Could someone please give me a full break down of this it makes no sense to me. Thanks
The principle: http://en.wikipedia.org/wiki/Hardy-Weinberg_principle
Racists likes this old story: http://en.wikipedia.org/wiki/Disappearing_blonde_gene
Could the story happen or be proven? And in the end, could any recessive gene disappear?
This is for a peer-reviewed paper for my graduate study.
Because I have no idea what I'm looking at anymore.
Hi All, Need some help I'm super confused. I just read the post about violating rules etc - I really hope I'm not violating any rule since it's my second time posting here and I'm new to reddit etc. If I am violating, please just PM me and I'll take this down. thanks.
Here's the question:
An autosomal recessive affects 1 in 40,000 of the general population. The mom is a carrier. The father is unknown.
how do we figure out the probability of the child having the disease?
can someone please explain how they worked through this? apparently it's 1/2 x 1/100 x 1/2 = 1/400 and I'm not sure why we're multiplying by 1/2..
isn't the odds of having a child who is affected 1/4 ? (25% in an autosomal recessive disease)?
thanks!
I understand the concept. But I think my terrible math skills aren’t letting me understand the math and reach to the right answer on Uworld or nbmes. Can someone please help me with this? Thank you.
Hi everyone,
Literally I suck in that topic, every qs that I have that equation I feel in nowhere. How can I really learn and solving that type of qs
And which is usually not valid?
Why in a rare autosomal recessive disorder p is approximate to 1? and the Carrier frequency is 2q instead of 2pq?
https://preview.redd.it/1su1d5n5xsf71.jpg?width=986&format=pjpg&auto=webp&s=1f7f942d1e44a162390ebb96ab3423e26dd0218f
hey guys, quick question. is there any need to study hardy weinberg stuff for biostats step 3?
Taking an exam today in one hour... I can Venmo anyone $50 for a passing grade. No jokes. No tricks. This is real
For evolution NOT to occur,
- The population must be large (why? I initially thought it was to reduce the effect of mutations, but another condition is that no mutations occur)
2/3) Mating is random AND none of the characteristics have a selective advantage- are these not essentially the same point? Evolution occurs because of the fact mating is not random due to advantages that alleles give in the phenotype.
- Generations do not overlap- I can't see why this would be a problem in preventing evolution, as surely if the allele frequency was the same in every generation, there would be no problem in mixing.
Any help would be really appreciated, thanks!
Yes? Really? Am I right? Anyway I’ll keep struggling. Best of luck to everyone ✌🏽
I have no idea why I'm tearing my hair out so much over this one- I haven't even reviewed biostats or genetics yet so I might be completely off base, but this is driving me crazy. I got the right answer by another route, but only because the one I was looking for wasn't an option.
>In a clinical study of a molecular variant hypothesized to be related to schizophrenia, 200 subjects are examined for a particular single nucleotide polymorphism.
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>Genotype AA : 50 subjects
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>Genotype AG: 80 subjects
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>Genotype GG: 70 subjects
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>If A is one allele and G is the other, which of the following is the frequency of allele A?
The answer is 180/400 (every subject has two alleles so 400 total, AA subjects have two A alleles, AG subjects have 80)
But shouldn't you be able to get at this through the Hardy-Weinberg equation? Shouldn't the frequency of allele A just be the square root of 50/200?
Just learning and stumped on a question!
Rare AR disease affects 1 in 40,000; mother is a carrier, father is random sperm donor with no personal or family history of the disease, carrier status unknown. Probability of having an affected child?
I got q=1/100 and since in rare AR diseases p~1, 2pq=1/200, which is the probability of a random person being a carrier. Now this is where I messed up, since the question didnt mention that he had the disease, I assumed he didnt and in my calculations, I used 2/3 as the probability of him passing on the diseased allele. Since he cant be homozygous for the mutant allele, so he's either hetero carrier or homo for normal allele
1/2 (mother) x 1/100 x 2/3 (random sperm donor) = 2/300 [my answer]
1/2 x 1/100 x 1/2 = 1/400 [correct answer]
My question is, should I not have assumed that the patient is normal? Because there was another question about inheritance in cystic fibrosis and in that question they assumed the mother was not homozygous for mutant alleles because she wasnt affected by CF and the chance of her being a carrier was 2/3.
Edit: forgot to mention, in the CF question, the mothers sister had CF, so it was assumed that her parents were heterozygous carriers.
Hi guys, I tend to score pretty poorly on questions that tackle stuff about chance of transmission of disease and using the Hardy Weinberg equation, most of my mistakes in UWSA1 and NBME are consistently in them, regardless of how many times I go over the concept. Is there an effective resource to help in these concepts? Would be much obliged, thankyou!
How do I calculate genotype frequency in Hardy Weinberg Equation? I am NOT understanding the mathematical side of genetics.
This is my teacher’s question:
“genotype frequencies can be calculated using the HW model of (p+q) (p+q) = P^2 + 2PQ+ Q^2 = 1. If the frequency of the “p” allele is .2 what is the frequency of the “q” allele? What would be the expected genotype frequency of the heterozygote in this population?”
My guess is that the q allele would be .8 because p+q=1 but I have no idea what the genotype frequency would be.
Fun, fun, fun.
Any help would be massively appreciated and I’ll be very impressed by those of you who actually understand this side to evolution. Because I’m super lost.
Hello people smarter than me!
Q: Disease B is characterized by excessive bleeding. Disease B overwhelmingly affects males with an incidence of approximately 1 out of 4900 births. Estimate the frequency of carriers of Disease B in the population.
I know that the frequency of carriers is 2PQ. It seems to me what disease B is X-linked recessive, so do carriers have to be female? If so, do I have to multiple 2PQ by 1/2 to factor in that 1/2 of the population is female and that males cannot be carriers?
Thanks!
https://preview.redd.it/oo7yihrjyol61.png?width=768&format=png&auto=webp&s=d721a2cb598589ab6f19abc500feddef4f99adbc
For the F gene, the predicted frequency is 0.2116 + 0.4876 + 0.2809 = 0.9801... The observed frequency is 0.34 + 0.25 + 0.41 = 1.
I checked the answer on my worksheet and it said this:
