Friedel Crafts Reaction Puns

It would be great if it is explained like in 2 parts for acylation and alkylation if there are any differences at all.

Can someone help with this? Thanks a lot :)

https://preview.redd.it/q712kpmlhi151.jpg?width=2048&format=pjpg&auto=webp&s=efd59c67bbee1eca4bf953b360904c93fbf219f9

The direct Friedel‐Crafts‐type coupling and dedinitrogenation reactions of vinyldiazo compounds with aromatic compounds using a metal‐free strategy are described. This acid‐catalyzed methodology is efficient for the formation of α‐diazo‐β‐carbocations (vinyldiazonium ions), vinyl carbocations, and allylic or homoallylic carbocation species via vinyldiazo compounds. By choosing suitable nucleophilic reagents to selectively capture these intermediates, both trisubstituted α,β‐unsaturated esters, β‐indole‐substituted diazo esters, and dienes are obtained in good to high yields and selectivities. Experimental insights implicate a reaction mechanism involving the selective protonation of vinyldiazo compounds and the subsequent release of dinitrogen to form vinyl cations that undergo intramolecular 1,3‐ and 1,4‐ hydride transfer processes as well as fragmentation.

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https://imgur.com/EK2DO3q

Based on the reagent used in this reaction, it is a Friedel Crafts Acylation reaction but what would be the mechanism in order to get to the product?

If you wanted say to use (CH3)3COH and H2SO4 to add a tert butyl group to benzene, wouldn't it be necessary to have water as a solvent for the Sulphuric acid?

Am I missing something fundamental?

I am having some trouble in the following question.
In Friedel Craft reaction, I know that the Electrophile will attack the ring. In the option D, during resonance, +charge will resonate through the ring. However the answer given is c in the answer key. How is it so?

https://preview.redd.it/1ohwnh919ia21.jpg?width=1597&format=pjpg&auto=webp&s=3e523bb3e48c94064a3e7e1ca652b2286694ad37

While practicing for an organic quiz, I came across a reaction that involved a Friedel-Craft reaction after bromination of a benzene ring. In the answer book, they used aluminum chloride and chloromethane to attach a methyl group. I was wondering if using aluminum bromide and bromomethane was a viable option as to stick with bromine and not switch back and forth between bromine and chlorine?

https://preview.redd.it/2fjyltkuead11.png?width=1224&format=png&auto=webp&s=2dc1e95cf625bd85d700fe3c043dae7012b5af4b

It's not homework but I was hoping you could help. I can always go see the TA on Tuesday but it'd be nice to have it for the long weekend. Thanks for your help!

I'm talking about allylbenzene from benzene. He doesn't go into any detail.

Sorry if it's a stupid question.

Hi all, I would like to ask about the friedel-crafts alkylation of aryl halides with CH3Cl(to generate the carbocation) and AlCl3 anhydrous. My teacher claims that this reaction would occur slowly due to AlCl3 being a Lewis acid and interacting with the halide group. My question is if this is actually what happens in real life? As I have tried searching for literature on this but did not manage to find anything about this. (Note: sorry if this violates any rules:( )

http://onlinelibrary.wiley.com/doi/10.1002/chin.200620115/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+17+March+from+10-14+GMT+%2806-10+EDT%29+for+essential+maintenance&userIsAuthenticated=false&deniedAccessCustomisedMessage=

So my thought was using something like SOCl2 + D-Alanine and then reacting the resulting D-Choloroalanine with AlCl3 and a Benzene to yield pure D-Amphetamine.

However I believe to read somewhere that the Alanine undergoes a racemisation during the process.

Whta are Your opinions?

Is this possible and is it possible to yield (more or less) pure D-Amph?

Edit: (R or S) 1 Lactic acid could be another approach, given the chlorination happens at the carboxyl acid. The amination should be easy afterwards if my memory isn't mistaken.

1 ( Given if the substituted amine keeps the position or switches to the opposite R or S )

Edit2: Things like fumaric acid may also be used if You are sure how and when to remove the Carboxylic acid.

Consider a Friedels Craft Acylation as well if the amine is at the 4th position. However I heard it tends towards polyerization (?) I'm not sure

Edit: a related Hive discussion

https://the-hive.archive.erowid.org/forum/showflat.pl?static=1&Cat=&Number=395607

and Science Madness

http://www.sciencemadness.org/talk/viewthread.php?tid=92162

Wiki entry:

https://en.wikipedia.org/wiki/Hell%E2%80%93Volhard%E2%80%93Zelinsky_halogenation

How do I calculate the theoretical yield for both acetylferrocene and diacetylferrocene that results from the friedel-crafts acetylation reaction of ferrocene?

I understand that I need 1 part acetyl chloride per 1 part ferrocene to create 1 part of acetyl ferrocene. (2 parts acetyl chloride if I need to create diacetylferrocene)

Does the diacetylferrocene theoretically form if acetyl chloride is the limiting reactant?

Does diacetylferrocene ever become the dominant reactant formed, in the case that there is more than enough acetyl chloride?

Any help would be appreciated! Thank you :)

**edit: mistake in question: changed percentage yield to theoretical yield.

I’m reactions benzoyl chloride with 4-chloroaniline with ZnCl2 catalyst in DCM at 0C. How long should that stir in the flask? Afterwards I’m going to stir the product mixture in some moderately acidic water, as per a video I’m using to base my reaction off. If that last step sounds familiar, how long should I stir that? Or, just share experiences with Friedel-Crafts acylations! Thanks

Can I use a lewis acid and an electrophile that have different halogens? For example, bromomethane and AlCl3?

if the acid halide is chloride can I use aluminum bromide instead of aluminum chloride.

Am I crazy or is this possible? And if so, what effect does it have on the yield? Thanks for any replies.

What would happen if you did a Friedel Crafts Alkylation on a ring that already has a chlorine? I think that the chlorine from the Cl-AlCl3 would grab the Cl on the end of the chain, leaving a carbocation at its spot... and then the ring would close by the pi system attacking the carbocation (nucleophile). But I'm not sure if

1. it's possible
2. how the second methyl would form

Here is what I mean

https://preview.redd.it/otn920g02i461.png?width=382&format=png&auto=webp&s=2167b2037a4fb2f5ade97b196d6ba185c6d76ebb