I was doing some research on dawn phenomenon and came across this article. I can't find much else related to this research, but it got me wondering... so I might do a Tim Ferriss test on myself since DP affects me significantly.

I don't have access to methscopolamine bromide but could try one of two things:

1) behind-the-ear scopolamine anti-nausea patch before bed

2) 25 mg of Benadryl before bed

3) 50 mg of Benadryl before bed

Has anyone else seen relevant research on this? I'm going to run it by my endo next time I see him but would love input from this community.

Here's some further reading, if you're interested: 10.1177/154405910508400703

I'm aware that anticholinergics have their place and purpose. It's equally unmysterious that we've likely all taken them at some point (for those without context, anticholinergics span a pretty diverse range of drugs and supplements, including anxiolytics, sleep aids, and antihistamines). But I've just spent the past hour tumbling down an internet rabbit hole about the theoretical (and apparently even causal links) between regular use of anticholinergics and future Alzheimer's/Dementia. It suffices to say that I got spooked enough to go search for a list of anticholinergic substances, to know what to avoid. My fruitless quest for such a list brought me here. I know of some of the OTC and prescription drugs that are anticholinergic, but I'm reliably uneducated about them in the biohacking circles.

Anyone know of some of the major anticholinergics circulating the Nootropics and supplement communities? A list would be better. If I'm lucky enough to make it to my 60s, I'd prefer to spend them lucid, not wandering aimlessly in the produce section of a Ralphs.

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

https://www.mdpi.com/1420-3049/26/19/5914/htm

Some highlights in no particular order:

> "Among the substances investigated, the essential oils of Myristica fragrans (nutmeg), Heracleum transcaucasicum, Heracleum anisactis, Anethum graveolens (dill), Apium nodiflorum, Petroselinum crispum (parsley), Pycnocycla bashagardiana and Piper sarmentosum, all containing high concentrations of myristicin, ranging between 12% and 96% of the composition, are noteworthy. "
>
>" An interesting publication discusses the anticonvulsant and inhibitory effects on glial activation of Myristica fragrans (nutmeg) extract. This material, containing about 11% myristicin, was tested in male NMRI rats that were induced to have seizures. Behavioral studies have shown that pretreatment with nutmeg extract effectively reduced seizure behavior, decreased cell death in the hypothalamus and improved glial activation [71]. "
>
>" A publication on the aqueous extract of the aerial part of parsley (Petroselinum crispum) sought to investigate the antihypertensive activity of the plant. In vivo studies were performed with male albino rats, and an in vitro study used isolated thoracic aorta rings. The results show a potent vasorelaxant activity in aortic vascular rings, while in animals the extract induced a decrease in blood pressure parameters. More detailed studies showed that there was a blockage of calcium channels present in the vascular wall, but also suggest that other pathways may be involved in the antihypertensive effect such as, for example, increased nitric oxide synthesis [67].
>
>The ability of myristicin to protect neurons from hypoxia-induced injuries was investigated. To conduct these assays, rat dorsal root ganglion (DRG) neurons were used. The results showed that myristicin reduced the viability of neurons when exposed to concentrations greater than 50 mM. However, at lower concentrations, it significantly increased cell viability in neurons when exposed to hypoxia, as it protected against hypoxic injury, not causing apoptosis. Complementary trials showed that myristicin decreased cleaved caspase-3 and bcl-2 levels in these hypoxia-induced neurons. Therefore, it was observed that it can reverse hypoxia-induced apopto

Increasing dopamine without tolerance or addiction:

Hey guys. I've been hoarding all this information for the past year, and I think it's time I release it to the public. Bromantane and ALCAR are some of the most promising dopaminergics on the market, and this post will explain why.

For those of you confused about dopamine:

To put it simply, it's the motivating neurotransmitter. And this bleeds into things such as optimism, confidence, social interaction, mood, learning etc. It would take 10 posts to go over everything dopamine does, so hopefully you accept the generalization.

Here's a simplified version of the dopamine/ CREB cascade:

Dopamine --> D1 activation --> Adenylate Cyclase --> Cyclic Adenosine Monophosphate (cAMP) production --> Protein Kinase A --> CREB (key factor in learning and memory) --> (ΔFosB --> inhibits C-Fos), Dynorphin (inhibits dopamine release), (Tyrosine Hydroxylase activation --> more dopamine), and so much more.

