that I find important, and try to give kids battling today the same opportunity I was lucky to have in life. Link is in my bio to donate, big or small, it all counts, even if you share the link to raise awareness, it’ll all be appreciated. I set a goal of $1000, but I’m confident we can smash that.
Much of the adjuvant squalene attention has focused on proprietary adjuvants AS03, AF03, and MF59. It seems possible that Amyris could forge a supply agreement with one of these adjuvant makers once the manufacturing process has been validated. Note that Eduardo on the last cc stated that:
> "We are in a critical phase of our process development, technology transfer and are planning to scale up -- the scale up to start by the end of this year.”
I wanted to provide an alternative scenario that seems to fit with the Amyris goal of making innovative clean chemistry widely available. A clinical trial was just posted here, which highlights a study designed to assess another squalene-containing adjuvant, SWE. There are a couple of interesting things about this particular study. First, it is being sponsored by the Bill & Melinda Gates Medical Research Institute (and a collaborator Iqvia). Obviously, there is history between Amyris and the Gates foundation going back to the artemisinin work. Second, SWE is an adjuvant developed by the Vaccine Formulation Institute, a Swiss not-for-profit company that specifically formulated SWE to be non-proprietary. Notably, BARDA was partially involved in supporting its development. From their website:
>The development of SWE started with the support of various funders, such as the European Commission, US HHS-BARDA, the German Government Technical Cooperation.
>
>Over the years, SWE was demonstrated safe and effective, both in terms of enabling adjuvanticity and dose-sparing, when included in numerous preclinical vaccine candidates, including against Inactivated Polio Virus, Influenza, Respiratory Syncytial Virus, Rabies, and Group A streptococcus.
Third, the start date for this study is April 14, 2022. This timing falls in line with Eduardo's statement of scaling squalene at the end of the year. Note that the hang-up for SWE as an adjuvant is that it's never been through clinical trials. So validation of its safety and effectiveness in this context will open a huge opportunity for adjuvanted vaccines in regions of the world that are unable to afford proprietary adjuvants from big pharma players. This seems like the perfect opportunity for Amyris to expand the adjuvant squalene market without closing doors on additional partnerships with more mainstream adjuvant makers.
https://preview.redd.it/pkr
... keep reading on reddit ➡Initial focus of the collaboration is to improve infectious disease readiness through surveillance and clinical diagnostic validation activities for COVISTIX/COVITRACK Diagnostic Tests and COVIDROPS/COVI-AMG neutralizing antibody treatments for COVID-19 patients.
Please sign this petition to help these internationally-recognised researchers and dedicated students continue their research toward understanding the brain and furthering treatment options for diseases like Parkinson’s, Alzheimer’s and many more.
https://www.change.org/p/anu-students-protect-neuroscience-at-the-anu-dbbdf435-fc02-48d7-9561-c42fa9d9b637?recruiter=1030649510&utm_source=share_petition&utm_medium=facebook&utm_campaign=psf_combo_share_initial&utm_term=share_email_responsive&recruited_by_id=f7dc84a0-2496-11ea-904a-79442f573d52&utm_content=fht-27905499-en-au%3A0
