A requirement of serotonergic p38[alpha] mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors - Peripheral inflammation and the brain nature.com/tp/journal/v5/…
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πŸ‘€︎ u/burtzev
πŸ“…︎ Nov 06 2015
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So Mitogen-activated protein kinase and protein kinase A walk into a nucleus:

The nucleus says to them "you guys have come a long way from that axon terminal, how'd you find your way here?" Protein kinase A says "well, it would have been tough, but luckily I brought a MAP."

^^I'm ^^sorry.

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πŸ‘€︎ u/imafryingpan
πŸ“…︎ Oct 26 2013
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Abstract of article: A requirement of serotonergic p38[alpha] mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors - Peripheral inflammation and the brain nature.com/tp/journal/v5/…
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πŸ‘€︎ u/burtzev
πŸ“…︎ Nov 06 2015
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[J] [RWS: Biomarkers: hsp27 and p38 mitogen-activated protein kinase (p38MAPK)] [Brain Zapping] 'Effect of 3G cell phone exposure with computer controlled 2-D stepper motor on non-thermal activation of the hsp27/p38MAPK stress pathway in rat brain.' ncbi.nlm.nih.gov/pubmed/2…
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πŸ“…︎ Mar 06 2016
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A requirement of serotonergic p38[alpha] mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors - Peripheral inflammation and the brain nature.com/tp/journal/v5/…
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πŸ‘€︎ u/burtzev
πŸ“…︎ Nov 06 2015
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A requirement of serotonergic p38[alpha] mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors - Peripheral inflammation and the brain nature.com/tp/journal/v5/…
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πŸ‘€︎ u/burtzev
πŸ“…︎ Nov 06 2015
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[Request] The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease

Title: The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease

Authors: Zhu X, Lee H-G, Raina AK, Perry G, Smith MA

Link: http://www.karger.com/Article/FullText/67426

Thank you in advance!

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πŸ‘€︎ u/mj1v1
πŸ“…︎ Feb 09 2013
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AMPK Pathway Activation | AMP-Activated Protein Kinase [2019]: GREAT VIDEO on AMPK & Supplements youtube.com/watch?v=G-3vA…
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πŸ‘€︎ u/JuniorCreator
πŸ“…︎ Feb 27 2020
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Resveratrol Up-regulates AMPA Receptor Expression via AMP-activated protein kinase ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/Disturbed83
πŸ“…︎ Feb 18 2019
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Ketogenic diet delays the phase of circadian rhythms and does not affect AMP-activated protein kinase (AMPK) in mouse liver. ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ Sep 29 2015
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Amino acids regulate energy utilization through mammalian target of rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway in porcine enterocytes. - March 2020

https://www.ncbi.nlm.nih.gov/pubmed/32211535 ; https://www.sciencedirect.com/science/article/pii/S2405654519301970?via%3Dihub

Xiao H1,2, Zha C1, Shao F3, Wang L1, Tan B2,4.

Abstract

As major fuels for the small intestinal mucosa, dietary amino acids (AA) are catabolized in the mitochondria and serve as sources of energy production. The present study was conducted to investigate AA metabolism that supply cell energy and the underlying signaling pathways in porcine enterocytes. Intestinal porcine epithelial cells (IPEC-J2) were treated with different concentrations of AA, inhibitor, or agonist of mammalian target of rapamycin complex 1 (mTORC1) and adenosine monophosphate activated protein kinase (AMPK), and mitochondrial respiration was monitored. The results showed that AA treatments resulted in enhanced mitochondrial respiration, increased intracellular content of pyruvic acid and lactic acid, and increased hormone-sensitive lipase mRNA expression. Meanwhile, decreased citrate synthase, isocitrate dehydrogenase alpha, and carnitine palmitoyltransferase 1 mRNA expression were also observed. We found that AA treatments increased the protein levels of phosphorylated mammalian target of rapamycin (p-mTOR), phosphorylated-p70 ribosomal protein S6 kinase, and phosphorylated-4E-binding protein 1. What is more, the protein levels of phosphorylated AMPK Ξ± (p-AMPKΞ±) and nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase sirtuin-1 (SIRT1) were decreased by AA treatments in a time depending manner. Mitochondrial bioenergetics and the production of tricarboxylic acid cycle intermediates were decreased upon inhibition of mTORC1 or AMPK. Moreover, AMPK activation could up-regulate the mRNA expressions of inhibitor of nuclear factor kappa-B kinase subunit beta (IkbkΞ²), integrin-linked p