Your idea of dopamine receptor upregulation may be wrong.

So many things are said to "upregulate dopamine receptors", but what does that truly mean? Well it's not so simple. Usually receptor upregulation just hints at temporarily lowered neurotransmitter causing increased sensitivity to maintain homeostasis. So keep that in mind when discussing Uridine. This source for instance. Or Sulbutiamine. So besides Uridine being GABAergic, that has to be part of Nootropic Depot's motivation to include it in the sleep support stack. Reviews are mixed, but I felt sedated by Uridine Monophosphate.

Cocaine upregulates dopamine receptors. And I'll reference this study later. But basically the transition of CREB to ΔFosB and Dynorphin, leading to a depletion of CREB and dopamine is evidence of tolerance to cocaine. So looking at receptors alone is SIMPLISTIC, especially when you consider the inhibitory role of D2 receptors which people here misconceive to be a good thing. It's almost as simplistic as assuming Tyrosine Hydroxylase upregulation is why Bromantane is so great, which is one of many misconceptions I had in the past. It's the mechanism that makes it great, not just downstream activity.

And by

Anticholinergic drugs are among the most widely prescribed class of drugs today, used in the treatment of conditions from motion sickness to psychosis. Of the two 200 most prescribed drugs, a significant portion of them are Anticholinergic. I have limited the following studies to within the last two years, honestly because it was too depressing to dig any deeper.

Do Anticholinergic drugs cause dementia?:

Anticholinergic Drug Exposure and the Risk of DementiaA Nested Case-Control Study > There were significant increases in dementia risk for the anticholinergic antidepressants (adjusted OR [AOR], 1.29; 95% CI, 1.24-1.34), antiparkinson drugs (AOR, 1.52; 95% CI, 1.16-2.00), antipsychotics (AOR, 1.70; 95% CI, 1.53-1.90), bladder antimuscarinic drugs (AOR, 1.65; 95% CI, 1.56-1.75), and antiepileptic drugs (AOR, 1.39; 95% CI, 1.22-1.57) all for more than 1095 TSDDs.

Increased risk of incident dementia following use of anticholinergic agents: A systematic literature review and meta-analysis >Anticholinergic use for ≥3 months increased the risk of dementia on average by an estimated 46% versus nonuse. This relationship was consistent in studies assessing overactive bladder medications. The risk of developing dementia should be carefully considered in the context of potential benefit before prescribing anticholinergics.

Dose response relationship of cumulative anticholinergic exposure with incident dementia: validation study of Korean anticholinergic burden scale >This study confirmed the dose response relationship for cumulative anticholinergic burden measured using the Korean specific anticholinergic burden scale with incident dementia.

Anticholinergic drugs and the risk of dementia: A systematic review and meta-analysis >After pooling fourteen longitudinal and case-control studies with a total of 1,564,181 subjects, anticholinergic drug use was associated with an increased risk of all-cause dementia and Alzheimer's disease. Both low and high anticholinergic drug burdens were associated with dementia. Moreover, there was a dose-dependent relationship between anticholinergic drugs and risk of dementia. With respect to the categories of anticholinergic drugs, antiparkinson,

Do your worst!

I'm surprised it hasn't decade.

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

It really does, I swear!

They’re on standbi

Related Series:

Are Psychiatric drugs driving the incidence of neurodevelopmental conditions and falling fertility rates?

Are Psychiatric drugs driving dementia rates?

How effective are our current treatments for depression?

Divergent Outcomes in Cognitive-Behavioral Therapy and Pharmacotherapy for Adult Depression

>Cognitive-behavioral therapy (CBT) and pharmacotherapy are, on average, equally and moderately efficacious acute-phase treatments for unipolar depression. For example, 50%−60% of patients receiving CBT or pharmacotherapy for depression respond, compared with 40% receiving pill placebo, and the average CBT or pharmacotherapy patient has posttreatment symptom levels roughly 0.3 SD below those of patients receiving pill placebo. However, these favorable averages may obscure some patients’ negative outcomes. Moreover, beyond conventionally defined response (≥50% symptom reduction) and remission (posttreatment scores ≤7 on the Hamilton Depression Rating Scale [HAM-D]), only patients with unusually positive outcomes have no residual symptoms with attendant dysfunction.

>Perhaps 5%−10% of psychotherapy patients show reliable deterioration (increases exceeding the symptom measure’s reliable change threshold), with evidence of higher risk among children than adults, in routine practice compared with randomized clinical trials, and in psychotherapy considered more broadly than CBT specifically.

>“Reliable deterioration” was an increase meeting the p<0.05, two-tailed, change threshold of ≥8 points on the HAM-D (28) or ≥9 points on the BDI (29).

This found 40% of people have no response to CBT. If we subtract placebo [no treatment] from the "response" group, we find that CBT provides a demonstrable effect for only 20% of all patients. The average symptom decrease is relatively small for those who do respond. Among the non responders 5-10% are significantly harmed by "treatment". Significantly harmed means a catastrophic increase in symptom severity.

Depression: How effective are antidepressants?

>The various antidepressants have been compared i

Pilot on me!!

Nothing, he was gladiator.

Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.

This sub is mostly just NSFW puns now.

If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.

Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.

When I got home, they were still there.

What did 0 say to 8 ?

" Nice Belt "

So What did 3 say to 8 ?

" Hey, you two stop making out "

I won't be doing that today!

[Removed]

Not interested in trying Deliriant’s, I’d rather die. Was just curious if there are any know rc’s with Deliriant property’s?

This morning, my 4 year old daughter.

Daughter: I'm hungry

Me: nerves building, smile widening

Me: Hi hungry, I'm dad.

She had no idea what was going on but I finally did it.

Thank you all for listening.

Where ever you left it 🤷‍♀️🤭

There hasn't been a post all year!

You take away their little brooms

It was about a weak back.

Hi Everyone,

Most of the people who dwell on this subreddit likely do not remember who I am but I used to contribute quite frequently to the efforts on how to go about treating HPPD and would often post large lists of medications and personal experiences with those medications, how they'd affect me, and recommendations.

Since then, I've been still experimenting with various other compounds in order to better improve symptoms of HPPD which I acquired in the middle of 2019 due to a Serotonin Syndrome drug experience. Thankfully I've found something that works and I've been sticking to that regimen ever since and have seen a complete elimination of all my symptoms.

This won't be a low quality post, I'm going to go over exactly the mental decisions that lead me to pick each one of these medications/supplements to my regimen to help keep the symptoms of HPPD at bay and eliminate them mostly from affecting how I live my life.

Morning:

2mg Rexulti (Brexipiprazole) ; Alternative is Lurasidone OR Aripiprazole if you don't have good insurance // The rexulti provides mood stabilization when taken with a stimulant such as concerta and really helps elevate both mood and inspiration in doing things, additionally in comparison to other antipsychotics such as Olanzapine or Seroquel it has almost no side effects minus slight weight gain if you don't watch your eating habits.

27mg Methylphenidate (Concerta XR) // This stimulant I've found to have little to no detrimental effects on HPPD symptoms, if anything it helps me be more productive, think about my problems just a little bit less, and focus more on getting better at the things I do (work, exercise, personal relationships)

PQQ Disodium // This is a supplement however it has very potent free-radical scavenging capability and has demonstrated some efficacy as an anti-parkinsonian agent, can help elevate dopamine levels and raise endogenous protective factors. Additionally it's a great cellular mitochondrial improvement agent, cannot recommend it enough.

Eutropoflavin (4'-Dimethylamino-7,8-dihydroxyflavone) // This is a BDNF mimic that you can find easily on some nootropic websites. Amazing boost to memory recall, emotional stability, and towards my depression. The only negative I have to say about Eutropoflavin is that it causes hair loss which I can say does happen.

Night:

30 mg Remeron (Mirtazapine) // **This is a sleep aid/antidepressant that acts as a potent histamine and ser

Why

It’s pronounced “Noel.”

After all his first name is No-vac

I was doing some research on dawn phenomenon and came across this article. I can't find much else related to this research, but it got me wondering... so I might do a Tim Ferriss test on myself since DP affects me significantly.

I don't have access to methscopolamine bromide but could try one of two things:

1) behind-the-ear scopolamine anti-nausea patch before bed

2) 25 mg of Benadryl before bed

3) 50 mg of Benadryl before bed

Has anyone else seen relevant research on this? I'm going to run it by my endo next time I see him but would love input from this community.

Edit: Linked article above!