... keep reading on reddit ➑

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πŸ‘€︎ u/Ricosss
πŸ“…︎ Mar 27 2020
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Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5β€² adenosine monophosphate-activated protein kinase pathway sciencedirect.com/science…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ Aug 22 2015
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Resveratrol Up-regulates AMPA Receptor Expression via AMP-activated protein kinase - mediated Protein Translation (2015) ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/FW900
πŸ“…︎ Mar 22 2015
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Ketogenic diet delays the phase of circadian rhythms and does not affect AMP-activated protein kinase (AMPK) in mouse liver. ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ Sep 29 2015
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l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. (2018) ncbi.nlm.nih.gov/pubmed/3…
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πŸ‘€︎ u/superaromatic
πŸ“…︎ Oct 10 2018
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Ketogenic diet delays the phase of circadian rhythms and does not affect AMP-activated protein kinase (AMPK) in mouse liver. - PubMed - NCBI

http://www.ncbi.nlm.nih.gov/pubmed/26408964

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πŸ‘€︎ u/hastasiempre
πŸ“…︎ Sep 29 2015
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[Scientific Studies] Cholinesterase Inhibitor Donepezil Increases Mitochondrial Biogenesis through AMP-Activated Protein Kinase in the Hippocampus (2016) ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/flagrantpinwheel
πŸ“…︎ Dec 29 2016
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Adenosine monophosphate-activated protein kinase activation mediates the leptin-induced attenuation of cognitive impairment in a streptozotocin-induced rat model spandidos-publications.co…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ May 29 2015
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Obesity impairs skeletal muscle regeneration via inhibition of AMP-activated protein kinase ncbi.nlm.nih.gov/pubmed/2…
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πŸ‘€︎ u/dustofoblivion123
πŸ“…︎ Nov 25 2015
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5' AMP-activated protein kinase (or AMPK, or AMPKΞ±) and why we should care about it.

Full name 5' adenosine monophosphate-activated protein kinase is an enzyme that popped up a lot when I was looking into acetic acid (e.g. [1], [2]). I'm not going to pretend that I know how to analyse this stuff, I'm not a biochemist or even have proper training in medicine, but what I do know for sure is that this enzyme appears a lot when catabolism is involved, and not just for acetic acid.

For example:

Glucagon Activates the AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Pathway in Adipocytes: http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/995.4

AMPK is the target of Metformin, the most popular anti-diabetic drug: http://circres.ahajournals.org/content/100/3/328.short

Leptin stimulates fatty-acid oxidation by activating AMPK: http://www.nature.com/nature/journal/v415/n6869/abs/415339a.html

Insulin directly affects AMPK in fat: http://www.biovision.com/signaling-pathways-1864/ampk-insulin-and-leptin-signaling-1874

That last implication should ring a lot of bells in our community. Basically all the famous hormones we're talking about are involved in the stimulation or inhibition of AMPK.

PS! Consider this as a "wow, look what I found" note and not a proper biochemistry post. Feel free to make new proper ketoscience posts on it.

User /u/callesen58 was very helpful in a subthread of the vinegar post and he theorized that it may be the acidity itself that does the work and not the type of acid, even though there is evidence that at least in digestion in isolation, that might not be true.

Most generic literature on the enzyme appears to suggest that it's activated when the AMP:ATP ratio changes. I do not know if that's the only way or one of the ways. It appears to make perfect sense when it's done naturally via exercise/hard work, ATP is simply used up.

What is also certain though is that the enzyme appears to be very involved in overall body catabolism when it's activated. And while it is possible that might not be true in all parts of the body, it is almost certain that remedies like stimulati

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πŸ‘€︎ u/ZeroCarb
πŸ“…︎ Jan 19 2015
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